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| Product | Description | |
|---|---|---|
| Etoposide | 100mg Pack Size. Group: Bioactive Small Molecules. Formula: C29H32O13. CAS No. 33419-42-0. Prepack ID 12487027-100mg. Molecular Weight 588.56. See USA prepack pricing. |  |
| Etoposide | An antitumor agent. A topoisomerase II inhibitor. A derivative of podophyllotoxin that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in human T cells, mouse thymocytes, and HL-60 human leukemia cells. Group: Biochemicals. Alternative Names: 4?-De methyl epipodophyllotoxin; 9-(4,6-O-ethylidene- β-D-glucopyranoside); (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene- β -D-glucopyranosyl]oxy]-5, 8, 8a, 9-tetrahydro-5- (4-hydroxy-3, 5-dimethoxyphenyl) furo[3, 4: 6, 7]naphtho[2, 3-d]-1, 3-dioxol-6 (5aH) -one; EPEG; VP 16-213; VePesid; Vepesid J; Zuyeyidal; trans-Etoposide. Grades: Highly Purified. CAS No. 33419-42-0. Pack Sizes: 100mg, 250mg, 500mg. Molecular Formula: C??H??O??, Molecular Weight: 588.56. US Biological Life Sciences. |  Worldwide |
| Etoposide | Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. Synonyms: 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-b-D-glucopyranoside). Grade: >98%. CAS No. 33419-42-0. Molecular formula: C29H32O13. Mole weight: 588.55. |  |
| Etoposide | Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II , thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy [1]. Uses: Scientific research. Group: Natural products. Alternative Names: VP-16; VP-16-213. CAS No. 33419-42-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg. Product ID: HY-13629. |  |
| Etoposide | Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-Demethylepipodophyllotoxin-beta-d-ethylideneglucoside. Product Category: Inhibitors. Appearance: Powder. CAS No. 33419-42-0. Molecular formula: C29H32O13. Mole weight: 588.56. Purity: 0.98. IUPACName: (5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one. Canonical SMILES: CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O. Density: 1.29 g/ml. Product ID: ACM33419420. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Etoposide | synthetic, 98.0-105.0%, powder. Group: Fluorescence/luminescence spectroscopyapi standardsbritish pharmacopoeiaeuropean pharmacopoeia (ph. eur.)pharmaceutical toxicologypharmacopoeial standards. Alternative Names: Eposin, Topok, Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-beta-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5alpha,5abeta,8aalpha,9beta(R*)]]-, VP 16 (pharmaceutical), 4'-Demethyl-1-O-[4,6-O-(ethylidene)-beta-D-glucopyranosyl]epipodophyllotoxin, Bioposide, Epipodophyllotoxin VP 16213, VP 16-123, Furo[3',4':6,7]naphtho[2,3-d]-1,3-. |  |
| Etoposide | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Etoposide-[13C,d3] | One of the isotope labelled form of Etoposide, which is a cytotoxic anticancer drug which belongs to the topoisomerase inhibitor drug class and could be used in form of its salt etoposide phosphate. Synonyms: (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one-13C-d3. Molecular formula: C28[13C]H29D3O13. Mole weight: 592.58. | |
| Etoposide 3',4'-Quinone | Precursor to the semiquinone free radical of Etoposide, believed to inactivate ?X174 DNA. Group: Biochemicals. Alternative Names: 5-[(5R,5aR,8aR,9S)-9-[(4,6-O-(1R)-Ethylidene- β-D-glucopyranosyl)oxy]-5, 5a, 6, 8, 8a, 9-hexahydro-6-oxofuro[3', 4':6, 7]naphtho[2, 3-d]-1, 3-dioxol-5-yl]-3-methoxy-3, 5-cyclohexadiene-1, 2-dione; Etoposide o-Quinone. Grades: Highly Purified. CAS No. 105016-65-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Etoposide, 95.0-105.0% (HPLC) USP | Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a progressive inhibition of DNA replication. p53 activator. Blocks the cell cycle between the end of the S phase and the early G2 phase. Oncoprotein Mdm2 synthesis inhibitor. Apoptosis inducer through the cytochrome c/Apaf-1/caspase-9 pathway and the Fas-mediated death signaling pathway. Cell cycle checkpoint activator. Affects gene expression at different levels (chromatin remodeling, transcrip- tion and alternative splicing). Chemotherapeutic compound used in cancers. Used in conditioning regimen prior to a bone marrow or blood stem cell transplantation. Highly effective in mobilizing stem cells. Group: Biochemicals. Alternative Names: 4-Des methyl epipodophyllotoxin; VP-16-213, NSC 141540. Grades: USP. CAS No. 33419-42-0. Pack Sizes: 250mg, 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Etoposide - CAS 33419-42-0 | A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC?? = 59.2 μM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Group: Fluorescence/luminescence spectroscopy. | |
