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Product | Description | |
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1,2,3,4,6-Penta-O-galloyl-D-glucopyranose Quick inquiry Where to buy Suppliers range | 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose is a naturally occurring polyphenolic compound found in plants. It exhibits cytotoxicity against several cancer cells and inhibits various enzymes related to cancer progression. It also has potent antioxidant activity and anti-inflammatory properties. Synonyms: D-Glucopyranose, pentakis(3,4,5-trihydroxybenzoate);[(2R,3R,4S,5R)-3,4,5,6-tetrakis[(3,4,5-trihydroxybenzoyl)oxy]oxan-2-yl]methyl 3, 4, 5-trihydroxybenzoate; (3R, 4S, 5R, 6R) -6- ( ( (3, 4, 5-Trihydroxybenzoyl) oxy) methyl) tetrahydro-2H-pyran-2, 3, 4, 5-tetrayl tetrakis(3,4,5-trihydroxybenzoate); 3-O-Digalloyl-1,2,6-trigalloylglucose; PD179123; 1,2,3,4,6-penta-O-galloyl--d-glucopyranose;D-Glucose, 2,3,4,5,6-pentakis(3,4,5-trihydroxybenzoate). CAS No. 50678-27-8. Molecular formula: C41H32O26. Mole weight: 940.68. | |
1,4-Dicyanonaphthalene Quick inquiry Where to buy Suppliers range | 1,4-Dicyanonaphthalene is used in biological studies as electron transfer mechanism of nucleic acid precursors and ctDNA with protein enzymes and several fluorescence probes in both static and excited states. Group: Biochemicals. Grades: Highly Purified. CAS No. 3029-30-9. Pack Sizes: 2.5g, 5g. Molecular Formula: C12H6N2, Molecular Weight: 178.19. US Biological Life Sciences. | Worldwide |
2',3',6'-TBnz-Guo Quick inquiry Where to buy Suppliers range | 2',3',6'-TBnz-Guo, a nucleoside analogue, serves as a therapeutic agent against several viral infections, such as hepatitis B and C. Notably, this compound hinders viral replication whilst curbing inflammation, owing to an active inhibition of viral polymerase enzyme. Furthermore, 2',3',6'-TBnz-Guo is a versatile research tool employed to uncover intricate mechanisms of antiviral agents and nucleotide chemistry. CAS No. 66048-63-1. Molecular formula: C31H26N6O8. Mole weight: 696.6. | |
2,3-Dideoxy-2-methylene-D-glycero-D-galacto-nononic acid γ-lactone Quick inquiry Where to buy Suppliers range | 2,3-Dideoxy-2-methylene-D-glycero-D-galacto-nononic acid γ-lactone, a groundbreaking biomedicine with remarkable antiviral attributes, has garnered immense attention within the scientific domain. By effectively obstructing the replication of targeted viruses and mitigating the severity of associated ailments, this compound exhibits immense therapeutic potential. Its intricate mechanism involves disrupting crucial viral enzymes and vital processes, presenting a promising avenue for combating viral infections. Synonyms: (5S)-3-methylidene-5-[(1S,2S,3R,4R)-1,2,3,4,5-pentahydroxypentyl]oxolan-2-one; 2,3-DIDEOXY-2-METHYLENE-D-GLYCERO-D-GALACTO-NONONIC ACID ?-LACTONE; 2,3-Dideoxy-2-methylene-D-glycero-D-galacto-nononic Acid gamma-Lactone;2,3-Dideoxy-2-methylene-D-glycero-d-galacto-nononic acid-lactone; (5S)-3-Methylidene-5-[(1S,2S,3R,4R)-1,2,3,4,5-pentahydroxypentyl]dihydrofuran-2(3H)-one (non-preferred name). CAS No. 289697-66-1. Molecular formula: C10H16O7. Mole weight: 248.23. | |
2'-Deoxy-2'-fluoroadenosine 5'-monophosphate triethylammonium Quick inquiry Where to buy Suppliers range | 2'-Deoxy-2'-fluoroadenosine 5'-monophosphate triethylammonium is a complex nucleotide analog, frequently employed in advanced biomedical research. The compound has been observed to interact with several essential enzymes, specifically those catalyzing the removal of RNA molecule's 3'-end. Promisingly, 2'-Deoxy-2'-fluoroadenosine 5'-monophosphate triethylammonium has not only displayed inhibitory properties against viruses such as hepatitis C and HIV but has also shown potential as a therapeutic agent for these viral diseases. Synonyms: [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate di(triethylammonium). Grades: ≥95%. Molecular formula: C22H43FN7O6P. Mole weight: 551.59. | |
2'-Deoxyuridine-5'-triphosphate trisodium salt Quick inquiry Where to buy Suppliers range | dUTP is a deoxynucleoside triphosphate (dNTP) that acts as a substrate for several enzymes. It can be used in PCR and qPCR. Synonyms: Deoxyuridine triphosphate trisodium salt; deoxy-UTP trisodium salt; dUTP trisodium salt; 2'-deoxy-Uridine 5'-(tetrahydrogen triphosphate) trisodium salt. Grades: ≥99% by HPLC. CAS No. 102814-08-4. Molecular formula: C9H12N2O14P3·3Na. Mole weight: 534.09. | |
2-Fluoro-2'-O-methyl adenosine Quick inquiry Where to buy Suppliers range | 2-Fluoro-2'-O-methyl adenosine is a vital compound in biomedicine used for its potential in drug development. With its unique chemical structure, it exhibits promising prospects in treating various diseases, including cancer and viral infections. Extensive research highlights its role in inhibiting specific enzymes and pathways, making it a valuable asset in the fight against several health conditions. Synonyms: 2'-O-methyl-2-fluoroadenosine; (2R,3R,4R,5R)-5-(6-Amino-2-fluoropurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol. CAS No. 116525-89-4. Molecular formula: C11H14FN5O4. Mole weight: 299.26. | |
