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| Product | Description | |
|---|---|---|
| APE1 Inhibitor III (Apurinic Endonuclease 1 Inhibitor III) (Apurinic/Apyrimidinic Endonuclease 1 Inhibitor III)(N-(3-(1,3-Benzo[d]thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide) | A cell-permeable benzothiazolyltetra hydrothienopyridine compound that acts as a potent, competitive, and active site targeting inhibitor of APE1 (IC50=2.0uM in a fluorescence based HTS assay; and 12uM in a radiotracer incision assay). Shown to block APE1 activity in HEK293T and HeLa cells extract (IC50=600nM) and increase genomic AP site accumulation. Potentiates the cytotoxicity of DNA-damaging alkylating agents in HeLa cells by ~3-fold. Exhibits favorable pharmacokinetic properties and desirable ADME attributes. Due to its lipophilic nature, it crosses the blood-brain barrier rather easily and shows desirable stability (t1/2=80min). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Restriction Endonuclease Alw 44 I (ApaL I ) | Heterocyclic Organic Compound. CAS No. 100630-51-1. Catalog: ACM100630511. |  |
| RESTRICTION ENDONUCLEASE SNAB I FROM*SPH AEROTILUS N | Heterocyclic Organic Compound. Alternative Names: RESTRICTION ENDONUCLEASE SNAB I FROM*SPH AEROTILUS N;isolatedfromsphaerotilusnatans. CAS No. 103780-21-8. Purity: 0.96. Catalog: ACM103780218. | |
| rRNA endonuclease | Also acts on bacterial rRNA. Group: Enzymes. Synonyms: α-sarcin. Enzyme Commission Number: EC 3.1.27.10. CAS No. 1407-48-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3599; rRNA endonuclease; EC 3.1.27.10; 1407-48-3; α-sarcin. Cat No: EXWM-3599. |  |
| Structure-specific endonuclease subunit SLX4 (603-615) | Structure-specific endonuclease subunit SLX4 (603-615) is a 13-aa peptide. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. Synonyms: BTB/POZ domain-containing protein 12 (603-615). |  |
| T7 Endonuclease I | T7 Endonuclease I. T7 endonuclease i is a junction-resolving enzyme of 149 amino acid residue, encoded by gene 3 of bacteriophage t7, existing as a stable dimer. not only does it selectively bind and cleave four-way dna (holliday) junctions with high specificity for branched structures in double-stranded dna, such as cruciform dna, but also it has a strong preference for cutting single-stranded dna. it requires metal ions such as magnesium for activity. this product is purified from e. coli expressing the recombinant t7 endonuclease i (t7ei) gene. Group: DNA Modifying Enzymes. Purity: 250U; 5*250U. Storage: Store at -20°C. Cat No: ME-4004. | |
| 1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester. | 1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester has been studied as a novel influenza endonuclease inhibitor. They also function as high-affinity ligands at the benzodiazepine site of brain GABAA receptors. Group: Biochemicals. Alternative Names: 3-Ethoxycarbonyl-4(1H)-quinolone; 4-Oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester; Ethyl 1,4-dihydro-4-oxoquinoline-3-carboxylate; Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate. Grades: Highly Purified. CAS No. 52980-28-6. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 4-Chloro-3-hydroxybenzoic Acid | 4-Chloro-3-hydroxy-Benzoic Acid acts as a potential inhibitor of influenza endonuclease used in the treatment of influenza. Also used in the synthesis of highly selective Tie-2 kinase inhibitors used in the treatment of tumors. Group: Biochemicals. Alternative Names: 3-Hydroxy-4-chlorobenzoic Acid; 4-Chloro-3-hydroxybenzoic Acid. Grades: Highly Purified. CAS No. 34113-69-4. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| APE1 Inhibitor III | APE1 Inhibitor III is a selective and competitive inhibitor of apurinic/apyrimidinic (AP) endonuclease 1 (APE1) with 2.0 micromolar activity against the purified APE1 enzyme. Synonyms: N-[3-(1,3-Benzothiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide. Grades: 99%. CAS No. 524708-03-0. Molecular formula: C19H21N3OS2. Mole weight: 371.52. | |
| AR03 | AR03 is a specific inhibitor of apurinic/apyrimidinic (AP) endonuclease 1 (APE1). Synonyms: BMH-23; BMH 23; BMH23; AR03; AR 03; AR-03; 2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine. Grades: 99%. CAS No. 510721-85-4. Molecular formula: C15H15N3. Mole weight: 237.3. | |
| Aspergillus nuclease S1 | Aspergillus nuclease S1 is an endonuclease enzyme derived from Aspergillus oryzae that splits single-stranded DNA (ssDNA) and RNA into oligo- or mononucleotides. Group: Enzymes. Synonyms: endonuclease S1 (Aspergillus); single-stranded-nucleate endonuclease; deoxyribonuclease S1; deoxyribonuclease S1; nuclease S1; Neurospora crassa single-strand specific endonuclease; S1 nuclease; single-strand endodeoxyribonuclease; single-stranded DNA specific endonuclease; single-strand-specific endodeoxyribonuclease; single strand-specific DNase; Aspergillus oryzae S1 nuclease. Enzyme Commission Number: EC 3.1.30.1. CAS No. 37288-25-8. Nuclease. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3707; Aspergillus nuclease S1; EC 3.1.30.1; 37288-25-8; endonuclease S1 (Aspergillus); single-stranded-nucleate endonuclease; deoxyribonuclease S1; deoxyribonuclease S1; nuclease S1; Neurospora crassa single-strand specific endonuclease; S1 nuclease; single-strand endodeoxyribonuclease; single-stranded DNA specific endonuclease; single-strand-specific endodeoxyribonuclease; single strand-specific DNase; Aspergillus oryzae S1 nuclease. Cat No: EXWM-3707. | |
