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| Product | Description | |
|---|---|---|
| α-Lipoic acid | α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DL-6-Thioctic acid. Product Category: Inhibitors. Appearance: Yellow powder. CAS No. 1077-28-7. Molecular formula: C8H14O2S2. Mole weight: 206.33. Purity: 0.98. IUPACName: 5-(Dithiolan-3-yl)pentanoic acid. Canonical SMILES: C1CSSC1CCCCC(=O)O. Density: 1.2888 g/cm³. Product ID: ACM1077287-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| α-Lipoic Acid | α-Lipoic Acid is a metabolic antioxidant that regulates NFκB signal transduction and can protect against oxidative injury. The exogenous compound is reduced intracellularly by enzymes. Its reduced form is involved in radical scavenging, recycling of other antioxidants, accelerating GSH synthesis, and regulating transcription factor activity, specifically NFkappaB. It also acts as a conenzyme that is required for the activity of pyruvate dehydrogenase and glycine decarboxylase, among other enzyme complexes. Studies show that it can prevent a decrease in the renal antioxidant defense system and prevent the increase of lipid peroxidation, platinum content and plasma creatinine concentrations. In other studies, lipoic acid decreased the phagocytosis of myelin by macrophages, acting as a non-specific scavenger of reactive oxygen species (ROS). Applications: A metabolic antioxidant that regulates nf-κb signal transduction. Group: Coenzymes. Synonyms: DL-Thioctic Acid; DL-6,8-Dithiooctanoic acid; 1,2-Dithiolane-3-valeric acid. CAS No. 1077-28-7. Purity: ≥95%. Mole weight: 206.32. Form: Solid. DL-Thioctic Acid; DL-6,8-Dithiooctanoic acid; 1,2-Dithiolane-3-valeric acid; α-Lipoic Acid; 1077-28-7. Cat No: COEC-041. |  |
| D-Glucose ethylenedithioacetal | D-Glucose ethylenedithioacetal, coveted for its therapeutic potential, serves as a viable vehicle for novel drug development. This chemical compound imparts its potency in selectively targeting cells and enzymes involved in the etiology of fatal diseases such as cancer and diabetes. In vitro testing has proven crucial for elucidating metabolic pathways and biomarkers - fundamental steps for successful therapeutic intervention. Synonyms: D-Glucose ethylenedithioacetal; D-Glucose cyclic ethylene dithioacetal; (1R,2S,3R,4R)-1-(1,3-dithiolan-2-yl)pentane-1,2,3,4,5-pentol; 6EB466KY92; D-GLUCOSE ETHYLENEDITHIOACETAL 97; D-Glucose, cyclic 1,2-ethanediyl dithioacetal; D-Glucose, ethylenedithioacetal; D-Glucose, cyclic 1,2-ethanediyl mercaptal; NSC-143003; EINECS 222-889-6; 1-(1,3-dithiolan-2-yl)pentane-1,2,3,4,5-pentol; UNII-6EB466KY92; D-Glucose ethylenedithioacetal 97; DTXSID401250945; AKOS015898541; D-Glucose, ethylenedithioacetal, 97%; NSC 143003; A823277; W-202516. CAS No. 3650-65-5. Molecular formula: C8H16O5S2. Mole weight: 256.34. |  |
| D-proline reductase (dithiol) | The reaction is observed only in the direction of D-proline reduction. Other dithiols can function as reducing agents; the enzyme contains a pyruvoyl group and a selenocysteine residue, both essential for activity. Group: Enzymes. Enzyme Commission Number: EC 1.21.4.1. CAS No. 37255-43-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1256; D-proline reductase (dithiol); EC 1.21.4.1; 37255-43-9. Cat No: EXWM-1256. | |
| mercury(II) reductase | A dithiol enzyme. Group: Enzymes. Synonyms: mercuric reductase; mercurate(II) reductase; mercuric ion reductase; mercury reductase; reduced NADP:mercuric ion oxidoreductase; mer A. Enzyme Commission Number: EC 1.16.1.1. CAS No. 67880-93-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1065; mercury(II) reductase; EC 1.16.1.1; 67880-93-7; mercuric reductase; mercurate(II) reductase; mercuric ion reductase; mercury reductase; reduced NADP:mercuric ion oxidoreductase; mer A. Cat No: EXWM-1065. | |
