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EuphorbiaFactor L2 is a diterpenoid isolated from Euphorbia lathyris L with cytotoxic activity against lung carcinoma A549 cells. Synonyms: EuphorbiaFactor L2; 218916-51-9. Grades: 0.98. CAS No. 218916-51-9. Molecular formula: C38H42O9. Mole weight: 642.7.
Prostratin is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). It is an unusual non-tumorigenic phorbol ester and is found in the bark of the mamala tree of Samoa, Homalanthus nutans (Euphorbiaceae). It has potential to be useful in the treatment of HIV as it could flush viral reservoirs in latently infected CD4+ T-cells. It exhibits promising therapeutic potential against other diseases such as cancer and Alzheimer's disease. It inhibits growth and induces differentiation of AML cell lines. It inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models. Uses: Prostratin has potential to be useful in the treatment of hiv. it exhibits promising therapeutic potential against other diseases such as cancer and alzheimer's disease. Synonyms: (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl- 5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one;13-O-Acetylphorbol;NSC 623310;(1aR)-1, 1aα, 1bβ, 4, 4a, 7aα, 7b, 8, 9, 9a-Decahydro-4a. Grades: 95%. CAS No. 60857-08-1. Molecular formula: C22H30O6. Mole weight: 390.47.
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