| AV5124 | AV5124, a prodrug of AV5116, is an orally active influenza virus cap-dependent endonuclease (CEN) endonuclease inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2417851-93-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-164927. |  |
| Baloxavir | Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Baloxavir acid; S-033447. CAS No. 1985605-59-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109025A. | |
| Baloxavir | Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Synonyms: Baloxavir acid; BXA; Xofluza; S-033447. Grades: ≥98%. CAS No. 1985605-59-1. Molecular formula: C24H19F2N3O4S. Mole weight: 483.49. | |
| Baloxavir marboxil | Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Synonyms: S-033188; HY-109025. Grades: ≥98%. CAS No. 1985606-14-1. Molecular formula: C27H23F2N3O7S. Mole weight: 571.55. | |
| Baloxavir marboxil | Baloxavir marboxil (S-033188) is a selective inhibitor of influenza cap-dependent endonuclease. Baloxavir marboxil, a potent antiviral agent, shows activity against influenza A and B virus [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S-033188; RG 6152. CAS No. 1985606-14-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-109025. | |
| β-Agarase I from E. coli, Recombinant | Agarase is an enzyme with system name agarose 4-glycanohydrolase. It found in agarolytic bacteria and is the first enzyme in the agar catabolic pathway. It is responsible for allowing them to use agar as their primary source of Carbon and enables their ability to thrive in the ocean. Agarases are classified as either α-agarases or β-agarases based upon whether they degrade αor β linkages in agarose, breaking them into oligosaccharides. When secreted, α-agarases yield oligosaccharides with 3.6 anhydro-L-galactose at the reducing end whereas β-agarases result in D-galactose residues. Β-agarase cleaves the agarose subunit, unsubstituted...garase i can be used to purify both large (> 50 kb) and small (< 50 kb) fragments of dna from gels. the remaining carbohydrate molecules and β-agarase i will not, in general, interfere with subsequent dna manipulations such as restriction endonuclease digestion, ligation, and transformation. Group: Enzymes. Synonyms: agarase; AgaA; AgaB; endo-β-agarase; agarose 3-glycanohydrolase; EC 3.2.1.81; 37288-57-6. Agarase. Storage: at -20°C. Form: 50 mM Bis Tris-HCl (pH 6.5), 1 mM Na2EDTA and 50% glycerol. Source: E. coli. Species: E. coli. agarase; AgaA; AgaB; endo-β-agarase; agarose 3-glycanohydrolase; EC 3.2.1.81; 37288-57-6; β-Agarase I. Cat No: NATE-1282. | |
| CC-preferring endodeoxyribonuclease | Prefers CC sites in double-stranded circular and linear DNA. Greater affinity for double-stranded than single-stranded DNA. Produces nicks, generating double-stranded fragments with 5'- and/or 3'-protruding single-stranded tails. Requires magnesium ions for activity. The endonuclease from Chlorella-like green algae infected with NYs-1 virus 4 may be the same enzyme. Group: Enzymes. Synonyms: Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease. Enzyme Commission Number: EC 3.1.21.6. CAS No. 37211-67-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3576; CC-preferring endodeoxyribonuclease; EC 3.1.21.6; 37211-67-9; Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease. Cat No: EXWM-3576. | |
| crossover junction endodeoxyribonuclease | The enzyme from Saccharomyces cerevisiae has no endonuclease or exonuclease activity on single-stranded or double-stranded DNA molecules that do not contain Holliday junctions. Group: Enzymes. Synonyms: Hje endonuclease; Holliday junction endonuclease CCE1; Holliday junction resolvase; Holliday junction-cleaving endonuclease; Holliday junction-resolving endoribonuclease; RusA Holliday junction resolvase; RusA endonuclease; RuvC endonuclease; SpCCe1 Holliday junction resolvase; crossover junction endoribonuclease; cruciform-cutting endonuclease; endo X3; endonuclease RuvC; endonuclease VII; endonuclease X3; resolving enzyme CCE1. Enzyme Commission Number: EC 3.1.22.4. CAS No. 99676-43-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3582; crossover junction endodeoxyribonuclease; EC 3.1.22.4; 99676-43-4; Hje endonuclease; Holliday junction endonuclease CCE1; Holliday junction resolvase; Holliday junction-cleaving endonuclease; Holliday junction-resolving endoribonuclease; RusA Holliday junction resolvase; RusA endonuclease; RuvC endonuclease; SpCCe1 Holliday junction resolvase; crossover junction endoribonuclease; cruciform-cutting endonuclease; endo X3; endonuclease RuvC; endonuclease VII; endonuclease X3; resolving enzyme CCE1. Cat No: EXWM-3582. | |
| deoxyribodipyrimidine endonucleosidase | Deoxyribodipyrimidine endonucleosidase (EC 3.2.2.17) is an enzyme with systematic name deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase. Group: Enzymes. Synonyms: pyrimidine dimer DNA-glycosylase; endonuclease V; deoxyribonucleate pyrimidine dimer glycosidase; pyrimidine dimer DNA glycosylase; T4-induced UV endonuclease; PD-DNA glycosylase. Enzyme Commission Number: EC 3.2.2.17. CAS No. 75302-33-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3971; deoxyribodipyrimidine endonucleosidase; EC 3.2.2.17; 75302-33-9; pyrimidine dimer DNA-glycosylase; endonuclease V; deoxyribonucleate pyrimidine dimer glycosidase; pyrimidine dimer DNA glycosylase; T4-induced UV endonuclease; PD-DNA glycosylase. Cat No: EXWM-3971. | |
