Dorsomorphin Suppliers USA
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Product | Description | |
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Dorsomorphin Quick inquiry Where to buy Suppliers range | Dorsomorphin Inhibitor. Uses: Scientific use. Product Category: T1977. CAS No. 866405-64-3. | |
Dorsomorphin Quick inquiry Where to buy Suppliers range | Dorsomorphin is a potent and selective inhibitor of AMPK (AMP-activated protein kinase) (Ki = 109 nM), induced by AICAR and metformin. It also inhibits bone morphogenetic protein (BMP) receptors including BMPR-IA (ALK3) and BMPR-IB (ALK6). Dorsomorphin can induce myocardial differentiation in mouse embryonic stem cells (mESCs). Uses: Protein kinase inhibitors. Synonyms: 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine; Compound C; AMPK Inhibitor, Compound C; BML-275. Grades: >98%. CAS No. 866405-64-3. Molecular formula: C24H25N5O. Mole weight: 399.49. | |
Dorsomorphin Quick inquiry Where to buy Suppliers range | Dorsomorphin. Group: Biochemicals. Alternative Names: Compound C, AMPK Inhibitor, BML-275, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine. Grades: Highly Purified. CAS No. 866405-64-3. Pack Sizes: 10mg, 50mg. Molecular Formula: C24 H25 N5, Molecular Weight: 399.5. US Biological Life Sciences. | Worldwide |
Dorsomorphin 2HCl Quick inquiry Where to buy Suppliers range | Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3. CAS No. 1219168-18-9. Molecular formula: C24H25N5O.2HCl. Mole weight: 472.414. | |
AMPK Inhibitor, Compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, BMP Inhibitor I) Quick inquiry Where to buy Suppliers range | A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50=25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFbR-I, ZAPK, Syk, PKCth, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100=2.5uM) and VEGF signaling-dependent intersomitic vessel formation (EC50=5uM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR and/or Metformin for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. CAS Number:866405-64-3. Group: Biochemicals. Grades: Highly Purified. CAS No. 866405-64-3. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??N?O. US Biological Life Sciences. | Worldwide |
BMP Inhibitor III, LDN-212854 (Abl Inhibitor V, LDN212854, Bone Morphogenetic Protein Inhibitor III, PDGFR Tyrosine Kinase Inhibitor XXIV, RIP2 Inhibitor I, RIPK2 Inhibitor I, 5-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline) Quick inquiry Where to buy Suppliers range | A cell-permeable pyrazolopyrimidinyl quinoline that is superior to Dorsomorphin and DMH1 as an ATP-site-targeting, ALK1/2 inhibitor (IC50 = 2.40 and 1.30nM, respectively; [ATP] = 6uM) with respect to both potency and selectivity over ALK3/4/5 (IC50 = 0.858, 2.133, and 9.276uM, respectively). Also a potent RIPK2 inhibitor (IC50 = 6nM) with reduced potency against ABL1/c-abl, PDGFR-beta, ALK3, and PDGFR-alpha (IC50 = 40, 68, 85.8, and 650nM, respectively) and little inhibitory activity toward a panel of more than 190 kinases. Effectively inhibits ALK2- and ALK3-mediated C2C12 osteogenic differentiation (IC50 = 10 and 40.5nM, respectively) in vitro and prevents constitutively active ALK2 Q207D mutant-induced heterotopic ossification in mice (6mg/kg/12h via i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?. US Biological Life Sciences. | Worldwide |
DMH-1 Quick inquiry Where to buy Suppliers range | DMH-1 is a second-generation small-molecule BMP inhibitor based on dorsomorphin. It effectively inhibits ALK1/2/3. It was shown to induce neuronal differentiation in human-induced pluripotent stem cells (hiPSCs). Synonyms: DMH 1; 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline. Grades: >98%. CAS No. 1206711-16-1. Molecular formula: C24H20N4O. Mole weight: 380.44. |