2-O-(2-Nitrophenyl)-a-D-N-acetylneuraminic acid Quick inquiry Where to buy Suppliers range | 2-O-(2-Nitrophenyl)-α-D-N-acetylneuraminic acid, a synthetic organic compound utilized in the biomedical industry, serves as a substrate for sialidase enzymes and acts as a diagnostic tool for detecting sialidosis, an uncommon genetic ailment resulting from sialidase enzyme paucity. Moreover, it plays a pivotal role in the therapeutic drug development for combatting viral infections like influenza and HIV, alongside several malignancies, thus exhibiting substantial clinical significance. The efficaciousness of this compound in multiple biomedical applications remains unparalleled, driving it towards becoming an essential component in the research industry. Synonyms: ONP-a-NeuNAc. CAS No. 157707-92-1. Molecular formula: C17H22N2O11. Mole weight: 430.36. | |
3-(((4-Amino-2-methylpyrimidin-5-yl)methyl)thio)propane-1,2-diol Quick inquiry Where to buy Suppliers range | 3-(((4-Amino-2-methylpyrimidin-5-yl)methyl)thio)propane-1,2-diol is a derivative of Toxopyrimidine (T686980), an intermediate in thiamin biosynthetic pathway and a cofactor crucial for several enzymes involved in carbohydrate/amino acid metabolism. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C9H15N3O2S, Molecular Weight: 229.3. US Biological Life Sciences. | Worldwide |
3-Nitropropionic Acid Quick inquiry Where to buy Suppliers range | A cell-permeable, irreversible inactivator (~3mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38mg/kg/day) is shown to cause activation of c-Jun kinase in striatum. Group: Biochemicals. Alternative Names: 3-NP, 3-NPA, 3NPA. Grades: Highly Purified. CAS No. 504-88-1. Pack Sizes: 50mg. Molecular Formula: C?H?NO?. US Biological Life Sciences. | Worldwide |
4-Methylphenyl 4,6-O-benzylidene-b-D-thioglucopyranoside Quick inquiry Where to buy Suppliers range | 4-Methylphenyl 4,6-O-benzylidene-b-D-thioglucopyranoside, a widely utilized chemical compound within the realm of biomedical research, showcases its significance as a substrate in several enzymatic reactions, consequently enhancing the comprehensive exploration of carbohydrate metabolism. Furthermore, its utilization extends towards the domain of drug discovery and development, with a particular focus on potential therapeutic interventions targeting diabetes and metabolic ailments, firmly establishing its value within the scientific community. CAS No. 868241-49-0. Molecular formula: C20H22O5S. Mole weight: 374.45. | |
4-Nitrophenyl butyrate Quick inquiry Where to buy Suppliers range | 4-Nitrophenyl butyrate, a substrate that detects esterase activity, plays a crucial role in researching various biological systems. Esterases, the pivotal enzymes that hydrolyze esters, have been linked to several diseases like Niemann-Pick disease and Gaucher's disease. The biomedical industry, leveraging this substrate, focuses on examining the efficacy of esterase-targeted drug therapies. Furthermore, this substrate helps us better understand the association between enzyme deficiencies and pathologies, promoting novel treatments breakthroughs. Synonyms: Butyric acid 4-nitrophenyl ester. CAS No. 2635-84-9. Molecular formula: C10H11NO4. Mole weight: 209.20. | |
4-Nitrophenyl palmitate Quick inquiry Where to buy Suppliers range | 4-Nitrophenyl palmitate is an indispensable biochemical tool in the field of enzymology, specifically in the investigation and characterization of lipases and esterases. As a substrate, this compound serves as a reliable indicator of enzyme activity, crucial in unraveling the intricate mechanisms underlying the metabolism of dietary lipids into their energy-yielding components. By facilitating the identification and manipulation of these enzymes, the application of 4-Nitrophenyl palmitate holds great promise in the study of several pathophysiological conditions, including obesity, diabetes, and cardiovascular disease. Synonyms: 4-Nitrophenyl hexadecanoate Palmitic acid 4-nitrophenyl ester. CAS No. 1492-30-4. Molecular formula: C22H35NO4. Mole weight: 377.52. | |
5'-O-(3'-Guanylyl)uridine Quick inquiry Where to buy Suppliers range | 5'-O-(3'-Guanylyl)uridine, a biomolecule ubiquitous in the biomedical industry, facilitates RNA processing and translation. Notwithstanding, this biomolecule's salience is not restricted to solely association with these fundamental processes. Remarkably, it also serves as a substrate for various enzymes, mitigating the severity of viral infections, and demonstrating its potential therapeutic applications. Synonyms: guanylyl(3'-5')uridine; GpU RNA Dinucleotide (5'-3'). Grades: ≥95% by AX-HPLC. Molecular formula: C19H24N7O13P. Mole weight: 589.40. | |
7-TFA-ap-7-Deaza-2',3'-dideoxyguanosine Quick inquiry Where to buy Suppliers range | 7-TFA-ap-7-Deaza-2',3'-dideoxyguanosine, a highly potent antiviral compound that demonstrates selectivity and efficacy, has been used extensively for treating several viral infections, specifically HIV and HBV. The compound acts as a nucleoside analogue, restraining the reverse transcriptase enzyme that is fundamental for viral replication. Owing to its unique molecular makeup, it offers greater potency than other nucleoside analogues. Synonyms: 7-TFA-ap-7-Deaza-ddG; Acetamide, N-[3-[2-amino-4,7-dihydro-4-oxo-7-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]-3H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-propyn-1-yl]-2,2,2-trifluoro-; N-(3-{2-Amino-7-[(2R,5S)-5-(hydroxymethyl)tetrahydro-2-furanyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-propyn-1-yl)-2,2,2-trifluoroacetamide. Grades: ≥97% by HPLC. CAS No. 114748-68-4. Molecular formula: C16H16F3N5O4. Mole weight: 399.32. | |
