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DPQ is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD + /ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 129075-73-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114869.
DPQ
DPQ is a potent inhibitor of poly(ADP-ribose) polymerases (PARPs), which is a family of enzymes that plays an important role in DNA repair and apoptosis in response to reactive oxygen and nitrogen species. DPQ inhibits PARP1 with an IC50 value of 40 nM. It is approximately 10-fold less potent against PARP2. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: PARP Inhibitor III; 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone. Grades: ≥99%. CAS No. 129075-73-6. Molecular formula: C18H26N2O2. Mole weight: 302.4.
DPQ
Very potent PARP-1 inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 129075-73-6. Pack Sizes: 1mg, 5mg. Molecular Formula: C18H26N2O2. US Biological Life Sciences.
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PARP Inhibitor III, DPQ - CAS 129075-73-6
The PARP Inhibitor III, DPQ, also referenced under CAS 129075-73-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy.