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1- (1- ( (3, 3-Diphenylpropyl) (methyl)amino)-2-methylpropan-2-yl)-5- (methoxycarbonyl)-2, 6-dimethyl-4- (3-nitrophenyl)-1, 4-dihydropyridine-3-carboxylic Acid is an impurity of Lercanidipine (HCl: L179000), a long acting calcium antagonist that causes systemic vasodilation, and is used to treat patients with hypertension. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C36H41N3O6, Molecular Weight: 611.73. US Biological Life Sciences.
Rabeprazole impurity. A degradation product formed in stressed tablets of Rabeprazole sodium. Group: Biochemicals. Alternative Names: 1-(1H-Benzimidazol-2-yl)-1,4-dihydro-3-methyl-4-oxo-2-pyridinecarboxylic Acid; Rabeprazole Related Compound A (USP); Rabeprazole EP Impurity C. Grades: Highly Purified. CAS No. 1163685-30-0. Pack Sizes: 1mg. Molecular Formula: C??H??N?O?, Molecular Weight: 269.26. US Biological Life Sciences.
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1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid Sodium Salt
1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid is an impurity of Rabeprazole. It is also a degradation product formed in stressed tablets of Rabeprazole sodium. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C14H10N3NaO3. US Biological Life Sciences.
Worldwide
1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid Sodium Salt
1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid Sodium Salt. Uses: For analytical and research use. Group: Impurity standards. Catalog: APS00161. Format: Neat.
2-((2-Azidoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid Diethyl Ester is an intermediate in the synthesis of Amlodipine Besilate (A633500) related compounds. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 500mg. Molecular Formula: C21H25ClN4O5. US Biological Life Sciences.
3-ethyl 5-isopropyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate is an impurity of Amlodipine. Amlodipine is a long-acting dihydropyridine L-type calcium channel blocker. Amlodipine is used to lower blood pressure and prevent chest pain. Synonyms: 3-Ethyl 5-isopropyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate. CAS No. 158151-92-9. Molecular formula: C22H29ClN2O5. Mole weight: 436.93.
An impurity of Amlodipine. Amlodipine is a long-acting dihydropyridine L-type calcium channel blocker. Amlodipine is used to lower blood pressure and prevent chest pain. CAS No. 2170716-02-4. Molecular formula: C22H29ClN2O5. Mole weight: 436.93.
A dihydropyridine. Group: Biochemicals. Alternative Names: 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
bis(2-cyanoethyl)4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate is an impurity of clevidipine, a dihydropyridine calcium channel blocker used as an oral antihypertensive drug. Synonyms: Bis(2-cyanoethyl)4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate. CAS No. 175688-79-6. Molecular formula: C21H19Cl2N3O4. Mole weight: 448.30.
A structurally novel activator of SIRT1 (EC150=1uM). Displays selectivity over SIRT2 and 3 (EC150=25 and 50uM respectively). Cell permeable. Group: Biochemicals. Alternative Names: N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
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Carbonylhydrido[6-(di-t-butylphosphinomethylene)-2-(N,N-diethylaminomethyl)-1,6-dihydropyridine]ruthenium(II), min. 98% Milstein Catalyst
Ruthenium catalyst for the direct synthesis of amides from alcohols and primary amines. Ruthenium catalyst for the hydrogenation of esters in high yields under mild pressure and neutral conditions. Ruthenium catalyst for the dehydrogenative coupling of alcohols to form esters in high yields under neutral conditions. Ruthenium catalyst for the synthesis of amides from esters and amines with liberation of hydrogen gas. Ruthenium catalyst for the hydrogenation of 3-methyl-2-oxalidinone. Group: Ruthenium series catalysts. Alternative Names: 863971-63-5; Carbonylhydrido[6-(di-t-butylphosphinomethylene)-2-(N, N-diethylaminomethyl)-1, 6-dihydropyridine]ruthenium(II); DTXSID40856225; Ruthenium(2+) hydride (2E)-2-[ (di-tert-butylphosphanyl)methylidene]-6-[ (diethylamino)methyl]-2H-pyridin-1-ide--carbon monooxide (1/1/1/1). CAS No. 863971-63-5. Molecular formula: C20H35N2OPRu. Mole weight: 451.557g/mol. IUPACName: carbon monoxide; N-[[(6E)-6-(ditert-butylphosphanylmethylidene)pyridin-1-id-2-yl]methyl]-N-ethylethanamine; hydride; ruthenium(2+). Canonical SMILES: [H-]. CCN (CC)CC1=CC=CC (=CP (C (C) (C)C)C (C) (C)C)[N-]1. [C-]#[O+]. [Ru+2]. Catalog: ACM863971635.
