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| Product | Description | |
|---|---|---|
| Epothilone | Epothilone. Uses: For analytical and research use. Group: Impurity standards. CAS No. 189453-10-9. Molecular Formula: C27H41NO5S. Mole Weight: 491.69. Catalog: APB189453109. |  |
| Epothilone A | Epothilone A is a competitive inhibitor of the binding of [ 3 H] paclitaxel to tubulin polymers, with a K i of 0.6-1.4 μM. Uses: Scientific research. Group: Natural products. Alternative Names: Epo A. CAS No. 152044-53-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13503. |  |
| Epothilone A | Epothilone A is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Epothilone A acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. Epothilone A is under investigation as an antitumor agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 152044-53-6. Pack Sizes: 100ug. US Biological Life Sciences. |  Worldwide |
| Epothilone B | Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. Group: Biochemicals. Grades: Highly Purified. CAS No. 152044-54-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Epothilone B | Epothilone B is a microtubule stabilizer with a K i of 0.71μM. It acts by binding to the αβ-tubulin heterodimer subunit which causes decreasing of αβ-tubulin dissociation. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EPO 906; Patupilone. CAS No. 152044-54-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17029. | |
| Epothilone B (synthetic) | Epothilone B (synthetic). Group: Biochemicals. Alternative Names: (1S, 3S, 7S, 10R, 11S, 12S, 16R)-7, 11-Dihydroxy-8, 8, 10, 12, 16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4, 17-dioxabicyclo[14. 1. 0]heptadecane-5, 9-dione; (-)-Epothilone B; EPO 906. Grades: Highly Purified. CAS No. 152044-54-7. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C27H41NO6S. US Biological Life Sciences. | Worldwide |
| Epothilone B (synthetic) (EpoB) | Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumors. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division. Group: Biochemicals. Alternative Names: EpoB. Grades: Highly Purified. CAS No. 52044-54-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Epothilone C | Epothilone C is a novel microtubule inhibitor and acts as an antineoplastic agent. Epothilones are originally isolated from cellulose-degrading myxobacterium Sorangium cellulosum. Synonyms: (-)-Deoxyepothilone A; (-)-Desoxyepothilone A; Desoxyepothilone A. CAS No. 186692-73-9. Molecular formula: C26H39NO5S. Mole weight: 477.66. |  |
| Epothilone D | Epothilone D (KOS 862) is a potent microtubule stabilizer. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KOS 862. CAS No. 189453-10-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15278. | |
| Epothilone D (synthetic) | Epothilone D (synthetic). Group: Biochemicals. Alternative Names: (4S, 7R, 8S, 9S, 13Z, 16S) -4, 8-Dihydroxy-5, 5, 7, 9, 13-pentamethyl-16- [ (1E) -1-methyl-2- (2-methyl-4-thiazolyl) ethenyl] oxacyclohexadec-13-ene-2, 6-dione; (-)-Desoxyepothilone B; (-)-Epothilone D. Grades: Highly Purified. CAS No. 189453-10-9. Pack Sizes: 1mg. Molecular Formula: C27H41NO5S. US Biological Life Sciences. | Worldwide |
| Epothilone D (synthetic) (12,13-Deoxyepothilone B, EpoA) | Epothilones are polyketid. Group: Biochemicals. Alternative Names: 12,13-Deoxyepothilone B, EpoA. Grades: Highly Purified. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Epothilone F | Epothilone F, an active metabolite of Epothilone D, prevents cancer cells from dividing by interfering with tubulin. Synonyms: (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-3-[(E)-1-[2-(hydroxymethyl)-1,3-thiazol-4-yl]prop-1-en-2-yl]-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; epothilone F. Grades: >98%. CAS No. 208518-52-9. Molecular formula: C27H41NO7S. Mole weight: 523.69. | |
| 1,4-Butanediol | 1,4-Butanediol is used in the synthesis of epothilones, a new class of cancer drugs. Also used in the stereoselective synthesis of (-)-Brevisamide. Group: Biochemicals. Alternative Names: 1,4-Butylene Glycol; 1,4-Dihydroxybutane; 1,4-Tetramethylene glycol; 1,4BD; 14BG; Butylene Glycol; Dabco DBO; Diol 14B; NSC 406696; Polycure D; Sucol B; Tetramethylene 1,4-diol; Tetramethylene Glycol; Vibracure A 250; ZM 0025. Grades: Highly Purified. CAS No. 110-63-4. Pack Sizes: 1000ml. US Biological Life Sciences. | Worldwide |