| Etoposide-d3 | A labeled DNA topoisomerase II inhibitor. Semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide. Antineoplastic. Group: Biochemicals. Alternative Names: (5R,5aR,8aR,9S)-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Etoposide-[d3] | Etoposide-[d3] is a deuterium labelled form of Etoposide, which is a cytotoxic anticancer drug which belongs to the topoisomerase inhibitor drug class. Synonyms: (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one-d3; Etoposide D3. Grade: 96% by CP; 99% atom D. Molecular formula: C29H29D3O13. Mole weight: 591.58. | |
| Etoposide-[d4] | Etoposide-[d4] is a deuterium labelled form of Etoposide, which is a cytotoxic anticancer drug which belongs to the topoisomerase inhibitor drug class. Synonyms: Etoposide D4. Grade: 98% by CP; 98% atom D. Molecular formula: C29H28D4O13. Mole weight: 592.58. | |
| Etoposide D-glucuronide | Etoposide D-glucuronide, a vital pharmaceutical compound extensively employed in the biomedical sector, acts as a pivotal metabolite of Etoposide, a potent anticancer medication. Through the process of glucuronidation within the liver, Etoposide D-glucuronide undertakes a crucial function in the eradication of harmful toxins from the system. Its predominant utilization lies within the treatment of specific forms of malignancies, notably lung cancer and testicular cancer. This scientifically profound product embodies the potential for significant advancements and breakthroughs in cancer therapy. Synonyms: Etoposide glucuronide; 100007-55-4; F65IJO84A1; (2S,3S,4S,5R,6S)-6-[4-[(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-9-yl]-2,6-dimethoxyphenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid; UNII-F65IJO84A1; CHEMBL2074759; ETOPOSIDE 4'-GLUCURONIDE; Q27277698.B. CAS No. 100007-55-4. Molecular formula: C35H40O19. Mole weight: 764.68. | |
| Etoposide EP Impurity B | An impurity of Etoposide. Etoposide is a cytotoxic anticancer drug which belongs to the topoisomerase inhibitor drug class. It is used in form of its salt etoposide phosphate. Synonyms: cis-Etoposide; (5R,5aS,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aα,8aα,9β(R*)]]-; Picro ethylidene lignan P; Picroetoposide; Pptoxin IV; Etoposide Impurity B. Grade: >95%. CAS No. 100007-56-5. Molecular formula: C29H32O13. Mole weight: 588.57. | |
| Etoposide EP Impurity C | α-Etoposide, a cytotoxic drug, is a drug-type topoisomerase II inhibitor used as an antineoplastic drug. Synonyms: α-Etoposide; (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-α-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-α-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-; Etoposide Impurity C. Grade: >95%. CAS No. 100007-53-2. Molecular formula: C29H32O13. Mole weight: 588.57. | |
| Etoposide Hydroxy Acid | An impurity of Etoposide. Etoposide is a cytotoxic anticancer drug which belongs to the topoisomerase inhibitor drug class. It is used in form of its salt etoposide phosphate. Synonyms: Etoposide Hydroxy Acid (Mixture of Diastereomers). Grade: > 95%. Molecular formula: C29H34O14. Mole weight: 606.59. | |
| Etoposide Hydroxy Acid (Mixture of Diastereomers) | Etoposide hydroxy acid is a derivative of Etoposide. Etoposide is a topoisomerase I inhibitor that induces apoptosis and is used as a chemotherapeutic agent for various types of cancer, such as small-cell lung cancer. Molecular formula: C29H34O14. Mole weight: 606.57. | |
| Etoposide Impurity 4 | Etoposide Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 101648-60-6. Molecular formula: C35H32Cl6O16. Mole weight: 921.33. Catalog: APB101648606. | |
