Everolimus Suppliers USA
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Product | Description | |
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Everolimus Quick inquiry Where to buy Suppliers range | Everolimus is an immunosuppressant analog of rapamycin (sirolimus) and inhibits growth factor-mediated proliferation of hematopoietic and nonhematopoietic cells. Everolimus shows a potent inhibitory effect on posttransplant lymphoproliferative disorder (PTLD)-derived cells in vitro and in vivo, in a dose range that can prevent allograft rejection, and may demonstrate activity in both the prevention and treatment of PTLDs in transplant patients. Group: Biochemicals. Alternative Names: Afinitor, Certican, RAD-001, Zortress; 40-O- (2-Hydroxyethyl) rapamycin; 42-O-(2-Hydroxy)ethyl Rapamycin; RAD; RAD 001; SDZ-RAD; XIENCE V. Grades: Highly Purified. CAS No. 159351-69-6. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
Everolimus Quick inquiry Where to buy Suppliers range | Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cytokine-mediated lymphocyte proliferation. Everolimus can be used as an immunosuppressant in the treatment of renal cell cancer and other cancers. Uses: Immunosuppressant. Synonyms: RAD-001; RAD001; RAD 001; Afinitor; Certican; Zortress; RAD001; SDZ-RAD. Grades: >98%. CAS No. 159351-69-6. Molecular formula: C53H83NO14. Mole weight: 958.24. | |
Everolimus Quick inquiry Where to buy Suppliers range | Everolimus is a Kinase Inhibitor and mTOR Inhibitor Immunosuppressant. The mechanism of action of everolimus is as a Protein Kinase Inhibitor and Cytochrome P450 3A4 Inhibitor and P-Glycoprotein Inhibitor and Cytochrome P450 2D6 Inhibitor and mTOR Inhibitor. The physiologic effect of everolimus is by means of Decreased Immunologic Activity. Uses: API. CAS No. 159351-69-6. Product ID: Z10-101-155. | |
Everolimus 27-O-Desmethyl Impurity Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 27-O-Desmethyl Everolimus. Grades: > 95%. Molecular formula: C52H81NO14. Mole weight: 944.22. | |
Everolimus 28-Ethylhydroxy Impurity Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 28-Ethylhydroxy Rapamycin. Grades: > 95%. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
Everolimus, Cyclosporine and Tacrolimus Mix Standard Quick inquiry Where to buy Suppliers range | Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Cyclosporine is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Tacrolimus is also an immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Molecular formula: C53H83NO14/C62H111N11O12/C44H69N. Mole weight: 958.22/1202.61/612.02. | |
Everolimus-d4 Quick inquiry Where to buy Suppliers range | Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Alternative Names: 40-O-(2-Hydroxyethyl-d4)rapamycin; 42-O-(2-Hydroxy)ethyl-d4 Rapamycin; Afinitor-d4; Certican-d4; RAD-d4; RAD 001-d4; SDZ-RAD-d4; XIENCE V-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Everolimus-d4 (~90%) Quick inquiry Where to buy Suppliers range | Everolimus-d4 (~90%). Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Alternative Names: Everolimus-(2-hydroxyethyl-D4). CAS No. 1338452-54-2. Molecular formula: C532H4H79NO14. Mole weight: 962.25. Catalog: APS1338452542. SMILES: [2H]C ([2H]) (O)C ([2H]) ([2H])O[C@@H]1CC[C@@H] (C[C@@H] (C)[C@@H]2CC (=O)[C@H] (C)\C=C (/C)\[C@@H] (O)[C@@H] (OC)C (=O)[C@H] (C)C[C@H] (C)\C=C\C=C\C=C (/C)\[C@H] (C[C@@H]3CC[C@@H] (C)[C@@] (O) (O3)C (=O)C (=O)N4CCCC[C@H]4C (=O)O2)OC)C[C@H]1OC. Format: Neat. Product Type: Stable Isotope Labelled. | |
Everolimus Dehydrate Impurity Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: Everolimus Dehydro Seco Acid. Grades: > 95%. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
Everolimus for impurity C identification Quick inquiry Where to buy Suppliers range | Everolimus for impurity C identification. Uses: For analytical and research use. Group: European Pharmacopoeia (Ph. Eur.); Pharmacopoeial Standards. Catalog: APS008045. Format: Mixture. Shipping: Dry ice. | |
Everolimus for system suitability Quick inquiry Where to buy Suppliers range | Everolimus for system suitability. Uses: For analytical and research use. Group: European Pharmacopoeia (Ph. Eur.); Pharmacopoeial Standards. Catalog: APS008046. Shipping: Dry ice. | |
