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| Product | Description | |
|---|---|---|
| Fibronectin | Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans [1]. Uses: Scientific research. Group: Natural products. CAS No. 86088-83-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3160. |  |
| Fibronectin Adhesion-promoting Peptide | It is a heparin-binding amino acid sequence found in the heparin-binding domain at the carboxy-terminal of fibronectin. Synonyms: Heparin Binding Peptide; H-Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile-OH; L-tryptophyl-L-glutaminyl-L-prolyl-L-prolyl-L-arginyl-L-alanyl-L-arginyl-L-isoleucine. Grades: ≥97% by HPLC. CAS No. 125720-21-0. Molecular formula: C47H74N16O10. Mole weight: 1023.19. |  |
| Fibronectin Adhesion-promoting Peptide acetate | It is a heparin-binding amino acid sequence found in the heparin-binding domain at the carboxy-terminal of fibronectin. Synonyms: Heparin Binding Peptide acetate. Molecular formula: C49H78N16O12. Mole weight: 1083.25. | |
| Fibronectin CS1 Peptide | Fibronectin CS1 Peptide lacks a domain containing Arg-Gly-Asp, and it can effectively inhibit tumor metastasis in both spontaneous and experimental metastatic models. Synonyms: Fibronectin CS-1 Fragment (1978-1985); H-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr-OH; L-alpha-glutamyl-L-isoleucyl-L-leucyl-L-alpha-aspartyl-L-valyl-L-prolyl-L-seryl-L-threonine; (3S,6S,9S,12S,15S)-15-amino-12-sec-butyl-3-((S)-2-((S)-1-((1S,2R)-1-carboxy-2-hydroxypropylamino)-3-hydroxy-1-oxopropan-2-ylcarbamoyl)pyrrolidine-1-carbonyl)-6-(carboxymethyl)-9-isobutyl-2-methyl-5,8,11,14-tetraoxo-4,7,10,13-tetraazaoctadecan-18-oic acid. Grades: ≥95%. CAS No. 136466-51-8. Molecular formula: C38H64N8O15. Mole weight: 872.96. | |
| Fibronectin CS1 Peptide acetate | Fibronectin CS1 Peptide lacks a domain containing Arg-Gly-Asp, and it can effectively inhibit tumor metastasis in both spontaneous and experimental metastatic models. Synonyms: H-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr-OH.CH3CO2H; L-alpha-glutamyl-L-isoleucyl-L-leucyl-L-alpha-aspartyl-L-valyl-L-prolyl-L-seryl-L-threonine acetic acid. Grades: ≥95%. CAS No. 2760881-56-7. Molecular formula: C40H68N8O17. Mole weight: 933.01. | |
| YRGDS Fibronectin Fragment | YRGDS Fibronectin Fragment is an adhesion peptide, a fibronectin fragment which displays strong binding affinity to thrombin-stimulated platelets. Synonyms: H-Tyr-Arg-Gly-Asp-Ser-OH; YRGDS. Grades: 95%. CAS No. 134282-68-1. Molecular formula: C24H36N8O10. Mole weight: 596.59. | |
| 8-pCPT-2-O-Me-cAMP-AM (007-AM) (8-(4-Chlorophenylthio)-2'-O-methylad enosine-3',5'-cyclic monophosphate acetoxymethyl ester) | Selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage. Group: Biochemicals. Grades: Highly Purified. CAS No. 1152197-23-3. Pack Sizes: 100ug. US Biological Life Sciences. |  Worldwide |
| Arg-Gly-Asp-Cys acetate | Arg-Gly-Asp-Cys, a fibronectin binding motif to cell adhesion molecules, inhibits platelet aggregation and fibrinogen binding. Synonyms: L-arginyl-glycyl-L-alpha-aspartyl-L-cysteine; RGDC peptide. Molecular formula: C17H31N7O9S. Mole weight: 509.54. | |
| Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Uses: Platelet aggregation inhibitors. Synonyms: Arg Gly Asp Ser; RGDS peptide; Fibronectin Inhibitor. Grades: >98%. CAS No. 91037-65-9. Molecular formula: C15H27N7O8. Mole weight: 433.42. | |
| Arg-Gly-Asp-Ser acetate | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Molecular formula: C17H31N7O10. Mole weight: 493.47. | |
