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| Product | Description | |
|---|---|---|
| Everolimus | Everolimus is an immunosuppressant analog of rapamycin (sirolimus) and inhibits growth factor-mediated proliferation of hematopoietic and nonhematopoietic cells. Everolimus shows a potent inhibitory effect on posttransplant lymphoproliferative disorder (PTLD)-derived cells in vitro and in vivo, in a dose range that can prevent allograft rejection, and may demonstrate activity in both the prevention and treatment of PTLDs in transplant patients. Group: Biochemicals. Alternative Names: Afinitor, Certican, RAD-001, Zortress; 40-O- (2-Hydroxyethyl) rapamycin; 42-O-(2-Hydroxy)ethyl Rapamycin; RAD; RAD 001; SDZ-RAD; XIENCE V. Grades: Highly Purified. CAS No. 159351-69-6. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. |  Worldwide |
| Everolimus | Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cytokine-mediated lymphocyte proliferation. Everolimus can be used as an immunosuppressant in the treatment of renal cell cancer and other cancers. Uses: Immunosuppressant. Synonyms: RAD-001; RAD001; RAD 001; Afinitor; Certican; Zortress; RAD001; SDZ-RAD. Grades: >98%. CAS No. 159351-69-6. Molecular formula: C53H83NO14. Mole weight: 958.24. |  |
| Everolimus | Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RAD001; SDZ-RAD. CAS No. 159351-69-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10218. |  |
| Everolimus 27-O-Desmethyl Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 27-O-Desmethyl Everolimus. Grades: > 95%. Molecular formula: C52H81NO14. Mole weight: 944.22. | |
| Everolimus 28-Ethylhydroxy Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 28-Ethylhydroxy Rapamycin. Grades: > 95%. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
| Everolimus, Cyclosporine and Tacrolimus Mix Standard | Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Cyclosporine is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Tacrolimus is also an immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Molecular formula: C53H83NO14/C62H111N11O12/C44H69N. Mole weight: 958.22/1202.61/612.02. | |
| Everolimus-d4 | Everolimus-d 4 is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: RAD001-d4; SDZ-RAD-d4. CAS No. 1338452-54-2. Pack Sizes: 500 μg. Product ID: HY-10218S. | |
| Everolimus-d4 | Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Alternative Names: 40-O-(2-Hydroxyethyl-d4)rapamycin; 42-O-(2-Hydroxy)ethyl-d4 Rapamycin; Afinitor-d4; Certican-d4; RAD-d4; RAD 001-d4; SDZ-RAD-d4; XIENCE V-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Everolimus Dehydrate Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: Everolimus Dehydro Seco Acid. Grades: > 95%. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
| Everolimus EP Impurity B | Everolimus EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1062122-63-7. Molecular Formula: C53H83NO14. Mole Weight: 958.24. Catalog: APB1062122637. |  |
| Everolimus EP Impurity B (19-Z-Isomer) | Everolimus EP Impurity B (19-Z-Isomer). Uses: For analytical and research use. Group: Impurity standards. CAS No. 763911-41-7. Molecular Formula: C53H83NO14. Mole Weight: 958.24. Catalog: APB763911417. | |
| Everolimus EP Impurity C | Everolimus EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C52H81NO14. Mole Weight: 944.21. Catalog: APB07747. | |
| Everolimus EP Impurity D | Everolimus EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C53H83NO14. Mole Weight: 958.24. Catalog: APB07748. | |
| Everolimus EP Impurity E | Everolimus EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Everolimus EP Impurity E. CAS No. 1237826-25-3. Molecular Formula: C52H79NO14. Mole Weight: 942.18. Catalog: APB1237826253. | |
