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1,8-cineole synthase Requires Mn2+ or Zn2+. Mg2+ is less effective than either. 1,8-Cineole is the main product from the enzyme with just traces of other monoterpenoids. The oxygen atom is derived from water. The reaction proceeds via linalyl diphosphate and α-terpineol, the stereochemistry of both depends on the organism. However neither intermediate can substitute for geranyl diphosphate. The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)-linalyl diphosphate while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate. Group: Enzymes. Synonyms: 1,8-cineole cyclase; geranyl pyrophoshate:1,8-cineole cyclase; 1,8-cineole synthetase. Enzyme Commission Number: EC 4.2.3.108. CAS No. 110637-19-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5119; 1,8-cineole synthase; EC 4.2.3.108; 110637-19-9; 1,8-cineole cyclase; geranyl pyrophoshate:1,8-cineole cyclase; 1,8-cineole synthetase. Cat No: EXWM-5119. Creative Enzymes
(-)-α-pinene synthase Cyclase II of Salvia officinalis (sage) gives about equal parts (-)-α-pinene, (-)-β-pinene and (-)-camphene, plus traces of other monoterpenoids. (3S)-Linalyl diphosphate can also be used by the enzyme in preference to (3R)-linalyl diphosphate. The 4-pro-S-hydrogen of geranyl diphosphate is lost. Requires Mg2+ (preferred to Mn2+). The enzyme from Abies grandis (grand fir) gives roughly equal parts (-)-α-pinene and (-)-β-pinene. However the clone ag11 gave 35% (-)-limonene, 24% (-)-α-pinene and 20% (-)-β-phellandrene. It requires Mn2+ and K+ (Mg2+ is ineffective). Synthase I from Pinus taeda (loblolly pine) produces (-)-α-pinene with traces...ve roughly equal proportions of (-)-α-pinene and (-)-camphene plus traces of other monoterpenoids. See also EC 4.2.3.120, (-)-β-pinene synthase; EC 4.2.3.117, (-)-camphene synthase; EC 4.2.3.16, (-)-limonene synthase; and EC 4.2.3.52, (-)-β-phellandrene synthase. Group: Enzymes. Synonyms: (-)-α-pinene/(-)-camphene synthase; (-)-α-pinene cyclase. Enzyme Commission Number: EC 4.2.3.119. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5131; (-)-α-pinene synthase; EC 4.2.3.119; (-)-α-pinene/(-)-camphene synthase; (-)-α-pinene cyclase. Cat No: EXWM-5131. Creative Enzymes
(-)-β-pinene synthase Cyclase II of Salvia officinalis (sage) produces about equal parts (-)-α-pinene, (-)-β-pinene and (-)-camphene, plus traces of other monoterpenoids. The enzyme, which requires Mg2+ (preferred to Mn2+), can also use (3S)-Linalyl diphosphate (preferred to (3R)-linalyl diphosphate). The enzyme from Abies grandis (grand fir) produces roughly equal parts of (-)-α-pinene and (-)-β-pinene. Cyclase IV from Pinus contorta (lodgepole pine) produces 63% (-)-β-pinene, 26% 3-carene, and traces of α-pinene. Synthase III from Pinus taeda (loblolly pine) forms (-)-β-pinene with traces of α-pinene and requires Mn2+ and K+ (Mg2+ is ineffective). A clone...a spruce) forms 30% (-)-β-pinene and 70% (-)-α-pinene. See also EC 4.2.3.119, (-)-α-pinene synthase, EC 4.2.3.117, (-)-camphene synthase, and EC 4.2.3.107 (+)-3-carene synthase. Group: Enzymes. Synonyms: β-geraniolene synthase; (-)-(1S,5S)-pinene synthase; geranyldiphosphate diphosphate lyase (pinene forming). Enzyme Commission Number: EC 4.2.3.120. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5133; (-)-β-pinene synthase; EC 4.2.3.120; β-geraniolene synthase; (-)-(1S,5S)-pinene synthase; geranyldiphosphate diphosphate lyase (pinene forming). Cat No: EXWM-5133. Creative Enzymes