| Etoposide Impurity A | Etoposide Impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: benzyl (4-((5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-6-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxyphenyl) carbonate. CAS No. 124151-67-3. Molecular formula: C37H38O15. Mole weight: 722.69. Catalog: APB124151673. | |
| Etoposide Impurity B | Etoposide Impurity B. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (5R,5aS,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one. CAS No. 100007-56-5. Molecular formula: C29H32O13. Mole weight: 588.56. Catalog: APB100007565. | |
| Etoposide Impurity C | Etoposide Impurity C. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (5R,5aR,8aR,9S)-9-(((2R,4aR,6S,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one. CAS No. 100007-53-2. Molecular formula: C29H32O13. Mole weight: 588.56. Catalog: APB100007532. | |
| Etoposide Impurity D | An impurity of Etoposide. Etoposide is a cytotoxic anticancer drug which belongs to the topoisomerase inhibitor drug class. It is used in form of its salt etoposide phosphate. Synonyms: Lignan P; (5R,5aR,8aR,9S)-9-(β-D-Glucopyranosyloxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-uro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one. Grade: > 95%. CAS No. 23363-35-1. Molecular formula: C27H30O13. Mole weight: 562.53. | |
| Etoposide Impurity H | Etoposide Impurity H. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (5R,5aR,8aR,9S)-9-ethoxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one. CAS No. 102306-95-6. Molecular formula: C23H24O8. Mole weight: 428.43. Catalog: APB102306956. | |
| Etoposide Impurity Q | Etoposide Impurity Q. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one. CAS No. 153975-26-9. Molecular formula: C21H16O7. Mole weight: 380.35. Catalog: APB153975269. | |
| Etoposide phosphate | Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor?to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as?active?equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest,?apoptosis, and?autophagy. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 117091-64-2. Molecular formula: C29H33O16P. Mole weight: 668.54. Product ID: ACM117091642. Alfa Chemistry ISO 9001:2015 Certified. | |
| Etoposide phosphate | Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMY-40481. CAS No. 117091-64-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13630. | |
| Etoposide Phosphate | Etoposide Phosphate. Group: Biochemicals. Alternative Names: [5R-[5α,5a β,8aα,9 β(R*)]]-5-[3,5-Dimethoxy-4-(phosphonooxy)phenyl]-9-[(4,6-O-ethylidene- β-D-glucopyranosyl)oxy]-5, 8, 8a, 9-tetrahydrofuro[3', 4':6, 7]naphtho[2, 3-d]-1, 3-dioxol-6(5aH)-one; BMY 40481; Etopofos; Etopophos; Etoposide 4'-Phosphate; (5R,5aR,8aR,9S)-5-[3,5-Dimethoxy-4-(phosphonooxy)phenyl]-9-[[4,6-O-(1R)-ethylidene- β-D-glucopyranosyl]oxy]-5, 8, 8a, 9-tetrahydrofuro[3', 4':6, 7]naphtho[2, 3-d]-1, 3-dioxol-6(5aH)-one. Grades: Highly Purified. CAS No. 117091-64-2. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Etoposide Phosphate | Etoposide Phosphate is a derivative of Etoposide. Etoposide is a topoisomerase II inhibitor that is widely used as an apoptosis inducer. Etoposide exhibits antineoplastic and anti-mitotic properties. It inhibits DNA synthesis and induces double-strand and single-strand DNA breaks. Synonyms: BMY-40481; Etopofos; Etoposide 4'-Phosphate. Grade: >98%. CAS No. 117091-64-2. Molecular formula: C29H33O16P. Mole weight: 668.54. | |
| Etoposide phosphate 98+% (HPLC) | Etoposide phosphate 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 25mg, 1g. US Biological Life Sciences. | Worldwide |
| Etoposide Phosphate Diammonium Salt | A bioequivalent prodrug of the DNA topoisomerase II inhibitor Etoposide. Antineoplastic used for a wide variety of hematological malignancies and solid tumors treatment. Synonyms: (5R,5aR,8aR,9S)-5-[3,5-Dimethoxy-4-(phosphonooxy)phenyl]-9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one diammonium salt; Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5-[3,5-dimethoxy-4-(phosphonooxy)phenyl]-9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-, [5R-[5α,5aβ,8aα,9β(R*)]]-, diammonium salt; BMY 40481 diammonium salt; Etopofos diammonium salt; Etopophos diammonium salt; Etoposide 4'-phosphate diammonium salt. Molecular formula: C29H31O16P.2NH4. Mole weight: 702.60. | |