8,11-Eicosadiynoic acid Quick inquiry Where to buy Suppliers range | 8,11-Eicosadiynoic acid is an acetylenic fatty acid which inhibits arachidonic acid metabolism at several unrelated stages. 8,11-Eicosadiynoic acid inhibits the enzymes, arachidonoyl synthase, acyl-CoA synthase, Δ-5-desaturase, COX, and also arachidonic acid uptake by platelets. Synonyms: EDYA; Eicosa-8,11-diynoic acid. Grades: ≥95%. CAS No. 82073-91-4. Molecular formula: C20H32O2. Mole weight: 304.5. | |
Acetylsalicylic Acid Impurity E Quick inquiry Where to buy Suppliers range | Sasapyrine (salsalate) is a nonsteroidal oral anti-inflammatory agent.Relative to other NSAIDs, salsalate has a weak inhibitory effect on the cyclooxygenase enzyme and decreases the production of several pro inflammatory chemical signals such as interleukin-6, TNF-alpha, and C-reactive protein. Synonyms: NSC-49171. Grades: >98%. CAS No. 552-94-3. Molecular formula: C14H10O5. Mole weight: 258.23. | |
Acetyl Vitamin B12 Quick inquiry Where to buy Suppliers range | Acetyl Vitamin B12 is a derivative of Vitamin B12. Vitamin B12 gets converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment. Synonyms: Coβ-cyano-O5R-acetylcobalamin. Grades: 80%. CAS No. 855207-36-2. Molecular formula: C65H90CoN14O15P. Mole weight: 1397.4. | |
Acetyl Vitamin B12 Quick inquiry Where to buy Suppliers range | Acetyl Vitamin B12 is a derivative of Vitamin B12 (V676020). Vitamin B12 gets converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment. Group: Biochemicals. Grades: Highly Purified. CAS No. 855207-36-2. Pack Sizes: 10mg, 25mg. Molecular Formula: C65H90CoN14O15P. US Biological Life Sciences. | Worldwide |
Altenusin Quick inquiry Where to buy Suppliers range | Altenusin is a a biphenyl derivative with an IC50 value of 4.3±0.3 μM in the TR assay, which is isolated from the endophytic fungus Alternaria. It inhibits Src kinase with an IC50 value of 20 nM. Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM. Altenusin is known to have antioxidant properties and to inhibit several enzymes, including myosin light chain kinase, sphingomyelinase, acetylcholinesterase, cFMS kinase, pp60c-SRc kinase and HIV-1 integrase. Synonyms: Alutenusin; MS 341; MS-341; MS341. Grades: ≥98%. CAS No. 31186-12-6. Molecular formula: C15H14O6. Mole weight: 290.27. | |
beta-Naphthyl stearate Quick inquiry Where to buy Suppliers range | Beta-Naphthyl Stearate, a chemical compound, is well-known for its utilization as a prime substrate for lipase enzymes and as a quintessential reference compound for mass spectrometry. Along with this, it has also been extensively researched for its implications as a potential biomarker for several detrimental ailments, particularly Alzheimer's disease. CAS No. 6343-74-4. Molecular formula: C28H42O2. Mole weight: 410.63. | |
Cerulenin Quick inquiry Where to buy Suppliers range | Cerulenin is an epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function. It has a role as an antifungal agent, an antiinfective agent, an antilipemic drug, an antimetabolite, a fatty acid synthesis inhibitor and an antimicrobial agent. Uses: Microbial Fermentation Products. CAS No. 17397-89-6. Product ID: MFP-057. | |
cis-4-Hydroxy-L-proline Quick inquiry Where to buy Suppliers range | Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline. Group: Biochemicals. Alternative Names: (4S)-4-Hydroxy-L-proline; (2S,4S)-4-Hydroxyproline; (S)-Allo-hydroxyproline; (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic Acid; L-Allohydroxyproline; cis-4-Hydroxyproline; cis-Hydroxyproline. Grades: Highly Purified. CAS No. 618-27-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
Cobicistat Quick inquiry Where to buy Suppliers range | Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate. Uses: Anti-hiv agents. Synonyms: Cobicistat, GS-9350; GS 9350; GS9350. Grades: 0.99. CAS No. 1004316-88-4. Molecular formula: C40H53N7O5S2. Mole weight: 776.028. | |
Corey lactone THP Quick inquiry Where to buy Suppliers range | Corey lactone THP, being an organic compound, has proven to be an essential building block in synthesizing several drugs, distinguishedly an antitumor agent and an angiotensin-converting enzyme inhibitor. Additionally, it finds its application as a safeguarding group for alcohols during organic synthesis. Its utilization in these domains is of critical significance owing to its potential in enhancing drug efficacy. Synonyms: (3aR,4S,5R,6aS)-4-(Hydroxymethyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one; 2H-Cyclopenta[b]furan-2-one, hexahydro-4-(hydroxymethyl)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-, (3aR,4S,5R,6aS)-. Grades: 95%. CAS No. 69222-61-3. Molecular formula: C13H20O5. Mole weight: 256.29. | |