| molybdopterin molybdotransferase | Catalyses the insertion of molybdenum into the ene-dithiol group of molybdopterin. In eukaryotes this reaction is catalysed by the N-terminal domain of a fusion protein whose C-terminal domain catalyses EC 2.7.7.75, molybdopterin adenylyltransferase. Requires divalent cations such as Mg2+ or Zn2+ for activity. Group: Enzymes. Synonyms: MoeA; Cnx1 (ambiguous). Enzyme Commission Number: EC 2.10.1.1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2024; molybdopterin molybdotransferase; EC 2.10.1.1; MoeA; Cnx1 (ambiguous). Cat No: EXWM-2024. | |
| molybdopterin synthase | Catalyses the synthesis of molybdopterin from cyclic pyranopterin monophosphate. Two sulfur atoms are transferred to cyclic pyranopterin monophosphate in order to form the characteristic ene-dithiol group found in the molybdenum cofactor. Molybdopterin synthase consists of two large subunits forming a central dimer and two small subunits (molybdopterin-synthase sulfur-carrier proteins) that are thiocarboxylated at the C-terminus by EC 2.8.1.11, molybdopterin synthase sulfurtransferase. The reaction occurs in prokaryotes and eukaryotes. Group: Enzymes. Synonyms: MPT synthase. Enzyme Commission Number: EC 2.8.1.12. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3357; molybdopterin synthase; EC 2.8.1.12; MPT synthase. Cat No: EXWM-3357. | |
| Oltipraz | Oltipraz is a synthetic, substituted 1,2-dithiole-3-thione previously used in humans as an antischistosomal agent. Animal studies have demonstrated that oltipraz is a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Oltipraz is now known to be used for tumor prevention purposes. Group: Biochemicals. Alternative Names: 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione; NSC 347901; RP 35972. Grades: Highly Purified. CAS No. 64224-21-1. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| thiol sulfotransferase | Also acts on dithiols; substrates include glutathione, dithioerythritol and 2,3-mercaptopropanol. Group: Enzymes. Synonyms: phosphoadenylylsulfate-thiol sulfotransferase; PAPS sulfotransferase; adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase. Enzyme Commission Number: EC 2.8.2.16. CAS No. 70356-45-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3374; thiol sulfotransferase; EC 2.8.2.16; 70356-45-5; phosphoadenylylsulfate-thiol sulfotransferase; PAPS sulfotransferase; adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase. Cat No: EXWM-3374. | |
| thiosulfate-dithiol sulfurtransferase | The enzyme from Chlorella shows very little activity towards monothiols such as glutathione and cysteine (cf. EC 2.8.1.3 thiosulfate-thiolsulfurtransferase). The enzyme probably transfers the sulfur atom onto one thiol group to form -S-S-, and sulfide is spontaneously expelled from this by reaction with the other thiol group. May be identical with EC 2.8.1.1 thiosulfate sulfurtransferase. Group: Enzymes. Synonyms: thiosulfate reductase; TSR. Enzyme Commission Number: EC 2.8.1.5. CAS No. 9059-49-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3363; thiosulfate-dithiol sulfurtransferase; EC 2.8.1.5; 9059-49-8; thiosulfate reductase; TSR. Cat No: EXWM-3363. | |
| vitamin-K-epoxide reductase (warfarin-sensitive) | Vitamin K 2,3-epoxide is reduced to vitamin K and possibly to vitamin K hydroquinone by 1,4-dithiothreitol, which is oxidized to a disulfide; some other dithiols and 4-butanethiol can also act. Inhibited strongly by warfarin [cf. EC 1.17.4.5, vitamin-K-epoxide reductase (warfarin-insensitive)]. Group: Enzymes. Enzyme Commission Number: EC 1.17.4.4. CAS No. 55963-40-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1092; vitamin-K-epoxide reductase (warfarin-sensitive); EC 1.17.4.4; 55963-40-1. Cat No: EXWM-1092. | |
| 3H-1,2-Dithiole-3-thione (D3T) | A chemoprotective chemical. It is known to induce detoxication enzymes and inhibit chemica-induced tumors in multiple tissues. Group: Biochemicals. Alternative Names: D3T. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
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