| ATN-161 trifluoroacetate salt | ATN-161 trifluoroacetate salt is a beta integrin antagonist with antitumor activity. It is a five -amino-acid peptide derived from the synergy region of fibronectin. It inhibited VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. Synonyms: ATN-161 TFA salt; ATN 161 TFA salt; ATN161 TFA salt. Grades: >98%. CAS No. 904763-27-5. Molecular formula: C25H36F3N9O10S. Mole weight: 711.67. | |
| CALP1 | CALP1 is a cell-permeable calmodulin (CaM) agonist binding to the EF-hand/Ca2+-binding site and activating phosphodiesterase. CALP1 also binds to cytoplasmic sites on other Ca2+ channels such as NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). It was shown to suppress VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo. Synonyms: Calcium-like peptide 1. CAS No. 145224-99-3. Molecular formula: C40H75N9O10. Mole weight: 842.09. | |
| Cilengitide TFA salt | Cilengitide TFA salt, is a cyclic Arg-Gly-Asp acid pentapeptide that induces anoikis in angiogenic blood vessels and brain tumor, selectively and potently blocks the ligation of theαvβ3 andαvβ5 integrins to provisional matrix proteins such as vitronectin, fibronectin, fibrinogen, von Willebrand factor, osteopontin, and others. Synonyms: Cilengitide trifluoroacetate. Grades: >98%. CAS No. 199807-35-7. Molecular formula: C29H41F3N8O9. Mole weight: 702.68. | |
| Collagenase, Type II | Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-E70005B. | |
| Collagenase, Type V | Collagenase, Type V is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type V breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-E70005E. | |
| Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro) | Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro), a cyclic RGD peptide, stimulates the contraction of rat afferent arterioles and is used for targeted delivery of cisplatin. It inhibits the adhesion of mouse B16 melanoma cells to fibronectin coated wells. Synonyms: cyclo[L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-glycyl]; c(GRGDSP). Grades: ≥90%. CAS No. 135432-37-0. Molecular formula: C22H35N9O9. Mole weight: 569.58. | |
| Cytostatin (5,6-Dihydro-6-(6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrienyl)-5-methyl-2H-pyran-2-one) | Potent and selective protein phosphatase 2A (PP2A) inhibitor. Cell adhesion inhibitor. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to fibronectin. Antitumor agent. Antimetastatic. Apoptosis inducer. Group: Biochemicals. Grades: Purified. CAS No. 156856-30-3. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Dispase II | Dispase II is a neutral protease that hydrolyzes the N-terminal peptide bonds of non-polar amino acid residues. It may be used for separating many tissues and cells grown in vitro. The enzyme is very gentle and does not damage cell membranes. It can also be used to prevent clumping in suspension cultures. This protease cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin.[3] Dispase II is specific for the cleavage of Leucine-Phenylalanine bonds. Ca2+, Mg2+, Mn2+, Fe2+, Fe3+ and Al3+ activate the enzyme. EDTA, EGTA, Hg2+ and other heavy metals inhibit the enzyme activity.[6] The enzyme contains 1g-atom of zinc per g-mol of purified enzyme. If this zinc component is removed by chelating agents such as EDTA or EGTA, an inactive apoenzyme is obtained. The enzyme is not inhibited by serum. Group: Biochemicals. Grades: Highly Purified. CAS No. 42613-33-2. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences. | Worldwide |
