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| Product | Description | |
|---|---|---|
| Ebselen | 100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C13H9NOSe. CAS No. 60940-34-3. Prepack ID 33962193-100mg. Molecular Weight 274.18. See USA prepack pricing. |  |
| Ebselen | Ebselen, also known as SPI-1005, is an organoselenium compound with potential anti-oxidant, anti-inflammatory and cytoprotective activity. Upon oral administration of SPI-1005, this agent mimics the activity of glutathione peroxidase (GPx) and can utilize glutathione to reduce other unstable molecules, thus preventing the formation of reactive oxygen species (ROS) and reducing oxidative stress on the cell. In the cochlea, this agent may prevent drug-induced injury to the auditory hair cells thereby preventing hearing loss. GPx is the main antioxidant enzyme in the cochlea and protects the inner ear from loud sounds and biochemical damage. In addition, ebselen is able to inhibit the activity of many enzymes involved in inflammation. Synonyms: SPI-1005; SPI1005; SPI 1005; Ebselen; PZ 51; PZ51; PZ-51; DR3305; DR 3305; DR-3305. Grades: >98%. CAS No. 60940-34-3. Molecular formula: C13H9NOSe. Mole weight: 274.192. |  |
| Ebselen | Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker [1] [2]. Ebselen potently inhibits M pro ( IC 50 =0.67 μM) and COVID-19 virus ( EC 50 =4.67 μM) [3].Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SPI-1005; PZ-51; CCG-39161. CAS No. 60940-34-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13750. |  |
| Ebselen | Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker. Ebselen potently inhibits Mpro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM).Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity. Group: Inhibitors. Alternative Names: 2-phenyl-2-benzisoselenazol-3(2h)-one;PZ51;2-phenyl-benzo[d]isoselenazol-3-one;2-PHENYL-1,2-BENZISOSELENAZOL-3(2H)-ONE;EBSELEN;EBSELEN (PZ51, 2-PHENYL-1,2-BENZISOSELEN AZOL-3(2H)-ONE);EBSELEN 99%;2-phenyl-1,2-benzisoselenazol-. CAS No. 60940-34-3. Molecular formula: C13H9NOSe. Mole weight: 274.18. Appearance: light yellow solid. Purity: 0.96. IUPACName: 2-phenyl-1,2-benzoselenazol-3-one. Canonical SMILES: C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2. ECNumber: 612-054-8. Catalog: ACM60940343. |  |
| Ebselen | Glutathione peroxidase mimetic. Peroxynitrite scavenger. Anti-inflammatory Antioxidant. Protein kinase C (PKC), NADPH, lipoxygenase, COX, NOS, H+-ATPase and NADPH oxidase inhibitor. Antifungal. Group: Biochemicals. Grades: Highly Purified. CAS No. 60940-34-3. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C13H9NOSe. US Biological Life Sciences. |  Worldwide |
| Ebselen oxide | Heterocyclic Organic Compound. Alternative Names: Ebselen Oxide, NSC639772, 1,2-Benzisoselenazole-1,3-dione, 2-phenyl, 104473-83-8, 1-oxo-2-phenyl-1, AC1L7XFX, 1,3-dione, 2-phenyl, AC1Q6JS0, CTK8E9752, MolPort-009-019-492, NSC-639772. CAS No. 104473-83-8. Molecular formula: C13H9NO2Se. Mole weight: 290.2. Appearance: A crystalline solid. Purity: ≥98%. IUPACName: 1-oxo-2-phenyl-1$l^{4},2-benzoselenazol-3-one. Canonical SMILES: C1=CC=C (C=C1)N2C (=O)C3=CC=CC=C3[Se]2=O. Catalog: ACM104473838. | |
| 2-Phenyl-1,2-benzoselenazol-3-one | 2-Phenyl-1,2-benzoselenazol-3-one. Group: Biochemicals. Alternative Names: 2-Phenyl-1,2-benzoisoselenazol-3(2H)-one; CCG-39161; Ebselen; Lopac E 3520; NSC 639762; PZ 51. Grades: Highly Purified. CAS No. 60940-34-3. Pack Sizes: 10mg. Molecular Formula: C13H9NOSe, Molecular Weight: 274.18. US Biological Life Sciences. | Worldwide |
| NOX Inhibitor VII, Thr101 (NADPH Oxidase Inhibitor VII, 6-Fluoro-2-o-tolylbenzo [d]isothiazol-3 (2H) -one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one) | A cell-permeable, selenium-to-sulfur substituted Ebselen derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phox c-terminal PRD (proline-rich domain) and p47phoxbis-SH3 interaction. Although less potent than Ebselen in cell-free p22phox PRD-p47phoxbis-SH3 binding (IC50 = 4 vs. 0.3uM) and NOX2 activity (IC50 = 4 vs. 0.6uM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50 /Ebselen IC50 = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7uM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??FNOS, Primary Target: Blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction. US Biological Life Sciences. | Worldwide |
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