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| Product | Description | |
|---|---|---|
| Erastin | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Erastin | Erastin Inhibitor. Uses: Scientific use. Product Category: T1765. CAS No. 571203-78-6. |  |
| Erastin | Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces non-apoptotic tumor cell death by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. Reversal of tubulin-VDAC interaction by erastin antagonizes Warburg metabolism and restores oxidative mitochondrial metabolism. Synonyms: Erastin. Grades: 0.98. CAS No. 571203-78-6. Molecular formula: C30H31ClN4O4. Mole weight: 547.04454. |  |
| Erastin | Erastin is a selective antitumor agent that displays greater lethality in human tumor cells harboring mutations in the oncogenes HRAS, KRAS or BRAF. It binds to mitochondrial volatage-dependent anion channels (VDAC) proteins, more specifically on VDAC2 and alters its gating. Erastin rapidly induces an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling. Group: Biochemicals. Alternative Names: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone. Grades: Highly Purified. CAS No. 571203-78-6. Pack Sizes: 1mg. Molecular Formula: C??H??ClN?O?, Molecular Weight: 547.04. US Biological Life Sciences. |  Worldwide |
| Erastin2 | Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter, which inhibits glutamate release in CCF-STTG1 cells with an IC50 of 0.0035 μM. Synonyms: 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-4(3H)-quinazolinone. Grades: ≥98%. CAS No. 1695533-44-8. Molecular formula: C36H35ClN4O4. Mole weight: 623.14. | |
| Erastin - CAS 571203-78-6 | A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Group: Fluorescence/luminescence spectroscopy. | |
| Imidazole ketone erastin | Imidazole ketone erastin Inhibitor. Uses: Scientific use. Product Category: T5523. CAS No. 1801530-11-9. | |
| Ferrostatin-1 | Cell-permeable. A potent ferroptosis (an iron-dependent form of non-apoptotic cell death) inhibitor. Inhibits erastin-induced ferroptosis in HT-1080 cells with an EC50 of 60nm. Ferrostatin-1 inhibits ferroptosis in cancer cells as well as blocks glutamate-induced cell death in organotypic rat brain slices. Group: Biochemicals. Alternative Names: Fer-1, Ethyl 3-amino-4- (cyclohexylamino) benzoate. Grades: Highly Purified. CAS No. 347174-05-4. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Ferrostatin-1 (Ferrostatin1, Ethyl-3-amino-4- (cyclohexylamino) benzoate) | A cell-permeable 3,4-diaminoethylbenzoate-based antioxidant that effectively prevents Glutamate- (5mM; 3h) induced neurotoxicity in cultured rat OHSC (by 56%, 65%, and 71%, respectively, in CA1, CA3, and Dentrate gyrus; [Fer-1] = 2uM, added 0.5h prior to Glutamate) and Erastin- (50uM; 24h) induced HT-1080 death (EC50 = 60nM) by blocking cytosolic and lipid ROS accumulation (by >80% at 0.5uM in 10uM Erastin-treated HT-1080 cells). Fer-1 does not prevent H2O2- induced necrosis, STS-induced apoptosis, or Iron-independent oxidative death by Rotenone. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| SRS11-92 | SRS11-92 is an effective iron death inhibitor. It inhibits Erastin-induced iron death cells in HT-1080 human fibrosarcoma cells (EC50=6 nM). Synonyms: 4-(Cyclohexylamino)-3-[(Phenylmethyl)Amino]-Benzoic acid, Ethylester. Grades: 98%. CAS No. 1467047-25-1. Molecular formula: C22H28N2O2. Mole weight: 352.5. | |
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