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| Product | Description | |
|---|---|---|
| Exatecan | Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 10H,13H-BENZO[DE]PYRANO[3,4:6,7]INDOLIZINO[1,2-B]QUINOLINE-10,13-DIONE, 1-AMINO-9-ETHYL-5-FLUORO-1,2,3,9,12,15-HEXAHYDRO-9-HYDROXY-4-METHYL-, (1S,9S)-, MONOMETHANESULFONATE (SALT);exatecan alideximer;(1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3,4:6,7)indolizino(1,2-b)quinoline-10,13-dione;Exatecan;DX 8951. Product Category: Inhibitors. CAS No. 171335-80-1. Molecular formula: C24H22FN3O4. Mole weight: 435.45. Purity: 0.994. Product ID: ACM171335801. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Exatecan | Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC 50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DX-8951. CAS No. 171335-80-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13631. |  |
| Exatecan | Exatecan is an inhibitor of DNA topoisomerase I, with an IC50 of 2.2 μM (0.975 μg/mL). It can be used to study cancer. Uses: Topoisomerase i inhibitors. Synonyms: DX-8951; (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione; 10H,13H-Benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S-trans)-; NSC-829066. Grade: ≥95%. CAS No. 171335-80-1. Molecular formula: C24H22FN3O4. Mole weight: 435.45. |  |
| Exatecan-d5 mesylate | Exatecan-d5 (DX8951f-d5) mesylate is deuterium labeled Exatecan mesylate (HY-13631A). Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 ?M (0.975 ?g/mL). Exatecan mesylate can be used in cancer research[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: DX8951f-d5; Deuterated labeled Exatecan mesylate. CAS No. 2819276-88-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13631AS. | |
| Exatecan free base | Exatecan, also known as DX 8951, is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DX 8951; DX 8951; DX 8951; Exatecan free base. Product Category: Others. Appearance: Solid powder. CAS No. 171335-80-1. Molecular formula: C24H22FN3O4. Mole weight: 435.46. Purity: >98%. IUPACName: (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione. Canonical SMILES: O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O. Product ID: ACM171335801-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| Exatecan mesilate hydrate | Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. Synonyms: Exatecan methanesulfonate dihydrate; DX 8951 mesilate hydrate. CAS No. 197720-53-9. Molecular formula: C25H30FN3O9S. Mole weight: 567.58. | |
| Exatecan mesylate | Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor, with an IC 50 of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DX8951f. CAS No. 169869-90-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-13631A. | |
| Exatecan Mesylate | Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting the religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogs. Synonyms: DX 8951 mesylate; (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione mesylate; 10H,13H-Benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S-trans)-, mesylate (1:1); NSC-829066 mesylate. Grade: >98%. CAS No. 169869-90-3. Molecular formula: C25H26FN3O7S. Mole weight: 531.56. | |
| Exatecan (mesylate) (GMP) | Exatecan mesylate (DX8951f ) GMP is a GMP-class Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 ?M (0.975 ?g/mL), and can be used in cancer research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DX8951f (GMP). CAS No. 169869-90-3. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-13631AG. | |
| Exatecan (Standard) | Exatecan (Standard) is the analytical standard of Exatecan. This product is intended for research and analytical applications. Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 ?M (0.975 ?g/mL), and can be used in cancer research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DX-8951 (Standard). CAS No. 171335-80-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13631R. | |
| (1R,9R)-Exatecan | (1R,9R)-Exatecan is an isomer of Exatecan, which is a DNA topoisomerase I inhibitor used to study cancer. Synonyms: (1R,9R)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione. CAS No. 2489613-15-0. Molecular formula: C24H22FN3O4. Mole weight: 435.45. | |
| (1R,9R)-Exatecan mesylate | (1R,9R)-Exatecan mesylate((1R,9R)-DX8951f) is an isomer of Exatecan mesylate (HY-13631A). Exatecan mesylate (DX8951f) is an inhibitor of DNA topoisomerase I with an IC50 of 2.2 ?M (0.975 ?g/mL) and can be used in cancer research[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (1R,9R)-DX8951f. CAS No. 2938875-39-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13631J. | |
| (1R,9S)-Exatecan | (1R,9S)-Exatecan is an isomer of Exatecan, which is a DNA topoisomerase I inhibitor used to study cancer. Synonyms: Exatecan (1R,9S); Exatecan (1R,9S-isomer); (1R,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione; 10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1R,9S)-; Exatecan Impurity 4; (1R,9S)-DX8951f. Grade: ≥95%. CAS No. 2231666-57-0. Molecular formula: C24H22FN3O4. Mole weight: 435.45. | |