Cyanocobalamin (Vitamin B12) Quick inquiry Where to buy Suppliers range | Prototype of the family of naturally occurring cobalt coordination compounds knows as corrinoids. Analogs of vitamin B12 which differ only in the β-ligand of the cobalt are termed cobalamins. Synthesized almost exclusively by bacteria. Dietary sources include fish, meat, liver, and dairy products; plants have little or no cobalamins. Converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment. Group: Biochemicals. Alternative Names: 5,6-Dimethyl-1-(3-O-phosphono-α-D-ribofuranosyl)-1H-benzimidazole Monoester Cobinamide Cyanide Inner Salt; 5,6-Dimethylbenzimidazolyl Cyanocobamide; 5,6-Dimethylbenzimidazolyl-Co-cyanocobamide; Anacobin; Antipernicin; Apikobal; B-Twelve; B-Twelve Ora; Bedodeka; Bedoz; Behepan; Berubi; Berubigen; Dobetin; Docemine; Docibin; Poyamin; Rebramin; Redamina; Vitarubin; Vitral. Grades: Cell Culture Grade. CAS No. 68-19-9. Pack Sizes: 1g, 5g, 10g, 25g. Molecular Formula: C63H88CoN14O14P, Molecular Weight: 1355.38. US Biological Life Sciences. | Worldwide |
dA-H-Phosphonate, TEA Salt Quick inquiry Where to buy Suppliers range | dA-H-Phosphonate, TEA Salt is a compound of biochemical importance in the pharmaceutical industry, owing to its utilization as a phosphonate ester in synthesizing drugs. Furthermore, it finds application as a versatile research reagent for investigating several diseases, ranging from cancer, HIV, to Alzheimer's. The unique chemical characteristics of this compound make it an efficient inhibitor of enzymes and cellular processes, thereby aiding researchers in better comprehending the intricacies of biological pathways. Synonyms: 5'-Dimethoxytrityl-N-benzoyl-2'-deoxyAdenosine, 3'-H-phosphonate, TEA salt. Molecular formula: C44H51N6O8P. Mole weight: 822.9. | |
DL-Pyroglutamic acid Quick inquiry Where to buy Suppliers range | Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is an uncommon and little studied amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate. This is one of several forms of blocked N-terminals which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue. Synonyms: 5-oxoproline; DL-2-Pyrrolidone-5-carboxylic acid; DL-Pyroglutamic acid; 2-Pyrrolidone-5-carboxylic acid; 5-Oxopyrrolidine-2-carboxylic Acid. Grades: ? 95%. CAS No. 149-87-1. Molecular formula: C5H7NO3. Mole weight: 129.11. | |
DMBO (CCDC-272761) Quick inquiry Where to buy Suppliers range | An oxazine that appears to mimic the pyranosidic moiety of heparin sulfate, and is shown to interact directly with several growth factors and cytokines including VEGF, TNF-a and heparin-binding-EGF in a surface plasmon resonance assay. At concentrations of 10-80uM, this compound dose-dependently inhibits the proliferation of VEGF-expressing LM8G7 cells (IC50=13uM), and TNF-a-expressing OVSAHO cells (IC50=19uM). At 195uM, a 99% reduction in cell growth is observed in HB-EGF-expressing SKOV-3 cultures. This compound inhibits heparanase-mediated degradation of heparin sulfate in LM8G7 cells (IC50=65uM and 104-206uM, in an enzymatic and a cell based assay, respectively). At 0.5-5uM, it markedly prevents the migration and invasion of the same culture, in a dose-dependent manner. In addition, it completely suppresses liver metastatic nodules of osteosarcoma mice injected with LM8G7 cells at 0.5mg/kg without any signs of toxicity in vivo, and demonstrates a synergistic anti-tumor effect when Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
DUB Inhibitor IV, b-AP15 (NSC687852, 3, 5-bis ( (4-Nitrophenyl) methylidene) -1-prop-2-enoylpiperidin-4-one, (3E, 5E) -1-Acryloyl-3, 5-bis (4-nitrobenzylidene) piperidin-4-one, USP14 Inhibitor III, UCH-L5/UCH37 Inhibitor II) Quick inquiry Where to buy Suppliers range | A cell-permeable bis-nitrobenzylidene-piperidinone compound that acts as a potent, reversible and selective inhibitor of 19S regulatory-particle-associated deubiquitylating enzymes (DUBs) UCH-L5 and USP-14 (IC50=2.1uM against Ub-AMC substrate), with no effect on UCH-L1, UCH-L3, USP2, USP7, USP8 and BAP1 and on the proteasomal proteolytic activities. Shown to prevent proteasomal degradation (IC50=0.8uM in MelJuSo-UbG76V-YFP cells), and cause accumulation of higher molecular weights polyubiquitinated proteins in HCT-116 cells. Preferentially induces cell-cycle arrest and apoptosis in several colon cancer and in CNS cells, and effectively suppresses tumor growth in various mouse model (5mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. CAS No. 1009817-63-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Molecular Weight: 419.4. US Biological Life Sciences. | Worldwide |
Elacridar Quick inquiry Where to buy Suppliers range | Elacridar hydrochloride (GF120918A) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects. Synonyms: GF120918; GF-120918; GF 120918; GF-120918A; GF120918A; GF 120918A; GG 918; D03968. Elacridar hydrochloride. CAS No. 143664-11-3. Molecular formula: C34H33N3O5. Mole weight: 563.654. | |
Epigenetic Multiple Ligand - CAS 1020399-52-3 Quick inquiry Where to buy Suppliers range | A cell-permeable bis-arylidene compound that acts as an epigenetic multiple ligand (epi-ML) and inhibits substrates processing by several chromatin-associated enzymes. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1020399-52-3. Pack Sizes: 10MG. Mole weight: 623.91. Catalog: AP1020399523. Assay: ≥97% (HPLC). | |