Everolimus Hydrolized Impurity Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: seco Everolimus B; (2S)-1-[2-[(2R, 3R, 6S)-6-[(2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 20S, 21R)-14, 20-Dihydroxy-22-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxo-3, 5, 7, 15-docosatetraen-1-yl]tetrahydro-. Grades: > 95%. CAS No. 769905-89-7. Molecular formula: C53H85NO15. Mole weight: 976.27. | |
Everolimus Isomer C Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 9,14-Deepoxy-15-deoxo-14-deoxy-9,15-epoxy-15-hydroxy-42-O-(2-hydroxyethyl)-14-oxorapamycin. Grades: 80%. CAS No. 908340-97-6. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
Everolimus O-Desmethyl Impurity (Mixture of Diastereomers) Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 27-O-Desmethyl Everolimus. Grades: > 95%. Molecular formula: C52H81NO14. Mole weight: 944.22. | |
Everolimus O-Ethyl Impurity Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 7-O-Desmethyl-7-O-ethyl Everolimus. Grades: > 95%. CAS No. 1704711-12-5. Molecular formula: C54H85NO14. Mole weight: 972.28. | |
Everolimus O-Silyl Impurity Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin; 42-O-[2-[[ (1, 1-Dimethylethyl) dimethylsilyl]oxy]ethyl]rapamycin. Grades: > 95%. CAS No. 159351-68-5. Molecular formula: C59H97NO14Si. Mole weight: 1072.52. | |
Everolimus Related Compound 1 Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: O-Desmethyl Everolimus. Grades: > 95%. CAS No. 745779-75-3. Molecular formula: C52H81NO14. Mole weight: 944.22. | |
Everolimus Related Compound 3 Quick inquiry Where to buy Suppliers range | Everolimus Ring-Opening Impurity. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: (2S)-1-[[(2R,3R,6S)-6-[(2S,3E,5E,7E,9S,11R)-2,13-Dimethoxy-3,9,11-trimethyl-12-oxo-3,5,7-tridecatrienyl]tetrahydro-2-hydroxy-3-methyl-2H-pyran-2-yl]oxoacetyl]-2-piperidinecarboxylic Acid. Grades: 65%. CAS No. 147438-30-0. Molecular formula: C32H49NO9. Mole weight: 591.75. | |
Everolimus Related Compound 4 Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: (2S)-1-[2-[(2R, 3R, 6S)-6-[(2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 20S, 21R)-14, 20-Dihydroxy-22-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxo-3, 5, 7, 15-docosatetraen-1-yl]tetrahydro-2-hydroxy-3-methyl-. Grades: > 95%. Molecular formula: C57H91NO16. Mole weight: 1046.36. | |
Everolimus Related Compound 5 Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: Di-tert-butyl-4-methylene-2,5-cyclohexadienone; 2,6-Di-t-butyl-4-methylene-2,5-cyclohexadienone. Grades: > 95%. CAS No. 2607-52-5. Molecular formula: C15H22O. Mole weight: 218.34. | |
Everolimus Retroaldol Degradation Product Quick inquiry Where to buy Suppliers range | Everolimus Retroaldol Degradation Product. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Pack Sizes: 10MG. Catalog: APS008047. Format: Neat. Product Type: Impurity. Shipping: Room Temperature. | |
Everolimus Ring-Opening Impurity Quick inquiry Where to buy Suppliers range | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: Everolimus Retroaldol Degradation Product. Grades: > 95%. CAS No. 1708118-13-1. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
28-Ethylhydroxy Everolimus-d4 Impurity Quick inquiry Where to buy Suppliers range | 28-Ethylhydroxy Everolimus-d4 Impurity is a deuterium labelled 28-Ethylhydroxy-everolimus Impurity (E945435). It is also an impurity of Everolimus (E945400), which is a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C55H83D4NO15, Molecular Weight: 1006.3. US Biological Life Sciences. | Worldwide |
28-Ethylhydroxy Everolimus Impurity Quick inquiry Where to buy Suppliers range | 28-Ethylhydroxy Everolimus Impurity is an impurity of Everolimus (E945400), which is a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C55H87NO15, Molecular Weight: 1002.28. US Biological Life Sciences. | Worldwide |
31-Oxo Everolimus (~80%) Quick inquiry Where to buy Suppliers range | 31-Oxo Everolimus (~80%). Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates; Impurity Standards. Catalog: APS00405. Format: Neat. Product Type: Impurity. | |
O-Desmethyl Everolimus (>80%) Quick inquiry Where to buy Suppliers range | O-Desmethyl Everolimus (>80%). Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates; Impurity Standards. Pack Sizes: 5MG. Catalog: APS010713. Format: Neat. Product Type: Impurity. Shipping: Room Temperature. | |
(19E/Z)-seco-[4-O-[2-Hydroxy(ethyl)-d4]] Rapamycin Sodium Salt Quick inquiry Where to buy Suppliers range | A labelled metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C53H78D4NNaO14, Molecular Weight: 984.23. US Biological Life Sciences. | Worldwide |
