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| Product | Description | |
|---|---|---|
| Erastin | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Erastin | Erastin Inhibitor. Uses: Scientific use. Product Category: T1765. CAS No. 571203-78-6. |  |
| Erastin | Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation[1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Uses: Scientific research. Group: Signaling pathways. CAS No. 571203-78-6. Pack Sizes: 1 mg; 1 mg * 5; 1 mg * 10. Product ID: HY-15763. |  |
| Erastin | Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces non-apoptotic tumor cell death by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. Reversal of tubulin-VDAC interaction by erastin antagonizes Warburg metabolism and restores oxidative mitochondrial metabolism. Synonyms: Erastin. Grades: 0.98. CAS No. 571203-78-6. Molecular formula: C30H31ClN4O4. Mole weight: 547.04454. |  |
| Erastin | Erastin is a selective antitumor agent that displays greater lethality in human tumor cells harboring mutations in the oncogenes HRAS, KRAS or BRAF. It binds to mitochondrial volatage-dependent anion channels (VDAC) proteins, more specifically on VDAC2 and alters its gating. Erastin rapidly induces an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling. Group: Biochemicals. Alternative Names: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone. Grades: Highly Purified. CAS No. 571203-78-6. Pack Sizes: 1mg. Molecular Formula: C??H??ClN?O?, Molecular Weight: 547.04. US Biological Life Sciences. |  Worldwide |
| Erastin2 | Erastin2, an Erastin (HY-15763) analog, is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1695533-44-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139087. | |
| Erastin2 | Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter, which inhibits glutamate release in CCF-STTG1 cells with an IC50 of 0.0035 μM. Synonyms: 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-4(3H)-quinazolinone. Grades: ≥98%. CAS No. 1695533-44-8. Molecular formula: C36H35ClN4O4. Mole weight: 623.14. | |
| Erastin - CAS 571203-78-6 | A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Group: Fluorescence/luminescence spectroscopy. | |
| Imidazole ketone erastin | Imidazole ketone erastin Inhibitor. Uses: Scientific use. Product Category: T5523. CAS No. 1801530-11-9. | |
| Imidazole ketone erastin | Imidazole ketone erastin is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system xc- and an activator of ferroptosis. Imidazole ketone erastin has anti-tumor activity[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IKE. CAS No. 1801530-11-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114481. | |
| Ferrostatin-1 | Cell-permeable. A potent ferroptosis (an iron-dependent form of non-apoptotic cell death) inhibitor. Inhibits erastin-induced ferroptosis in HT-1080 cells with an EC50 of 60nm. Ferrostatin-1 inhibits ferroptosis in cancer cells as well as blocks glutamate-induced cell death in organotypic rat brain slices. Group: Biochemicals. Alternative Names: Fer-1, Ethyl 3-amino-4- (cyclohexylamino) benzoate. Grades: Highly Purified. CAS No. 347174-05-4. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Ferrostatin-1 | Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Fer-1. CAS No. 347174-05-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100579. | |
| Ferrostatin-1 (Ferrostatin1, Ethyl-3-amino-4- (cyclohexylamino) benzoate) | A cell-permeable 3,4-diaminoethylbenzoate-based antioxidant that effectively prevents Glutamate- (5mM; 3h) induced neurotoxicity in cultured rat OHSC (by 56%, 65%, and 71%, respectively, in CA1, CA3, and Dentrate gyrus; [Fer-1] = 2uM, added 0.5h prior to Glutamate) and Erastin- (50uM; 24h) induced HT-1080 death (EC50 = 60nM) by blocking cytosolic and lipid ROS accumulation (by >80% at 0.5uM in 10uM Erastin-treated HT-1080 cells). Fer-1 does not prevent H2O2- induced necrosis, STS-induced apoptosis, or Iron-independent oxidative death by Rotenone. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| SRS11-92 | SRS11-92 is an effective iron death inhibitor. It inhibits Erastin-induced iron death cells in HT-1080 human fibrosarcoma cells (EC50=6 nM). Synonyms: 4-(Cyclohexylamino)-3-[(Phenylmethyl)Amino]-Benzoic acid, Ethylester. Grades: 98%. CAS No. 1467047-25-1. Molecular formula: C22H28N2O2. Mole weight: 352.5. | |
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