| (1R,9S)-Exatecan mesylate | (1R,9S)-Exatecan mesylate is an isomer of Exatecan mesylate, which is a DNA topoisomerase I inhibitor used to study cancer. Synonyms: Exatecan (1R,9S-isomer); (1R,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione methanesulfonate; 10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1R,9S)-, methanesulfonate (1:1); Exatecan (1R,9S) methanesulfonate; (1R,9S)-DX8951f mesylate. Grade: ≥95%. CAS No. 2231666-58-1. Molecular formula: C25H26FN3O7S. Mole weight: 531.56. | |
| (1S,9R)-Exatecan | (1S,9R)-Exatecan is an isomer of Exatecan, which is a DNA topoisomerase I inhibitor used to study cancer. Synonyms: Exatecan (1S,9R); (1S,9R)-DX8951f; (1S,9R)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione; Exatecan (1S,9R-isomer); 10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S,9R)-. Grade: ≥95%. CAS No. 2489613-17-2. Molecular formula: C24H22FN3O4. Mole weight: 435.45. | |
| (1S,9R)-Exatecan mesylate | (1S,9R)-Exatecan mesylate ((1S,9R)-DX8951f) is an isomer of Exatecan mesylate (HY-13631A). Exatecan mesylate (DX8951f) is an inhibitor of DNA topoisomerase I with an IC50 of 2.2 ?M (0.975 ?g/mL) and can be used in cancer research[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (1S,9R)-DX8951f. CAS No. 2938875-54-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13631I. | |
| (1S,9R)-Exatecan mesylate | (1S,9R)-Exatecan mesylate is an isomer of Exatecan mesylate, which is a DNA topoisomerase I inhibitor used to study cancer. Synonyms: (1S,9R)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione methanesulfonate; (1S,9R)-DX8951f mesylate; Exatecan (1S,9R-isomer) mesylate; 10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S,9R)-, methanesulfonate (1:1); Exatecan (1S,9R) methanesulfonate. Grade: ≥95%. CAS No. 2938875-54-6. Molecular formula: C24H22FN3O4.CH4O3S. Mole weight: 531.56. | |
| (4-NH2)-Exatecan | (4-NH2)-Exatecan is a derivative of Exatecan. (4-NH2)-Exatecan is a topoisomerase inhibitor and can be used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: (S)-4-Amino-9-ethyl-9-hydroxy-2,3,12,15-tetrahydrobenzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione. CAS No. 2495742-21-5. Molecular formula: C23H21N3O4. Mole weight: 403.43. | |
| Cyclopropaneacetamide-Exatecan | Cyclopropaneacetamide-Exatecan is an Exatecan (HY-13631) analogue and an ADC Cytotoxin. Cyclopropaneacetamide-Exatecan can be used to synthesize ADC molecules for cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2414254-36-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156617. | |
| DBCO-PEG3-VC-Exatecan | DBCO-PEG3-VC-Exatecan (compound 25) is a Drug-Linker Conjugate for ADC. DBCO-PEG3-VC-Exatecan contains the ADC linker (DBCO-PEG3-VC) and a DNA topoisomerase I inhibitor Exatecan (HY-13631)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2754384-70-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-164792. | |
| Gly-Gly-Phe-Gly-NH-O-CO-Exatecan | Gly-Gly-Phe-Gly-NH-O-CO-Exatecan is an ADC cytotoxin. Uses: Scientific research. Group: Signaling pathways. CAS No. 1599440-12-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13631M. | |
| Gly-Gly-Phe-Gly-NH-O-CO-Exatecan hydrochloride | Gly-Gly-Phe-Gly-NH-O-CO-Exatecan, as a drug-linker conjugate composed of linker Gly-Gly-Phe-Gly-NH-O-CO and Exatecan, can be used to prepare antibody conjugate drugs. Exatecan is a DNA topoisomerase I inhibitor that can be used in cancer research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3053688-78-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13631F. | |
| Mal-Gly-PAB-Exatecan-D-glucuronic acid | Mal-Gly-PAB-Exatecan-D-glucuronic acid can be used for Antibody-Drug Conjugates (ADCs) synthesis. Mal-Gly-PAB-Exatecan-D-glucuronic acid can be used for research of tumor research and diagnosis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2763252-25-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153179. | |
| Mal-PEG8-Val-Ala-PAB-Exatecan | Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b) is an antibody-drug conjugate linker (ADC linker) that binds to Nectin-4 polypeptides conjugated to chemotherapeutic agents. Mal-PEG8-Val-Ala-PAB-Exatecan can be used for cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2679821-39-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147271. | |
| Mal-Val-Ala-PAB-N(SO2Me)-Exatecan | Mal-Val-Ala-PAB-N(SO2Me)-Exatecan (Compound LE14) is a conjugate of an ADC toxin Exatecan (HY-13631) and a linker Mal-Val-Ala-PAB-N(SO2Me). Mal-Val-Ala-PAB-N(SO2Me)-Exatecan can be used for synthesis of ADC FZ-AD005. FZ-AD005 is a delta-like ligand 3 (DLL3, KD=58.3 pM) targeting ADC, that exhibits antitumor efficacy against SCLC cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2575682-08-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-159072. | |
| MC-GGFG-Exatecan | MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MC-GGFG-DX8951. CAS No. 1600418-29-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114233. | |
