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Fibrinopeptide A, human, located at the NH2-termini of the Aα chain, is a short peptide with 16 residues cleaved from fibrinogen by thrombin. Synonyms: Human fibrinopeptide A; H-Ala-Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg-OH; L-alanyl-L-alpha-aspartyl-L-seryl-glycyl-L-alpha-glutamyl-glycyl-L-alpha-aspartyl-L-phenylalanyl-L-leucyl-L-alanyl-L-alpha-glutamyl-glycyl-glycyl-glycyl-L-valyl-L-arginine. Grades: ≥95%. CAS No. 25422-31-5. Molecular formula: C63H97N19O26. Mole weight: 1536.56.
[Glu1]-Fibrinopeptide B
[Glu1]-Fibrinopeptide B is derived from fibrinopeptide B amino acid residues 1-14. Human fibrinopeptide B (hFpB), a thrombin-derived proteolytic cleavage product of the fibrinogen B beta-chain, to stimulate neutrophils (PMN), monocytes, and fibroblasts. Uses: Scientific research. Group: Peptides. CAS No. 103213-49-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0308.
[Glu1]-Fibrinopeptide B, generated from fibrinopeptide B amino acid residues 1-14, is used as a mass spec (MS) standard in proteomic research. Synonyms: [Glu1]-Fibrinopeptide B; H-Glu-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg-OH; L-alpha-glutamyl-glycyl-L-valyl-L-asparagyl-L-alpha-aspartyl-L-asparagyl-L-alpha-glutamyl-L-alpha-glutamyl-glycyl-L-phenylalanyl-L-phenylalanyl-L-seryl-L-alanyl-L-arginine. Grades: ≥95%. CAS No. 103213-49-6. Molecular formula: C66H95N19O26. Mole weight: 1570.57.
[Tyr15]-fibrinopeptide b. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FIBRINOPEPTIDE B, L-TYR;FIBRINOPEPTIDE B-TYR;GLP-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-PHE-SER-ALA-ARG-TYR;(TYR15)-FIBRINOPEPTIDE B;[TYR15] FIBRINOPEPTIDE B, HUMAN;PGLU-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-PHE-SER-ALA-ARG-TYR;PYROGLU-GLY-VAL-ASN-ASP-ASN-GLU. Product Category: Heterocyclic Organic Compound. CAS No. 125455-56-3. Molecular formula: C75H102N20O27. Mole weight: 1715.73. Purity: 0.96. IUPACName: Fibrinopeptide B-Tyr. Canonical SMILES: CC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(CC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)O)NC(=O)CNC(=O)C4CCC(=O)N4. Product ID: ACM125455563. Alfa Chemistry ISO 9001:2015 Certified.
H-Gly-His-Arg-Pro-NH2
The fibrin central E region contains two sets of polymeric knobs A and B, which are hidden in fibrinogen but are exposed after thrombin cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB) from the N-terminus of the Aα- and Bβ-chains, respectively. The location of the binding holes and possible models for knob-hole interactions can be known by X-ray crystallographic studies using synthetic peptide analogs of knobs A and B. When fibrinogen fragment D and dual D are crystallized in the presence of two peptide analogs, the knob A peptide mimic H-Gly-Pro-Arg-Pro-NH2 (GPRP-amide) interacts with residues γ364Asp, γ330Asp, γ329Gln, and γ340His found in hole a to form H bonds, the knob B peptide mimic H-Gly-His-Arg-Pro-NH2 (GHRP-amide) interacts with Bβ397Glu, Bβ398Asp, and Bβ432Asp in hole b. Synonyms: GHRP amide; H-GHRP-NH2; glycyl-L-histidyl-L-arginyl-L-prolinamide; Glycyl-L-histidyl-N5-(diaminomethylene)-L-ornithyl-L-prolinamide; (S)-1-((S)-2-((S)-2-(2-aminoacetamido)-3-(1H-imidazol-4-yl)propanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamide. Grades: ≥95%. CAS No. 209623-54-1. Molecular formula: C19H32N10O4. Mole weight: 464.53.
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