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| Product | Description | |
|---|---|---|
| Faldaprevir | Faldaprevir, also called as BI 201335, is a potent, once-daily (QD), hepatitis C virus (HCV) NS3/4A protease inhibitor with the potential to treat HCV infection. Faldaprevir (BI 201335) is undergoing testing in a Phase II clinical study in Hepatitis C released by Trek Therapeutics. Synonyms: Faldaprevir; BI-201335; BI 201335; BI201335; (1S,2R)-1-[[(2S,4R)-4-[8-bromo-7-methoxy-2-[2-(2-methylpropanoylamino)-1,3-thiazol-4-yl]quinolin-4-yl]oxy-1-[(2S)-2-(cyclopentyloxycarbonylamino)-3,3-dimethylbutanoyl]pyrrolidine-2-carbonyl]amino]-2-ethenylcyclopropane-1-carboxylic acid; BI 201335; BI-201335; BI201335; faldaprevir; N-((cyclopentyloxy)carbonyl)-3-methylvalyl-4-((8-bromo-7-methoxy-2-(2-((2-methylpropanoyl)amino)-1,3-thiazol-4-yl)quinolin-4-yl)oxy)-N-(1-carboxy-2-ethenylcyclopropyl)prolinamide. Grades: ≥98% (HPLC). CAS No. 801283-95-4. Molecular formula: C40H49BrN6O9S. Mole weight: 869.84. |  |
| Faldaprevir | Faldaprevir, also known as BI-201335, is a potent NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Faldaprevir; BI-201335; BI 201335; BI201335. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 801283-95-4. Molecular formula: C40H49BrN6O9S. Mole weight: 869.83. Purity: >98%. IUPACName: (1R,2S)-1-((2S,4R)-4-((8-bromo-2-(2-isobutyramidothiazol-4-yl)-7-methoxyquinolin-4-yl)oxy)-1-((S)-2-(((cyclopentyloxy)carbonyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-2-vinylcyclopropane-1-carboxylic acid. Canonical SMILES: O=C([C@]1(NC([C@H]2N(C([C@@H](NC(OC3CCCC3)=O)C(C)(C)C)=O)C[C@H](OC4=CC(C5=CSC(NC(C(C)C)=O)=N5)=NC6=C(Br)C(OC)=CC=C46)C2)=O)[C@H](C=C)C1)O. Product ID: ACM801283954. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Faldaprevir | Faldaprevir (BI 201335) is a potent, orally active and selective noncovalent inhibitor of NS3/4A protease of HCV (hepatitis C virus) genotypes 1a and 1b, with K i values of 2.6 and 2.0 nM, respectively. Faldaprevir inhibits HCV RNA replication, with EC 50 values of 6.5 and 3.1 nM, respectively. Faldaprevir has potent antiviral activity against chronic HCV infection [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BI 201335. CAS No. 801283-95-4. Pack Sizes: 1 mg. Product ID: HY-15256. |  |
| Deleobuvir | Deleobuvir, also known as BI207127, a non-nucleoside hepatitis C virus NS5B polymerase inhibitor for the treatment of hepatitis C. Deleobuvir was tested in combination regimens with pegylated interferon and ribavirin, and in interferon-free regimens with other direct-acting antiviral agents including faldaprevir. Deleobuvir showed that a triple combination of deleobuvir, faldaprevir, and ribavirin performed well in HCV genotype 1b patients. Efficacy fell below 50%, however, for dual regimens without ribavirin and for genotype 1a patients. In December 2013, deleobuvir was discontinued since recent findings from phase III trials did not suggest sufficient efficacy. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BI207127; BI-207127; BI 207127; Deleobuvir; BI-207127NA; BI-207127Na. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 863884-77-9. Molecular formula: C34H33BrN6O3. Mole weight: 653.58. Purity: >98%. IUPACName: (E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid. Canonical SMILES: O=C(O)/C=C/C1=CC=C2N=C(C3(NC(C4=CC5=C(C=C4)C(C6CCCC6)=C(C7=NC=C(Br)C=N7)N5C)=O)CCC3)N(C)C2=C1. Product ID: ACM863884779. Alfa Chemistry ISO 9001:2015 Certified. | |
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