gamma-L-Glutamyl-alpha-naphthylamide Quick inquiry Where to buy Suppliers range | Gamma-L-Glutamyl-alpha-naphthylamide, a widely used enzymatic substrate, serves as a crucial tool in the identification of gamma-glutamyl transferase (GGT) activity in diverse physiological and pathological scenarios. Converging evidence has linked elevated levels of GGT to several diseases, spanning from liver and pancreatic cancer to alcoholism and cholestasis. By exploiting Gamma-L-Glutamyl-alpha-naphthylamide as a probe, scholars have unraveled new facets of GGT-related biochemistry, paving the way to the development of innovative therapeutic interventions. CAS No. 81012-91-1. Molecular formula: C16H18N2O5. Mole weight: 318.32. | |
Globotriaosylsphingosine Quick inquiry Where to buy Suppliers range | Globotriaosylsphingosine, or Gb3, is a crucial biomarker used in the biomedical industry to diagnose and monitor the progression of Fabry disease. This rare genetic disorder results from the deficiency of a specific enzyme, leading to the abnormal accumulation of Gb3 within various organs. Precise and sensitive detection of Gb3 helps physicians determine the severity of Fabry disease and devise personalized treatment plans accordingly. Synonyms: a-D-Gal-(1?4)-b-D-Gal-(1?4)-b-D-Glc-1?O-sphingosine; Lysoglobotriaosylceramide; Ceramide trihexoside; lysoGb3. Grades: >99%. CAS No. 126550-86-5. Molecular formula: C36H67NO17. Mole weight: 785.91. | |
GSK321 Quick inquiry Where to buy Suppliers range | GSK321 is a highly potent, selective inhibitor of mutant IDH1 enzymes, with IC50= 4.6 nM against R132H, 3.8 nM against R132C and 2.9 nM against R132G. GSK321 stably decreased 2-hydroxyglutarate (2-HG) production in several different IDH1 mutant AML cells within a 2-3 week time frame ex vivo. Because of the allosteric nature of the interaction, GSK321 is able to inhibit multiple mutant forms of IDH1, which is consistent with our cell biological observations. Furthermore, GSK321 retains excellent potency in cells, since it does not compete with the tightly bound cofactor. Synonyms: (7R)-1-[(4-fluorophenyl)methyl]-N-[3-[(1S)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrole-2-carbonyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-3-carboxamide; (7R)-1-[(4-fluorophenyl)methyl]-N-[3-[(1S)-1-hydroxyethyl]phenyl]-7-methyl-5-(1H-pyrrole-2-carbonyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-3-carboxamide; GSK321; GSK 321; GSK-321; BDBM195601. Grades: >98%. CAS No. 1816331-63-1. Molecular formula: C28H28FN5O3. Mole weight: 501.56. | |
Guanosine 5'-triphosphate Quick inquiry Where to buy Suppliers range | Guanosine triphosphate (GTP) is a guanine nucleotide containing three phosphate groups esterified to the sugar moiety. GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA. Synonyms: D-Guanosine 5'-triphosphate; Guanosine triphosphate; Guanosine 5'-triphosphoric acid; pppG; guanosine 5'-O-(triphosphate); [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate. Grades: ≥98% by AX-HPLC. CAS No. 86-01-1. Molecular formula: C10H16N5O14P3. Mole weight: 523.18. | |
Imatinib, Methanesulfonate Salt (STI-571, CGP-57148B) Quick inquiry Where to buy Suppliers range | A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). Imatinib inhibits bcr-abl tyrosine kinase activity, upon which some types of tumor cells depend for growth. Imatinib acts by binding to the ATP binding site of bcr-abl and competitively inhibiting its tyrosine kinase activity. Imatinib is selective for bcr-abl, but it also targets several other kinases (c-kit and PDGF-R). (1). Group: Biochemicals. Alternative Names: 4- [ (4-Methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] phenyl] benzamide Methanesulfonate; CGP 57148B; Imatinib Mesilate; Imatinib Methanesulfonate; Imatinib Mesylate; STI 571; Bcr-abl Inhibitor IV; Abl Inhibitor V, PDGFR Tyrosine Kinase Inhibitor XXIV, c-Kit Inhibitor IV. Grades: Highly Purified. CAS No. 220127-57-1. Pack Sizes: 25mg, 1g, 5g, 10g. US Biological Life Sciences. | Worldwide |
KT182 Quick inquiry Where to buy Suppliers range | KT182 is a potent inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6). ABHD6 is a transmembrane serine hydrolase hydrolyzing transmembrane serine hydrolase in nernous system. ABHD6 inhibition was shown to decrease seizure incidence in several mouse models of epilepsy, suggesting its potential for Dravet Syndrome treatment. Uses: Enzyme inhibitors. Synonyms: [4-[4-[3-(hydroxymethyl)phenyl]phenyl]triazol-1-yl]-(2-phenylpiperidin-1-yl)methanone. Grades: ≥98%. CAS No. 1402612-62-7. Molecular formula: C27H26N4O2. Mole weight: 438.5. | |