| Etoposide phosphate disodium | Etoposide phosphate disodium is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy. Synonyms: BMY-40481 disodium. CAS No. 122405-33-8. Molecular formula: C29H31Na2O16P. Mole weight: 712.50. | |
| Etoposide Resolution Mixture | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| 2'',3''-Bis-O-(Dichloroacetyl) Etoposide | 2'',3''-Bis-O-(Dichloroacetyl) Etoposide is an impurity of Etoposide (E933750). Etoposide is a DNA topoisomerase II inhibitor. Etoposide is semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide and it is an Antineoplastic. Group: Biochemicals. Grades: Highly Purified. CAS No. 260974-95-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C33H32Cl4O15, Molecular Weight: 810.41. US Biological Life Sciences. | Worldwide |
| 2'',3''-Bis-O-(Dichloroacetyl) Etoposide | 2'',3''-Bis-O-(Dichloroacetyl) Etoposide is an impurity of Etoposide. Etoposide is a DNA topoisomerase II inhibitor. Etoposide is a semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide and it is an antineoplastic. Synonyms: 9-[[2,3-Bis-O-(2,2-dichloroacetyl)-4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one 6-Acetate; (5R,5aR,8aR,9S)-9-[[2,3-Bis-O-(dichloroacetyl)-4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one. CAS No. 260974-95-6. Molecular formula: C33H32Cl4O15. Mole weight: 810.41. | |
| 3-O-Desmethyl Etoposide | An Etoposide metabolite. Group: Biochemicals. Alternative Names: (5R,5aR,8aR,9S)-5-(3,4-Dihydroxy-5-methoxyphenyl)-9-[[4,6-O-(1R)-ethylidene- β-D-glucopyranosyl]oxy]-5, 8, 8a, 9-tetrahydro-furo[3', 4':6, 7]naphtho[2, 3-d]-1, 3-dioxol-6(5aH)-one; 3'-Demethyl Etoposide; 3'-O-Demethyletoposide. Grades: Highly Purified. CAS No. 100007-54-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-O-Desmethyl Etoposide-d4 | 3-O-Desmethyl Etoposide-d4. Group: Biochemicals. Alternative Names: (5R,5aR,8aR,9S)-5-(3,4-Dihydroxy-5-methoxyphenyl)-9-[[4,6-O-(1R)-ethylidene- β-D-glucopyranosyl]oxy]-5, 8, 8a, 9-tetrahydro-furo[3', 4':6, 7]naphtho[2, 3-d]-1, 3-dioxol-6(5aH)-one-d4; 3'-Demethyl Etoposide-d4; 3'-O-Demethyletoposide-d4. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C28H26D4O13, Molecular Weight: 578.549999999999. US Biological Life Sciences. | Worldwide |
| 4'-O-Benzyl 3'-O-Desmethyl Etoposide | An analogue of Etoposide. Synonyms: (5R,5aR,8aR,9S)-5-[5-Methoxy-4-(phenylmethoxy)phenyl]-9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-[3-hydroxy-5-methoxy-4-(phenylmethoxy)phenyl]-, [5R-[5α,5aβ,8aα,9β(R*)]]-. CAS No. 129498-97-1. Molecular formula: C35H36O13. Mole weight: 664.65. | |
| 4'-O-Benzyl Etoposide-d3 | An analogue of Etoposide. Synonyms: (5R,5aR,8aR,9S)-5-[3,5-Dimethoxy-4-(phenylmethoxy)phenyl]-9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one-d3. Molecular formula: C36H35D3O13. Mole weight: 681.7. | |
| 4'-(O-Podophyllotoxin-9-oxy) Etoposide | 4'-(O-Podophyllotoxin-9-oxy) Etoposide is an impurity of Etoposide. Etoposide is a DNA topoisomerase II inhibitor, as well as semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide and it is an antineoplastic. Molecular formula: C50H50O20. Mole weight: 970.92. | |
| α-Etoposide | α-Etoposide. Group: Biochemicals. Alternative Names: (5R, 5aR, 8aR, 9S)-9-[[4, 6-O-(1R)-Ethylidene-α-D-glucopyranosyl]oxy]-5, 8, 8a, 9-tetrahydro-5-(4-hydroxy-3, 5-dimethoxyphenyl)-furo[3', 4':6, 7]naphtho[2, 3-d]-1, 3-dioxol-6(5aH)-one; Pyrano[3,2-d]-1,3-dioxin Furo[3', 4':6, 7]naphtho[2, 3-d]-1, 3-dioxol-6(5aH)-one Deriv. Grades: Highly Purified. CAS No. 100007-53-2. Pack Sizes: 2.5mg. Molecular Formula: C29H32O13, Molecular Weight: 588.559999999999. US Biological Life Sciences. | Worldwide |
| (-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase | This cytochrome P450 enzyme, characterized from the plant Sinopodophyllum hexandrum, produces the direct precursor to etoposide, a potent anticancer drug. It can also act on (-)-deoxypodophyllotoxin with lower efficiency. Group: Enzymes. Synonyms: CYP82D61 (gene name). Enzyme Commission Number: EC 1.14.13.214. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0816; (-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase; EC 1.14.13.214; CYP82D61 (gene name). Cat No: EXWM-0816. |  |