| 1,4-Butanediol-13C4 | Isotope labelled 1,4-Butanediol is used in the synthesis of epothilones, a new class of cancer drugs. Also used in the stereoselective synthesis of (-)-Brevisamide. Group: Biochemicals. Grades: Highly Purified. CAS No. 286012-95-1. Pack Sizes: 5mg, 10mg. Molecular Formula: 13C4H10O2. US Biological Life Sciences. | Worldwide |
| 1,4-Butanediol-2,2,3,3-d4 | 1,4-Butanediol-2,2,3,3-d4 is the d4 labelled analogue of 1,4-Butanediol (B690005) which is used in the synthesis of epothilones, a new class of cancer drugs. Also used in the stereoselective synthesis of (-)-Brevisamide. Group: Biochemicals. Grades: Highly Purified. CAS No. 38274-25-8. Pack Sizes: 50mg, 100mg. Molecular Formula: C4H6D4O2, Molecular Weight: 94.15. US Biological Life Sciences. | Worldwide |
| 1,4-Butanediol-d8 | 1,4-Butanediol-d8 is the labelled d8 analogue of 1,4-Butanediol (B690005) which is a reagent used in organic synthesis including the synthesis of epothilones, a new class of cancer drugs. Also used in the stereoselective synthesis of (-)-Brevisamide. Group: Biochemicals. Grades: Highly Purified. CAS No. 74829-49-5. Pack Sizes: 50mg, 100mg. Molecular Formula: C4H2D8O2. US Biological Life Sciences. | Worldwide |
| 1-Methyl-4- (tributylstannyl) imidazole | 1-Methyl-4- (tributylstannyl) imidazole is used as a reagent in the synthesis of methylthiopyrazole epothilone B which is a highly potent anticancer drug. Group: Biochemicals. Grades: Highly Purified. CAS No. 446285-73-0. Pack Sizes: 500mg, 1g. Molecular Formula: C16H32N2Sn, Molecular Weight: 371.15. US Biological Life Sciences. | Worldwide |
| (3S, 6R, 7S, 12Z, 15S, 16E)-3, 7-Bis-{[tert-butyl (dimethyl)silyl]oxy}-15-hydroxy-4, 4, 6, 8, 12, 16-hexamethyl-17- (2-methyl-1, 3-thiazol-4-yl)-5-oxoheptadeca-12, 16-dienoic Acid | An intermediate in the synthesis of Epothilones. Epothilones are polyketid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 0.1mg. US Biological Life Sciences. | Worldwide |
| (3S, 6R, 7S, 8S, 12Z, 15S, 16E)-1, 3, 15-Tris-{[tert-butyl (dimethyl)silyl]oxy}-7-hydroxy-4, 4, 6, 8, 12, 16-hexamethyl-17- (2-methyl-1, 3-thiazol-4-yl)heptadecyl-12, 16-dien-5-one | An intermediate in the synthesis of Epothilones. Epothilones are polyketid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| (3S, 6R, 7S, 8S, 12Z, 15S, 16E)-1, 3, 7, 15-Tetrakis-{[tert-butyl (dimethyl)silyl]oxy}-4, 4, 6, 8, 12, 16-hexamethyl-17- (2-methyl-1, 3-thiazol-4-yl)heptadeca-12, 16-dien-5-one | An intermediate in the synthesis of Epothilones. Epothilones are polyketid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| (3S, 6R, 7S, 8S, 12Z, 15S, 16E)-3, 7, 15-Tris-{[tert-butyl (dimethyl)silyl]oxy}-1-hydroxy-4, 4, 6, 8, 12, 16-hexamethyl-17- (2-methyl-1, 3-thiazol-4-yl)heptadeca-12, 16-dien-5-one | An intermediate in the synthesis of Epothilones. Epothilones are polyketid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| (3S, 6R, 7S, 8S, 12Z, 15S, 16E)-3, 7, 15-Tris-{[tert-butyl (dimethyl)silyl]oxy}-4, 4, 6, 8, 12, 16-hexamethyl-17- (2-methyl-1, 3-thiazol-4-yl)-5-oxo-heptadeca-12, 16-dienoic Acid | An intermediate in the synthesis of Epothilones. Epothilones are polyketid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| 4,5-Dihydro-2-methyl-4-thiazolecarboxylic Acid | 4,5-Dihydro-2-methyl-4-thiazolecarboxylic Acid, can be used as a chain-initiating methylthiazole ring in the synthesis of Epothilone derivatives. It can also be used for the synthesis of DL-cysteines. Synonyms: 2-Methyl-2-thiazoline-4-carboxylic Acid. Grades: > 95%. CAS No. 84184-18-9. Molecular formula: C5H7NO2S. Mole weight: 145.18. | |