| Everolimus EP Impurity F | Everolimus EP Impurity F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Everolimus EP Impurity F. Molecular Formula: C55H89NO16. Mole Weight: 1020.29. Catalog: APB05420. | |
| Everolimus Hydrolized Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: seco Everolimus B; (2S)-1-[2-[(2R, 3R, 6S)-6-[(2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 20S, 21R)-14, 20-Dihydroxy-22-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxo-3, 5, 7, 15-docosatetraen-1-yl]tetrahydro-. Grades: > 95%. CAS No. 769905-89-7. Molecular formula: C53H85NO15. Mole weight: 976.27. | |
| Everolimus Impurity 003-09 | Everolimus Impurity 003-09. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Everolimus Impurity 003-09. Molecular Formula: C107H167N2O28. Mole Weight: 1929.47. Catalog: APB05415. | |
| Everolimus Impurity 005-98 | Everolimus Impurity 005-98. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (1R, 9S, 12S, 15R, 16Z, 18R, 19R, 21R, 23S, 24Z, 26Z, 28Z, 30S, 32S, 35R)-1, 18, 30-Trihydroxy-12-{(2R)-1-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2-propanyl}-19-methoxy-15, 17, 21, 23, 29, 35-hexamethyl-11, 36 ; -dioxa-4-azatricyclo[30.3.1.0]hexatriaconta-16,24,26. CAS No. 745779-75-3. Molecular Formula: C52H81NO14. Mole Weight: 944.2. Catalog: APB745779753. | |
| Everolimus Impurity 008-96 | Everolimus Impurity 008-96. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Everolimus Impurity 008-96. Molecular Formula: C54H85NO14. Mole Weight: 972.25. Catalog: APB02224. | |
| Everolimus Impurity 012-99 | Everolimus Impurity 012-99. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-(2R,3S,6R,E)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-2,6,8-trimethyl-5,9-dioxonon-7-en-3-yl 1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2. CAS No. 1708118-13-1. Molecular Formula: C53H83NO14. Mole Weight: 958.22. Catalog: APB1708118131. | |
| Everolimus Impurity 013-99 | Everolimus Impurity 013-99. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic acid. CAS No. 147438-30-0. Molecular Formula: C32H49NO9. Mole Weight: 591.73. Catalog: APB147438300. | |
| Everolimus Impurity 11 | Everolimus Impurity 11. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((tert-butyldimethylsilyl)oxy)ethyl trifluoromethanesulfonate. Molecular Formula: C9H19F3O4SSi. Mole Weight: 308.39. Catalog: APB05419. | |
| EverolimusImpurity12 | EverolimusImpurity12. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Everolimus Impurity 12. Molecular Formula: C55H87NO15. Mole Weight: 1002.28. Catalog: APB05418. | |
| Everolimus Impurity 13 | Everolimus Impurity 13. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Everolimus Impurity 13. Molecular Formula: C53H83NO14. Mole Weight: 958.22. Catalog: APB05417. | |
| Everolimus Impurity 14 | Everolimus Impurity 14. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Everolimus Impurity 14. Molecular Formula: C53H83NO14. Mole Weight: 958.22. Catalog: APB05416. | |
| Everolimus Impurity 16 | Everolimus Impurity 16. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C53H83NO14. Mole Weight: 958.22. Catalog: APB02225. | |
| Everolimus Impurity 211-97 | Everolimus Impurity 211-97. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Everolimus Impurity 211-97. Molecular Formula: C52H81NO14. Mole Weight: 944.2. Catalog: APB05422. | |
| Everolimus Impurity 23 (Everolimus-13C2-D4) | Everolimus Impurity 23 (Everolimus-13C2-D4). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1661009-29-5. Molecular Formula: C5113C2H79D4NO14. Mole Weight: 964.25. Catalog: APB1661009295. | |
