Dithiothreitol Suppliers USA
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Dithiothreitol (DTT) Quick inquiry Where to buy Suppliers range | Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent. DTT's oxidized form is a disulfide-bonded 6-membered ring. Its name derives from the four-carbon sugar, threose. DTT has an epimeric ('sister') compound, dithioerythritol (DTE).DTT is an unusually strong reducing agent, owing to its high conformational propensity to form a six-membered ring with an internal disulfide bond. It has a redox potential of -0.33 V at pH 7. The reduction of a typical disulfide bond proceeds by two sequential thiol-disulfide exchange reactions and is illustrated below. The intermediate mixed-disulfide state is unstable (i.e., poorly populated) because the second thiol of DTT has a high propensity to close the ring, forming oxidized DTT and leaving behind a reduced disulfide bond. The reducing power of DTT is limited to pH values above ~7, since only the negatively charged thiolate form -S- is reactive (the protonated thiol form -SH is not); the pKa of thiol groups is typically ~8.3.Applications:A common use of DTT is as a reducing or "deprotecting" agent for thiolated DNA. The terminal sulfur atoms of thiolated DNA have a tendency to form dimers in solution, especially in the presence of oxygen. Dimerization greatly lowers the efficiency of subsequent coupling reactions such as DNA immobilization on gold in biosensors. Typically DTT is mixed with a DNA solution and allowed to react, and then is removed by filtration (for the solid catalyst) or by chromatography (for the liquid form). The DTT removal procedure is often called "desalting."DTT is frequently used to reduce the disulfide bonds of proteins and, more generally, T... Group: Biochemicals. Alternative Names: Cleland's reagent;; (2R,3R)-rel-1,4-Dimercapto-2,3-butanediol; (±)-1,4-Dimercapto-2,3-butanediol; (±)-Dithiothreitol; 1,4-Dithio-DL-threitol; 1,4-Dithiothreitol; DL-1,4-Dimercapto-2,3-dihydroxybutane; DL-1,4-Dithiothreitol; DL-Dithiothreitol; Sputolysin; WR 34678; threo-1,4-Dimercapto-2,3-butanediol; threo-2,3-Dihydroxy-1,4-butanedithiol; threo-2,3-Dihydroxy-1,4-dithiolbutane. Grades: Molecular Biology Grade. CAS No. 3483-12-3. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C4H10O2S2, Molecular Weight: 154.24. US Biological Life Sciences. | Worldwide |
DL-Dithiothreitol Quick inquiry Where to buy Suppliers range | DL-Dithiothreitol. Uses: Used for research and manufacturing. Group: Cosmetic Ingredients. Alternative Names: threo-1,4-Dimercapto-2,3-butanediol, Clelands reagent, DTT. CAS No. 3483-12-3. Pack Sizes: 1, 5, 10, 25, 100 g in poly bottle. Product ID: CDC10-0048. | |
DL-Dithiothreitol Quick inquiry Where to buy Suppliers range | DL-Dithiothreitol. Group: Biobased Products. Alternative Names: 1,4-Dithiothreitol. Grades: 98%. CAS No. 3483-12-3. Product ID: BBC3483123. Molecular formula: C4H10O2S2. Mole weight: 154.25. IUPAC Name: (2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol. Appearance: White powder. Density: 1.04 g/ml. SMILES: C([C@H]([C@@H](CS)O)O)S. | |
DL-Dithiothreitol (DTT), ?99.0% Quick inquiry Where to buy Suppliers range | DL-Dithiothreitol (DTT), ?99.0%. Group: Biological Buffers. CAS No. 27565-41-9. Pack Sizes: 1gm. ID EBT538. | |
DL-Dithiothreitol (DTT), ?99.0% Quick inquiry Where to buy Suppliers range | DL-Dithiothreitol (DTT), ?99.0%. Group: Biological Buffers. CAS No. 27565-41-9. Pack Sizes: 50gm. ID EBT538. | |
DTT (Dithiothreitol) Quick inquiry Where to buy Suppliers range | 25g Pack Size. Group: Analytical Reagents, Biochemicals, Carbohydrates. Formula: C4H10O2S2. CAS No. 3483-12-3. Prepack ID 19733320-25g. Molecular Weight 154.25. See USA prepack pricing. | |
DTT (Dithiothreitol) Quick inquiry Where to buy Suppliers range | 100g Pack Size. Group: Analytical Reagents, Biochemicals, Carbohydrates. Formula: C4H10O2S2. CAS No. 3483-12-3. Prepack ID 19733320-100g. Molecular Weight 154.25. See USA prepack pricing. | |
DTT (Dithiothreitol) Quick inquiry Where to buy Suppliers range | 5g Pack Size. Group: Analytical Reagents, Biochemicals, Carbohydrates. Formula: C4H10O2S2. CAS No. 3483-12-3. Prepack ID 19733320-5g. Molecular Weight 154.25. See USA prepack pricing. | |