| EILEVPST | EILEVPST is a recombinant human fibronectinderived low-molecular-weight peptide fragment. EILEVPST can promote cell type-specific α4 integrin-mediated adhesion. EILEVPST can be used for the research of thrombogenesis [1]. Uses: Scientific research. Group: Peptides. CAS No. 239075-62-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P3533. | |
| Fibrinogen Binding Inhibitor Peptide | Fibrinogen Binding Inhibitor Peptide is an effective inhibitor of the binding of fibrinogen, fibronectin and von Willebrand factor to thrombin- or ADP-stimulated platelets. It is also a synthetic dodecapeptide that represents the specific platelet receptor recognition site for the human fibrinogen G-chain (residues 400-411). Synonyms: H-His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val-OH; L-histidyl-L-histidyl-L-leucyl-glycyl-glycyl-L-alanyl-L-lysyl-L-glutaminyl-L-alanyl-glycyl-L-alpha-aspartyl-L-valine; fibrinogen-γ fragment 400-411. Grades: ≥95%. CAS No. 89105-94-2. Molecular formula: C50H80N18O16. Mole weight: 1189.28. | |
| gelatinase A | A secreted endopeptidase in peptidase family M10 (interstitial collagenase family), but possessing an additional fibronectin-like domain. Group: Enzymes. Synonyms: 72-kDa gelatinase; matrix metalloproteinase 2; type IV collagenase (ambiguous); 3/4 collagenase (obsolete); matrix metalloproteinase 5 (obsolete); 72 kDa gelatinase type A; collagenase IV (ambiguous); collagenase type IV (ambiguous); MMP 2; type IV collagen metalloproteinase (ambiguous); type IV collagenase/gelatinase (ambiguous). Enzyme Commission Number: EC 3.4.24.24. CAS No. 146480-35-5. Matrix Metalloproteinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4305; gelatinase A; EC 3.4.24.24; 146480-35-5; 72-kDa gelatinase; matrix metalloproteinase 2; type IV collagenase (ambiguous); 3/4 collagenase (obsolete); matrix metalloproteinase 5 (obsolete); 72 kDa gelatinase type A; collagenase IV (ambiguous); collagenase type IV (ambiguous); MMP 2; type IV collagen metalloproteinase (ambiguous); type IV collagenase/gelatinase (ambiguous). Cat No: EXWM-4305. |  |
| Glu-Ile-Leu-Asp-Val | Synonyms: Fibronectin CS-1 Fragment (1978-1982). CAS No. 150525-67-0. Molecular formula: C26H45N5O10. Mole weight: 587.67. | |
| GRGDS | GRGDS is a synthetic integrin antagonist. Synonyms: GRGDS; GRGDS 1/2ACOH 2H2O; GRGDS, FIBRONECTIN ATTACHMENT PEPTIDE; GLY-ARG-GLY-ASP-SER; GLY-ARG-GLY-ASP-SER 1/2ACOH 2H2O; H-GLY-ARG-GLY-ASP-SER-OH; glycyl-arginyl-glycyl-aspartyl-serine; GLY-ARG-GLY-ASP-SER ACETATE. Grades: ≥97% by HPLC. CAS No. 96426-21-0. Molecular formula: C17H30N8O9. Mole weight: 490.5. | |
| GRGDS acetate | GRGDS acetate, a synthetic integrin antagonist, is a cell-binding protein domain derived from the cell-binding region of fibronectin. Synonyms: Gly-Arg-Gly-Asp-SerGRGDS acetate; H-Gly-Arg-Gly-Asp-Ser-OH.CH3CO2H; GRGDS.CH3CO2H; glycyl-L-arginyl-glycyl-L-alpha-aspartyl-L-serine acetate. Grades: ≥95%. Molecular formula: C19H34N8O11. Mole weight: 550.52. | |
| H-Arg-Gly-Asp-Cys-OH | H-Arg-Gly-Asp-Cys-OH, a fibronectin binding motif to cell adhesion molecules, inhibits platelet aggregation and fibrinogen binding. Synonyms: RGDC; H-RGDC-OH; L-arginyl-glycyl-L-alpha-aspartyl-L-cysteine; (6S,12S,15R)-1,6-diamino-12-(carboxymethyl)-1-imino-15-(mercaptomethyl)-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-oic acid. Grades: 95%. CAS No. 109292-46-8. Molecular formula: C15H27N7O7S. Mole weight: 449.48. | |
