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| Product | Description | |
|---|---|---|
| EHop-016 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| EHop-016 | EHop-016 is a potent and selective Rac GTPase Rac1 and Rac3 inhibitor. EHop-016 inhibits Rac1 activity with an IC 50 of 1.1 μM in MDA-MB-435 cells. EHop-016 inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1380432-32-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12810. |  |
| EHop-016 | EHop-016 is a rac GTPase inhibitor that blocks the interaction of Rac with GEF Vav in metastatic human breast cancer cells. Synonyms: N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine; N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine. Grades: 98%. CAS No. 1380432-32-5. Molecular formula: C25H30N6O. Mole weight: 430.5. |  |
| Rac Inhibitor III, EHop-016 | A cell-permeable NSC23766 analog that is more selective against Rac interaction with Vav2 (by 45% blockage at 4uM) than Tiam (35% blockage at 50uM) and ~100-times more potent than NSC23766 in suppressing Rac1-GTP level in MDA-MB-435 (IC50=1.1 vs. 95uM, respectively) cultures. Effectively inhibits PAK Thr423 phosphorylation (IC50 <2uM), while reducing Cdc42-GTP level only at higher concentrations (by 18% at 5uM), in MDA-MB-435 cultures.Rac Inhibitor III, EHop-016, CAS 1380432-32-5, is a cell-permeable analog of NSC23766. It is ~100-fold more potent than NSC23766 in suppressing Rac1-GTP level in MDA-MB-435 cells. Group: Biochemicals. Alternative Names: N?-(9-Ethyl-9H-carbazol-3-yl)-N²-(3-morpholin-4-yl-propyl)-pyrimidine-2,4-diamine. Grades: Highly Purified. CAS No. 1380432-32-5. Pack Sizes: 10mg. Molecular Formula: C??H??N?O. US Biological Life Sciences. |  Worldwide |
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