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| Product | Description | |
|---|---|---|
| Elubrixin | Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist. It is potentially useful for Inflammatory bowel disease therapies. It inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. It may be an effective agent in neutrophil-predominant diseases. It was developed by GlaxoSmithKline and was in clinic phase 2 trials, but now it is terminated. Uses: Elubrixin is potentially useful for inflammatory bowel disease therapies. it may be an effective agent in neutrophil-predominant diseases. Synonyms: 1-(2-Chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea;SB-656933;SB656933;SB-656933-AAF;SB-656933-AAA;SB656933AAA;SB656933AAF;1-(4-Chloro-2-hydroxy-3-(piperazin-1-ylsulfonyl)phenyl)-3-(2-chloro-3-fluorophenyl)urea. Grades: 98%. CAS No. 688763-64-6. Molecular formula: C17H17Cl2FN4O4S. Mole weight: 463.30. |  |
| Elubrixin tosylate | Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation ( IC 50 of 260.7 nM) and shape change ( IC 50 of 310.5 nM). Elubrixin tosylate has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-656933 tosylate. CAS No. 960495-43-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18263C. |  |
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