| Everolimus Impurity 24 (Everolimus-D4) | Everolimus Impurity 24 (Everolimus-D4). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1338452-54-2. Molecular Formula: C53H79D4NO14. Mole Weight: 962.26. Catalog: APB1338452542. | |
| Everolimus Impurity 25 | Everolimus Impurity 25. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C53H83NO14. Mole Weight: 958.24. Catalog: APB07749. | |
| Everolimus Impurity 26 | Everolimus Impurity 26. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C32H49NO9. Mole Weight: 591.74. Catalog: APB07750. | |
| Everolimus Impurity 27 | Everolimus Impurity 27. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C54H85NO14. Mole Weight: 972.27. Catalog: APB07751. | |
| Everolimus Impurity 28 | Everolimus Impurity 28. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C54H85NO14. Mole Weight: 972.27. Catalog: APB07752. | |
| Everolimus Impurity 501-95 | Everolimus Impurity 501-95. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Everolimus Impurity 501-95. Molecular Formula: C53H83NO14. Mole Weight: 958.22. Catalog: APB05421. | |
| Everolimus Impurity 6 | Everolimus Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1704711-12-5. Molecular Formula: C54H85NO14. Mole Weight: 972.27. Catalog: APB1704711125. | |
| Everolimus Impurity 7 | Everolimus Impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2402744-97-0. Molecular Formula: C53H83NO14. Mole Weight: 958.24. Catalog: APB2402744970. | |
| Everolimus Impurity 9-O-Hydroxyethyl sirolimus (009-96) | Everolimus Impurity 9-O-Hydroxyethyl sirolimus (009-96). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Everolimus Impurity 9-O-Hydroxyethyl sirolimus(009-96). Molecular Formula: C53H83NO14. Mole Weight: 958.22. Catalog: APB05424. | |
| Everolimus Impurity Everolimus-19-ene open ring (804-95) | Everolimus Impurity Everolimus-19-ene open ring (804-95). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-1-(2-((2R, 3R, 6S)-2-hydroxy-6-((2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 19E, 21R)-14-hydroxy-22-((1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxodocosa-3, 5, 7, 15, 19-pentaen-1-yl)-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic acid. Molecular Formula: C53H83NO14. Mole Weight: 958.22. Catalog: APB05423. | |
| Everolimus Isomer C | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 9,14-Deepoxy-15-deoxo-14-deoxy-9,15-epoxy-15-hydroxy-42-O-(2-hydroxyethyl)-14-oxorapamycin. Grades: 80%. CAS No. 908340-97-6. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
| Everolimus Isomer C | Everolimus Isomer C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 908340-97-6. Molecular Formula: C53H83NO14. Mole Weight: 958.24. Catalog: APB908340976. | |
| Everolimus O-Desmethyl Impurity (Mixture of Diastereomers) | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 27-O-Desmethyl Everolimus. Grades: > 95%. Molecular formula: C52H81NO14. Mole weight: 944.22. | |
| Everolimus O-Ethyl Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 7-O-Desmethyl-7-O-ethyl Everolimus. Grades: > 95%. CAS No. 1704711-12-5. Molecular formula: C54H85NO14. Mole weight: 972.28. | |
| Everolimus Open-Ring Acid Impurity | Everolimus Open-Ring Acid Impurity. Uses: For analytical and research use. Group: Impurity standards. CAS No. 769905-89-7. Molecular Formula: C53H85NO15. Mole Weight: 976.25. Catalog: APB769905897. | |
| Everolimus O-Silyl Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin; 42-O-[2-[[ (1, 1-Dimethylethyl) dimethylsilyl]oxy]ethyl]rapamycin. Grades: > 95%. CAS No. 159351-68-5. Molecular formula: C59H97NO14Si. Mole weight: 1072.52. | |
| Everolimus Related Compound 1 | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: O-Desmethyl Everolimus. Grades: > 95%. CAS No. 745779-75-3. Molecular formula: C52H81NO14. Mole weight: 944.22. | |
