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| Product | Description | |
|---|---|---|
| Emavusertib | Emavusertib, also known as CA-4948 is a potent IRAK4/FLT3 inhibitor with anti-tumor activity. CA-4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CA-4948; CA 4948; CA4948; Emavusertib. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1801344-14-8. Molecular formula: C24H25N7O5. Mole weight: 491.51. Purity: >98%. IUPACName: (R)-N-(5-(3-hydroxypyrrolidin-1-yl)-2-morpholinooxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide. Canonical SMILES: O=C(C1=COC(C2=CC(C)=NC=C2)=N1)NC3=C(N4C[C@H](O)CC4)N=C5C(OC(N6CCOCC6)=N5)=C3. Product ID: ACM1801344148. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Emavusertib | Emavusertib is an orally active inhibitor for IRAK4 ( IC 50 =57 nM) and FLT3. Emavusertib inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib exhibits antitumor activity in mouse model. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CA-4948. CAS No. 1801344-14-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135317. |  |
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