| Deoxyribonuclease B, Recombinant | Deoxyribonuclease B (DNAse B) is one of several extracellular enzymes produced by group A beta-hemolytic streptococci. Since DNAse B is produced extensively by group A serotypes and is not produced in significant amounts by other serological groups (C and G), anti-DNAse B is a reliable streptococcal antibody test for both skin and throat infections. Applications: Used in the formulation of anti-dnase b assays which are used in the diagnosis of group a streptococcal based illnesses. Group: Enzymes. Synonyms: DNASE1; deoxyribonuclease I; deoxyribonuclease-1; DNase I; 9003-98-9; EC 3.1.21.1; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNas. Enzyme Commission Number: EC 3.1.21.1. Purity: > 97%. Mole weight: 21 - 31kD. Form: Frozen liquid. Source: Escherichia coli. DNASE1; deoxyribonuclease I; deoxyribonuclease-1; DNase I; 9003-98-9; EC 3.1.21.1; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease. Cat No: NATE-1153. | |
| deoxyribonuclease I | Preference for double-stranded DNA. Group: Enzymes. Synonyms: pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; DNase I; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease. Enzyme Commission Number: EC 3.1.21.1. CAS No. 9003-98-9. DNASE1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3571; deoxyribonuclease I; EC 3.1.21.1; 9003-98-9; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; DNase I; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease. Cat No: EXWM-3571. | |
| Deoxyribonuclease I from Bovine pastoris, Recombinant | Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis. Recombinant bovine pancreatic deoxyribonuclease 1 produced in pichia pastoris. chromatogr....1.21.1. CAS No. 9003-98-9. Purity: Chromatographically purified. DNASE1. Activity: > 5000 units per mg protein. Storage: Store at 2-8°C. Form: lyophilized powder. Source: Pichia pastoris. Species: Bovine pancreatic. DNASE1; deoxyribonuclease I; deoxyribonuclease-1; DNase I; 9003-98-9; EC 3.1.21.1; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nucle | |
| Deoxyribonuclease II | Deoxyribonuclease II (DNase II) is an endonuclease that hydrolyzes the phosphodiester bonds of deoxyribonucleotides in native and denatured DNA, producing 3' phosphate and 5'-hydroxyl termini. Deoxyribonuclease II works best at acidic pH and is commonly used in biochemical research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DNase II. CAS No. 9025-64-3. Pack Sizes: 40 KU. Product ID: HY-P2863. | |
| deoxyribonuclease IV | The enzyme is an apurinic/apyrimidinic (AP) site endonuclease that primes DNA repair synthesis at AP sites. It specifically cleaves the DNA backbone at AP sites and also removes 3' DNA-blocking groups such as 3' phosphates, 3' phosphoglycolates, and 3' α,β-unsaturated aldehydes that arise from oxidative base damage and the activity of combined glycosylase/lyase enzymes. It is also the only known repair enzyme that is able to cleave the DNA backbone 5' of the oxidative lesion α-deoxyadenosine. The enzyme has a strong preference for single-stranded DNA. Group: Enzymes. Synonyms: deoxyribonuclease IV. coli endonuclease IV; endodeoxyribonuclease (misleading); redoxyendonuclease; deoxriboendonuclease (misleading); endonuclease II; endonuclease IV; DNA-adenine-transferase; nfo (gene name). Enzyme Commission Number: EC 3.1.21.2. CAS No. 63363-78-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3572; deoxyribonuclease IV; EC 3.1.21.2; 63363-78-0; deoxyribonuclease IV (phage-T4-induced) (misleading); endodeoxyribonuclease IV (phage T4-induced) (misleading); E. coli endonuclease IV; endodeoxyribonuclease (misleading); redoxyendonuclease; deoxriboendonuclease (misleading); endonuclease II; endonuclease IV; DNA-adenine-transferase; nfo (gene name). Cat No: EXWM-3572. | |
| deoxyribonuclease (pyrimidine dimer) | Acts on a damaged strand, 5' from the damaged site. Group: Enzymes. Synonyms: endodeoxyribonuclease (pyrimidine dimer); endodeoxyribonuclease (pyrimidine dimer); bacteriophage T4 endodeoxyribonuclease V; T4 endonuclease V. Enzyme Commission Number: EC 3.1.25.1. CAS No. 66143-22-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3584; deoxyribonuclease (pyrimidine dimer); EC 3.1.25.1; 66143-22-4; endodeoxyribonuclease (pyrimidine dimer); endodeoxyribonuclease (pyrimidine dimer); bacteriophage T4 endodeoxyribonuclease V; T4 endonuclease V. Cat No: EXWM-3584. | |
| DNA-(apurinic or apyrimidinic site) lyase | Nicking of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. This group of enzymes was previously listed as endonucleases, under EC 3.1.25.2. Group: Enzymes. Synonyms: AP lyase; AP endonuclease class I; endodeoxyribonuclease (apurinic or apyrimidinic); deoxyribonuclease (apurinic or apyrimidinic); E. coli endonuclease III; phage-T4 UV endonuclease; Micrococcus luteus UV endonuclease; AP site-DNA 5'-phosphomonoester-lyase; X-ray endonuclease III. Enzyme Commission Number: EC 4.2.99.18. CAS No. 61811-29-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5265; DNA-(apurinic or apyrimidinic site) lyase; EC 4.2.99.18; 61811-29-8; AP lyase; AP endonuclease class I; endodeoxyribonuclease (apurinic or apyrimidinic); deoxyribonuclease (apurinic or apyrimidinic); E. coli endonuclease III; phage-T4 UV endonuclease; Micrococcus luteus UV endonuclease; AP site-DNA 5'-phosphomonoester-lyase; X-ray endonuclease III. Cat No: EXWM-5265. | |