Clevidipine Butyrate Impurity V is an impurity of Clevidipine Butyrate, an ultrashort-acting intravenous dihydropyridine calcium-channel blocker that has been approved by the FDA. CAS No. 105580-45-8.
Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is a ferrochelatase inhibitor that blocks heme synthesis. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate induces Mallory Denk bodies (MDB) formation. Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate can be used in the fields of iron metabolism, oxidative stress, and liver-related diseases [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 632-93-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-118594.
A metabolite of Felodipine. Felodipine is a calcium channel blocker. Uses: Nemadipine b (felodipine ep impurity c) is the diethyl ester analogue analogue of the calcium channel blocker felodipine (f232375) with antihypertensive activity. Synonyms: 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester; diethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate. Grades: > 95 %. CAS No. 79925-38-5. Molecular formula: C19H21Cl2NO4. Mole weight: 398.28.
(E)-Ethyl 4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)-3,4-dihydropyridine-1(2H)-carboxylate is one of loratadine impurities. Loratadine is a nonsedating-type histamine H1-receptor antagonist used to treat allergies. Synonyms: Dehydro Loratadine Isomer A. Grades: 95%. Molecular formula: C22H21ClN2O2. Mole weight: 380.87.
(E)-Ethyl 4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)-3,4-dihydropyridine-1(2H)-carboxylate. Uses: For analytical and research use. Group: Impurity standards. Catalog: APS0092. Format: Neat.
(S)-4-((E)-2-(((S)-1-carboxy-2-(4-hydroxyphenyl)ethyl)amino)vinyl)-2,3-dihydropyridine-2,6-dicarboxylic acid. Uses: For analytical and research use. Group: Impurity standards. CAS No. 135545-98-1. Molecular Formula: C18H18N2O7. Mole Weight: 374.35. Catalog: APB135545981.
Survivin Inhibitor III, LLP-3 (Survivin-Ran Interaction Blocker, LLP3, 4-(3,5-bis(Benzyloxy)phenyl)-6-(5-chloro-2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile)
A cell-permeable, dihydropyridinone compound that selectively disrupts survivin-Ran interaction in cell-free binding assays (IC50 <0.3uM) and in U87 glioma cells (by 55% in 24h; 20uM) via direct binding at survivin protein-protein interaction interface, while exhibiting much reduced or little potency against survivin-Smac/DIABLO, survivin-survivin, or XIAP-Smac/DIABLO interaction. LLP-3 treatment abrogates neurosphere formation in GMB cultures (IC50 ≤35uM) by selectively depleting CD133+ GSC population via apoptosis induction. TMZ, in comparison, enriches GMB GSC population by preferentially eradicating non-GSC population. LLP-3 is also efficacious in treating human GMB xenograft in mice in vivo (25mg/kg/day via i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
(Z)-Ethyl 4-(8-Chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)-3,4-dihydropyridine-1(2H)-carboxylate is one of loratadine impurities. Loratadine is a nonsedating-type histamine H1-receptor antagonist used to treat allergies. Synonyms: Loratadine Impurity. Grades: 95%. Molecular formula: C22H21ClN2O2. Mole weight: 380.87.
An impurity of Nifedipine, which is a dihydropyridine calcium channel blocker that primarily blocks L-type calcium channels. Synonyms: Methyl 1,2,3,4-tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylate. CAS No. 108139-78-2. Molecular formula: C19H18N4O6. Mole weight: 398.37.
1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylic Acid Methyl Ester-d3. (Mixture of Diastereomers)
1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylic Acid Methyl Ester-d3 is the isotope labelled analog of 1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylic Acid Methyl Ester (T295600); an impurity of Nifedipine (N457000) which is a dihydropyridine calcium channel blocker. Also used as an antihypertensive and antianginal. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 50mg. Molecular Formula: C19H15D3N4O6, Molecular Weight: 401.39. US Biological Life Sciences.
