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| Product | Description | |
|---|---|---|
| Elagolix sodium | Elagolix is a selective gonadotropin-releasing hormone receptor (GnRHR) antagonist with KD of 54 pM. It is in phase III clinical trials for the treatment of endometriosis and uterine leiomyoma. Elagolix was also under investigation for the treatment of prostate cancer and benign prostatic hyperplasia, but development for these indications was ultimately not pursued. Uses: Endometriosis; uterine leiomyoma. Synonyms: Sodium (R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoate; NBI56418; NBI-56418; NBI 56418. Grade: 98%. CAS No. 832720-36-2. Molecular formula: C32H29F5N3NaO5. Mole weight: 653.58. |  |
| Elagolix sodium | Elagolix sodium is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (K D = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NBI-56418 sodium. CAS No. 832720-36-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14369. |  |
| 2,6(1H,3H)-Pyrimidinedione, 5-(2-fluoro-3-methoxyphenyl)-3-((2-fluoro-6-(trifluoromethyl)phenyl)methyl)-1-(2-(hydroxyimino)-2-phenylethyl)-4-methyl- | An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Grade: 95%. CAS No. 2486454-65-1. Molecular formula: C28H22F5N3O4. Mole weight: 559.5. | |
| 3-[[2-Fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione | An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Grade: 95%. CAS No. 2354391-45-8. Molecular formula: C13H10F4N2O2. Mole weight: 302.22. | |
| 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]amino] ethyl ester | An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Synonyms: Ethyl (R)-4-[[2-[5-(2-Fluoro-3-methoxyphenyl)-3-[2-fluoro-6-(trifluoromethyl)benzyl]-4-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl]-1-phenylethyl]amino]butanoate. Grade: 95%. CAS No. 832720-84-0. Molecular formula: C34H34F5N3O5. Mole weight: 659.6. | |
| 5-(2-fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-oxo-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione | An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Grade: 95%. CAS No. 2409132-61-0. Molecular formula: C28H21F5N2O4. Mole weight: 544.5. | |
| Butanoic acid, 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]hydroxyamino]-, sodium salt | An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Grade: 95%. CAS No. 2486454-63-9. Molecular formula: C32H30F5N3O6Na. Mole weight: 670.58. | |
| Elagolix | Elagolix is a Gonadotropin-Releasing Hormone (GnRH) Antagonist. Elagolix inhibits gonadatropin releasing hormone (GnRH) receptors in the pituitary gland and ultimately reduces circulating sex hormone levels. To date, elagolix has been studied in over 20 clinical trials totaling more than 1,000 subjects. A Phase 2a trial of elagolix for the treatment of uterine fibroids is also ongoing. Endometriosis can be a debilitating disease that affects millions of women around the world and the exploration of new treatments could offer other options for women with this disease. Synonyms: Elagolix, Elagolix sodium, NBI-56418; NBI 56418; NBI56418. CAS No. 834153-87-6. Molecular formula: C32H30F5N3O5. Mole weight: 631.6. | |
| Elagolix-3-methoxy Desfluoro impurity | An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Synonyms: (R)-4-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(3-methoxyphenyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoic acid. Grade: 95%. Molecular formula: C32H31F4N3O5. Mole weight: 613.6. | |
| Elagolix (S)-enantiomer | Elagolix (S)-enantiomer is an enantiomer of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Grade: 95%. CAS No. 2409132-65-4. Molecular formula: C32H30F5N3O5. Mole weight: 631.6. | |
| Formamide, N-[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]- | An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Grade: 95%. CAS No. 2409132-63-2. Molecular formula: C29H24F5N3O4. Mole weight: 573.5. | |
| (R)-3-(2-Amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione | An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Synonyms: (R)-3-(2-Amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione. Grade: 95%. CAS No. 830346-50-4. Molecular formula: C28H24F5N3O3. Mole weight: 545.5. | |
| (R)-4,4'-((2-(5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)azanediyl)dibutyric acid | An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Synonyms: 4,4'-((2-(5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)azanediyl)dibutyric acid, (R)-; Butanoic acid, 4,4'-(((1R)-2-(5-(2-fluoro-3-methoxyphenyl)-3-((2-fluoro-6-(trifluoromethyl)phenyl)methyl)-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl)-1-phenylethyl)imino)bis-. Grade: 95%. CAS No. 2409132-60-9. Molecular formula: C36H36F5N3O7. Mole weight: 717.7. | |
| (R)-5-(2-fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(2-oxopyrrolidin-1-yl)-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione | An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-(2-fluoro-3-methoxyphenyl)-1-((2-fluoro-6-(trifluoromethyl)phenyl)methyl)-6-methyl-3-((2R)-2-(2-oxo-1-pyrrolidinyl)-2-phenylethyl)-. Grade: 95%. CAS No. 2248628-93-3. Molecular formula: C32H28F5N3O4. Mole weight: 613.6. | |
| (R)-diethyl 4,4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)azanediyl)dibutanoate | An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Synonyms: (R)-Diethyl 4,4'-((2-(5-(2-fluoro-3-methoxy phenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)azanediyl)dibutanoate. Grade: 95%. CAS No. 2316733-81-8. Molecular formula: C40H44F5N3O7. Mole weight: 773.8. | |
| Sodium 4-{[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-4-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl]-1-phenylethyl]amino}butanoate | Sodium 4-{[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-4-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl]-1-phenylethyl]amino}butanoate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Elagolix sodium; UNII-5948VUI423. Product Category: Heterocyclic Organic Compound. CAS No. 832720-36-2. Molecular formula: C32H29F5N3NaO5. Mole weight: 653.5715. Purity: 0.96. IUPACName: sodium;4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoate. Canonical SMILES: CC1=C(C(=O)N(C(=O)N1CC2=C(C=CC=C2F)C(F)(F)F)CC(C3=CC=CC=C3)NCCCC(=O)[O-])C4=C(C(=CC=C4)OC)F.[Na+]. Product ID: ACM832720362. Alfa Chemistry ISO 9001:2015 Certified. |  |
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