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| Product | Description | |
|---|---|---|
| DY131 | DY131. Group: Biochemicals. Grades: Purified. CAS No. 95167-41-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| DY131 | DY131 is a novel selective agonist of ERRβ and ERRγ, which displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. It could potentiate the ERRγ-induced growth inhibition in DU145- ERRγ and LNCaP- ERRγ prostate cancer cells in a dose-dependent manner. It inhibited the growth of the ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells. It had no effect on the structurally related receptors ERRα or the estrogen receptors alpha and beta (ERalpha/beta). It appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists. It has been demonstrated an antiproliferative/tumor-suppressing function for ERRγ in prostate cancer. Uses: Dy131 has been demonstrated an antiproliferative/tumor-suppressing function for errγ in prostate cancer. Synonyms: N-[ (E) -[4- (diethylamino) phenyl]methylideneamino]-4-hydroxybenzamide; GSK4716; GW4716; GW574716; DY131; DY-131; DY 131; GSK-9089; GSK 9089; GSK9089. Grades: >99 %. CAS No. 95167-41-2. Molecular formula: C18H21N3O2. Mole weight: 311.38. |  |
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