Epothilone Suppliers USA
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Product | Description | |
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Epothilone A Quick inquiry Where to buy Suppliers range | Epothilone A is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Epothilone A acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. Epothilone A is under investigation as an antitumor agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 152044-53-6. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
Epothilone B Quick inquiry Where to buy Suppliers range | Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. Group: Biochemicals. Grades: Highly Purified. CAS No. 152044-54-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
Epothilone B Quick inquiry Where to buy Suppliers range | Epothilone B is an epithilone that is epithilone D in which the double bond in the macrocyclic ring has been oxidised to the corresponding epoxide (the S,S stereoisomer). It has a role as an apoptosis inducer, an antineoplastic agent and a microtubule-stabilising agent. Uses: Microbial Fermentation Products. CAS No. 152044-54-7. Product ID: MFP-028. | |
Epothilone B (synthetic) Quick inquiry Where to buy Suppliers range | Epothilone B (synthetic). Group: Biochemicals. Alternative Names: (1S, 3S, 7S, 10R, 11S, 12S, 16R)-7, 11-Dihydroxy-8, 8, 10, 12, 16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4, 17-dioxabicyclo[14. 1. 0]heptadecane-5, 9-dione; (-)-Epothilone B; EPO 906. Grades: Highly Purified. CAS No. 152044-54-7. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C27H41NO6S. US Biological Life Sciences. | Worldwide |
EPOTHILONE B (SYNTHETIC) Quick inquiry Where to buy Suppliers range | EPOTHILONE B (SYNTHETIC). CAS No. 152044-54-7. | |
Epothilone B (synthetic) (EpoB) Quick inquiry Where to buy Suppliers range | Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumors. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division. Group: Biochemicals. Alternative Names: EpoB. Grades: Highly Purified. CAS No. 52044-54-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Epothilone C Quick inquiry Where to buy Suppliers range | Epothilone C is an epothilone that is 1-oxacyclohexadec-13-ene-2,6-dione which is substituted by hydroxy groups at positions 4 and 9, methyl groups at positions 5, 5, 7, and 9, and by a (1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl group at position 16 (the 4S,7R,8S,9S,13Z,16S stereoisomer). Uses: Microbial Fermentation Products. CAS No. 186692-73-9. Product ID: MFP-029. | |
Epothilone C Quick inquiry Where to buy Suppliers range | Epothilone C is a novel microtubule inhibitor and acts as an antineoplastic agent. Epothilones are originally isolated from cellulose-degrading myxobacterium Sorangium cellulosum. Synonyms: (-)-Deoxyepothilone A; (-)-Desoxyepothilone A; Desoxyepothilone A. CAS No. 186692-73-9. Molecular formula: C26H39NO5S. Mole weight: 477.66. | |
Epothilone D (synthetic) Quick inquiry Where to buy Suppliers range | Epothilone D (synthetic). Group: Biochemicals. Alternative Names: (4S, 7R, 8S, 9S, 13Z, 16S) -4, 8-Dihydroxy-5, 5, 7, 9, 13-pentamethyl-16- [ (1E) -1-methyl-2- (2-methyl-4-thiazolyl) ethenyl] oxacyclohexadec-13-ene-2, 6-dione; (-)-Desoxyepothilone B; (-)-Epothilone D. Grades: Highly Purified. CAS No. 189453-10-9. Pack Sizes: 1mg. Molecular Formula: C27H41NO5S. US Biological Life Sciences. | Worldwide |
EPOTHILONE D (SYNTHETIC) Quick inquiry Where to buy Suppliers range | EPOTHILONE D (SYNTHETIC). CAS No. 189453-10-9. | |
Epothilone D (synthetic) (12,13-Deoxyepothilone B, EpoA) Quick inquiry Where to buy Suppliers range | Epothilones are polyketid. Group: Biochemicals. Alternative Names: 12,13-Deoxyepothilone B, EpoA. Grades: Highly Purified. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
Epothilone F Quick inquiry Where to buy Suppliers range | Epothilone F, an active metabolite of Epothilone D, prevents cancer cells from dividing by interfering with tubulin. Synonyms: (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-3-[(E)-1-[2-(hydroxymethyl)-1,3-thiazol-4-yl]prop-1-en-2-yl]-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; epothilone F. Grades: >98%. CAS No. 208518-52-9. Molecular formula: C27H41NO7S. Mole weight: 523.69. | |