L-(-)-Dithiothreitol Quick inquiry Where to buy Suppliers range | L-(-)-Dithiothreitol. Group: Biochemicals. Alternative Names: (-)-Cleland's Reagent; L-DTT. Grades: Highly Purified. CAS No. 16096-97-2. Pack Sizes: 1g, 2g, 5g. Molecular Formula: C4H10O2S2. US Biological Life Sciences. | Worldwide |
L-Dithiothreitol Quick inquiry Where to buy Suppliers range | L-Dithiothreitol. Group: Biochemicals. Grades: Reagent Grade. CAS No. 16096-97-2. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
1,4-Dithio-DL-threitol Quick inquiry Where to buy Suppliers range | Reagent for the quantitative reduction of disulfide group. Prevents the oxidation of cholecystokinin during its extraction from brain and duodenal tissues. Cleavage of disulfide bonds in proteins. Uses: Used as a reagent in biochemistry to prevent oxidation of thiol groups and to reduce disulfides to dithiols; has been used as a radioprotectant; dithiothreitol (dtt) is the common name for a small-molecule redox reagent known as cleland's reagent. Synonyms: DL-1,4-Dithiothreitol; DTT; Cleland's reagent; threo-1,4-Dimercapto-2,3-butanediol; Dithiothreitol; dl-Dithiothreitol; 1,4-Dithiothreitol; D-Dtt; 1,4-Dithio-dl-threitol; DL-Dithiothreitol; threo-1,4-Dimercapto-2,3-butanediol. Grades: ≥ 99 % (Assay by titration). CAS No. 3483-12-3. Molecular formula: C4H10O2S2. Mole weight: 154.25. | |
Acid-PEG4-S-S-PEG4-acid Quick inquiry Where to buy Suppliers range | Acid-PEG4-SS-PEG4-acid is a homobifunctional cleavable linker with carboxylic acid groups at both sides. The terminal carboxylic acids can be reacted with primary amines in the presences of activators such as EDC and HATU to form stable amide bonds. The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent. Synonyms: 4,7,10,13,20,23,26,29-octaoxa-16,17-dithiadotriacontanedioic acid; 4,7,10,13,20,23,26,29-Octaoxa-16,17-dithiadotriacontane-1,32-dioic acid. Grades: ≥95%. CAS No. 2055015-40-0. Molecular formula: C22H42O12S2. Mole weight: 562.69. | |
Menoxymycin A Quick inquiry Where to buy Suppliers range | Menoxymycin A is an antibiotic produced by Str. sp. KB10. It has a cytotoxic effect. It inhibits KB and N18-RE-105 cells with IC50 of 0.86 μmol/L and 0.14 μmol/L. Dithiothreitol (DDT) can reduce A and B cytotoxicity effect. Synonyms: [(2R)-2alpha-Methyl-3beta-hydroxy-6alpha-[(3aR)-2,6,11-trioxo-5alpha-methyl-7-hydroxy-3,3aalpha,5,6,11,11balpha-hexahydro-2H-furo[3,2-b]naphtho[2,3-d]pyran-10-yl]tetrahydro-2H-pyran-4alpha-yl]dimethylamine oxide. CAS No. 160492-65-9. Molecular formula: C24H27NO9. Mole weight: 473.47. | |
Menoxymycin B Quick inquiry Where to buy Suppliers range | Menoxymycin B is an antibiotic produced by Str. sp. KB10. It has a cytotoxic effect. It inhibits KB and N18-RE-105 cells with IC50 of 0.22 μmol/L and 0.023 μmol/L. Dithiothreitol (DDT) can reduce A and B cytotoxicity effect. CAS No. 160523-76-2. Molecular formula: C25H31NO9. Mole weight: 489.51. | |
OBP-801 Quick inquiry Where to buy Suppliers range | OBP-801, also known YM753 and spiruchostatin A, is a novel cyclic-peptide-based HDAC inhibitor. YM753 is a bacteria-derived natural product containing a disulfide bond. It potently inhibited HDAC enzyme with an IC50 of 2.0 nM in the presence of dithiothreitol. YM753 was rapidly converted to a reduced form in tumor cells, and then induced accumulation of acetylated histones, followed by p21WAF1/Cip1 expression, tumor cell growth inhibition and tumor-selective cell death. In an in vitro washout study, YM753 showed prolonged accumulation of acetylated histones in WiDr human colon carcinoma cells. In vivo YM753 dosing of mice harboring WiDr colon tumor xenografts significantly inhibited the tumor growth via sustained accumulation of acetylated histones in the tumor tissue. In a pharmacokinetic study, YM753 rapidly disappeared from the plasma, but its reduced form remained in the tumor tissue. Moreover, the accumulation of acetylated histones induced by YM753 was tumor tissue selective compared to several normal tissues. YM753 has attractive pharmacodynamic and pharmacokinetic properties giving it potential as an antitumor agent. Synonyms: OBP 801; OBP801; spiruchostatin A; YM-753; YM 753; (1S,5S,6R,9S,20R,E)-5-hydroxy-6-isopropyl-20-methyl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetraone. Grades: >98%. CAS No. 328548-11-4. Molecular formula: C20H31N3O6S2. Mole weight: 473.60. |