| Aclarubicin A | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. It intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. It is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. It has potent antineoplastic activity. It is used in the treatment of cancer. It can induce histone eviction from chromatin upon intercalation. It has been listed. Uses: Aclarubicin has potent antineoplastic activity. it is used in the treatment of cancer. it can induce histone eviction from chromatin upon intercalation. Synonyms: 11-Dioxo-4-((2,3,6-trideoxy-4-o-(2,6-dideoxy-4-o-((2r-trans)-tetrahydro-6-met; 1-naphthacenecarboxylicacid,2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6; (1R,2R,4S)-methyl 4-(((2R,5S,6S)-4-(dimethylamino)-5-(((2S,4S,5S,6S)-4-hydroxy-6-methyl-5-(((2R,6S). Grade: ≥95%. CAS No. 57576-44-0. Molecular formula: C42H53NO15. Mole weight: 811.88. | |
| Aclarubicin hydrochloride | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting replication and repair of DNA and RNA, and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin. Uses: Antibiotics, antineoplastic. Synonyms: Aclacinon; Aclaplastin; Aclacinomycin A Hydrochloride; Aclarubicin HCl; Aclarubicina Clorhidrato [Spanish]. Grade: >98%. CAS No. 75443-99-1. Molecular formula: C42H54ClNO15. Mole weight: 848.33. | |
| ARN-21934 | ARN-21934 is a potent, highly selective and blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. Compared with anticancer agent Etoposide (IC50 = 120 μM), ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM. It is a promising anticancer lead compound with good pharmacokinetic profile in vivo. Synonyms: 4,6-Quinazolinediamine, N4-[4-(dimethylamino)phenyl]-5,6,7,8-tetrahydro-2-(4-pyridinyl)-; N4-[4-(Dimethylamino)phenyl]-2-(4-pyridinyl)-5,6,7,8-tetrahydro-4,6-quinazolinediamine. Grade: ≥98%. CAS No. 2230854-93-8. Molecular formula: C21H24N6. Mole weight: 360.46. | |
| CCT 241533 dihydrochloride | CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM) displaying >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. CCT 241533 inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells, and blocks ionizing radiation-induced apoptosis of mouse thymocytes. Synonyms: CCT 241533 dihydrochloride; CCT241533 dihydrochloride; CCT-241533 dihydrochloride; (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride. Grade: ≥98% by HPLC. CAS No. 1962925-28-5. Molecular formula: C23H27FN4O4.2HCl. Mole weight: 515.41. | |
| CHS-828 | CHS-828 is a synthetic guanidine-based small anticancer molecule. CHS 828 was found to exert potent cytotoxic effects in human breast and lung cancer cell lines, with lesser effects on normal fibroblasts and endothelial cells. In nude mice bearing human tumor xenografts, CHS 828, at doses from 20 to 50 mg/kg/day p.o., inhibited the growth of MCF-7 breast cancer tumors and caused regression of NYH small cell lung cancer tumors. Oral administration of CHS 828 once weekly improved efficacy without increasing toxicity. CHS 828 was found to compare favorably with established chemotherapeutic agents such as cyclophosphamide, etoposide, methotrexate, and paclitaxel. In mice with NYH tumors, long-term survival (>6 months) was observed after treatment with CHS 828 was stopped. CHS 828 is an effective new antitumor agent, with a potentially new mechanism of action. CHS-828 appeared to kill cancer cells by depleting NAD. CHS 828 is presently being tested in Phase I clinical trials in collaboration with the European Organization for Research and Treatment of Cancer. Synonyms: CHS 828; CHS828; CHS-828; GMX-1778; GMX1778; GMX 1778. CAS No. 200484-11-3. Molecular formula: C19H22ClN5O. Mole weight: 371.869. | |