(+)-β-pinene synthase Cyclase III from Salvia officinalis (sage) gives roughly equal parts of (+)-β-pinene and (+)-α-pinene. See EC 4.2.3.121, (+)-α-pinene synthase. Group: Enzymes. Synonyms: (+)-pinene cyclase; cyclase III. Enzyme Commission Number: EC 4.2.3.122. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5135; (+)-β-pinene synthase; EC 4.2.3.122; (+)-pinene cyclase; cyclase III. Cat No: EXWM-5135. Creative Enzymes
(+)-bornyl diphosphate synthase Requires Mg2+. The enzyme from Salvia officinalis (sage) can also use (3R)-linalyl diphosphate or more slowly neryl diphosphate in vitro. The reaction proceeds via isomeration of geranyl diphosphate to (3R)-linalyl diphosphate. The oxygen and phosphorus originally linked to C-1 of geranyl diphosphate end up linked to C-2 of (+)-bornyl diphosphate. cf. EC 5.5.1.22 [(-)-bornyl diphosphate synthase]. Group: Enzymes. Synonyms: bornyl pyrophosphate synthase (ambiguous); bornyl pyrophosphate synthetase (ambiguous); (+)-bornylpyrophosphate cyclase; geranyl-diphosphate cyclase (ambiguous); (+)-bornyl-diphosphate lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.8. CAS No. 72668-91-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5634; (+)-bornyl diphosphate synthase; EC 5.5.1.8; 72668-91-8; bornyl pyrophosphate synthase (ambiguous); bornyl pyrophosphate synthetase (ambiguous); (+)-bornylpyrophosphate cyclase; geranyl-diphosphate cyclase (ambiguous); (+)-bornyl-diphosphate lyase (decyclizing). Cat No: EXWM-5634. Creative Enzymes
(+)-camphor 6-exo-hydroxylase A cytochrome P-450 monooxygenase isolated from Salvia officinalis (sage). Involved in the catabolism of camphor in senescent tissue. Group: Enzymes. Synonyms: (+)-camphor 6-hydroxylase. Enzyme Commission Number: EC 1.14.13.161. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0761; (+)-camphor 6-exo-hydroxylase; EC 1.14.13.161; (+)-camphor 6-hydroxylase. Cat No: EXWM-0761. Creative Enzymes
Danshensu Danshensu is an active component of Salvia miltiorrhiza that shows wide cardiovascular benefit. It suppresses the formation of reactive oxygen species and inhibits platelet adhesion and aggregation. It also protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. It increases production of collagenin Detroit 551 cells and attenuates the α-MSH-stimulated melanin production of B16 cells. It may be used as active ingredients in would healing, cosmetic treatments or treating hyperpigmentation. It significantly decreased the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size in vitro. It also had ROS scavenging activity and boosted endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which was mediated by Akt and ERK1/2 in western blot analysis. It significantly lowered tHcy in rats with elevated tHcy. Danshensu is a natural compound, which can also be used in cosmetics material. Synonyms: Benzenepropanoic acid, α,3,4-trihydroxy-, (αR)-; (αR)-α,3,4-Trihydroxybenzenepropanoic acid; Benzenepropanoic acid, α,3,4-trihydroxy-, (R)-; (R)-(+)-3-(3,4-Dihydroxyphenyl)lactic acid; (R)-3-(3,4-Dihydroxyphenyl)-2-hydroxypropionic acid; 3-(3',4'-Dihydroxyphenyl)-(2R)-lactic acid; D-(+)-β-(3,4-Dihydroxyphenyl)lactic acid; Dan Shen Su; Dan shen suan A; DS 182; Salianic acid A; Salvianic acid A; Tanshinol. Grades: >98%. CAS No. 76822-21-4. Molecular formula: C9H10O5. Mole weight: 198.17. BOC Sciences 10
ferruginol synthase The enzyme is found in some members of the Lamiaceae (mint family). The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant. Group: Enzymes. Synonyms: miltiradiene oxidase (incorrect); CYP76AH1; miltiradiene,NADPH:oxygen oxidoreductase (ferruginol forming) (incorrect). Enzyme Commission Number: EC 1.14.13.190. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0790; ferruginol synthase; EC 1.14.13.190; miltiradiene oxidase (incorrect); CYP76AH1; miltiradiene,NADPH:oxygen oxidoreductase (ferruginol forming) (incorrect). Cat No: EXWM-0790. Creative Enzymes