| H-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro-OH | H-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro-OH, an RGD peptide, inhibits the adhesion of fibronectin to fibroblasts. Synonyms: R-G-D-S-P-A-S-S-K-P; L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-L-alanyl-L-seryl-L-seryl-L-lysyl-L-proline; N5-(Diaminomethylene)-L-ornithylglycyl-L-α-aspartyl-L-seryl-L-prolyl-L-alanyl-L-seryl-L-seryl-L-lysyl-L-proline. Grades: 95%. CAS No. 91575-25-6. Molecular formula: C40H68N14O16. Mole weight: 1001.05. | |
| H-Gly-Arg-Gly-Glu-Ser-OH | H-Gly-Arg-Gly-Glu-Ser-OH is an active peptide fragment of fibronectin, a glycoprotein that interacts with integrins. Synonyms: H-GRGES-OH; glycyl-L-arginyl-glycyl-L-alpha-glutamyl-L-serine; L-Serine, glycyl-L-arginylglycyl-L-α-glutamyl-; Glycyl-N5-(diaminomethylene)-L-ornithylglycyl-L-α-glutamyl-L-serine; (6S,12S,15S)-1-amino-6-(2-aminoacetamido)-12-(2-carboxyethyl)-15-(hydroxymethyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-oic acid; Fibronectin Active Fragment Control. Grades: ≥90%. CAS No. 97461-84-2. Molecular formula: C18H32N8O9. Mole weight: 504.49. | |
| H-Gly-Arg-Gly-Glu-Ser-Pro-OH | H-Gly-Arg-Gly-Glu-Ser-Pro-OH is an inactive fibronectin fragment analog used as a control for tests with GRGDSP. Synonyms: H-GRGESP-OH; glycyl-L-arginyl-glycyl-L-alpha-glutamyl-L-seryl-L-proline; L-Proline, 1-(N-(N-(N-(N2-glycyl-L-arginyl)glycyl)-L-alpha-glutamyl)-L-seryl)-; Glycyl-N5-(diaminomethylene)-L-ornithylglycyl-L-α-glutamyl-L-seryl-L-proline; (S)-1-((6S,12S,15S)-1-amino-6-(2-aminoacetamido)-12-(2-carboxyethyl)-15-(hydroxymethyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-oyl)pyrrolidine-2-carboxylic acid. Grades: ≥95%. CAS No. 99896-88-5. Molecular formula: C23H39N9O10. Mole weight: 601.61. | |
| HMR 1031 | HMR 1031 is a potent and specific integrin α4β1 or very late antigen 4 (VLA-4) receptor antagonist binding to vascular cell adhesion molecule-1 (VCAM-1) and fibronectin. HMR1031 has the potential used as an inhaled drug for the treatment of asthma. Uses: Potential inhaled drug for asthma. Synonyms: HMR-1031; HMR 1031; HMR1031; Rnm7wqo98Y; (3S) -3-[[ (2S) -2-[4, 4-dimethyl-3-[[4-[ (2-methylphenyl) carbamoylamino]phenyl]methyl]-2, 5-dioxoimidazolidin-1-yl]-4-methylpentanoyl]amino]-3-phenylpropanoic acid. Grades: 98%. CAS No. 479203-71-9. Molecular formula: C35H41N5O6. Mole weight: 627.73. | |
| Human Factor XIII | Factor XIII is the zymogenic form of the glutaminyl-peptide g-glutamyl transferase factor XIIIa (fibrinoligase, plasma transglutaminase, fibrin stabilizing factor, E.C. 2.3.2.13). Factor XIII is unique among transamidases in that it is a zymogen in vivo. Factor XIII is found both extracellularly in plasma and intracellularly in platelets, megakaryocytes, monocytes, placenta, uterus, liver and prostrate tissues. Plasma factor XIII is synthesized in the liver and circulates as a tetramer (Mr=320,000), composed of 2 pairs of nonidentical subunits (A2B2). The intra-cellular forms are synthesized in the tissues where they reside as dimers (Mr=146,000) of 2 identical A chains (A2). The A ...nly after the Ca2+ (Kd=10-3M) and fibrin(ogen) (Kd=10-8M) dependent dissociation of the B subunit dimer from the A2' dimer.In the coagulation cascade, factor XIIIa functions to stabilize the fibrin clot by crosslinking the a and g-chains of fibrin. Other proteins known to be substrates for Factor XIIIa which may be hemostatically important include fibronectin, α2-antiplasmin, collagen, factor V, von Willebrand Factor and thrombospondin.Factor XIII is purified from fresh frozen human plasma by a modification of the procedures described by Folke and Lorand involving barium citrate, ammonium sulfate and glycine precipitations, ion exchange chromatography and gel filtration. Factor | |