| E3330 | E3330 (APX-3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. E3330 shows anticancer activities. Group: Inhibitors. CAS No. 136164-66-4. Molecular formula: C21H30O6. Mole weight: 378.46. Appearance: Solid. Purity: 0.9934. Canonical SMILES: CCCCCCCCC/C (C (O)=O)=C\C1=C (C)C (C (OC)=C (OC)C1=O)=O. Catalog: ACM136164664. | |
| FEN1-IN-5 | FEN1-IN-5 (compound 12A) is a potent inhibitor of Flap endonuclease-1 ( FEN1 , IC 50 =12 nM), involving in DNA repair [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 824983-93-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153790. | |
| Hycanthone | Hycanthone is a thioxanthenone DNA intercalator and inhibits RNA synthesis as well as the DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a K D of 10 nM. Hycanthone is a bioactive metabolite of Lucanthone (HY-B2098) and has anti-schistosomal agent [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3105-97-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-B1099. | |
| Hycanthone | Hycanthone is the active metabolite of the anthelmintic prodrug Lucanthone, which is used in the treatment of schistosomiasis. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a KD of 10 nM. Synonyms: 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)-9H-thioxanthen-9-one; 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)thioxanthen-9-one; Hycanthon; NCI 142982; NSC 134434; NSC 142982; Win 24933. CAS No. 3105-97-3. Molecular formula: C20H24N2O2S. Mole weight: 356.48. | |
| Immobilized RNase A on G3m | RNase A is an endonuclease that cleaves RNA but not DNA. RNase A specifically cuts pyrimidine ribonucleotides at the 3'-adjacent phosphodiester bond Py/pN, with the intermediary formation of nucleoside-2',3'-cyclophosphate. G3m: 25 ug (2. 5 Kunitz units) RNase A per CR-column immobilized on dextranThis G3m-column digests at least 200 ug RNA per application. Nr. 5 Storage buffer: 50 mM Tris/HCl, pH 7. 5Nr. 5 Reaction buffer: 50 mM Tris/HCl, pH 7. 5 (also active with 1% SDS)Nr. 6 Washing buffer: 50 mM Tris/HCl, 1 M NaCl, pH 7. 5The columns are provided in storage buffer. Group: Enzymes. Synonyms: Pancreatic ribonucleases; EC 3. 1. 27. 5; RNase; RNase I; RNase A; pancreatic RNase; ...lease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase; 9001-99-4. Enzyme Commission Number: EC 3. 1. 27. 5. Storage: 4 °C. Source: Bovine pancreas. Pancreatic ribonucleases; EC 3. 1. 27. 5; RNase; RNase I; RNase A; pancreatic RNase; ribonuclease I; endoribonuclease I; ribonucleic phosphatase; alkaline ribonuclease; ribonuclease; gene S glycoproteins; Ceratitis capitata alkaline ribonuclease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase; 9001-99-4; Immobilized RNase A. Cat No: NATE-1773. | |
| Irestatin 9389 | Irestatin 9389 is a potent inhibitor of the endonuclease IRE1 (IC50 = 6.3 nM). Synonyms: AC1LJRTA; BAS 06901326; BAS06901326; BAS-06901326; 2-[[3-cyano-4-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide. Grades: 99%. CAS No. 626221-47-4. Molecular formula: C16H13F3N4OS2. Mole weight: 398.43. | |
| L-742001 hydrochloride | L-742001 hydrochloride is an influenza virus PA endonuclease inhibitor, with an EC 90 of 4.3 μM for vRNP activity in HEK293T cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 174605-64-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-118368. | |
| LNT 1 | LNT 1 is a potent and selective inhibitor of flap endonuclease 1 (FEN1), an enzyme for repair of double-strand breaks in DNA. Synonyms: FEN1-IN-1; FEN1 Inhibitor C1; 1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione. Grades: ≥98% by HPLC. CAS No. 824983-91-7. Molecular formula: C15H12N2O5S. Mole weight: 332.33. | |
| Lucanthone | Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 ( APE-1 ). Uses: Scientific research. Group: Signaling pathways. CAS No. 479-50-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B2098. | |
| Lucanthone | Lucanthone is orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1), with anti-schistosomal and potential antineoplastic activity. Lucanthone intercalates DNA and interferes with the activity of topoisomerases I and II during replication and transcription, thereby inhibiting the synthesis of macromolecules. In addition, this agent specifically inhibits the endonuclease activity of APE1, without affecting its redox activity, resulting in unrepaired DNA strand breaks which may induce apoptosis. Therefore, lucanthone may sensitize tumor cells to radiation and chemotherapy. Furthermore, lucanthone inhibits autophagy through the disruption of lysosomal function. The multifunctional nuclease APE1 is a key component for DNA repair; its expression is often correlated with tumor cell resistance to radio- and chemotherapy. Uses: Schistosomicides. Synonyms: Lucanthonum; 1-{[2-(Diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one; CCRIS 1106. CAS No. 479-50-5. Molecular formula: C20H24N2OS. Mole weight: 340.48. | |
| Micrococcal Nuclease | Micrococcal Nuclease. Micrococcal nuclease is obtained by expression of a recombinant micrococcal nuclease gene in escherichia coli, molecular weight is 16.8 kda. it is a non-specific exo or endonuclease that consumes double-stranded, single-stranded, circularized, and linear nucleic acids, and has a better digestion of single strands, and it tend to digest ats or the aus region of the dna or rna, producing a single nucleotide and a dinucleotide with 3' phosphoric acid.; high activity.; high protein purity, sds-page purity >95%.; good stability. Group: DNA Modifying Enzymes. Purity: 100KU; 200KU. Storage: Store at -20°C. Cat No: ME-4002. | |