miltiradiene synthase Isolated from the plants Rosmarinus officinalis (rosemary) and Salvia miltiorrhiza. The enzyme from the plant Selaginella moellendorffii is mutifunctional and also catalyses EC 5.5.1.12, copalyl diphosphate synthase. Group: Enzymes. Synonyms: SmMDS; SmiKSL; RoKSL. Enzyme Commission Number: EC 4.2.3.131. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5145; miltiradiene synthase; EC 4.2.3.131; SmMDS; SmiKSL; RoKSL. Cat No: EXWM-5145. Creative Enzymes
pelargonidin 3-O-(6-caffeoylglucoside) 5-O-(6-O-malonylglucoside) 4'''-malonyltransferase Isolated from the plant Salvia splendens (scarlet sage). Group: Enzymes. Synonyms: malonyl-CoA:anthocyanin 5-glucoside 4'''-O-malonyltransferase; Ss5MaT2. Enzyme Commission Number: EC 2.3.1.214. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2160; pelargonidin 3-O-(6-caffeoylglucoside) 5-O-(6-O-malonylglucoside) 4'''-malonyltransferase; EC 2.3.1.214; malonyl-CoA:anthocyanin 5-glucoside 4'''-O-malonyltransferase; Ss5MaT2. Cat No: EXWM-2160. Creative Enzymes
(+)-sabinene 3-hydroxylase Requires cytochrome P-450. The enzyme has been characterized from Salvia officinalis (sage). Group: Enzymes. Enzyme Commission Number: EC 1.14.13.153. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0753; (+)-sabinene 3-hydroxylase; EC 1.14.13.153. Cat No: EXWM-0753. Creative Enzymes
(+)-sabinene synthase Isolated from Salvia officinalis (sage). The recombinant enzyme gave 63% (+)-sabinene, 21% γ-terpinene, and traces of other monoterpenoids. See EC 4.2.3.114 γ-terpinene synthase. Group: Enzymes. Synonyms: SS. Enzyme Commission Number: EC 4.2.3.110. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5122; (+)-sabinene synthase; EC 4.2.3.110; SS. Cat No: EXWM-5122. Creative Enzymes
sclareol synthase Isolated from the plant Salvia sclarea (clary sage). Originally thought to be synthesized in one step from geranylgeranyl diphosphate it is now known to require two enzymes, EC 4.2.1.133, copal-8-ol diphosphate synthase and EC 4.2.3.141, sclareol synthase. Sclareol is used in perfumery. Group: Enzymes. Synonyms: SS. Enzyme Commission Number: EC 4.2.3.141. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5155; sclareol synthase; EC 4.2.3.141; SS. Cat No: EXWM-5155. Creative Enzymes
(+)-α-pinene synthase Cyclase I of Salvia officinalis (sage) gives about equal parts (+)-α-pinene and (+)-camphene, whereas cyclase III gives about equal parts of (+)-α-pinene and (+)-β-pinene. (3R)-Linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. The 4-pro-R-hydrogen of geranyl diphosphate is lost. Requires Mg2+ (preferred to Mn2+). With synthase II of Pinus taeda (loblolly pine) (+)-α-pinene was the only product. Requires Mn2+ (preferred to Mg2+). See also EC 4.2.3.122, (+)-β-pinene synthase, and EC 4.2.3.116, (+)-camphene synthase. Group: Enzymes. Synonyms: (+)-α-pinene cyclase; cyclase I. Enzyme Commission Number: EC 4.2.3.121. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5134; (+)-α-pinene synthase; EC 4.2.3.121; (+)-α-pinene cyclase; cyclase I. Cat No: EXWM-5134. Creative Enzymes
anthocyanin 5-O-glucoside 6'''-O-malonyltransferase Specific for the penultimate step in salvianin biosynthesis. The enzyme also catalyses the malonylation of shisonin to malonylshisonin [cyanidin 3-O-(6''-O-p-coumaryl-β-D-glucoside)-5-(6'''-O-malonyl-β-D-glucoside)]. The compounds 4'''-demalonylsalvianin, salvianin, pelargonidin 3,5-diglucoside and delphinidin 3,5-diglucoside cannot act as substrates. Group: Enzymes. Enzyme Commission Number: EC 2.3.1.172. CAS No. 380229-66-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2113; anthocyanin 5-O-glucoside 6'''-O-malonyltransferase; EC 2.3.1.172; 380229-66-3. Cat No: EXWM-2113. Creative Enzymes
