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| Product | Description | |
|---|---|---|
| Diphyllin | Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities. Group: Inhibitors. CAS No. 22055-22-7. Molecular formula: C21H16O7. Mole weight: 380.35. Purity: 0.9985. Catalog: ACM22055227. |  |
| Diphyllin | Diphyllin is an orally active V-ATPase inhibitor ( IC 50 =17 nM) and HIV-1 inhibitor (IC 50 =0.38 μM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC 50 =0.6 nM for acid influx inhibition), thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 22055-22-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2532. |  |
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