L+Lactic Acid, Calcium Salt, Pentahydrate Quick inquiry Where to buy Suppliers range | Lactic acid (2-hydroxypropanoic acid), also known as milk acid, is a chemical compound that plays a role in several biochemical processes. It was first isolated in 1780 by a Swedish chemist, Carl Wilhelm Scheele, and is a carboxylic acid with a chemical formula of C3H6O3. It has a hydroxyl group adjacent to the carboxyl group, making it an alpha hydroxy acid (AHA). In solution, it can lose a proton from the acidic group, producing the lactate ion CH3CH(OH)COO?. It is miscible with water or ethanol, and is hygroscopic. Lactic acid is chiral and has two optical isomers. One is known as L-(+)-lactic acid or (S)-lactic acid and the other, its mirror image, is D-(-)-lactic acid or (R)-lactic acid. L-(+)-Lactic acid is the biologically important isomer.In animals, L-lactate is constantly produced from pyruvate via the enzyme lactate dehydrogenase (LDH) in a process of fermentation during normal metabolism and exercise. It does not increase in concentration until the rate of lactate production exceeds the rate of lactate removal which is governed by a number of factors including: monocarboxylate transporters, concentration and isoform of LDH and oxidative capacity of tissues. The concentration of blood lactate is usually 1-2 mmol/L at rest, but can rise to over 20 mmol/L during intense exertion. Industrially, lactic acid fermentation is performed by Lactobacillus bacteria, among others. These bacteria can operate in the mouth; the acid they produce is responsible for the tooth decay known as caries.In medicine, lactate is one of the main components of Ringer's lactate or lactated Ringer's solution (Compound Sodium Lactate or Hartmann's Solution in the UK). This intravenous fluid consists of sodium and potassium cations, with lactate and chloride anions, in solution with distilled water in concentration so as to be isotonic compared to human blood. It is most commonly used for fluid resuscitation after blood loss due to trauma, surgery, or a burn injury. Group: Biochemicals. Alternative Names: Lactic Acid Calcium Salt (2:1) Pentahydrate; Propanoic Acid 2-Hydroxycalcium Salt Pentahydrate; Calcium Lactate Pentahydrate; Puracal DC. Grades: USP. CAS No. 5743-47-5. Pack Sizes: 100g, 250g, 500g, 1Kg, 2.5Kg. Molecular Formula: C6H10O6 Ca 5H2O, Molecular Weight: 308.29. US Biological Life Sciences. | Worldwide |
Mant-GMP Quick inquiry Where to buy Suppliers range | Mant-GMP, a fluorescent nucleotide analog, is extensively utilized in the biochemical and biomedical realms for several purposes, such as labeling, sequencing, and detection, owing to its proficiency in integrating within DNA and RNA. In tandem with its efficacy in studying enzymes involved in DNA and RNA metabolism, it has also been employed in the development of novel cancer and viral infection therapeutics. Synonyms: 2'/3'-O-(N-Methyl-anthraniloyl)-guanosine-5'-monophosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C18H21N6O9P (free acid). Mole weight: 496.37 (free acid). | |
Mant-XDP Quick inquiry Where to buy Suppliers range | Mant-XDP, a fluorescent probe, is a tool of promise utilized for monitoring MMPs' activity, enzymes that instigate tissue degradation underlying several diseases claiming countless lives. As a diagnostic tool, it shows sufficient prospects for use in conditions, ranging from cancer to rheumatoid arthritis, while simultaneously illuminating its potential therapeutic applications. Synonyms: 2'/3'-O-(N-Methyl-anthraniloyl)-xanthosine-5'-diphosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C18H21N5O13P2(free acid). Mole weight: 577.33 (free acid). | |
Methicillin Sodium, USP Quick inquiry Where to buy Suppliers range | Methicillin sodium is a narrow spectrum β-lactam antibiotic related to Penicillin. β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBPs are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Methicillin is mostly resistant to β-lactamases. Methicillin targets primarily the cell wall of Gram positive organisms especially Staphylococcus aureus. Group: Biochemicals. Alternative Names: Sodium (2, 6-dimethoxyphenyl) penicillin; (2S, 5R, 6R) -6-[ (2, 6-Dimethoxybenzoyl) amino]-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3. 2. 0]heptane-2-carboxylic Acid Sodium Salt; Meticillin; Staphcillin. Grades: USP. CAS No. 132-92-3. Pack Sizes: 50mg, 250mg, 500mg. US Biological Life Sciences. | Worldwide |
mPEG functionalized gelatin Quick inquiry Where to buy Suppliers range | 50% PEGylation, PEG average Mn 1k, gel strength 300 g Bloom. Uses: mPEG functionalized gelatin is Type A gelatin grafted with PEG that can be used in drug delivery research. Gelatin is a denatured protein that is obtained by hydrolysis of animal collagen. Its biodegradability, biocompatibility, chemical modification potential and cross-linking possibility make gelatin-based nanoparticles (GNPs) a promising carrier system for drug delivery applications. mPEG functionalization has several advantages - prolonged circulation in the body, decreased degradation by metabolic enzymes, and reduction or elimination of protein immunogencity. Group: Raw Materials. Alternative Names: PEGylated Gelatin. Pack Sizes: 100 mg. Product ID: MSMN-127. | |
Myriocin (Thermozymocidin, ISP) Quick inquiry Where to buy Suppliers range | Myriocin is an a-amino fatty acid derived from species of several genera of fungi, notably Myriococcum, Melanconis and Isaria. Myriocin is a potent inhibitor of sphingosine biosynthesis by blocking the first enzyme in the pathway, serine palmitoyltransferase. Myriocin induces apoptosis by depletion of cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 35891-70-4. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