1-[(3,3-Diphenylpropyl)methylamino]-2-methyl-2-propanol is an intermediate of Lercanidipine, which is a dihydropyridine calcium channel blocker. Uses: Lercanidipine intermediate. Synonyms: 2,N-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol; 2-Propanol, 1-[(3,3-diphenylpropyl)methylamino]-2-methyl-; 1-(3,3-Diphenyl-N-methylpropylamino)-2-methyl-2-propanol; N,2-Dimethyl-3,3-diphenylpropylamine-2-propanol; N,2-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol. Grades: 98%. CAS No. 100442-33-9. Molecular formula: C20H27NO. Mole weight: 297.43.
1, 4-Dihydro-2, 6-dimethyl-3- (2-cyanoethoxycarbonyl) -5-ethoxycarbonyl-4- (2, 3-dichlorophenyl) pyridine-13C4 is an intermediate in the synthesis of Felodipine-13C4, d3 (F232376), the labeled analogue of Felodipine (F232375), a dihydropyridine calcium channel blocker. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C1613C4H20Cl2N2O4, Molecular Weight: 427.26. US Biological Life Sciences.
1,4-Dihydropyridine derivative used in the prevention and therapy of atherosclerotic degradation of arterial walls. Group: Biochemicals. Alternative Names: 2-Cyanoethyl 5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate. Grades: Highly Purified. CAS No. 75130-24-4. Pack Sizes: 250mg. US Biological Life Sciences.
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-[2-[ (2-hydroxybenzoyl) amino]ethyl] Ester is a potential anti-hypertensive drug. 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-[2-[ (2-hydroxybenzoyl) amino]ethyl] Ester is functionally and structurally related to Manidipine Dihydrochloride (M164015) and Nifedipine (N457000). Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. Nifedipine is used as an antihypertensive and antianginal drug. Nifedipine is a dihydorpyridine calcium channel blocker. Group: Biochemicals. Grades: Highly Purified. CAS No. 92565-34-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C26H27N3O8, Molecular Weight: 509.51. US Biological Life Sciences.
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-[2-(4-methyl-1-piperazinyl)ethyl] Ester is an analogue of the drug Manidipine Dihydrochloride (M164015). Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 797013-83-3. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H32N4O6, Molecular Weight: 472.53. US Biological Life Sciences.
1,4-Dihydropyridine derivative used in the prevention and therapy of atherosclerotic degradation of arterial walls. Group: Biochemicals. Alternative Names: rac-1,4-Dihydro-5-(methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic Acid. Grades: Highly Purified. CAS No. 74936-72-4. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
1-(β-D-Ribofuranosyl)-1,4-dihydronicotinamide
It is a precursor which is an essential cofactor and substrate for many cells. Synonyms: 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridine; Dihydronicotinamide riboside; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,4-dihydropyridine-3-carboxamide; 1,4-Dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide; 1-Beta-D-ribofuranosyl-1,4-dihydronicotinamide; Reduced Nicotinamide Riboside; β-Reduced nicotinamide ribonucleoside. Grades: ≥95%. CAS No. 19132-12-8. Molecular formula: C11H16N2O5. Mole weight: 256.26.
1-(Ethoxycarbonyl)-1,2,3,4-tetrahydro-4-oxopyridine is a useful synthetic intermediate in the synthesis of (E)-Ethyl 4-(8-chloro-5H-benzo[5, 6]cyclohepta[1, 2-b]pyridin-11(6H)-ylidene)-3, 4-dihydropyridine-1(2H)-carboxylate (E902770); an impurity of Loratadine (L469575) which is a nonsedating-type histamine H1-receptor. Group: Biochemicals. Grades: Highly Purified. CAS No. 57330-84-4. Pack Sizes: 500mg, 1g. Molecular Formula: C8H11NO3, Molecular Weight: 169.18. US Biological Life Sciences.
1-Methyl-6-oxopyridine-3-carboxylic acid is an alkaloid with anti-inflammatory activity. Uses: A metabolite of tryptophan-niacin. Synonyms: 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid; 1,6-dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid. Grades: ≥95%. CAS No. 3719-45-7. Molecular formula: C7H7NO3. Mole weight: 153.14.
1-Phenylpiperidin-4-one
1-Phenylpiperidin-4-one is a reagent used in the preparation of isoteric N-arylpiperazine as dihydropyridine NPY1 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 19125-34-9. Pack Sizes: 10mg, 100 mg. Molecular Formula: C11H13NO, Molecular Weight: 175.23. US Biological Life Sciences.
2-[(2-Chlorophenyl)- β-hydroxy-methyl]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Ethyl Ester is an intermediate in the synthesis of Amlodipine Besilate (A633500); a dihydropyridine calcium channel blocker which is also used as an antianginal and antihypertensive. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C23H22ClNO7, Molecular Weight: 459.88. US Biological Life Sciences.