| Mc-PEG4-Val-Ala-PAB-Exatecan | Mc-PEG4-Val-Ala-PAB-Exatecan is a Drug-linker conjugate for ADC. Mc-PEG4-Val-Ala-PAB-Exatecan contains the ADC linker (Mc-PEG4-Val-Ala-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631)[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg. Product ID: HY-171580. | |
| MC-Val-Cit-PAB-Exatecan | MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) is a agent-linker conjugate for ADC. MC-Val-Cit-PAB-Exatecan is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MC-Val-Cit-PAB-DX8951. CAS No. 2504068-28-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145929. | |
| MC-VA-PAB-Exatecan | MC-VA-PAB-Exatecan is a agent-linker conjugate for ADC. MC-VA-PAB-Exatecan contains the ADC linker (peptide MC-VA-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631). MC-VA-PAB-Exatecan synthesized ADC shows good antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2680543-57-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-147270. | |
| Benzyl 2-cyclopropyl-2-hydroxyacetate | Benzyl 2-cyclopropyl-2-hydroxyacetate is an intermediate in the synthesis of ADC linker.The linker composed of Benzyl 2-cyclopropyl-2-hydroxyacetate can be coupled to Exatecan (HY-13631) and combined with antibodies (such as antibody hu2F7) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 182747-31-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-46572. | |
| Deruxtecan | Deruxtecan analog is a drug-linker conjugate for antibody-drug conjugate (ADC). Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan (DS-8201a), which is a HER2-targeting antibody-drug conjugate. DS-8201a significantly suppressed tumor growth in an immunocompetent mouse model with human HER2-expressing CT26.WT (CT26.WThHER2) cells. DS-8201a is currently in clinical trials. Synonyms: Deruxtecan Analog; Deruxtecan, Trastuzumab deruxtecan; DS-8201a; DS8201a; DS 8201a; Exatecan derivative; DX-8951 derivative; DX 8951; DX8951; N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]glycylglycyl-L-phenylalanyl-N-[(2-{[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino}-2-oxoethoxy)methyl]glycinamide. Grade: ≥95%. CAS No. 1599440-13-7. Molecular formula: C52H56FN9O13. Mole weight: 1034.05. | |
| Deruxtecan | Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan (DS-8201a), which is a HER2-targeting antibody-drug conjugate. DS-8201a significantly suppressed tumor growth in an immunocompetent mouse model with human HER2-expressing CT26.WT (CT26.WThHER2) cells. DS-8201a is currently in clinical trials. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Deruxtecan, Trastuzumab deruxtecan; DS-8201a; DS8201a; DS 8201a; exatecan derivative; DX-8951 derivative; DX 8951; DX8951. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1599440-13-7. Molecular formula: C52H56FN9O13. Mole weight: 1034.07. Purity: >98%. IUPACName: Glycinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12Hbenzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]-. Canonical SMILES: CC[C@@]1(O)C(OCC2=C1C=C3N(C2=O)CC(C3=NC4=CC(F)=C5C)=C6C4=C5CC[C@@H]6NC(COCNC(CNC([C@@H](NC(CNC(CNC(CCCCCN7C(C=CC7=O)=O)=O)=O)=O)CC8=CC=CC=C8)=O)=O)=O)=O. Product ID: ACM1599440137. Alfa Chemistry ISO 9001:2015 Certified. | |
| Dxd | Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC 50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Exatecan derivative for ADC. CAS No. 1599440-33-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13631D. | |
| DXD | DXD, an Exatecan derivative for ADC, is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 μM. It can be used as a payload for antibody-conjugated drug ADCs targeting HER2. Synonyms: N-((1S,9S)-9-Ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinolin-1-yl)-2-hydroxyacetamide. Grade: ≥95%. CAS No. 1599440-33-1. Molecular formula: C26H24FN3O6. Mole weight: 493.48. | |
| Dxd-d5 | Dxd-d5 is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 ?M, used as a conjugated drug of HER2-targeting ADC (DS-8201a) [1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Exatecan-d5 derivative for ADC. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-13631DS. | |
| PB038 | PB038 is a Drug-liker containing a PEG unit and a cleavable linker attached to Exatecan[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2851058-71-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-153180. | |
| (R)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione | (R)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione is an intermediate of Exatecan, which is a DNA topoisomerase I inhibitor used to study cancer. Synonyms: (R)-Exatecan Intermediate 1; (4R)-4-ethyl-4-hydroxy-1H,3H,4H,6H,7H,8H,10H-pyrano[3,4-f]indolizine-3,6,10-trione; (4R)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione. Grade: ≥95%. CAS No. 110351-91-2. Molecular formula: C13H13NO5. Mole weight: 263.25. | |
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