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| Product | Description | |
|---|---|---|
| Elacridar | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyenzyme activators, inhibitors & substrates. |  |
| Elacridar | Elacridar. Group: Biochemicals. Alternative Names: N-[4-[2- (3, 4-Dihydro-6, 7-dimethoxy-2 (1H) -isoquinolinyl) ethyl]phenyl]-9, 10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide; GF 120918; GG 918. Grades: Highly Purified. CAS No. 143664-11-3. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C??H??N?O?, Molecular Weight: 563.64. US Biological Life Sciences. |  Worldwide |
| Elacridar | Elacridar hydrochloride (GF120918A) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects. Synonyms: GF120918; GF-120918; GF 120918; GF-120918A; GF120918A; GF 120918A; GG 918; D03968. Elacridar hydrochloride. CAS No. 143664-11-3. Molecular formula: C34H33N3O5. Mole weight: 563.654. |  |
| Elacridar | Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GF120918; GW0918; GG918; GW120918. CAS No. 143664-11-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50879. |  |
| Elacridar | Elacridar. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide. Appearance: Solid. CAS No. 143664-11-3. Molecular formula: C34H33N3O5. Mole weight: 563.6. Purity: 0.98. Product ID: ACM143664113. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Elacridar-d4 (Major) | A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport. Group: Biochemicals. Alternative Names: N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl-d4]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide; GF 120918-d4; GG 918-d4; GW 0918-d4. Grades: Highly Purified. CAS No. 1189481-51-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Elacridar hydrochloride | Elacridar hydrochloride (GF120918A) is an orally active P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar hydrochloride can be used to examine the influence of efflux transporters on agent distribution to brain and it can be used for the research of cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GF120918A. CAS No. 143851-98-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50880. | |
| Elacridar hydrochloride | Elacridar is an orally bioavailable inhibitor of P-glycoprotein (P-gp) and ABCG2. Synonyms: Elacridar HCl; N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide hydrochloride. CAS No. 143851-98-3. Molecular formula: C34H33N3O5.HCl. Mole weight: 600.10. | |
| Elacridar hydrochloride (GF 120918, P-gp inhibitor, (N-[4-[2- (3, 4-Dihydro-6, 7-dimethoxy-2 (1H) -isoquinolinyl) ethyl]phenyl]-9, 10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride) | P-glycoprotein (P-gp/ABCG1) inhibitor. Blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin and vincristine in CHRC5 cells. Also inhibits breast cancer resistance protein (BCRP/ABCG2). Orally active. Group: Biochemicals. Grades: Highly Purified. CAS No. 143851-98-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Elacridar maleate | Elacridar maleate is a potent and selective inhibitor of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), two key efflux transporters involved in multidrug resistance and drug disposition. Structurally, it is a third-generation multidrug resistance modulator, with the maleate salt form improving its solubility and stability. By inhibiting these transporters, elacridar enhances the bioavailability and brain penetration of various drugs that are P-gp or BCRP substrates, making it a valuable tool in pharmacokinetics and drug development studies. Elacridar maleate is widely investigated for overcoming drug resistance in cancer therapy and improving central nervous system drug delivery. Synonyms: 4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-, (2Z)-2-butenedioate (1:1); 4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-, (Z)-2-butenedioate (1:1); Elacridar (2Z)-2-butenedioate; GF 120918 maleate; GF 129018 maleate; GG 918 maleate; GW 0918 maleate. Grade: ≥95%. CAS No. 143851-84-7. Molecular formula: C34H33N3O5.C4H4O4. Mole weight: 679.72. | |
| 4-[2- (3, 4-Dihydro-6, 7-dimethoxy-2 (1H) -isoquinolinyl) ethyl]benzenamine | Intermediate for the preparation of Elacridar. Group: Biochemicals. Alternative Names: [4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]amine. Grades: Highly Purified. CAS No. 82925-02-8. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 9,10-Dihydro-5-methoxy-9-oxo-4-acridinecarboxylic Acid | Intermediate for the preparation of Elacridar. Group: Biochemicals. Grades: Highly Purified. CAS No. 88377-31-5. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
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