(19E/Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin Quick inquiry Where to buy Suppliers range | (19E/Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin is a metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000). Group: Biochemicals. Grades: Highly Purified. CAS No. 1062122-63-7. Pack Sizes: 1mg, 5mg. Molecular Formula: C53H83NO14. US Biological Life Sciences. | Worldwide |
(19E/Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin Sodium Salt Quick inquiry Where to buy Suppliers range | Metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin. Group: Biochemicals. Alternative Names: (2S)-1-[2-oxo-2-[(2R, 3R, 6S)-tetrahydro-2-hydroxy-6-[(2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 19E/Z, 21R)-14-hydroxy-22-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxo-3, 5, 7, 15, 19-docosapentaen-1-yl]-3-methyl-2H-pyran-2-yl]acetyl]-2-piperidinecarboxylic Acid Sodium Salt; seco Everolimus Sodium Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
(19Z)-seco-[4-O-(2-hydroxyethyl)] rapamycin sodium salt Quick inquiry Where to buy Suppliers range | (19Z)-seco-[4-O-(2-hydroxyethyl)] rapamycin sodium salt. Group: Biochemicals. Alternative Names: (2S)-1-[2-oxo-2-[(2R, 3R, 6S)-tetrahydro-2-hydroxy-6-[(2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 19Z, 21R)-14-hydroxy-22-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxo-3, 5, 7, 15, 19-docosapentaen-1-yl]-3-methyl-2H-pyran-2-yl]acetyl]-2-piperidinecarboxylic acid sodium salt; seco everolimus sodium salt. Grades: Highly Purified. CAS No. 220127-31-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C53H82NNaO14. US Biological Life Sciences. | Worldwide |
28-Ethyl-d4-hydroxy Rapamycin Quick inquiry Where to buy Suppliers range | 28-Ethyl-d4-hydroxy Rapamycin is the labeled analogue of 28-Ethylhydroxy Rapamycin (E678640), an impurity of Everolimus (E945400),a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C53H79D4NO14, Molecular Weight: 962.25. US Biological Life Sciences. | Worldwide |
2- ( (tert-Butyldimethylsilyl) oxy) ethyl 2,2,2-trichloroacetimidate Quick inquiry Where to buy Suppliers range | 2- ( (tert-Butyldimethylsilyl) oxy) ethyl 2,2,2-trichloroacetimidate is an intermediate in the synthesis of 28-Ethylhydroxy Rapamycin (E678640), which is an impurity of Everolimus (E945400),a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg, 500mg. Molecular Formula: C10H20Cl3NO2Si. US Biological Life Sciences. | Worldwide |
42-O- [2- [ [Hydroxy [2- (trimethylammonio) ethoxy] phosphinyl] oxy] ethyl] Rapamycin Inner Salt Quick inquiry Where to buy Suppliers range | A phosphocholine ester metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin. Group: Biochemicals. Alternative Names: ATG 181. Grades: Highly Purified. CAS No. 1062645-51-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
42-O-tert-Butyldi methyl silyloxyethyl-d4 Rapamycin Quick inquiry Where to buy Suppliers range | Intermediate to make Everolimus-d4. Group: Biochemicals. Alternative Names: 42-O- [2- [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] ethyl-d4] rapamycin; Everolimus-d4 tert-Butyldimethylsilyl Ether. Grades: Highly Purified. CAS No. 1356839-88-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Rapamycin Quick inquiry Where to buy Suppliers range | Rapamycin is an mTOR inhibitor immunosuppressant and kinase inhibitor with both antifungal and antineoplastic properties. It selectively inhibits the transcriptional activation of cytokines. Uses: Antifungal and antineoplastic agent. Synonyms: Sirolimus; (-)-Rapamycin; AY 22989; AY-22989; I-2190A; NSC 226080; RAPA; RAP; RPM; SLM; WY-090217; Everolimus EP Impurity A. Grades: >98%. CAS No. 53123-88-9. Molecular formula: C51H79NO13. Mole weight: 914.19. | |
SAR-405 Quick inquiry Where to buy Suppliers range | SAR-405 is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM, Kd=1.5 nM) without disrupting other PI3K isoforms and mTOR (IC50 > 10,000 nM). Concomitant inhibition of Vps34 and mTOR, with SAR405 and mTOR inhibitor everolimus, results in synergistic antiproliferative activity in renal tumor cell lines. Synonyms: SAR 405; SAR405; 4H-Pyrimido[1,?2-a]?pyrimidin-4-one, 9-[(5-chloro-3-pyridinyl)?methyl]?-6,?7,?8,?9-tetrahydro-2-[(3R)?-3-methyl-4-morpholinyl]?-8-(trifluoromethyl)?-, (8S)?-; (8S)-9-[(5-Chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one. CAS No. 1523406-39-4. Molecular formula: C19H21ClF3N5O2. Mole weight: 443.85. |