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| Product | Description | |
|---|---|---|
| EG 00229 | EG 00229. Group: Biochemicals. Grades: Purified. CAS No. 1018927-63-3. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| EG 00229 | EG 00229 is a neuropilin 1 (NRP1) receptor antagonist, inhibiting VEGFA binding to the NRP1 b1 domain. Synonyms: EG00229; EG-00229; EG 00229; N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine. Grades: ≥98% by HPLC. CAS No. 1018927-63-3. Molecular formula: C17H19N7O5S3. Mole weight: 497.57. |  |
| EG 00229 Trifluoroacetate | EG00229 is a small molecule inhibitor of neuropilin-1(Nrp1) with an IC50 of 3μM. EG00229 has been reported to inhibit VEGF-A binding to PAE/NRP1 in the Nrp1and bt-VEGF-A binding to purified Nrp1 b1 domain in a cell-free assay with an IC50 value of 8μM and 3μM, respectively. In addition, EG00229 has also shown the inhibition of VEGF-A binding to VEGFR2, VEGFR1 and Nrp1 in human umbilical vein endothelial cells (HUVECs) in a dose-dependent manner with an IC50 value of 23μM [1]. Besides, EG00229 has been revealed to prevent tuftsin binding to the Nrp1 which is at the cell surface. Moreover, EG00229 has been noted to suppress the anti-inflammatory M2 shift in microglia induced by tuftsin and thus potently prevent tuftsin's action. Synonyms: EG 00229; EG-00229. Grades: >98%. CAS No. 1210945-69-9. Molecular formula: C19H20F3N7O7S3. Mole weight: 611.6. | |
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