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| Product | Description | |
|---|---|---|
| Flavopiridol | Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of CDKs , inhibiting CDK1, CDK2, CDK4 with IC 50 s of 30, 170, 100 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HMR-1275; Alvocidib; L86-8275. CAS No. 146426-40-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10005. |  |
| Flavopiridol Hydrochloride | An inhibitor of cyclin-dependent kinases; the (-)-cis form induces apoptosis in certain tumor cells. Group: Biochemicals. Alternative Names: rel-(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride; Alvocidib Hydrochloride; HL 275; MDL 107826A; NSC 649890. Grades: Highly Purified. CAS No. 131740-09-5. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Flavopiridol Hydrochloride | Flavopiridol Hydrochloride (Alvocidib Hydrochloride) is a broad inhibitor of CDK , competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC 50 s of 30, 170, 100 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Alvocidib Hydrochloride; L86-8275 Hydrochloride; HMR-1275 Hydrochloride. CAS No. 131740-09-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10006. | |
| Flavopiridol Hydrochloride | Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Synonyms: NSC 649890 HCl; NSC649890 HCl; NSC-649890 HCl. Grades: >98%. CAS No. 131740-09-5. Molecular formula: C21H20ClNO5.HCl. Mole weight: 438.3. |  |
| Flavopiridol hydrochloride hydrate | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Alvocidib | Alvocidib is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. Uses: For research used only. Synonyms: Flavopiridol; HMR 1275. HMR1275. HMR-1275. Grades: 0.98. CAS No. 146426-40-6. Molecular formula: C21H20ClNO5. Mole weight: 401.84. | |
| Dinaciclib | Cyclin-dependent kinases (CDKs) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. Dinaciclib inhibits CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC50 values of 3, 1, 1, and 4 nM, respectively. Compared to the pan-CDK inhibitor flavopiridol, dinaciclib is an equally potent inhibitor of CDK1 and CDK9 but a 12-14-fold more potent inhibitor of CDK2 and CDK5. It has been shown to inhibit DNA synthesis by blocking thymidine incorporation in A2780 ovarian cancer cells with an IC50 value of 4nM. At 5mg/kg it prevents tumor growth by 50% in an A2780 ovarian carcinoma mouse xenograft model and is active against a broad spectrum of human tumor cell lines in vitro (IC50s = 7-17nM). Group: Biochemicals. Alternative Names: Sch 727965; (2S) -1- [3-Ethyl-7- [ [ (1-oxido-3-pyridinyl) methyl]amino]pyrazolo [1, 5-a]pyrimidin-5-yl]-2-piperidineethanol. Grades: Highly Purified. CAS No. 779353-01-4. Pack Sizes: 5mg. Molecular Formula: C21H28N6O2. US Biological Life Sciences. | Worldwide |
| Dinaciclib | Dinaciclib, also known as SCH727965, is a potent CDK inhibitor with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC(50) values of 1, 1, 3, and 4 nmol/L, respectively. Compared with flavopiridol, Dinaciclib exhibits superior activity with an improved therapeutic index. Dinaciclib induced regression of established solid tumors in a range of mouse models following intermittent scheduling of doses below the maximally tolerated level. Synonyms: SCH 727965; SCH727965; SCH-727965; PS095760; PS 095760; PS-095760; Dinaciclib. 2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol. CAS No. 779353-01-4. Molecular formula: C21H28N6O2. Mole weight: 396.49. | |
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