| IDR 1002 | IDR-1002 is an anti-infective peptide that enhances the ability of human monocytes to migrate toward chemokines on fibronectin. IDR-1002 also induces adhesion and activation of β1-integrin, a mechanism that promotes monocyte recruitment [1]. Uses: Scientific research. Group: Peptides. CAS No. 1224095-25-3. Pack Sizes: 1 mg. Product ID: HY-P5812. | |
| Integrin Binding Peptide | Integrin Binding Peptide is derived by fibronectin. Integrin Binding Peptide can be used for PEG hydrogel preparation [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 278792-07-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2532. | |
| Irigenin | Irigenin is identified as an α-glucosidase inhibitors. Also, it is a lead compound to overcome Fibronectin EDA induced metastatic progression in lung carcinoma cells. Group: Biochemicals. Alternative Names: 3',5,7-Trihydroxy-4',5',6-trimethoxy-isoflavone; 5,7-Dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 548-76-5. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C??H??O?, Molecular Weight: 360.31. US Biological Life Sciences. | Worldwide |
| kallikrein 8 | The enzyme is activated by removal of an N-terminal prepropeptide. The highest amidolytic activity is observed using Boc-Val-Pro-Arg?7-amido-4-methylcoumarin, which is a substrate of α-thrombin. Substrates lacking basic amino acids in the P1 position are not cleaved. The enzyme degrades casein, fibronectin, gelatin, collagen type IV, fibrinogen, and high-molecular-mass kininogen and is associated with diseases such as ovarian cancer and Alzheimer's disease. Belongs in peptidase family S1A. Group: Enzymes. Synonyms: KLK8; PRSS19; human kallikrein 8; hK8; mK8; ovasin; tumor-associated differentially expressed gene 14; TADG-14; NP; neuropsin. Enzyme Commission Number: EC 3.4.21.118. CAS No. 171715-15-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4113; kallikrein 8; EC 3.4.21.118; 171715-15-4; KLK8; PRSS19; human kallikrein 8; hK8; mK8; ovasin; tumor-associated differentially expressed gene 14; TADG-14; NP; neuropsin. Cat No: EXWM-4113. | |
| L-Threonine,l-a-aspartyl-L-a-glutamyl-L-Leucyl-L-prolyl-L-glutaminyl-L-Leucyl-L-valyl-L-threonyl-L-Leucyl-L-prolyl-L-histidyl-L-prolyl-L-asparaginyl-L-Leucyl-l-histidylglycyl-l-prolyl-l-a-glutamyl-l- | L-Threonine,l-a-aspartyl-L-a-glutamyl-L-Leucyl-L-prolyl-L-glutaminyl-L-Leucyl-L-valyl-L-threonyl-L-Leucyl-L-prolyl-L-histidyl-L-prolyl-L-asparaginyl-L-Leucyl-l-histidylglycyl-l-prolyl-l-a-glutamyl-l-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 1-25;FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 1-;CS1 peptide;Fibronectin connecting segment 1;L-Threonine, L-alpha-aspartyl-L-alpha-glutamyl-L-leucyl-L-prolyl-L-glutaminyl-L-leucyl-L-valyl-L-threon. Product Category: Heterocyclic Organic Compound. CAS No. 107978-77-8. Molecular formula: C123H195N31O39. Mole weight: 2732.05. Purity: 0.96. IUPACName: FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 1-25. Product ID: ACM107978778. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Matrix Metalloproteinase-3 from Human, Recombinant | Matrix metalloproteinase-3 (MMP-3) also known as stromelysin-1 and transin (EC 3.4.24.17) cleaves a number of substrates including cartilage proteoglycan, collagen types II, III, IV, V and IX, fibronectin, laminin, and can activate MMP 1. MMP-3 is secreted as 57 and 59 kDa proenzymes and can be activated in vitro by organomercurials (e.g., 4 aminophenylmercuric acetate, APMA) and in vivo by proteases via intermediate forms to a 45 kDa active MMP 3 enzyme. Further autolysis to a 28 kDa form can also occur. MMP-3 is thought to