| cis-Diamineplatinum(II) dichloride | cis-Diamineplatinum(II) dichloride. Uses: Cisplatin is a cytostatic agent and it is used to treat various cancer types, including cancer of ovary, testis, lung, head, neck, bladder, neuroblastoma, and nephroblastoma, and hodgkin's disease and non-hodgkin lymphoma.cddp, also referred to as cisplatinum or cisplatin, is a yellow powder and has found widespread use a chemotherapeutic agent.cisplatin, combined with bleomycin and vinblastine or etoposide, produces cures in most patients with metastatic testicular cancer or germ cell cancer of the ovary. cisplatin also shows some activity against carcinomas of the head and neck, bladder, cervix, prostate, and lung. Group: Salt. Alternative Names: cis-Dichlorodiammine platinum(II). CAS No. 15663-27-1. Molecular formula: 300.05. Mole weight: Pt(NH3)2Cl2. Pt ≥65.0%. |  |
| Heptelidic acid | Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic [1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases [2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC 50 of 90 μM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Koningic acid. CAS No. 57710-57-3. Pack Sizes: 1 mg. Product ID: HY-120838. | |
| N- (9-Fluorenyl methoxycarbonyl ) -4, 6, 8, 11-tetra-O-benzoyl Doxorubicin | N- (9-Fluorenyl methoxycarbonyl ) Doxorubicin derivative. Used in the preparation of a modified Doxorubicin (ANG1007) and Etoposide (ANG1009) useful due to their brain penetration ability. Group: Biochemicals. Alternative Names: (8S, 10S) -7, 8, 9, 10-tetrahydro-8-hydroxy-6, 11-dibenzoyloxy-8- (2-benzoyloxyacetyl) -1-methoxy-10-[[2, 3, 6-trideoxy-3-[[ (9H-fluoren-9-ylmethoxy) carbonyl]amino]-4-benzyloxy-α -L-lyxo-hexopyranosyl]oxy]-5, 12-naphthacenedione. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| N- (9-Fluorenyl methoxycarbonyl ) Doxorubicin | Used in the preparation of a modified Doxorubicin (ANG1007) and Etoposide (ANG1009), useful due to their brain penetration ability. Group: Biochemicals. Alternative Names: (8S, 10S) -7, 8, 9, 10-tetrahydro-6, 8, 11-trihydroxy-8- (2-hydroxyacetyl) -1-methoxy-10-[[2, 3, 6-trideoxy-3-[[ (9H-fluoren-9-ylmethoxy) carbonyl]amino]-α -L-lyxo-hexopyranosyl]oxy]-5, 12-naphthacenedione. Grades: Highly Purified. CAS No. 136582-53-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Necrosis Inhibitor, Necrox-2 ([5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine) | A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1uM NecroX-2 prevented ~50% cell death in H9C2 cells exposed to 400uM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Necrosis Inhibitor, Necrox-5 ([5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine, Dihydrochloride) | A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1uM NecroX-5 prevented ~50% cell death in H9C2 cells exposed to 400uM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Pifithrin-α, p-Nitro, Cyclic | Pifithrin-?, p-Nitro, Cyclic (PFN-?) is cell-permeable and active-form p53 inhibitor. Pifithrin-?, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-? in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-?, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-?, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PFN-?. CAS No. 60477-38-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123076. | |
| Spautin-1 (6-fluoro-N- [4-fluorobenzyl] quinazolin-4-amine, Specific and Potent AUtophagy Inhibitor 1, C43, Autophagy Inhibitor II) | A quinazolin compound that acts as a specific and potent inhibitor of autophagy and promotes Vps34 PI 3-kinase complex degradation by blocking the activity of USP 10 (IC50 = 580nM) and USP 13 (IC50 = 690nM) deubiquitinating enzymes. However, it does not affect the lipid kinase activity of Vps34. Also shown to reduce the level of cytoplasmic and nuclear p53. Sensitizes breast cancer cell lines (BCAP37, MCF-7, and BT549) to apoptosis under conditions of nutritional deprivation. Also shown to inhibit etoposide-induced cell death in Bax/Bak double knockout (DKO) cells. Normal cell lines (e.g., MDCK cells) do not undergo autophagy in the presence of Spautin-1. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Topoisomerase II Inhibitor (BNS-22) | A potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC50=2.8uM and 0.42uM for TOP2a and TOP2b, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of y-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10uM. It also exhibits significant anti-proliferative activities against several human cancer cell lines. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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