| Everolimus Related Compound 3 | Everolimus Ring-Opening Impurity. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: (2S)-1-[[(2R,3R,6S)-6-[(2S,3E,5E,7E,9S,11R)-2,13-Dimethoxy-3,9,11-trimethyl-12-oxo-3,5,7-tridecatrienyl]tetrahydro-2-hydroxy-3-methyl-2H-pyran-2-yl]oxoacetyl]-2-piperidinecarboxylic Acid. Grades: 65%. CAS No. 147438-30-0. Molecular formula: C32H49NO9. Mole weight: 591.75. | |
| Everolimus Related Compound 4 | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: (2S)-1-[2-[(2R, 3R, 6S)-6-[(2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 20S, 21R)-14, 20-Dihydroxy-22-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxo-3, 5, 7, 15-docosatetraen-1-yl]tetrahydro-2-hydroxy-3-methyl-. Grades: > 95%. Molecular formula: C57H91NO16. Mole weight: 1046.36. | |
| Everolimus Related Compound 5 | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: Di-tert-butyl-4-methylene-2,5-cyclohexadienone; 2,6-Di-t-butyl-4-methylene-2,5-cyclohexadienone. Grades: > 95%. CAS No. 2607-52-5. Molecular formula: C15H22O. Mole weight: 218.34. | |
| Everolimus Related Compound 5 | Everolimus Related Compound 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2607-52-5. Molecular Formula: C15H22O. Mole Weight: 218.34. Catalog: APB2607525. | |
| Everolimus Ring-Opening Impurity | An impurity of Everolimus. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Synonyms: Everolimus Retroaldol Degradation Product. Grades: > 95%. CAS No. 1708118-13-1. Molecular formula: C53H83NO14. Mole weight: 958.25. | |
| 28-Ethylhydroxy Everolimus-d4 Impurity | 28-Ethylhydroxy Everolimus-d4 Impurity is a deuterium labelled 28-Ethylhydroxy-everolimus Impurity (E945435). It is also an impurity of Everolimus (E945400), which is a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C55H83D4NO15, Molecular Weight: 1006.3. US Biological Life Sciences. | Worldwide |
| 28-Ethylhydroxy Everolimus Impurity | 28-Ethylhydroxy Everolimus Impurity is an impurity of Everolimus (E945400), which is a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C55H87NO15, Molecular Weight: 1002.28. US Biological Life Sciences. | Worldwide |
| Rapamycin (Everolimus EP Impurity A) | Rapamycin (Everolimus EP Impurity A). Uses: For analytical and research use. Group: Impurity standards. CAS No. 53123-88-9. Molecular Formula: C51H79NO13. Mole Weight: 914.19. Catalog: APB53123889. | |
| (19E/Z)-seco-[4-O-[2-Hydroxy(ethyl)-d4]] Rapamycin Sodium Salt | A labelled metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C53H78D4NNaO14, Molecular Weight: 984.23. US Biological Life Sciences. | Worldwide |
| (19E/Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin | (19E/Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin is a metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000). Group: Biochemicals. Grades: Highly Purified. CAS No. 1062122-63-7. Pack Sizes: 1mg, 5mg. Molecular Formula: C53H83NO14. US Biological Life Sciences. | Worldwide |
| (19E/Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin Sodium Salt | Metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin. Group: Biochemicals. Alternative Names: (2S)-1-[2-oxo-2-[(2R, 3R, 6S)-tetrahydro-2-hydroxy-6-[(2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 19E/Z, 21R)-14-hydroxy-22-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxo-3, 5, 7, 15, 19-docosapentaen-1-yl]-3-methyl-2H-pyran-2-yl]acetyl]-2-piperidinecarboxylic Acid Sodium Salt; seco Everolimus Sodium Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (19Z)-seco-[4-O-(2-hydroxyethyl)] rapamycin sodium salt | (19Z)-seco-[4-O-(2-hydroxyethyl)] rapamycin sodium salt. Group: Biochemicals. Alternative Names: (2S)-1-[2-oxo-2-[(2R, 3R, 6S)-tetrahydro-2-hydroxy-6-[(2S, 3E, 5E, 7E, 9S, 11R, 13R, 14R, 15E, 17R, 19Z, 21R)-14-hydroxy-22-[(1S, 3R, 4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2, 13-dimethoxy-3, 9, 11, 15, 17, 21-hexamethyl-12, 18-dioxo-3, 5, 7, 15, 19-docosapentaen-1-yl]-3-methyl-2H-pyran-2-yl]acetyl]-2-piperidinecarboxylic acid sodium salt; seco everolimus sodium salt. Grades: Highly Purified. CAS No. 220127-31-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C53H82NNaO14. US Biological Life Sciences. | Worldwide |
| 28-Ethyl-d4-hydroxy Rapamycin | 28-Ethyl-d4-hydroxy Rapamycin is the labeled analogue of 28-Ethylhydroxy Rapamycin (E678640), an impurity of Everolimus (E945400),a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C53H79D4NO14, Molecular Weight: 962.25. US Biological Life Sciences. | Worldwide |
| 2- ( (tert-Butyldimethylsilyl) oxy) ethyl 2,2,2-trichloroacetimidate | 2- ( (tert-Butyldimethylsilyl) oxy) ethyl 2,2,2-trichloroacetimidate is an intermediate in the synthesis of 28-Ethylhydroxy Rapamycin (E678640), which is an impurity of Everolimus (E945400),a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg, 500mg. Molecular Formula: C10H20Cl3NO2Si. US Biological Life Sciences. | Worldwide |
| 42-O- [2- [ [Hydroxy [2- (trimethylammonio) ethoxy] phosphinyl] oxy] ethyl] Rapamycin Inner Salt | A phosphocholine ester metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin. Group: Biochemicals. Alternative Names: ATG 181. Grades: Highly Purified. CAS No. 1062645-51-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 42-O-tert-Butyldi methyl silyloxyethyl-d4 Rapamycin | Intermediate to make Everolimus-d4. Group: Biochemicals. Alternative Names: 42-O- [2- [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] ethyl-d4] rapamycin; Everolimus-d4 tert-Butyldimethylsilyl Ether. Grades: Highly Purified. CAS No. 1356839-88-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Rapamycin | Rapamycin is an mTOR inhibitor immunosuppressant and kinase inhibitor with both antifungal and antineoplastic properties. It selectively inhibits the transcriptional activation of cytokines. Uses: Antifungal and antineoplastic agent. Synonyms: Sirolimus; (-)-Rapamycin; AY 22989; AY-22989; I-2190A; NSC 226080; RAPA; RAP; RPM; SLM; WY-090217; Everolimus EP Impurity A. Grades: >98%. CAS No. 53123-88-9. Molecular formula: C51H79NO13. Mole weight: 914.19. | |
| SAR-405 | SAR-405 is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM, Kd=1.5 nM) without disrupting other PI3K isoforms and mTOR (IC50 > 10,000 nM). Concomitant inhibition of Vps34 and mTOR, with SAR405 and mTOR inhibitor everolimus, results in synergistic antiproliferative activity in renal tumor cell lines. Synonyms: SAR 405; SAR405; 4H-Pyrimido[1,?2-a]?pyrimidin-4-one, 9-[(5-chloro-3-pyridinyl)?methyl]?-6,?7,?8,?9-tetrahydro-2-[(3R)?-3-methyl-4-morpholinyl]?-8-(trifluoromethyl)?-, (8S)?-; (8S)-9-[(5-Chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one. CAS No. 1523406-39-4. Molecular formula: C19H21ClF3N5O2. Mole weight: 443.85. | |
| SAR-405 | SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells. Group: Inhibitors. Alternative Names: SAR-405; SAR 405; SAR405. CAS No. 1523406-39-4. Molecular formula: C19H21ClF3N5O2. Mole weight: 443.86. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-9-((5-chloropyridin-3-yl)methyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one. Canonical SMILES: O=C1C=C (N2[C@H] (C)COCC2)N=C3N (CC4=CC (Cl)=CN=C4)[C@H] (C (F) (F)F)CCN31. Catalog: ACM1523406394. |  |
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