NAD+, Lithium salt Quick inquiry Where to buy Suppliers range | NAD+, Lithium salt is the salt form of NAD+, which is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It plays a role in the activity of several enzymes, such as poly(ADP)-ribose polymerases and cADP-ribose synthases. NAD+ is commonly used as an oxidizing agent. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: β-Nicotinamide adenine Dinucleotide, Li; Beta-NAD lithium salt; Nicotinamide adenine dinucleotide lithium salt. CAS No. 64417-72-7. Molecular formula: C21H26LiN7O14P2. Mole weight: 669.362. | |
OBP-801 Quick inquiry Where to buy Suppliers range | OBP-801, also known YM753 and spiruchostatin A, is a novel cyclic-peptide-based HDAC inhibitor. YM753 is a bacteria-derived natural product containing a disulfide bond. It potently inhibited HDAC enzyme with an IC50 of 2.0 nM in the presence of dithiothreitol. YM753 was rapidly converted to a reduced form in tumor cells, and then induced accumulation of acetylated histones, followed by p21WAF1/Cip1 expression, tumor cell growth inhibition and tumor-selective cell death. In an in vitro washout study, YM753 showed prolonged accumulation of acetylated histones in WiDr human colon carcinoma cells. In vivo YM753 dosing of mice harboring WiDr colon tumor xenografts significantly inhibited the tumor growth via sustained accumulation of acetylated histones in the tumor tissue. In a pharmacokinetic study, YM753 rapidly disappeared from the plasma, but its reduced form remained in the tumor tissue. Moreover, the accumulation of acetylated histones induced by YM753 was tumor tissue selective compared to several normal tissues. YM753 has attractive pharmacodynamic and pharmacokinetic properties giving it potential as an antitumor agent. Synonyms: OBP 801; OBP801; spiruchostatin A; YM-753; YM 753; (1S,5S,6R,9S,20R,E)-5-hydroxy-6-isopropyl-20-methyl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetraone. Grades: >98%. CAS No. 328548-11-4. Molecular formula: C20H31N3O6S2. Mole weight: 473.60. | |
Paromamine Quick inquiry Where to buy Suppliers range | Paromamine is a disaccharide portion common to several aminoglycoside antibiotics that are susceptible to enzymic phosphorylation, into its 3'epimer. Synonyms: 4-O-(2-Amino-2-deoxy-alpha-D-glucopyranosyl)-2-deoxy-D-streptamine; (2R,3S,4R,5R,6S)-5-Amino-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol. Grades: > 95%. CAS No. 534-47-4. Molecular formula: C12H25N3O7. Mole weight: 323.34. | |
Pentostatin Quick inquiry Where to buy Suppliers range | Pentostatin is a purine analogue and antineoplastic agent used in the therapy of hairy cell leukemia and T cell lymphomas. Pentostatin is associated with a low rate of serum enzyme elevations during therapy and has been linked to rare instances of severe acute liver injury with jaundice. Uses: Microbial Fermentation Products. CAS No. 53910-25-1. Product ID: MFP-022. | |
Poly(A) polymerase gamma (724-734) Quick inquiry Where to buy Suppliers range | Poly(A) polymerase gamma (724-734) is a peptide corresponding to residues 724-734 of Poly(A) polymerase gamma. Poly(A) polymerase gamma is responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. Synonyms: PAP-gamma (724-734); Polynucleotide adenylyltransferase gamma (724-734); Signal recognition particle RNA-adenylating enzyme (724-734). | |
Prostaglandin EP2 Receptor Antagonist, TG6-10-1 ( (E) -N- (2- (2- (trifluoromethyl) -1H-indol-1-yl) ethyl) -3- (3, 4, 5-trimethoxyphenyl) acrylamide, EP2 Antagonist, TG6-10-1) Quick inquiry Where to buy Suppliers range | A cell-permeable, 3-acryl-acrylamide derivative that acts as a highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2, Kb = 17.8nM). Exhibits about 300-fold selectivity for the EP2 receptor over human EP3, EP4, and IP receptors, about 100- fold selectivity over human EP1, 25-fold selectivity against human FP and TP, and 10-fold selectivity against human DP1 receptors. Does not affect the activity of about 40 enzymes, ion channels, receptors, and neurotransmitters even at higher concentrations (10uM). Shown to significantly reduce the induction of several inflammatory cytokines and chemokines and reduces the opening of blood-brain barrier during neuronal inflammation. Displays good pharmacokinetic properties with a half-life of 1.6 h and brain to plasma ratio of 1.6 in a murine model (5mg/kg i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. | Worldwide |
RGB-286638 Quick inquiry Where to buy Suppliers range | RGB-286638 is a novel CDK inhibitor. It inhibited several tyrosine and serine/threonine non-CDK enzymes, i.e. GSK-3β, TAK1, AMPK, Jak2, MEK1. It demonstrated equimolar (50nM) activity in freshly isolated tumor cells from MM patients, while manifesting less cytotoxicity in healthy donor PBMCs. It reduced the phosphorylation of Rb at S807/811 in MM.1S and MM.1R cells, but had no effects on p-Rb S780. Synonyms: RGB-286638; RGB286638; RGB286638. Grades: >98%. CAS No. 784210-87-3. Molecular formula: C29H37Cl2N7O4. Mole weight: 618.55. | |
