Endonuclease Suppliers USA
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Product | Description | |
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APE1 Inhibitor III (Apurinic Endonuclease 1 Inhibitor III) (Apurinic/Apyrimidinic Endonuclease 1 Inhibitor III)(N-(3-(1,3-Benzo[d]thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide) Quick inquiry Where to buy Suppliers range | A cell-permeable benzothiazolyltetra hydrothienopyridine compound that acts as a potent, competitive, and active site targeting inhibitor of APE1 (IC50=2.0uM in a fluorescence based HTS assay; and 12uM in a radiotracer incision assay). Shown to block APE1 activity in HEK293T and HeLa cells extract (IC50=600nM) and increase genomic AP site accumulation. Potentiates the cytotoxicity of DNA-damaging alkylating agents in HeLa cells by ~3-fold. Exhibits favorable pharmacokinetic properties and desirable ADME attributes. Due to its lipophilic nature, it crosses the blood-brain barrier rather easily and shows desirable stability (t1/2=80min). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Structure-specific endonuclease subunit SLX4 (603-615) Quick inquiry Where to buy Suppliers range | Structure-specific endonuclease subunit SLX4 (603-615) is a 13-aa peptide. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. Synonyms: BTB/POZ domain-containing protein 12 (603-615). | |
Structure-specific endonuclease subunit SLX4 (603-615) Quick inquiry Where to buy Suppliers range | Structure-specific endonuclease subunit SLX4. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-169. | |
1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester. Quick inquiry Where to buy Suppliers range | 1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester has been studied as a novel influenza endonuclease inhibitor. They also function as high-affinity ligands at the benzodiazepine site of brain GABAA receptors. Group: Biochemicals. Alternative Names: 3-Ethoxycarbonyl-4(1H)-quinolone; 4-Oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester; Ethyl 1,4-dihydro-4-oxoquinoline-3-carboxylate; Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate. Grades: Highly Purified. CAS No. 52980-28-6. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
4-Chloro-3-hydroxybenzoic Acid Quick inquiry Where to buy Suppliers range | 4-Chloro-3-hydroxy-Benzoic Acid acts as a potential inhibitor of influenza endonuclease used in the treatment of influenza. Also used in the synthesis of highly selective Tie-2 kinase inhibitors used in the treatment of tumors. Group: Biochemicals. Alternative Names: 3-Hydroxy-4-chlorobenzoic Acid; 4-Chloro-3-hydroxybenzoic Acid. Grades: Highly Purified. CAS No. 34113-69-4. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
APE1 Inhibitor III Quick inquiry Where to buy Suppliers range | APE1 Inhibitor III is a selective and competitive inhibitor of apurinic/apyrimidinic (AP) endonuclease 1 (APE1) with 2.0 micromolar activity against the purified APE1 enzyme. Synonyms: N-[3-(1,3-Benzothiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide. Grades: 99%. CAS No. 524708-03-0. Molecular formula: C19H21N3OS2. Mole weight: 371.52. | |
AR03 Quick inquiry Where to buy Suppliers range | AR03 is a specific inhibitor of apurinic/apyrimidinic (AP) endonuclease 1 (APE1). Synonyms: BMH-23; BMH 23; BMH23; AR03; AR 03; AR-03; 2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine. Grades: 99%. CAS No. 510721-85-4. Molecular formula: C15H15N3. Mole weight: 237.3. | |
Baloxavir Quick inquiry Where to buy Suppliers range | Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Synonyms: Baloxavir acid; BXA; Xofluza; S-033447. Grades: ≥98%. CAS No. 1985605-59-1. Molecular formula: C24H19F2N3O4S. Mole weight: 483.49. | |
Baloxavir marboxil Quick inquiry Where to buy Suppliers range | Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Synonyms: S-033188; HY-109025. Grades: ≥98%. CAS No. 1985606-14-1. Molecular formula: C27H23F2N3O7S. Mole weight: 571.55. | |
Hycanthone Quick inquiry Where to buy Suppliers range | Hycanthone is the active metabolite of the anthelmintic prodrug Lucanthone, which is used in the treatment of schistosomiasis. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a KD of 10 nM. Synonyms: 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)-9H-thioxanthen-9-one; 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)thioxanthen-9-one; Hycanthon; NCI 142982; NSC 134434; NSC 142982; Win 24933. CAS No. 3105-97-3. Molecular formula: C20H24N2O2S. Mole weight: 356.48. | |