Epothilon A Quick inquiry Where to buy Suppliers range | Epothilons A is a 16-membered macrolide antibiotic produced by the myxobacterium Sorangium cellulosum. It has strong cytotoxicity and has the effect of resisting plant pathogenic fungi. Uses: Antineoplastic agents. Synonyms: (-)-Epothilone A; Epo A; NSC-684362; (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-5,7,9,9-tetramethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione. Grades: >98%. CAS No. 152044-53-6. Molecular formula: C26H39NO6S. Mole weight: 493.65. | |
Epothilon B Quick inquiry Where to buy Suppliers range | Epothilons B is a 16-membered macrolide antibiotic produced by the myxobacterium Sorangium cellulosum, which is used as a microtubule stabilization agent (EC0.01 = 1.8 μM). It has strong cytotoxicity and has the effect of resisting plant pathogenic fungi. Uses: Antineoplastic agents. Synonyms: Patupilone; (-)-Epothilone B. Grades: >98%. CAS No. 152044-54-7. Molecular formula: C27H41NO6S. Mole weight: 507.68. | |
1,4-Butanediol Quick inquiry Where to buy Suppliers range | 1,4-Butanediol is used in the synthesis of epothilones, a new class of cancer drugs. Also used in the stereoselective synthesis of (-)-Brevisamide. Group: Biochemicals. Alternative Names: 1,4-Butylene Glycol; 1,4-Dihydroxybutane; 1,4-Tetramethylene glycol; 1,4BD; 14BG; Butylene Glycol; Dabco DBO; Diol 14B; NSC 406696; Polycure D; Sucol B; Tetramethylene 1,4-diol; Tetramethylene Glycol; Vibracure A 250; ZM 0025. Grades: Highly Purified. CAS No. 110-63-4. Pack Sizes: 1000ml. US Biological Life Sciences. | Worldwide |
1,4-Butanediol-13C4 Quick inquiry Where to buy Suppliers range | Isotope labelled 1,4-Butanediol is used in the synthesis of epothilones, a new class of cancer drugs. Also used in the stereoselective synthesis of (-)-Brevisamide. Group: Biochemicals. Grades: Highly Purified. CAS No. 286012-95-1. Pack Sizes: 5mg, 10mg. Molecular Formula: 13C4H10O2. US Biological Life Sciences. | Worldwide |
1,4-Butanediol-2,2,3,3-d4 Quick inquiry Where to buy Suppliers range | 1,4-Butanediol-2,2,3,3-d4 is the d4 labelled analogue of 1,4-Butanediol (B690005) which is used in the synthesis of epothilones, a new class of cancer drugs. Also used in the stereoselective synthesis of (-)-Brevisamide. Group: Biochemicals. Grades: Highly Purified. CAS No. 38274-25-8. Pack Sizes: 50mg, 100mg. Molecular Formula: C4H6D4O2, Molecular Weight: 94.15. US Biological Life Sciences. | Worldwide |
1,4-Butanediol-d8 Quick inquiry Where to buy Suppliers range | 1,4-Butanediol-d8 is the labelled d8 analogue of 1,4-Butanediol (B690005) which is a reagent used in organic synthesis including the synthesis of epothilones, a new class of cancer drugs. Also used in the stereoselective synthesis of (-)-Brevisamide. Group: Biochemicals. Grades: Highly Purified. CAS No. 74829-49-5. Pack Sizes: 50mg, 100mg. Molecular Formula: C4H2D8O2. US Biological Life Sciences. | Worldwide |
1-Methyl-4- (tributylstannyl) imidazole Quick inquiry Where to buy Suppliers range | 1-Methyl-4- (tributylstannyl) imidazole is used as a reagent in the synthesis of methylthiopyrazole epothilone B which is a highly potent anticancer drug. Group: Biochemicals. Grades: Highly Purified. CAS No. 446285-73-0. Pack Sizes: 500mg, 1g. Molecular Formula: C16H32N2Sn, Molecular Weight: 371.15. US Biological Life Sciences. | Worldwide |
(3S, 6R, 7S, 12Z, 15S, 16E)-3, 7-Bis-{[tert-butyl (dimethyl)silyl]oxy}-15-hydroxy-4, 4, 6, 8, 12, 16-hexamethyl-17- (2-methyl-1, 3-thiazol-4-yl)-5-oxoheptadeca-12, 16-dienoic Acid Quick inquiry Where to buy Suppliers range | An intermediate in the synthesis of Epothilones. Epothilones are polyketid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 0.1mg. US Biological Life Sciences. | Worldwide |
(3S, 6R, 7S, 8S, 12Z, 15S, 16E)-1, 3, 15-Tris-{[tert-butyl (dimethyl)silyl]oxy}-7-hydroxy-4, 4, 6, 8, 12, 16-hexamethyl-17- (2-methyl-1, 3-thiazol-4-yl)heptadecyl-12, 16-dien-5-one Quick inquiry Where to buy Suppliers range | An intermediate in the synthesis of Epothilones. Epothilones are polyketid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
(3S, 6R, 7S, 8S, 12Z, 15S, 16E)-1, 3, 7, 15-Tetrakis-{[tert-butyl (dimethyl)silyl]oxy}-4, 4, 6, 8, 12, 16-hexamethyl-17- (2-methyl-1, 3-thiazol-4-yl)heptadeca-12, 16-dien-5-one Quick inquiry Where to buy Suppliers range | An intermediate in the synthesis of Epothilones. Epothilones are polyketid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
