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Eleclazine Eleclazine is a selective Sodium channel antagonist. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and end of the T-wave in the heart's electrical cycle) in patients with long QT-3 (LQT3) syndrome. Phase III clinical trilas for the treatment of Long QT syndrome, Phase II/III clinical trilas for the treatment of Hypertrophic cardiomyopathy and Phase II clinical trilas for the treatment of Ventricular arrhythmias are on-going. Uses: Long qt syndrome;hypertrophic cardiomyopathy;ventricular arrhythmias. Synonyms: GS-6615; GS 6615; GS6615; Eleclazine. 4-[(pyrimidin-2-yl)methyl]-7-[4-(trifluoromethoxy)phenyl]- 3,4-dihydro-1,4-benzoxazepin-5(2H)-one. Grades: 98%. CAS No. 1443211-72-0. Molecular formula: C21H16F3N3O3. Mole weight: 415.37. BOC Sciences 8
Eleclazine HCl Eleclazine HCl is a novel late Na+ current inhibitor. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Eleclazine Hydrochloride; Eleclazine HCl; GS-6615; GS 6615; GS6615. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1448754-43-5. Molecular formula: C21H17ClF3N3O3. Mole weight: 451.83. Purity: >98%. IUPACName: 4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one hydrochloride. Canonical SMILES: O=C1N(CC2=NC=CC=N2)CCOC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C13.[H]Cl. Product ID: ACM1448754435. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry.
Eleclazine hydrochloride Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC 50 value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine hydrochloride can be used to research cardiac arrhythmias [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS 6615 hydrochloride. CAS No. 1448754-43-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16738A. MedChemExpress MCE

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