| 4-Formyl-2-methoxyphenyl β-D-Glucopyranosiduronic Acid Triacetate Methyl Ester | Used in the preparation of epothilone-saccharide conjugates for the treatment of proliferative diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 704885-44-9. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| (4S, 7R, 8S, 9S, 13Z, 16S) -4, 8-Bis-{ [tert-butyl (dimethyl) silyl] oxy}-5, 5, 7, 9, 13-pentamethyl-16- [ (E) -1-methyl-2- (2-methyl-1, 3-thiazol-4-yl) ethenyl] oxocyclohexadec-13-ene-2, 6-dione | An intermediate in the synthesis of Epothilones. Epothilones are polyketid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Epothilon A | Epothilons A is a 16-membered macrolide antibiotic produced by the myxobacterium Sorangium cellulosum. It has strong cytotoxicity and has the effect of resisting plant pathogenic fungi. Uses: Antineoplastic agents. Synonyms: (-)-Epothilone A; Epo A; NSC-684362; (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-5,7,9,9-tetramethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione. Grades: >98%. CAS No. 152044-53-6. Molecular formula: C26H39NO6S. Mole weight: 493.65. | |
| Epothilon B | Epothilons B is a 16-membered macrolide antibiotic produced by the myxobacterium Sorangium cellulosum, which is used as a microtubule stabilization agent (EC0.01 = 1.8 μM). It has strong cytotoxicity and has the effect of resisting plant pathogenic fungi. Uses: Antineoplastic agents. Synonyms: Patupilone; (-)-Epothilone B. Grades: >98%. CAS No. 152044-54-7. Molecular formula: C27H41NO6S. Mole weight: 507.68. | |
| IRC-083927 | IRC-083927 is novel and potent microtubule inhibitor with potential anticancer activity. IRC-083927 inhibits the tubulin polymerization by a binding to the colchicine site. IRC-083927 inhibits in vitro cell growth of human cancer cell lines in the low nanomolar range. More interesting, it remains highly active against cell lines resistant to microtubule-interacting agents (taxanes, Vinca alkaloids, or epothilones). Chronic oral treatment with IRC-083927 (5 mg/kg) inhibits the growth of two human tumor xenografts in nude mice (C33-A, human cervical cancer and MDA-MB-231, human hormone-independent breast cancer). Together, the antitumor effects induced by IRC-083927 on tumor models resistant to tubulin agents support further investigations to fully evaluate its potential for the treatment of advanced cancers, particularly those resistant to current clinically available drugs. Synonyms: IRC-083927; IRC 083927; IRC083927. Grades: 98%. CAS No. 955082-09-4. Molecular formula: C22H20ClFN4O4S. Mole weight: 490.93. | |
| Ixabepilone | Ixabepilone (also known as azaepothilone B, or BMS-247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Ixabepilone was approved in 2007. Synonyms: Azaepothilone B; BMS247550; BMS-247550; BMS 247550; Ixempra. Grades: >98%. CAS No. 219989-84-1. Molecular formula: C27H42N2O5S. Mole weight: 506.7. | |
| Ixabepilone | Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis. Group: Inhibitors. Alternative Names: IXABEPILONE;(1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E) -1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14. 1.0]heptadecane-8,12-dione;Aza-epothilone B;Bms 247550-1;Ixempra;Ixempra kit;Unii-K27005np0a;Azi-epothilone B. CAS No. 219989-84-1. Molecular formula: C27H42N2O5S. Mole weight: 506.7. Appearance: Solid. Purity: 0.9984. Canonical SMILES: O=C ([C@@H] ([C@H] ([C@H] (CCC[C@]1 (O[C@]1 (C[C@H] (N2)/C (C)=C/C3=CSC (C)=N3)[H])C)C)O)C)C (C) ([C@H] (CC2=O)O)C. Catalog: ACM219989841. |  |
| Ixabepilone | Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-247550; Aza-epothilone B. CAS No. 219989-84-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-10222. | |
| KOS-1584 | KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration, and reduced CNS exposure. In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump. Synonyms: KOS 1584; KOS1584; 9,10-didehydroepothilone D; R1645. CAS No. 1032119-44-0. Molecular formula: C27H39NO5S. Mole weight: 489.67. | |
| Sagopilone | Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum. Synonyms: DE 03757; DE-03757; DE03757; ZK 219477; ZK219477; ZK-219477; ZK-EPO; (1S,3S,7S,10R,11S,12S,16R)-10-allyl-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methylbenzo[d]thiazol-5-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione. CAS No. 305841-29-6. Molecular formula: C30H41NO6S. Mole weight: 543.72. | |
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