play an important role in pathophysiological degradation processes associated with conditions such as rheumatoid arthritis and cancer cell invas...C 3.4.24.17; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Enzyme Commission Number: EC 3.4.24.17. CAS No. 79955-99-0. Purity: >95% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 57 kDa. Storage: < -70°C; Avoid freeze/thaw. Form: Lyophilized from 100 mM NaCl, 50 mM HEPES, pH 7.3. Species: Human. Stromelysin 1; EC 3.4.24.17; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Cat No: NATE-0861. | |
| MT-4 | MT-4 is a derivative of a tissue transglutaminase ( TG2 ) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel. Uses: Scientific research. Group: Signaling pathways. CAS No. 2327925-35-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128595. | |
| N-Acetyl-de-O-sulfated heparin sodium salt | N-Acetyl-de-O-sulfated heparin sodium salt is an enzyme substrate that inactivates thrombin through an antithrombin (AT) dependent mechanism, thereby preventing fibronectin formation. Synonyms: N-Acetyl-de-O-sulfated heparin (Heparin IV-A) sodium salt. CAS No. 133686-69-8. | |
| Native Bacillus polymyxa Dispase | Dispase is a protease which cleaves fibronectin, collagen IV, and to a lesser extent collagen I. It is found in some bacteria and can be isolated from culture filtrates of Bacillus polymyxa. It can be extracted, purified, and used in research. It can be particularly useful to separate embryonic epithelia and mesenchyme. Dispase II is specific for the cleavage of Leucine-Phenylalanine bonds. Dispase is often used to digest adhering primary cells in culture, since this treatment turned out to be milder than trypsin digestion. Applications: Dispase is a protease which cleaves fibronectin, collagen iv, and to a lesser extent collagen i. it is found in some bacteria and can be iso...d used in research. it can be particularly useful to separate embryonic epithelia and mesenchyme. dispase ii is specific for the cleavage of leucine-phenylalanine bonds. dispase is often used to digest adhering primary cells in culture, since this treatment turned out to be milder than trypsin digestion (sinclair et al., 2013). a recent article also finds that dispase can digest serine-phenylalanine. Group: Enzymes. Synonyms: Dispase; 42613-33-2; Proteinase; Bacillus polymyxa neutral. CAS No. 42613-33-2. Dispase. Activity: ~0.4 unit/mg solid. Storage: 2-8°C. Form: powder. Source: Bacillus polymyxa. Dispase; 42613-33-2; Proteinase; Bacillus polymyxa neutral. Cat No: NATE-0193. | |
| Native Bacillus polymyxa Dispase I | Dispase I is a rapid, effective, gentle and neutral protease that can separate intact epidermis from the dermis. It can also separate intact epithelial sheets in culture from the substratum. The enzyme preserves the viability of the epithelial cells while cleaving the basement membrane zone region. It can also be used to prevent clumping in suspension cultures. This protease cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin. It hydrolyzes N-terminal peptide bonds of non-polar amino acid residues. It preferentially attacks denatured and intercellular proteins with exposed hydrophobic amino acid residues. Ca2+, Mg2+, Mn2+...e i has also been used in a study to investigate a dityrosine-based substrate for a protease assay. dispase i has been used in lung digestion and processing for flow staining, as well as for cd4 cell isolation in mice. the enzyme has also been used to digest excised wounds and a small amount of surrounding skin for the detection of gfp+ (green fluorescence protein) cells. this study to investigated the effect of differentiation and angiogenesis of bone marrow-derived mesenchymal stem cells on wound healing. it has also been used to remove the epidermis during the isolation of dermal fibroblasts from mice. Group: Enzymes. Synonyms: Dispase I; Dispase; 42613-33-2; Protease fro | |