| Mutation Detection Kit | Mutation Detection Kit. Mutation detection kit provides a simple, reliable, and rapid method for the detection of site specific cleavage of genomic dna that is extracted from cells transfected with constructs expressing engineered nucleases such as transcription activator-like effector nucleases (talen), clustered regularly interspaced short palindromic repeats (crispr)/cas9, or zinc-finger nucleases (zfn). mutation detection kit includes high-fidelity dna polymerase for amplifying the target regions from cells, and t7 endonuclease i for recognizing and detecting the mismatches caused by gene editing tools. it provides an easy and reliable approach for estimating the efficiency of genome editing. components. high-fidelity dna polymerase. 5x pcr reaction buffer. t7 endonuclease i. 10x gencrispr t7 endonuclease i reaction buffer. control template dna. control primer mix. protease k. dntp. Group: Cloning Enzymes. Purity: 25 reactions/kit. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol pH7.4, at 25°C. Cat No: CE-3508. | |
| Native Aspergillus oryzae Nuclease S1 | Nuclease S1 isolated from Aspergillus oryzae exhibits endo-and exolytic hydrolytic activity for the phosphodiester bonds of single-stranded DNA and RNA yielding 5-phosphomononucleotide and 5-phosphooligonucleotide end-products. It is used to digest non-annealed polynucleotide tails and hairpin loops in RNA and DNA duplexes and can be used to convert superhelical DNA to the linear form. The nuclease s1 enzyme from aspergillus oryzae has the ability to degrade single-stranded oligonucleotides composed of either deoxynucleotides or ribonucleotides. Applications: Nuclease s1 from aspergillus oryzae has been used in a study to assess a bi ochemical method for mapping mutational...e S1 nuclease; EC 3.1.30.1; 37288-25-8. Enzyme Commission Number: EC 3.1.30.1. CAS No. 37288-25-8. Nuclease. Storage: -20°C. Form: Solution containing 30 mM sodium acetate, 50 mM NaCl, 1 mM ZnCl2, 50% glycerol, 2 mg/ml protein. Source: Aspergillus oryzae. endonuclease S1 (Aspergillus); single-stranded-nucleate endonuclease; deoxyribonuclease S1; deoxyribonuclease S1; nuclease S1; Neurospora crassa single-strand specific endonuclease; S1 nuclease; single-strand endodeoxyribonuclease; single-stranded DNA specific endonuclease; single-strand-specific endodeoxyribonuclease; single strand-specific DNase; Aspergillus oryzae S1 nuclease; EC 3.1.30.1; 37288-25-8. Cat No: NATE-0492. | |
| Native Bovine Deoxyribonuclease I | Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis. Protein determined by biuret. Applications: Used for the removal of dna from protein samples. dnase...rom bovine pancreas has also been used in a study to investigate the effects of minor and major groove-binding drugs and intercalators on the dna association of minor groove-binding proteins reca and deoxyribonuclease i. Group: Enzymes. Synonyms: DNASE1; deoxyribonuclease I; deoxyribonuclease-1; DNase I; 9003-98-9; EC 3.1.21.1; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA end | |
| Native Bovine Deoxyribonuclease I RNase-free solution | Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis. Applications: Used in molecular biology applications for removing dna during rna purifica...zyme Commission Number: EC 3.1.21.1. CAS No. 9003-98-9. DNASE1. Mole weight: mol wt 29.1 kDa. Storage: -20°C. Form: buffered aqueous glycerol solution. Source: Bovine pancreas. Species: Bovine. DNASE1; deoxyribonuclease I; deoxyribonuclease-1; DNase I; 9003-98-9; EC 3.1.21.1; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease. Cat No: NATE-0199. | |
| Native Bovine Phosphodiesterase II | Phosphodiesterase (PDE) is any enzyme that is used to breaks phosphodiester bonds. The enzyme acts on poly (A), poly (U), and poly (I). Native DNA and poly (C) are quite resistant to the action of this enzyme. Hydrolyzes RNA, RNA-Core, 3'-alkyl-and 3'-aryl-nucleoside phosphates, and polydeoxyribonucleotides with 3'-phosphate end groups to 3'-mononucleotides. Polynucleotides having 5'-phosphomonoester end groups are not attacked. Applications: Phosphodiesterase (pde) is any enzyme that is used to breaks phosphodiester bonds. it is a membrane-bound glycoprotein that is used to catalyze the hydrolysis of various nucleotide polyphosphates. phosphodiesterase ii has been used in t...yloxobutyl (pob) base adducts from dna. furthermore, it has been used along with micr oc occal endonuclease to hydrolyze purified dna to 3-nucleoside monophosphates. Group: Enzymes. Synonyms: 3'-exonuclease; spleen phosphodiesterase; 3'-nucleotide phosphodiesterase; phosphodiesterase II; spleen exonuclease; EC 3.1.16.1; 9068-54-6; PDE2. Enzyme Commission Number: EC 3.1.16.1. CAS No. 9068-54-6. PDE. Activity: > 5.0 units/mg protein. Storage: -20°C. Form: lyophilized powder. Source: Bovine spleen. Species: Bovine. 3'-exonuclease; spleen phosphodiesterase; 3'-nucleotide phosphodiesterase; phosphodiesterase II; spleen exonuclease; EC 3.1.16.1; 9068-54-6; PDE2. Cat No: NATE-0518. | |
