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| Product | Description | |
|---|---|---|
| E6446 | E6446 Inhibitor. Uses: Scientific use. Product Category: T4206. CAS No. 1219925-73-1. |  |
| E6446 | E6446 is a novel synthetic antagonist for nucleic acid-sensing TLRs. Synonyms: E6446; E 6446; E-6446; 6-(3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazoleBMS-790052; EBP 883; BMS 790052; EBP883; BMS790052; EBP-883; BMS-790052. CAS No. 1219925-73-1. Molecular formula: C27H35N3O3. Mole weight: 449.59. |  |
| E6446 | E6446 is a TLR inhibitor. E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG)-containing DNA, which stimulates TLR9. Uses: Designed for use in research and industrial production. Additional or Alternative Names: E6446; E 6446; E-6446. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1219925-73-1. Molecular formula: C27H35N3O3. Mole weight: 449.6. Purity: >98%. IUPACName: 6-(3-Pyrrolidin-1-yl-propoxy)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-benzooxazole. Canonical SMILES: C1(C2=CC=C(OCCCN3CCCC3)C=C2)=NC4=CC=C(OCCCN5CCCC5)C=C4O1. Product ID: ACM1219925731. Alfa Chemistry ISO 9001:2015 Certified. Categories: E.6/44. |  |
| E6446 dihydrochloride | E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 ?M), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1345675-25-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12756A. |  |
| E6446 dihydrochloride | E6446 is a novel synthetic antagonist for nucleic acid-sensing TLRs. Synonyms: E-6446 dihydrochloride; E 6446 dihydrochloride; E6446 dihydrochloride; 6-(3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole dihydrochloride. CAS No. 1345675-25-3. Molecular formula: C27H37Cl2N3O3. Mole weight: 522.51. | |
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