| Native Bacillus polymyxa Dispase II | Dispase II is a neutral protease that hydrolyzes the N-terminal peptide bonds of non-polar amino acid residues. It may be used for separating many tissues and cells grown in vitro. The enzyme is very gentle and does not damage cell membranes. It can also be used to prevent clumping in suspension cultures. This protease cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin. Dispase II is specific for the cleavage of Leucine-Phenylalanine bonds. Ca2+, Mg2+, Mn2+, Fe2+, Fe3+ and Al3+ activate the enzyme. EDTA, EGTA, Hg2+ and other heavy metals inhibit the enzyme activity. The enzyme contains 1g-atom of zinc per g-mol of purif... it has been used in the treatment of rat heart pieces during the isolation of mitochondria from rat heart. it has also been used for the isolation of dental pulp stem cells (dpscs) by enzymatic hydrolysis. these cells have been compared with dpscs isolated by explant method to analyse their stem cell and differentiation properties. Group: Enzymes. Synonyms: Dispase II; Dispase; 42613-33-2; Protease from Bacillus polymyxa. CAS No. 42613-33-2. Dispase. Activity: > 0.5 units/mg solid. Storage: 2-8°C. Form: lyophilized powder containing calcium acetate and milk sugar. Source: Bacillus polymyxa. Dispase II; Dispase; 42613-33-2; Protease from Bacillus polymyxa. Cat No: NATE-0192. | |
| Neutral protease I | Neutral protease I (Dispase I) is a rapid, effective, gentle and neutral protease that can separate intact epidermis from the dermis. Neutral protease I can also separate intact epithelial sheets in culture from the substratum. Neutral protease I preserves the viability of the epithelial cells while cleaving the basement membrane zone region. Neutral protease I can also be used to prevent clumping in suspension cultures. Neutral protease I cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dispase I. CAS No. 42613-33-2. Pack Sizes: 1 mg. Product ID: HY-131577A. | |
| Pegdinetanib | Pegdinetanib is a highly specific, synthetic peptide vascular endothelial growth factor receptor-2 (VEGFR-2) antagonist with potential antiangiogenic activity. Derived from human fibronectin with a proprietary protein engineering process, pegdinetanib may block the activation of VEGFR-2 by all known activating ligands, thereby inhibiting the growth of new tumor blood vessels. Synonyms: Pegdinetanib; BMS-844203; BMS 844203; BMS844203; CT-322; CT 322; CT322; Brand name: Adnectin; Angiocept. CAS No. 906450-24-6. Molecular formula: C27H46N6O13S. Mole weight: 694.75. | |
| Rhein | Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities.IC50 value:Target:In vitro: Rhein (0.1 and 1 mg/mL) evidently suppressed cell proliferation and mitogen-activated protein (MAP) kinase activation in human colon adenocarcinoma cells (Caco-2) but significantly lessened H2O2-induced DNA damage and the elevated MDA and ROS levels induced by H2O2/Fe2+ at the concentrations of 0.1-10 mg/mL.In vivo: Oral administration of rhein (150 mg/kg/d) evidently ameliorated renal interstitial fibrotic lesions and attenuated the expression of α-SMA and deposition of fibronectin (FN) in mice with renal interstitial fibrosis induced by unilateral ureteral obstruction. Rhein also suppressed TGF-β1 and its type I receptor expression in obstructed kidneys. The biochemical parameters results of IgAN model rats showed that rhein-prevented and rhein-treated both improved the biochemical parameters and relieved renal pathological injury. The expressions of renal tissue TLR4, TGF-β1, but not TLR9 were significantly elevated in IgAN model rats (P < 0.05). Rhein-prevented and rhein-treated both inhibited TLR4 and TGF-β1 expressions. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Chrysazin-3-carboxylicacid. Product Cat | |