| Native Penicillium citrinum Nuclease P1 | Nuclease P1 from Penicillium citrinum is a zinc-dependent endonuclease that exhibits increased activity in the presence of low concentrations of urea. Applications: Nuclease p1 from penicillium citrinum has been used in a study to assess crystal structures using ammonium sulphate or polyethylene glycol 4000 as a precipitating agent. it has also been used in a study to investigate a method for the direct sequence analysis 20-25 nucleotides from the terinini of 5? or 3? end group labeled rna. nuclease p1 is used to improve the sensitivity of a 32p-labeling method for the detection of dna adducts. the enzyme has an optimal temperature of approximately 70 oc, but for a long incubation, a temperature below 60 oc is more suitable. it is stable in the ph range of 5-8. Group: Enzymes. Synonyms: Endonuclease P1; EC 3.1.30.1; 54576-84-0; Nuclease P1; P1 nuclease. Enzyme Commission Number: EC 3.1.30.1. CAS No. 54576-84-0. Nuclease. Mole weight: 42-50 kDa. Activity: > 200 units/mg protein (E1%/280, 3?-5?-Phosphodiesterase). Storage: 2-8°C. Form: lyophilized powder. Source: Penicillium citrinum. Endonuclease P1; EC 3.1.30.1; 54576-84-0; Nuclease P1; P1 nuclease. Pack: vial of > 250 units (using RNA substrate). Cat No: NATE-0491. | |
| Native Staphylococcus aureus Nuclease micrococcal | Micrococcal Nuclease is an endo-exonuclease that preferentially digests single-stranded nucleic acids. The rate of cleavage is 30 times greater at the 5' side of A or T than at G or C and results in the production of mononucleotides and oligonucleotides with terminal 3'-phosphates. The enzyme is also active against double-stranded DNA and RNA and all sequences will be ultimately cleaved. Applications: Nuclease from staphyl oc occus aureus has been used in a study to assess coagulase and heat-resistant strains found in animals. it has also been used in a study to investigate the expression characteristic of two genes in s. aureus that encode two thermostable nucleases. Group: Enzymes. Synonyms: Micrococcal Nuclease; EC 3.1.31.1; spleen endonuclease; thermonuclease; nuclease T; micrococcal endonuclease; nuclease T'; staphylococcal nucle. Enzyme Commission Number: EC 3.1.31.1. CAS No. 9013-53-0. MNase. Activity: 100-300 units/mg protein. Storage: -20°C. Source: Staphylococcus aureus. Micrococcal Nuclease; EC 3.1.31.1; spleen endonuclease; thermonuclease; nuclease T; micrococcal endonuclease; nuclease T'; staphylococcal nuclease; spleen phosphodiesterase; Staphylococcus aureus nuclease; Staphylococcus aureus nuclease B; ribonucleate (deoxynucleate) 3'-nucleotidohydrolase; 9013-53-0; Endonuclease micrococcal; MNase. Cat No: NATE-0452. | |
| Nuclease P1 | Nuclease P1 is a single-stranded specific endonuclease, it hydrolyzes nucleic acids into 5'-mononucleotides and cleaves the single-stranded region of a double-stranded nucleic acid. Nuclease P1 is one of the most well-known single stranded specific nucleases in the field of molecular biology, it is widely used in the pharmaceutical and food industries [1]. Nuclease P1 can be obtained by fermentation of Penicillium citrinum: through extraction process, ultrafiltration concentration, drying and purification, etc. Uses: Scientific research. Group: Signaling pathways. CAS No. 54576-84-0. Pack Sizes: 250 U. Product ID: HY-P2963. | |
| Nuclease, restrictionendodeoxyribo-, BsmI | Heterocyclic Organic Compound. Alternative Names: BSM I;BSM I RESTRICTION ENZYME;RESTRICTION ENDONUCLEASES BSM I;restriction endonuclease bsm I*from bacillus;bsm i from bacillus stearothermophilus nub 36;RESTRICTION ENDONUCLEASE BSM I. CAS No. 122007-72-1. Catalog: ACM122007721. | |
| Nuclease, restrictionendodeoxyribo-, FspI | Heterocyclic Organic Compound. Alternative Names: RESTRICTION ENDONUCLEASES NCO I;NCO I RESTRICTION ENZYME;NCO I;FSP I;restriction endonuclease nco I from*nocardia cora;RESTRICTION ENDONUCLEASE NCO I FROM*NOCA RDIA CORALL;nco i from nocardia corallina;RESTRICTION ENDONUCLEASE FSP I. CAS No. 107824-63-5. Catalog: ACM107824635. | |
| Nuclease, restrictionendodeoxyribo-, NotI | Heterocyclic Organic Compound. Alternative Names: NOT I;NOT I RESTRICTION ENZYME;RESTRICTION ENDONUCLEASES NOT I;restriction endonuclease not I from*nocardia otid;RESTRICTION ENDONUCLEASE NOT I FROM*NOCA RDIA OTIDIS;NOT I 5'.GC GGCCGC.3' ISOLATED FROM NOCARDIA OTITDIS-CAVIARUM;not i from nocardia ot. CAS No. 103780-20-7. Molecular formula: C13H18O5S2. Mole weight: 318.40902;g/mol. Purity: 0.96. IUPACName: [(2R,3S,4R)-4-acetyl-4-(1,3-dithian-2-yl)-3-methyl-5-oxooxolan-2-yl]acetate. Canonical SMILES: CC1C (OC (=O)C1 (C2SCCCS2)C (=O)C)OC (=O)C. Catalog: ACM103780207. | |
| Nuclease, restrictionendodeoxyribo-, SpeI | Heterocyclic Organic Compound. Alternative Names: RESTRICTION ENDONUCLEASES SPE I;SPE I;SPE I RESTRICTION ENZYME;RESTRICTION ENDONUCLEASE SPE I FROM*SPHA EROTILUS SP; spei5'. actagt. 3'isolatedfromsphaerotilusspecies; spe i from sphaerotilus sp.;RESTRICTION ENDONUCLEASE SPE I. CAS No. 115926-60-8. Molecular formula: ClH. Mole weight: 36.46094;g/mol. Purity: 0.96. IUPACName: chlorane. Canonical SMILES: Cl. ECNumber: 231-595-7. Catalog: ACM115926608. | |
| Nuclease S1, Aspergillus oryzae | Nuclease S1, Aspergillus oryzae is a specific endonuclease that degrades single stranded DNA (ssDNA) and RNA. Nuclease S1 can also remove protruding single-strand ends from double-stranded DNA [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 37288-25-8. Pack Sizes: 10 KU. Product ID: HY-P2773. | |
