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Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Diminazene diaceturate. CAS No. 908-54-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-12404.
Diminazene Aceturate
Diminazene aceturate is an ACE activator, inhibiting MAPKs and STAT phosphorylation. Diminazene aceturate is an anti-trypanosome agent for livestock. Synonyms: 1,3-Bis[4-guanylphenyl]triazene diaceturate; 4,4'-(Diazoamino)dibenzamidine Diaceturate; 4,4'-Diamidinodiazoaminobenzene Diaceturate. Grades: >98%. CAS No. 908-54-3. Molecular formula: C22H29N9O6. Mole weight: 515.52.
Bruceine A
Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.IC50 value:Target:Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM. Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Powder. CAS No. 25514-31-2. Molecular formula: C26H34O11. Mole weight: 522.54. Purity: 0.98. Canonical SMILES: CC1=C(C(=O)CC2(C1CC3C45C2C(C(C(C4C(C(=O)O3)OC(=O)CC(C)C)(OC5)C(=O)OC)O)O)C)O. Product ID: ACM25514312. Alfa Chemistry ISO 9001:2015 Certified. Categories: Bruce Inkango.
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