2-[(3-Nitrophenyl)methylene]-3-oxo-butanoic Acid 2-[ (3, 3-Diphenylpropyl) methylamino]-1, 1-dimethylethyl Ester is an intermediate in synthesizing 5-Ethyl-demethyl Lercanidipine (E913200), which is an impurity of Lercanidipine (L179000), a dihydropyridine calcium channel blocker. Group: Biochemicals. Grades: Highly Purified. CAS No. 210579-45-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C31H34N2O5. US Biological Life Sciences.
2-[(3-Nitrophenyl)methylene]-3-oxo-butanoic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Ester is an intermediate in the synthesis of Lercanidipine, which is a dihydropyridine calcium channel blocker. Synonyms: 1-((3,3-diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl 2-(3-nitrobenzylidene)-3-oxobutanoate; Butanoic acid, 2-[(3-nitrophenyl)methylene]-3-oxo-, 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl ester; 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl 2-[(3-nitrophenyl)methylene]-3-oxobutanoate. CAS No. 210579-45-6. Molecular formula: C31H34N2O5. Mole weight: 514.61.
2-[(3-Nitrophenyl)methylene]-3-oxo-butanoic Acid 2-[ (3, 3-Diphenylpropyl) methylamino]-1, 1-dimethylethyl Ester Hydrochloride is an intermediate in synthesizing 5-Ethyl-demethyl Lercanidipine (E913200), which is an impurity of Lercanidipine (L179000), a dihydropyridine calcium channel blocker. Group: Biochemicals. Grades: Highly Purified. CAS No. 929212-20-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C31H34N2O5 HCl. US Biological Life Sciences.
2-[(3-Nitrophenyl)methylene]-3-oxo-butanoic Acid Propyl Ester is an intermediate in synthesizing 5-Ethyl-demethyl Lercanidipine (E913200), which is an impurity of Lercanidipine (L179000), a dihydropyridine calcium channel blocker. Group: Biochemicals. Grades: Highly Purified. CAS No. 77888-04-1. Pack Sizes: 10g, 25g. Molecular Formula: C14H15NO5. US Biological Life Sciences.
2-[(3-Nitrophenyl)methylene]-3-oxo-butanoic Acid Propyl Ester is an intermediate in the synthesis of Lercanidipine, which is a dihydropyridine calcium channel blocker. Synonyms: Propyl (3-Nitrobenzylidene)acetoacetate; Propyl 2-(3-Nitrobenzylidene)-3-oxobutanoate; Butanoic Acid, 2-[(3-Nitrophenyl)Methylene]-3-Oxo-, Propyl Ester. CAS No. 77888-04-1. Molecular formula: C14H15NO5. Mole weight: 277.27.
2,4-Piperidinedione
2,4-Piperidinedione is a reactant in the synthesis of 1,4-dihydropyridines as TGF β/Smad inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 50607-30-2. Pack Sizes: 250mg, 1g. Molecular Formula: C5H7NO2, Molecular Weight: 113.11. US Biological Life Sciences.
Worldwide
2-Cyanoethyl Acetoacetate
2-Cyanoethyl Acetoacetate is an intermediate in the synthesis of Felodipine-d3 (F232377), a labelled dihydropyridine calcium channel blocker. Group: Biochemicals. Grades: Highly Purified. CAS No. 65193-87-5. Pack Sizes: 100mg, 1g. Molecular Formula: C7H9NO3, Molecular Weight: 155.15. US Biological Life Sciences.
Worldwide
2-Hydroxy-6-(trifluoromethyl)nicotinamide
Pyridines. Alternative Names: 2-Oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide. CAS No. 116548-03-9. Molecular formula: C7H5F3N2O2. Mole weight: 206.12. Purity: 0.97. Catalog: ACM116548039.
2-Hydroxyisonicitonic Acid
2-Hydroxyisonicitonic Acid. Group: Biochemicals. Alternative Names: 1,2-Dihydro-2-oxo-4-pyridinecarboxylic Acid; 2-Oxo-1,2-dihydropyridine-4-carboxylic Acid; 2-Pyridone-4-carboxylic Acid; NSC 132888. Grades: Highly Purified. CAS No. 22282-72-0. Pack Sizes: 1g. Molecular Formula: C6H5NO3, Molecular Weight: 139.11. US Biological Life Sciences.
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