| NV-128 | NV-128 is a novel isoflavone derivative, which has been shown in pre-clinical studies to promote cancer cell death in multi drug resistant cancer cells by inducing caspase-independent DNA degradation and cancer cell death via the AKT-mTOR pathway. In contrast to phenoxodiol and triphendiol, NV-128 has been shown to induce caspase-independent DNA degradation and cancer cell death. It appears that in conjunction with autophagy induction, NV-128 induces caspase independent cell death via the AKT-mTOR pathway resulting in beclin sequestration of Bcl-2, Bax up-regulation and mitochondrial depolarization. As a consequence, endonuclease G translocates to the nucleus where it initiates DNA degradation and cell death. This offers an opportunity for use as a monotherapy in chemoresistant cancers and enhanced efficacy against cancer targets less susceptible to phenoxodiol. The option for co-administration of combinations of these drugs is also under investigation to extend the potential therapeutic range of this unique class of oncology compounds. Synonyms: NV-128; NV 128; NV128. CAS No. 1210335-22-0. | |
| Phosphoglycolic Acid | Phosphoglycolic Acid is used in studies pertaining to biological and metabolic processes. It can be used in the study of human apurinic/apyrimidinic endonuclease (Ape) and its role in double strand break repair. It also has been seen to complex with cPEPCK (cytosolic phosphoenolpyruvate carboxykinase) during the study of its inhibition by various substrate analogues. Group: Biochemicals. Alternative Names: 2-(Phosphonooxy)acetic Acid; (Phosphonooxy)acetic Acid; Glycolic Acid Phosphate; Glycolic Acid, di-H Phosphate; Glycolic Acid, Dihydrogen Phosphate; 2-Phosphoglycolic Acid; Glycophosphoric Acid. Grades: Highly Purified. CAS No. 13147-57-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ribonuclease H from Escherichia coli, Recombinant | Ribonuclease H (RNase H) is a family of non-sequence-specific endonucleases that catalyze the cleavage of RNA via a hydrolytic mechanism. Members of the RNase H family can be found in nearly all organisms, from bacteria to archaea to eukaryotes. RNase Hs ribonuclease activity cleaves the 3-O-P bond of RNA in a DNA/RNA duplex substrate to produce 3-hydroxyl and 5-phosphate terminated products. In DNA replication, RNase H is responsible for removing the RNA primer, allowing completion of the newly synthesized DNA. Applications: Ribonuclease h from escherichia coli has been used in a study to assess metallobi ochemistry of the magnesium ion. ribonuclease h has also been used in a study to investigate selective inhibitors of hiv-1 reverse transcriptase ass ociated rnase h activity. Group: Enzymes. Synonyms: Ribonuclease H; RNase H; EC 3.1.4.34; 9050-76-4. Enzyme Commission Number: EC 3.1.4.34. CAS No. 9050-76-4. Rnase. Activity: 1,000-4,000 units/mL. Storage: -20°C. Form: buffered aqueous glycerol solution; Solution in 50% glycerol containing 20 mM Tris-HCl, pH 7.5, 100 mM KCl, 10 mM MgCl2, 0.1 mM EDTA, 0.1 mM DTT and 0.05 mg BSA per ml. Source: E. coli. Species: Escherichia coli. Ribonuclease H; RNase H; EC 3.1.4.34; 9050-76-4. Pack: vial of ~30 units. Cat No: NATE-0657. | |
| ribonuclease M5 | Converts the 5S-rRNA precursor from Bacillus subtilis into 5S-rRNA, with 5'-phosphate and 3'-hydroxy groups. Group: Enzymes. Synonyms: RNase M5; 5S ribosomal maturation nuclease; 5S ribosomal RNA maturation endonuclease. Enzyme Commission Number: EC 3.1.26.8. CAS No. 62253-00-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3596; ribonuclease M5; EC 3.1.26.8; 62253-00-3; RNase M5; 5S ribosomal maturation nuclease; 5S ribosomal RNA maturation endonuclease. Cat No: EXWM-3596. | |
| Ribonuclease T2 from Aspergillus oryzae, Recombinant | Aspergillus oryzae Ribonuclease T2 is a member of the RNase T2 family of endonucleases that are present in a wide variety of microbial, plant and animal species. In contrast to Aspergillus oryzae Ribonuclease T1, which is an exclusively guanylic-acid specific endonuclease, all RNase T2-like enzymes are essentially base non-specific. However, RNase T2 endonucleases from different species can show slight base preferences. The fungal enzymes, including Aspargillus oryzae RNaseT2, show slight base preference in the following order: A>G>C, U. RNase T2 cleaves between the 3-phosphate residue of one base and the 5-OH residue of the adjacent nucleotide forming a 2, 3-cyclic phosphate intermediate followed by the generation of oligonucleotides with 3-phosphate residues. This enzyme is also used as a non-mammalian source of RNase in various applications. Group: Enzymes. Synonyms: Ribonuclease T2; RNase T2; Ribonuclease. Enzyme Commission Number: EC 3.1.27.1. Rnase. Mole weight: 36 kDa. Activity: ≥10,000 units per mg protein. Stability: Stable at 12-18 months at 2-8°C. Storage: Store at 2-8°C. Form: Lyophilized powder. Source: Pichia pastoris. Species: Aspergillus oryzae. Ribonuclease T2; RNase T2; Ribonuclease. Cat No: NATE-1930. | |
| Serratia marcescens nuclease | Hydrolyses double- or single-stranded substrate. Group: Enzymes. Synonyms: endonuclease (Serratia marcescens); barley nuclease; plant nuclease I; nucleate endonuclease. Enzyme Commission Number: EC 3.1.30.2. CAS No. 9025-65-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3708; Serratia marcescens nuclease; EC 3.1.30.2; 9025-65-4; endonuclease (Serratia marcescens); barley nuclease; plant nuclease I; nucleate endonuclease. Cat No: EXWM-3708. | |