(3S, 6R, 7S, 8S, 12Z, 15S, 16E)-3, 7, 15-Tris-{[tert-butyl (dimethyl)silyl]oxy}-1-hydroxy-4, 4, 6, 8, 12, 16-hexamethyl-17- (2-methyl-1, 3-thiazol-4-yl)heptadeca-12, 16-dien-5-one Quick inquiry Where to buy Suppliers range | An intermediate in the synthesis of Epothilones. Epothilones are polyketid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
(3S, 6R, 7S, 8S, 12Z, 15S, 16E)-3, 7, 15-Tris-{[tert-butyl (dimethyl)silyl]oxy}-4, 4, 6, 8, 12, 16-hexamethyl-17- (2-methyl-1, 3-thiazol-4-yl)-5-oxo-heptadeca-12, 16-dienoic Acid Quick inquiry Where to buy Suppliers range | An intermediate in the synthesis of Epothilones. Epothilones are polyketid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
4,5-Dihydro-2-methyl-4-thiazolecarboxylic Acid Quick inquiry Where to buy Suppliers range | 4,5-Dihydro-2-methyl-4-thiazolecarboxylic Acid, can be used as a chain-initiating methylthiazole ring in the synthesis of Epothilone derivatives. It can also be used for the synthesis of DL-cysteines. Synonyms: 2-Methyl-2-thiazoline-4-carboxylic Acid. Grades: > 95%. CAS No. 84184-18-9. Molecular formula: C5H7NO2S. Mole weight: 145.18. | |
4-Formyl-2-methoxyphenyl β-D-Glucopyranosiduronic Acid Triacetate Methyl Ester Quick inquiry Where to buy Suppliers range | Used in the preparation of epothilone-saccharide conjugates for the treatment of proliferative diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 704885-44-9. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
(4S, 7R, 8S, 9S, 13Z, 16S) -4, 8-Bis-{ [tert-butyl (dimethyl) silyl] oxy}-5, 5, 7, 9, 13-pentamethyl-16- [ (E) -1-methyl-2- (2-methyl-1, 3-thiazol-4-yl) ethenyl] oxocyclohexadec-13-ene-2, 6-dione Quick inquiry Where to buy Suppliers range | An intermediate in the synthesis of Epothilones. Epothilones are polyketid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
IRC-083927 Quick inquiry Where to buy Suppliers range | IRC-083927 is novel and potent microtubule inhibitor with potential anticancer activity. IRC-083927 inhibits the tubulin polymerization by a binding to the colchicine site. IRC-083927 inhibits in vitro cell growth of human cancer cell lines in the low nanomolar range. More interesting, it remains highly active against cell lines resistant to microtubule-interacting agents (taxanes, Vinca alkaloids, or epothilones). Chronic oral treatment with IRC-083927 (5 mg/kg) inhibits the growth of two human tumor xenografts in nude mice (C33-A, human cervical cancer and MDA-MB-231, human hormone-independent breast cancer). Together, the antitumor effects induced by IRC-083927 on tumor models resistant to tubulin agents support further investigations to fully evaluate its potential for the treatment of advanced cancers, particularly those resistant to current clinically available drugs. Synonyms: IRC-083927; IRC 083927; IRC083927. Grades: 98%. CAS No. 955082-09-4. Molecular formula: C22H20ClFN4O4S. Mole weight: 490.93. | |
Ixabepilone Quick inquiry Where to buy Suppliers range | Ixabepilone (also known as azaepothilone B, or BMS-247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Ixabepilone was approved in 2007. Synonyms: Azaepothilone B; BMS247550; BMS-247550; BMS 247550; Ixempra. Grades: >98%. CAS No. 219989-84-1. Molecular formula: C27H42N2O5S. Mole weight: 506.7. | |
Ixabepilone Quick inquiry Where to buy Suppliers range | Ixabepilone. Group: Heterocyclic Organic Compound. Alternative Names: IXABEPILONE;(1R, 5S, 6S, 7R, 10S, 14S, 16S)-6, 10-dihydroxy-1, 5, 7, 9, 9-pentamethyl-14-[(E) -1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14. 1.0]heptadecane-8,12-dione;Aza-epothilone B;Bms 247550-1;Ixempra;Ixempra kit;Unii-K27005np0a;Azi-epothilone B. CAS No. 219989-84-1. Product ID: ACM219989841. Molecular formula: C27H42N2O5S. Mole weight: 506.7. | |
KOS-1584 Quick inquiry Where to buy Suppliers range | KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration, and reduced CNS exposure. In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump. Synonyms: KOS 1584; KOS1584; 9,10-didehydroepothilone D; R1645. CAS No. 1032119-44-0. Molecular formula: C27H39NO5S. Mole weight: 489.67. | |
Sagopilone Quick inquiry Where to buy Suppliers range | Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum. Synonyms: DE 03757; DE-03757; DE03757; ZK 219477; ZK219477; ZK-219477; ZK-EPO; (1S,3S,7S,10R,11S,12S,16R)-10-allyl-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methylbenzo[d]thiazol-5-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione. CAS No. 305841-29-6. Molecular formula: C30H41NO6S. Mole weight: 543.72. |