Irestatin 9389 Quick inquiry Where to buy Suppliers range | Irestatin 9389 is a potent inhibitor of the endonuclease IRE1 (IC50 = 6.3 nM). Synonyms: AC1LJRTA; BAS 06901326; BAS06901326; BAS-06901326; 2-[[3-cyano-4-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide. Grades: 99%. CAS No. 626221-47-4. Molecular formula: C16H13F3N4OS2. Mole weight: 398.43. | |
LNT 1 Quick inquiry Where to buy Suppliers range | LNT 1 is a potent and selective inhibitor of flap endonuclease 1 (FEN1), an enzyme for repair of double-strand breaks in DNA. Synonyms: FEN1-IN-1; FEN1 Inhibitor C1; 1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione. Grades: ≥98% by HPLC. CAS No. 824983-91-7. Molecular formula: C15H12N2O5S. Mole weight: 332.33. | |
Lucanthone Quick inquiry Where to buy Suppliers range | Lucanthone is orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1), with anti-schistosomal and potential antineoplastic activity. Lucanthone intercalates DNA and interferes with the activity of topoisomerases I and II during replication and transcription, thereby inhibiting the synthesis of macromolecules. In addition, this agent specifically inhibits the endonuclease activity of APE1, without affecting its redox activity, resulting in unrepaired DNA strand breaks which may induce apoptosis. Therefore, lucanthone may sensitize tumor cells to radiation and chemotherapy. Furthermore, lucanthone inhibits autophagy through the disruption of lysosomal function. The multifunctional nuclease APE1 is a key component for DNA repair; its expression is often correlated with tumor cell resistance to radio- and chemotherapy. Uses: Schistosomicides. Synonyms: Lucanthonum; 1-{[2-(Diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one; CCRIS 1106. CAS No. 479-50-5. Molecular formula: C20H24N2OS. Mole weight: 340.48. | |
NV-128 Quick inquiry Where to buy Suppliers range | NV-128 is a novel isoflavone derivative, which has been shown in pre-clinical studies to promote cancer cell death in multi drug resistant cancer cells by inducing caspase-independent DNA degradation and cancer cell death via the AKT-mTOR pathway. In contrast to phenoxodiol and triphendiol, NV-128 has been shown to induce caspase-independent DNA degradation and cancer cell death. It appears that in conjunction with autophagy induction, NV-128 induces caspase independent cell death via the AKT-mTOR pathway resulting in beclin sequestration of Bcl-2, Bax up-regulation and mitochondrial depolarization. As a consequence, endonuclease G translocates to the nucleus where it initiates DNA degradation and cell death. This offers an opportunity for use as a monotherapy in chemoresistant cancers and enhanced efficacy against cancer targets less susceptible to phenoxodiol. The option for co-administration of combinations of these drugs is also under investigation to extend the potential therapeutic range of this unique class of oncology compounds. Synonyms: NV-128; NV 128; NV128. CAS No. 1210335-22-0. | |
Phosphoglycolic Acid Quick inquiry Where to buy Suppliers range | Phosphoglycolic Acid is used in studies pertaining to biological and metabolic processes. It can be used in the study of human apurinic/apyrimidinic endonuclease (Ape) and its role in double strand break repair. It also has been seen to complex with cPEPCK (cytosolic phosphoenolpyruvate carboxykinase) during the study of its inhibition by various substrate analogues. Group: Biochemicals. Alternative Names: 2-(Phosphonooxy)acetic Acid; (Phosphonooxy)acetic Acid; Glycolic Acid Phosphate; Glycolic Acid, di-H Phosphate; Glycolic Acid, Dihydrogen Phosphate; 2-Phosphoglycolic Acid; Glycophosphoric Acid. Grades: Highly Purified. CAS No. 13147-57-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
STF-083010 Quick inquiry Where to buy Suppliers range | STF-083010 is a novel small-molecule inhibitor of Ire1α; inhibits Ire1 endonuclease activity, without affecting its kinase activity after endoplasmic reticulum stress both in vitro and in vivo. Synonyms: STF-083010; STF 083010; STF083010, IRE1 Inhibitor I. Grades: >98%. CAS No. 307543-71-1. Molecular formula: C15H11NO3S2. Mole weight: 317.38. | |
Tenilsetam Quick inquiry Where to buy Suppliers range | Tenilsetam is an endonuclease modulator, also a nootropic agent and advanced glycation end product (AGE) inhibitor with the potential to treat Alzheimer's disease (AD). Preclinical studies indicated that tenilsetam may have an inhibitory effect on diabetic retinopathy, without amelioration of pericyte loss. Uses: Potential treatment of alzheimer's disease. Synonyms: 3-(thiophen-2-yl)piperazin-2-one; 3-thiophen-2-ylpiperazin-2-one; 3-(2-thienyl)piperazin-2-one. Grades: 99%. CAS No. 86696-86-8. Molecular formula: C8H10N2OS. Mole weight: 182.24. |