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| Product | Description | |
|---|---|---|
| Entrectinib | Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity. RXDX-101 has demonstrated potent pharmacological activity in preclinical studies and has the potential to be first-in-class against the Trk family of kinases. PXDX-101 has been well tolerated in patients with advanced solid tumors. PXDX-101 is currently in clinical trials, and is being developed by Ignyta. Uses: Designed for use in research and industrial production. Additional or Alternative Names: RXDX101; RXDX 101; RXDX-101; NMS E628; NMSE628; NMS-E628; Entrectinib. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1108743-60-7. Molecular formula: C31H34F2N6O2. Mole weight: 560.64. Purity: >98%. IUPACName: N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide. Canonical SMILES: O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=CC=C(N5CCN(C)CC5)C=C4NC6CCOCC6. Product ID: ACM1108743607. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Entrectinib | Entrectinib (NMS-E628) is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C , ROS1 and ALK , with IC 50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NMS-E628; RXDX-101. CAS No. 1108743-60-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12678. |  |
| Entrectinib | Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Phase 2. Uses: Protein kinase inhibitors. Synonyms: RXDX101; RXDX 101; RXDX-101; NMS E628; NMS-E628; Entrectinib; N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide. Grades: ≥98%. CAS No. 1108743-60-7. Molecular formula: C31H34F2N6O2. Mole weight: 560.64. |  |
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