| sgRNA Screening Kit | sgRNA Screening Kit. Sgrna screening kit provides a simple, reliable, and rapid method for assessing sgrna efficiency before cell transduction, allowing you to identify the highly effective crispr sgrna. cas9 nuclease nls is an rna-guided endonuclease that catalyzes site-specific cleavage of double stranded dna. the location of the break is within the target sequence 3 bases from the ngg pam (protospacer adjacent motif). the design of single guide rna (sgrna) is dependent on the target region close to the pam site. even if you pick a target sequence that fulfills all of the described requirements, sgrna specificity and activity is unpredictable. therefore, it is often recommended that multiple, different sgrnas be designed to target a gene of interest. components. gencrispr cas9 nuclease. 10x reaction buffer. positive control sgrna. positive control substrate. rnase-free water. Group: Cloning Enzymes. Purity: 30 reactions/kit. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol PH 7.4, at 25°C. Cat No: CE-3509. | |
| STF-083010 | STF-083010 is a novel small-molecule inhibitor of Ire1α; inhibits Ire1 endonuclease activity, without affecting its kinase activity after endoplasmic reticulum stress both in vitro and in vivo. Synonyms: STF-083010; STF 083010; STF083010, IRE1 Inhibitor I. Grades: >98%. CAS No. 307543-71-1. Molecular formula: C15H11NO3S2. Mole weight: 317.38. | |
| T4 β-glucosyltransferase, Recombinant | In enzymology, a DNA beta-glucosyltransferase is an enzyme that catalyzes the chemical reaction in which a beta-D-glucosyl residue is transferred from UDP-glucose to an hydroxymethylcytosine residue in DNA. It is analogous to the enzyme DNA alpha-glucosyltransferase. This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. T4-phage beta-glucosyltransferase, also known as udp glucose-dna ?-glucosyltransferase, (genbank accession no. np_049658) amino acids 1-351 (end) with c-terminal his-tag, mw= 41.6 kda, expressed in e. coli. Applications: Useful for the differentiation of hydroxymethylcytosine (hmc) from methylcytosine in dna, via glucosylating hmc and protecting hmc from endonuclease cleavage. Group: Enzymes. Synonyms: T4 Beta-glucosyltransferase; DNA beta-glucosyltransferase; T4-HMC-beta-glucosyl transferase; T4-beta-glucosy. Purity: > 83% (SDS-PAGE). β-glucosyltransferase. Mole weight: mol wt 41.6 kDa. Storage: -70°C. Form: aqueous solution, Formulated in 200 mM imidazole and 20% glycerol. Source: E. coli. T4 Beta-glucosyltransferase; DNA beta-glucosyltransferase; T4-HMC-beta-glucosyl transferase; T4-beta-glucosyl transferase; T4 phage beta-glucosyltransferase; UDP glucose-DNA beta-glucosyltransferase; uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase. Cat No: NATE-0773. | |
| T4 deoxyribonuclease II | Requires Mg2+. This phage T4 enzyme is involved in degradation of host DNA. The enzyme primarily catalyses nicking of the bottom strand of double stranded DNA between the first and second base pair to the right of a top-strand CCGC motif. Double-stranded breaks are produced 5- to 10-fold less frequently. It does not cleave the T4 native DNA, which contains 5-hydroxymethylcytosine instead of cytosine. Group: Enzymes. Synonyms: T4 endonuclease II; EndoII (ambiguous); denA (gene name). Enzyme Commission Number: EC 3.1.21.8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3578; T4 deoxyribonuclease II; EC 3.1.21.8; T4 endonuclease II; EndoII (ambiguous); denA (gene name). Cat No: EXWM-3578. | |
| T4 deoxyribonuclease IV | This phage T4 enzyme is involved in degradation of host DNA. The enzyme does not cleave double-stranded DNA or native T4 DNA, which contains 5-hydroxymethylcytosine instead of cytosine. Group: Enzymes. Synonyms: T4 endonuclease IV; EndoIV (ambiguous); denB (gene name). Enzyme Commission Number: EC 3.1.21.9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3579; T4 deoxyribonuclease IV; EC 3.1.21.9; T4 endonuclease IV; EndoIV (ambiguous); denB (gene name). Cat No: EXWM-3579. | |
| Tenilsetam | Tenilsetam is an endonuclease modulator, also a nootropic agent and advanced glycation end product (AGE) inhibitor with the potential to treat Alzheimer's disease (AD). Preclinical studies indicated that tenilsetam may have an inhibitory effect on diabetic retinopathy, without amelioration of pericyte loss. Uses: Potential treatment of alzheimer's disease. Synonyms: 3-(thiophen-2-yl)piperazin-2-one; 3-thiophen-2-ylpiperazin-2-one; 3-(2-thienyl)piperazin-2-one. Grades: 99%. CAS No. 86696-86-8. Molecular formula: C8H10N2OS. Mole weight: 182.24. | |
| tRNA-intron lyase | The enzyme catalyses the final stage in the maturation of tRNA molecules. Group: Enzymes. Synonyms: transfer ribonucleate intron endoribonuclease; tRNA splicing endonuclease; splicing endonuclease; tRNATRPintron endonuclease; transfer splicing endonuclease. Enzyme Commission Number: EC 4.6.1.16. CAS No. 117444-13-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5353; tRNA-intron lyase; EC 4.6.1.16; 117444-13-0; transfer ribonucleate intron endoribonuclease; tRNA splicing endonuclease; splicing endonuclease; tRNATRPintron endonuclease; transfer splicing endonuclease. Cat No: EXWM-5353. | |
| tRNase Z | No cofactor requirements. An homologous enzyme to that found in Arabidopsis thaliana has been found in Methanococcus janaschii. Group: Enzymes. Synonyms: 3 tRNase; tRNA 3 endonuclease; RNase Z; 3' tRNase. Enzyme Commission Number: EC 3.1.26.11. CAS No. 98148-84-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3587; tRNase Z; EC 3.1.26.11; 98148-84-6; 3 tRNase; tRNA 3 endonuclease; RNase Z; 3' tRNase. Cat No: EXWM-3587. | |
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