| stromelysin 1 | An extracellular endopeptidase of vertebrate tissues homologous with interstitial collagenase. Digests proteoglycan, fibronectin, collagen types III, IV, V, IX, and activates procollagenase. In peptidase family M10 (interstitial collagenase family). Group: Enzymes. Synonyms: matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Enzyme Commission Number: EC 3.4.24.17. CAS No. 79955-99-0. Matrix Metalloproteinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4298; stromelysin 1; EC 3.4.24.17; 79955-99-0; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Cat No: EXWM-4298. | |
| stromelysin 2 | In peptidase family M10 (interstitial collagenase family). Digests gelatin types I, III, IV, V, fibronectin and proteoglycan. Group: Enzymes. Synonyms: matrix metalloproteinase 10; transin 2; proteoglycanase 2. Enzyme Commission Number: EC 3.4.24.22. CAS No. 140610-48-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4303; stromelysin 2; EC 3.4.24.22; 140610-48-6; matrix metalloproteinase 10; transin 2; proteoglycanase 2. Cat No: EXWM-4303. | |
| Tautomycetin | Tautomycetin is a selective inhibitor of protein phosphatase (PP)1 (IC50 = 1.6 and 62 nM for PP1 and PP2, respectively) used as an immunosuppressive agent. Tautomycetin induces apoptosis in activated T cells, and inhibits PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Synonyms: (1R, 2S, 3R, 6S, 7S, 10S, 12R, 15E, βR, 3R)-16-Ethyl-3, 7-dihydroxy-1, 2, 6, 10, 12-pentamethyl-5, 14-dioxo-15, 17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester. Grades: ≥95% by HPLC. CAS No. 119757-73-2. Molecular formula: C33H50O10. Mole weight: 606.75. | |
| TG53 | TG53 is a novel inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 946369-04-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H22ClN5O2, Molecular Weight: 411.88. US Biological Life Sciences. | Worldwide |
| UK 370106 | UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC50 = 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14, respectively). UK 370106 inhibits fibronectin cleavage (IC50 = 320 nM), and substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers. Uses: The treatment of chronic dermal ulcers. Synonyms: UK 370106; UK370106; UK-370106; (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid; (3R)-3-[[(2S)-1-[[(1S)-2-methoxy-1-phenylethyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]-6-(3-methyl-4-phenylphenyl)hexanoic acid. Grades: ≥95% by HPLC. CAS No. 230961-21-4. Molecular formula: C35H44N2O5. Mole weight: 572.73. | |
| Volociximab | Volociximab (M200) is a chimeric human/murine IgG4 antibody IIA1 targeting integrin α5β1 ( EC 50 =0.2 nM). Integrin α5β1 is a major fibronectin receptor involved in angiogenesis. Volociximab has antiangiogenic and antitumor activities and inhibits the proliferation of human umbilical vein vascular endothelial cells (HUVECs) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: M200; Eos 200-4. CAS No. 558480-40-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99333. | |
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