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| Product | Description | |
|---|---|---|
| EPZ011989 | EPZ011989 is a potent, orally-available EZH2 inhibitor with robust in vivo activity. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma. EPZ011989 represents a powerful tool for the expanded exploration of EZH2 activity in biology. Inhibitors of the protein methyltransferase Enhancer of Zeste Homolog 2 (EZH2) may have significant therapeutic potential for the treatment of B cell lymphomas and other cancer indications. The ability of the scientific community to explore fully the spectrum of EZH2-associated pathobiology has been hampered by the lack of in vivo-active tool compounds for this enzyme. Group: Inhibitors. Alternative Names: EPZ011989; EPZ-011989; EPZ 011989. CAS No. 1598383-40-4. Molecular formula: C35H51N5O4. Mole weight: 605.82. Appearance: Solid powder. Purity: >98%. IUPACName: N- ( (4, 6-dimethyl-2-oxo-1, 2-dihydropyridin-3-yl)methyl)-3- (ethyl ( (1r, 4r)-4- ( (2-methoxyethyl) (methyl)amino)cyclohexyl)amino)-2-methyl-5- (3-morpholinoprop-1-yn-1-yl)benzamide. Canonical SMILES: O=C (NCC1=C (C)C=C (C)NC1=O)C2=CC (C#CCN3CCOCC3)=CC (N (CC)[C@H]4CC[C@H] (N (CCOC)C)CC4)=C2C. Catalog: ACM1598383404. |  |
| EPZ011989 | EPZ011989 is a potent, orally-available EZH2 inhibitor with robust in vivo activity. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma. Synonyms: EPZ011989; EPZ-011989; EPZ 011989. Grades: 98%. CAS No. 1598383-40-4. Molecular formula: C35H51N5O4. Mole weight: 605.82. |  |
| EPZ011989 trifluoroacetate | EPZ011989 trifluoroacetate is the trifluoroacetate salt form of EPZ011989. EPZ011989 is a potent and orally bioavailable inhibitor that specifically targets the protein methyltransferase Enhancer of Zeste Homolog 2 (EZH2), with significant tumor growth in. Synonyms: EPZ011989 TFA salt; EPZ011989 TFA; EPZ 011989 TFA; EPZ-011989 TFA; N-[ (4, 6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-[2-methoxyethyl (methyl)amino]cyclohexyl]amino]-2-methyl-5- (3-morpholin-4-ylprop-1-ynyl)benzamide; 2, 2, 2-trifluoroacetic acidEPZ011989 (trifluoroacetate). CAS No. 1598383-41-5. Molecular formula: C37H52F3N5O6. Mole weight: 719.83. | |
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