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| Product | Description | |
|---|---|---|
| Duvelisib | Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. By selectively targeting these PI3K isoforms, PI3K signaling in normal, non-neoplastic cells is minimally or not affected which would result in a more favorable side effect profile. Uses: For research used only. Synonyms: IPI145; IPI 145; IPI-145. INK-1197; INK 1197; INK1197; Duvelisib. CAS No. 1201438-56-3. Molecular formula: C22H17ClN6O. Mole weight: 416.869. |  |
| Duvelisib | Duvelisib (IPI-145) is a selectivite p100δ inhibitor with IC 50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IPI-145; INK1197. CAS No. 1201438-56-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17044. |  |
| Duvelisib D5 | Duvelisib D5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1261590-70-8. Molecular Formula: C23H13D5ClN5O. Mole Weight: 420.91. Catalog: APB1261590708. |  |
| Duvelisib Impurity 1 | Duvelisib Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 146553-06-2. Molecular Formula: C10H20N2O4. Mole Weight: 232.28. Catalog: APB146553062. | |
| Duvelisib Impurity 10 | Duvelisib Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1386861-47-7. Molecular Formula: C22H27ClN2O4. Mole Weight: 418.92. Catalog: APB1386861477. | |
| Duvelisib Impurity 11 | Duvelisib Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1425044-76-3. Molecular Formula: C22H23ClN2O3. Mole Weight: 398.89. Catalog: APB1425044763. | |
| Duvelisib Impurity 2 | Duvelisib Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 6833-13-2. Molecular Formula: C13H10ClNO. Mole Weight: 231.68. Catalog: APB6833132. | |
| Duvelisib Impurity 3 | Duvelisib Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2005486-11-1. Molecular Formula: C17H16N2O. Mole Weight: 264.33. Catalog: APB2005486111. | |
| Duvelisib Impurity 4 | Duvelisib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C10H5ClN8. Mole Weight: 272.66. Catalog: APB10440. | |
| Duvelisib Impurity 5 | Duvelisib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C32H27ClN10O2. Mole Weight: 619.09. Catalog: APB10441. | |
| Duvelisib Impurity 6 | Duvelisib Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1466565-90-1. Molecular Formula: C19H17ClN2O2. Mole Weight: 340.81. Catalog: APB1466565901. | |
| Duvelisib Impurity 7 | Duvelisib Impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 7753-30-2. Molecular Formula: C15H20N4O3. Mole Weight: 304.35. Catalog: APB7753302. | |
| Duvelisib Impurity 8 | Duvelisib Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 7780-74-7. Molecular Formula: C15H20N4O3. Mole Weight: 304.35. Catalog: APB7780747. | |
| Duvelisib Impurity 9 | Duvelisib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C15H13ClN8O. Mole Weight: 356.77. Catalog: APB10442. | |
| Duvelisib Intermediate 1 | Duvelisib Intermediate 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2199389-46-1. Molecular Formula: C17H15ClN2O. Mole Weight: 298.77. Catalog: APB2199389461. | |
| Duvelisib N-Glucuronide | Duvelisib N-Glucuronide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,3S,4S,5R)-6-(6-(((S)-1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)amino)-7H-purin-3-ium-3-yl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate. Molecular Formula: C28H25ClN6O7. Mole Weight: 592.99. Catalog: APB05102. | |
| Duvelisib Related Compound 1 | Duvelisib Related Compound 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1386861-46-6. Molecular Formula: C14H12ClNO. Mole Weight: 245.71. Catalog: APB1386861466. | |
| Duvelisib (R-enantiomer) | Duvelisib (R-enantiomer). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1261590-48-0. Molecular Formula: C22H17ClN6O. Mole Weight: 416.87. Catalog: APB1261590480. | |
| Duvelisib R enantiomer | The R isomer analogue of Duvelisib which is a high selective PI3K δ/γ inhibitor. Uses: The r isomer analogue of duvelisib which is a high selective pi3k δ/γ inhibitor. Synonyms: IPI-145 R enantiomer; IPI 145 R enantiomer; IPI145 R enantiomer; INK1197 R enantiomer; INK 1197 R enantiomer; INK-1197 R enantiomer. Grades: 95%. CAS No. 1261590-48-0. Molecular formula: C22H17ClN6O. Mole weight: 416.86. | |
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