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Elacestrant, also referred to RAD1901, is a selective and orally available estrogen receptor (ERR) degrader (IC50= 48 and 870 nM for ERα and ERβ, respectively) and selective estrogen receptor modulator (SERM). Synonyms: RAD1901; RAD-1901; RAD 1901. CAS No. 722533-56-4. Molecular formula: C30H38N2O2. Mole weight: 458.65.
Elacestrant
Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC 50 s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER + breast cancer cell lines in vitro and in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RAD1901. CAS No. 722533-56-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19822.
Elacestrant dihydrochloride
Elacestrant (RAD1901) dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) with IC 50 s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant dihydrochloride also can inhibit growth of ER + breast cancer cell lines in vitro and in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RAD1901 dihydrochloride. CAS No. 1349723-93-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19822A.
Elacestrant HCl
Elacestrant , also known as RAD1901, is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities. Upon oral administration of higher doses of RAD1901, this agent acts as a SERD, which binds to the estrogen receptor (ER) and induces a conformational change that results in the degradation of the receptor. This may inhibit the growth and survival of ER-expressing cancer cells. At lower doses of this agent, RAD1901 acts as a SERM and has estrogen-like effects in certain tissues, which can both reduce hot flashes and protect against bone loss. In addition, RAD1901 is able to cross the blood-brain barrier (BBB). Uses: Designed for use in research and industrial production. Additional or Alternative Names: RAD1901; RAD-1901; RAD 1901; RAD1901 HCl salt; Elacestrant dihydrochloride; Elacestrant HCl. Product Category: Others. Appearance: Solid powder. CAS No. 1349723-93-8. Molecular formula: C30H40Cl2N2O2. Mole weight: 531.56. Purity: >98%. IUPACName: (R)-6-(2-(ethyl(4-(2-(ethylamino)ethyl)benzyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol dihydrochloride. Canonical SMILES: OC1=CC=C2C[C@H](C3=CC=C(OC)C=C3N(CC4=CC=C(CCNCC)C=C4)CC)CCC2=C1.[H]Cl.[H]Cl. Product ID: ACM1349723938. Alfa Chemistry ISO 9001:2015 Certified.
Elacestrant S enantiomer
Elacestrant S enantiomer is a low activity enantiomer of Elacestrant, which is a selective and orally bioavailable small-molecule SERD (IC50s = 48 and 870 nM for ERα and ERβ, respectively). Synonyms: RAD1901 S enantiomer; 2-Naphthalenol, 6-[2-[ethyl[[4-[2- (ethylamino) ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5, 6, 7, 8-tetrahydro-, (6S)-; (6S)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol. CAS No. 2309762-29-4. Molecular formula: C30H38N2O2. Mole weight: 458.63.
Elacestrant S enantiomer dihydrochloride
Elacestrant S enantiomer dihydrochloride is a low activity enantiomer of Elacestrant, which is a selective and orally bioavailable small-molecule SERD (IC50s = 48 and 870 nM for ERα and ERβ, respectively). Synonyms: RAD1901 S enantiomer dihydrochloride; (6S)-6-[2-(Ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol dihydrochloride; 2-Naphthalenol, 6-[2-[ethyl[[4-[2- (ethylamino) ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5, 6, 7, 8-tetrahydro-, (6S)-, hydrochloride (1:2). Grades: ≥95%. CAS No. 2309762-30-7. Molecular formula: C30H40Cl2N2O2. Mole weight: 531.56.
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