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| Product | Description | |
|---|---|---|
| Doravirine | Doravirine is a non-nucleoside reverse transcriptase inhibitor under development of Merck & Co. IC 50 value is 12 nM against the wild type, 21nM against K103N, 31 nM against Y181C, 33nM against K103N/Y181C mutant viruses in vitro. MK-1439 exhibited similar antiviral activities against 10 different HIV-1 subtype viruses. Phase III for the treatment of HIV-1 infections is on-going. Uses: Hiv-1 infections. Synonyms: MK-1439; MK 1439; MK1439; MK-1439-019;3-Chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile. Grades: 98%. CAS No. 1338225-97-0. Molecular formula: C17H11ClF3N5O3. Mole weight: 425.75. |  |
| Doravirine | Doravirine (MK-1439) is a highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor with IC 50 s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C reverse transcriptase mutants, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-1439. CAS No. 1338225-97-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16767. |  |
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