(+)-camphene synthase Cyclase I of Salvia officinalis (sage) gives about equal parts (+)-camphene and (+)-α-pinene. (3R)-Linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. Requires Mg2+ (preferred to Mn2+). See also EC 4.2.3.121 (+)-α-pinene synthase. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.116. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5128; (+)-camphene synthase; EC 4.2.3.116. Cat No: EXWM-5128. Creative Enzymes
copalyl diphosphate synthase In some plants, such as Salvia miltiorrhiza, this enzyme is monofunctional. In other plants this activity is often a part of a bifunctional enzyme. For example, in Selaginella moellendorffii this activity is catalysed by a bifunctional enzyme that also catalyses EC 4.2.3.131, miltiradiene synthase, while in the tree Abies grandis (grand fir) it is catalysed by a bifunctional enzyme that also catalyses EC 4.2.3.18, abietadiene synthase. Group: Enzymes. Synonyms: (+)-copalyl-diphosphate lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.12. CAS No. 157972-08-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5613; copalyl diphosphate synthase; EC 5.5.1.12; 157972-08-2; (+)-copalyl-diphosphate lyase (decyclizing). Cat No: EXWM-5613. Creative Enzymes
Danshen Root Extract (Standard) Danshen Root Extract (Standard). Applications: Role of coronary artery: treatment of coronary heart disease, can improve the coronary circulation, inhibit thrombosis disease. danshensu a significant expansion of coronary artery, increase coronary blood flow, reducing myocardial oxygen consumption, heart rate and increase the role of myocardial contractility; danshen capsule expansion animals comfortable arteriole, the capillary network and opening up in number and speed up the flow of blood , flow, thus improving microcirculation; anti-infective; for the treatment of cervical erosion. Group: Others. Synonyms: Danshen Root Extract (Standard). Purity: 3%, 5%, 10%, 20%, HPLC. Appearance: Brown-red powder. Storage: 24 months with original packing under 18°C. Store in cool dry place,avoid sunlight and high temperature. Source: Salvia miltiorrhiza Bge. Danshen Root Extract (Standard); plant extract. Pack: 1kg, 5kg, 10kg aluminum foil vacuum bag; or 20kg, 25kg Fiber Drum. Cat No: EXTW-205. Creative Enzymes
Sage Extract Sage Extract. Applications: Used for women skin health care products, beauty products. Group: Others. Synonyms: Sage Extract; Salvia officinalis Linn. Purity: 10:1 By TLC. Appearance: Brown yellow fine powder. Storage: 2 years under well storage situation and stored away from direct sun light. Source: Whole herb. Species: Salvia officinalis Linn. Sage Extract; Salvia officinalis Linn; plant extract. Pack: 20KG-25KG/Drum with double plastic bag of foodstuff inside. Cat No: EXTW-090. Creative Enzymes
Salvia Miltiorrhiza Extract Salvia miltiorrhiza extract is prepared from the root of the perennial plant in the genus salvia, native in China and Japan. Salvia miltiorrhiza extract, also known as dan-shen extract, is used to normalize blood pressure, increase blood circulation and aid in the prevention of heart disease. Salvia miltiorrhiza extract has been widely for the treatment of cardiovascular and cerebrovascular diseases used in China. Group: Others. Mole weight: 294.33. Salvia Miltiorrhiza Extract; Salvia miltiorrhiza Bge. Cat No: EXTC-037. Creative Enzymes

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