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| Product | Description | |
|---|---|---|
| Etamicastat | Etamicastat is a selective dopamine β-hydroxylase (DBH) inhibitor. etamicastat can effectively decrease blood pressure, although can not prevent the development of hypertension in the spontaneously hypertensive rat. In Aug 2016, Phase-II for Hypertension in France was discontinued. Uses: Heart failure; hypertension. Synonyms: (R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione;BIA 5-453;677773-32-9 (HCl salt). Grades: 98%. CAS No. 760173-05-5. Molecular formula: C14H15F2N3OS. Mole weight: 311.35. |  |
| Etamicastat HCl salt | Etamicastat HCl salt is a potent, peripherally selective, reversible, dopamine β-hydroxylase inhibitor (DBH inhibitor). It effectively decreases blood pressure, although does not prevent the development of hypertension in the spontaneously hypertensive rat. It was developed by Bial-Portela and was in clinic phase 2 trials, but now it is terminated. Uses: Etamicastat hcl salt effectively decreases blood pressure, although does not prevent the development of hypertension in the spontaneously hypertensive rat. Synonyms: BIA5-453 HCl salt; BIA-5-453 HCl salt;(R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride. Grades: 98%. CAS No. 677773-32-9. Molecular formula: C14H16ClF2N3OS. Mole weight: 347.81. | |
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