RGB-286638 Free base Quick inquiry Where to buy Suppliers range | RGB-286638 is a novel CDK inhibitor. It inhibited several tyrosine and serine/threonine non-CDK enzymes, i.e. GSK-3β, TAK1, AMPK, Jak2, MEK1. It demonstrated equimolar (50nM) activity in freshly isolated tumor cells from MM patients, while manifesting less cytotoxicity in healthy donor PBMCs. It reduced the phosphorylation of Rb at S807/811 in MM.1S and MM.1R cells, but had no effects on p-Rb S780. Synonyms: 1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea; RGB 286638; RGB286638. Grades: >98%. CAS No. 784210-88-4. Molecular formula: C29H35N7O4. Mole weight: 545.63. | |
RN983 Quick inquiry Where to buy Suppliers range | RN983 is a selective BTK enzyme inhibitor. It inhibits IgG production in B-cells with an IC50 value of 2.5?±?0.7?nM and PGD2 production from mast cells with an IC50 value of 8.3?±?1.1?nM. RN983 showed similar activities in the allergic mouse model of asthma. RN983 may be effective as a stand-alone asthma therapy or used in combination with inhaled steroids and β-agonists in severe asthmatics. Uses: Asthma. Synonyms: RN983; RN-983; RN 983. 6-(tert-butyl)-8-fluoro-2-(3-(hydroxymethyl)-4-(1-methyl-5-((5-(1-methylpiperidin-4-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydropyridazin-3-yl)pyridin-2-yl)phthalazin-1(2H)-one. Grades: 98%. CAS No. 1423129-83-2. Molecular formula: C34H37FN8O3. Mole weight: 624.72. | |
Rosmarinic acid racemate Quick inquiry Where to buy Suppliers range | Rosmarinic acid racemate, the racemate of Rosmarinic acid, is found in many medicinal species of the plant Lamiaceae including Perilla frutescens. Rosmarinic acid appears to be a strong anti-inflammatory agent and is an antioxidant in several animal models. Rosmarinic acid inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively. Uses: Antiviral reagents. Synonyms: Benzenepropanoic acid, α-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-; Benzenepropanoic acid, α-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxy-; Cinnamic acid, 3,4-dihydroxy-, 2-ester with 3-(3,4-dihydroxyphenyl)lactic acid; Lactic acid, 3-(3,4-dihydroxyphenyl)-, 3,4-dihydroxycinnamate; α-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid. Grades: ≥95%. CAS No. 537-15-5. Molecular formula: C18H16O8. Mole weight: 360.31. | |
SAR-020106 Quick inquiry Where to buy Suppliers range | SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo. SAR-020106 can enhance antitumor activity with selected anticancer drugs in vivo and may therefore have clinical utility. Synonyms: SAR020106; SAR 020106; SAR-20106; SAR20106; SAR 20106. Grades: 98%. CAS No. 1184843-57-9. Molecular formula: C19H19ClN6O. Mole weight: 382.852. | |
Telaprevir Quick inquiry Where to buy Suppliers range | Telaprevir is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). Telaprevir forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (K(I)*) of 7 nM. Dissociation of the covalent enzyme-inhibitor complex of Telaprevir and genotype 1a HCV protease has a half-life of almost an hour. A >4-log10 reduction in the HCV RNA levels was observed after a 2-week incubation of replicon cells with Telaprevir, with no rebound of viral RNA observed after withdrawal of the inhibitor. In several animal species, Telaprevir exhibits a favorable pharmacokinetic profile with high exposure in the liver. In a recently developed HCV protease mouse model, Telaprevir showed excellent inhibition of HCV NS3-4A protease activity in the liver. Uses: Oligopeptides. Synonyms: Telavic; VRT 111950; VX 950; Incivek; Incivo; LY 570310; MP 424; S-Telaprevir; (1S, 3aR, 6aS) - (2S) -2-Cyclohexyl-N- (2-pyrazinylcarbonyl) glycyl-3-methyl-L-valyl-N- [ (1S) -1- [2- (cyclopropylamino) -2-oxoacetyl]butyl]octahydrocyclopenta [c]pyrrole-1-carboxamide. Grades: ≥98% (HPLC). CAS No. 402957-28-2. Molecular formula: C36H53N7O6. Mole weight: 679.85. | |
Thelephoric acid Quick inquiry Where to buy Suppliers range | Thelephoric acid is a terphenylquinone pigment found in several fungi, such as Omphalotus subilludens and Polyozellus multiplex. It is derived from atromentin, and its precusor can be from cyclovariegatin. Thelephoric acid has been shown to inhibit prolyl endopeptidase, an enzyme that plays a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Synonyms: 2,3,8,9-Tetrahydroxybenzo[1,2-b:4,5-b']bisbenzofuran-6,12-dione; Thelephorsaure; PM-B; 2,3'-Carbonyl-3,2'-carbonylbis(5,6-dihydroxybenzofuran); Thelephate. CAS No. 479-64-1. Molecular formula: C18H8O8. Mole weight: 352.25. | |
Trans-4-Hydroxy-L-Proline (non-animal) Quick inquiry Where to buy Suppliers range | A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline. Group: Biochemicals. Alternative Names: L-Hyp-OH; (-)-4-Hydroxy-2-pyrrolidinecarboxylic Acid; (2S,4R)-(-)-4-Hydroxyproline; (R)-4-Hydroxy-(S)-proline; 4(R)-Hydroxy-2(S)-pyrrolidinecarboxylic Acid; 4-trans-Hydroxy-L-proline; L-Hypro; NSC 46704. Grades: Cell Culture Grade. CAS No. 51-35-4. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C?H?NO?, Molecular Weight: 131.13. US Biological Life Sciences. | Worldwide |
UDP-xylose Quick inquiry Where to buy Suppliers range | UDP-xylose is a crucial compound acting as a substrate in the biosynthesis of xylose which is a sugar component involved in the glycosylation of several proteins and lipids. This enzymatic process plays an essential role in cell-cell recognition, cell signaling and immune responses. Synonyms: UDP-alpha-D-xylose. CAS No. 3616-6-6. Molecular formula: C14H22N2O16P2. Mole weight: 536.28. |