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Filipin are a mixture of polyene macrolide antibiotics produced by Streptomyces filipinensis and Str. durhamensis. Four components I-IV are separated. Grades: >95% by HPLC. CAS No. 11078-21-0. Molecular formula: C35H58O11 (for Flipin III). Mole weight: 654.8.
Filipin II
Filipin II is a polyene macrolide antibiotic produced by Streptomyces filipinensis and Str. durhamensis. It has anti-fungal activity and has the effect of inhibiting Mycoplasma Lebsiella. It also has an effect on the diseases caused by Aspergillus penicillium, stalk mold and other crops such as peas and tomatoes. Grades: >95% by HPLC. CAS No. 38620-77-8. Molecular formula: C35H58O10. Mole weight: 638.83.
Filipin Iii
Filipin III is the major component of Filipin, a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure. Group: Inhibitors. Alternative Names: 16,20,22,24-Octacosapentenoic Acid. CAS No. 480-49-9. Molecular formula: C35H58O11. Mole weight: 654.83. Appearance: White or light yellow solid. Purity: 0.98. IUPACName: (3R, 4S, 6S, 8S, 10R, 12R, 14R, 16S, 17E, 19E, 21E, 23E, 25E, 27S, 28R)-4, 6, 8, 10, 12, 14, 16, 27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17, 28-dimethyl-1-oxacyclooctacosa-17, 19, 21, 23, 25-pentaen-2-one. Canonical SMILES: CCCCC[C@H] (C1[C@H] (C[C@H] (C[C@H] (C[C@H] (C[C@H] (C[C@H] (C[C@@H] (/C (=C\\C=C\\C=C\\C=C\\C=C\\[C@@H] ([C@H] (OC1=O)C)O)/C)O)O)O)O)O)O)O)O. Catalog: ACM480499.
Filipin III
Filipin III is a polyene macrolide antibiotic produced by Streptomyces filipinensis and Str. durhamensis. It has anti-fungal activity and has the effect of inhibiting Mycoplasma Lebsiella. It also has an effect on the diseases caused by Aspergillus penicillium, stalk mold and other crops such as peas and tomatoes. Synonyms: 14-Deoxylagosin. Grades: >98%. CAS No. 480-49-9. Molecular formula: C35H58O11. Mole weight: 654.83.
Filipin III
Filipin III is the major component of Filipin, a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis , S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure [1]. Uses: Scientific research. Group: Natural products. CAS No. 480-49-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6718.
Filipin III (Filimirasin, Filmirisin)
Filipin III (Filimirasin, Filmirisin). Group: Biochemicals. Alternative Names: (17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one. Grades: Purified. CAS No. 480-49-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C35 H58 O11 , Molecular Weight: 654.8. US Biological Life Sciences.
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Biphenomycin A
Biphenomycin is an antibiotic produced by Streptomyces griseorubiginosus No. 43798 and Streptomyces filipinensis. Biphenomycin A has activity against gram-positive bacteria. Grades: >98%. CAS No. 100296-21-7. Molecular formula: C23H28N4O8. Mole weight: 488.49.
Cyclothialidine
It is produced by the strain of Streptomyces filipinensis NR 0484. It and its homologues inhibit escherichia coli DNA helicases with IC50 of 0.3 μmol/L, and the reference neomycin was 1.2 μmol/L. Synonyms: Cyclothialidine A; (2S)-2-[[(5S,8R)-5-[[(2S,3R)-1-(2-amino-3-hydroxypropanoyl)-3-hydroxypyrrolidine-2-carbonyl]amino]-13,15-dihydroxy-16-methyl-2,6-dioxo3-oxa-10-thia-7-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-8-carbonyl]amino]propanoic acid; N-[[(4R,7S)-1,3,4,5,6,7,8,10-octahydro-12,14-dihydroxy-7-[[(3R)-3-hydroxy-1-L-seryl-L-prolyl]amino]-11-methyl-6,10-dioxo-9,2,5-benzoxathiaazacyclododecin-4-yl]carbonyl]-L-alanine. CAS No. 147214-63-9. Molecular formula: C26H35N5O12S. Mole weight: 641.65.
Fungichromin
A pentaene antifungal produced by streptomyces; exhibits broad spectrum antifungal and antitumor activity and, like filipin, acts via interaction with cell membrane sterols. Synonyms: Cogomycin; Pentamycin; Lagosin; 14-Hydroxyfilipin; Antibiotic A-246; NSC-105388. Grades: >95% by HPLC. CAS No. 6834-98-6. Molecular formula: C35H58O12. Mole weight: 670.83.
Heneicomycin
It is produced by the strain of Streptomyces filipinensis MA-4581 (NRRL 11044). It has anti-gram-positive bacteria, negative bacteria and mycoplasma activities, and has the effect of promoting animal growth. Synonyms: 2H-Pyran-2-acetamide, N-((2E,4E,6S,7R)-7-((2S,3S,4R,5R)-5-((1E,3E,5E)-7-(1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1,3,5-heptatrienyl)tetrahydro-3,4-dihydroxy-2-furanyl)-6-methoxy-5-methyl-2,4-octadienyl)-alpha-ethyltetrahydro-2,4-dihydroxy-5,5-dimethyl-6-((1E,3Z)-1,3-pentadienyl)-, (alphaS,2S,4S,6S)-; 30-Deoxy-1-methylmocimycin; Antibiotic A 21A. CAS No. 66170-37-4. Molecular formula: C44H62N2O11. Mole weight: 794.98.
LL AF283beta
LL AF283beta is extracted from Streptomyces filipinensis with anti-gram-positive bacteria activity. Synonyms: LL-AF283beta; (3R,4S,7S,10S)-10-amino-7-((S)-3-((S)-2-amino-5-guanidinopentanamido)-2-hydroxypropyl)-14,24,3-trihydroxy-6,9-dioxo-5,8-diaza-1,2(1,3)-dibenzenacycloundecaphane-4-carboxylic acid. Grades: >98%. CAS No. 135529-34-9. Molecular formula: C29H40N8O9. Mole weight: 644.67.
Methylspinazarin
Methylspinazarin is a naphthoquinone bacterial metabolite produced by the strain of Streptomyces filipinensis and is an inhibitor of catechol O-methyltransferase (COMT). Methylspinazarin can reduce blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg. Synonyms: 2,3,5,8-Tetrahydroxy-6-methyl-1,4-naphthalenedione; Methylspinazaline. Grades: >95% by HPLC. CAS No. 41768-12-1. Molecular formula: C11H8O6. Mole weight: 236.18.
Natamycin
Pimaricin is a macrocyclic tetraene originally isolated from Streptomyces natalensis in 1957. Pimaricin exhibits broad spectrum antifungal activity against yeast and filamentous fungi by binding specifically to ergosterol to block fungal growth. Unlike the related polyenes, nystatin and filipin, pimaricin does not change the permeability of the plasma membrane. Pimaricin is used in the food industry for surface treatment of cheeses as a mould inhibitor. Group: Biochemicals. Alternative Names: Pimaricin; Antibiotic A 5283; Tennecetin; Cl-12625; Mycophyt; Myprozine; Natacyn; Synogil. Grades: Highly Purified. CAS No. 7681-93-8. Pack Sizes: 100mg. Molecular Formula: C??H??NO??, Molecular Weight: 665.73. US Biological Life Sciences.
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