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Fludarabine. Group: Biochemicals. Grades: Purified. CAS No. 21679-14-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Fludarabine
Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: F-ara-A; NSC 118218. CAS No. 21679-14-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0069.
Used as an antineoplastic. Group: Biochemicals. Alternative Names: 9-b-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine, 2-F-araA. Grades: Highly Purified. CAS No. 21679-14-1. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Fludarabine-Cl
Fludarabine-Cl has an inhibitory effect on RNA adenosine deaminase 1 ( ADAR1 ) with an IC 50 of 0.87 μM and can be used to prevent and/or study cancer or tumor-related diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2734853-80-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145443.
Fludarabine EP impurity A
Fludarabine EP impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((2R,3S,4S,5R)-5-(6-amino-2-hydroxy-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate. Molecular Formula: C10H14N5O8P. Mole Weight: 363.22. Catalog: APB05944.
Fludarabine EP impurity B
Fludarabine EP impurity B. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6-amino-7H-purin-2-ol. CAS No. 149297-79-0. Molecular Formula: C5H5N5O. Mole Weight: 151.13. Catalog: APB149297790.
Fludarabine EP impurity C
Fludarabine EP impurity C. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 9-(3,5-Di-O-phosphono-β-D-arabinofuranosyl)-2-fluoro-9H-purin-6-amine. CAS No. 548774-53-4. Molecular Formula: C10H14FN5O10P2. Mole Weight: 445.19. Catalog: APB548774534.
Fludarabine EP impurity D
Fludarabine EP impurity D. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-fluoro-7H-purin-6-amine. CAS No. 700-49-2. Molecular Formula: C5H4FN5. Mole Weight: 153.12. Catalog: APB700492.
Fludarabine EP impurity E
Fludarabine EP impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol. CAS No. 21679-14-1. Molecular Formula: C10H12FN5O4. Mole Weight: 285.23. Catalog: APB21679141.
Fludarabine EP impurity F
Fludarabine EP impurity F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((2R,3S,4S,5R)-5-(6-amino-2-ethoxy-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate. CAS No. 159002-28-5. Molecular Formula: C12H18N5O8P. Mole Weight: 391.27. Catalog: APB159002285.
Fludarabine EP impurity G
Fludarabine EP impurity G. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((2R,3R,4S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-4-chloro-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate; 9-(2-chloro-2-deoxy-5-Ophosphono-β-D-arabinofuranosyl)-2-fluoro-9H-purin-6-amine. CAS No. 548774-56-7. Molecular Formula: C10H12ClFN5O6P. Mole Weight: 383.66. Catalog: APB548774567.
Fludarabine EP impurity H
Fludarabine EP impurity H. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (1R,3R,4S,7R)-3-(6-amino-2-fluoro-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-ol; 9-(2,5-anhydro-β-D-arabinofuranosyl)-2-fluoro-9H-purin-6- amine. CAS No. 548774-57-8. Molecular Formula: C10H10FN5O3. Mole Weight: 267.22. Catalog: APB548774578.
Fludarabine EP impurity I
Fludarabine EP impurity I. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((2R,3S,4S,5R)-5-(2,6-diamino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate. CAS No. 7561-54-8. Molecular Formula: C10H15N6O7P. Mole Weight: 362.24. Catalog: APB7561548.
Fludarabine EP impurity J
Fludarabine EP impurity J. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((2R,3S,4S,5R)-5-(6-amino-2-methoxy-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate. Molecular Formula: C11H16N5O8P. Mole Weight: 377.25. Catalog: APB05943.
Fludarabine EP impurity K
Fludarabine EP impurity K. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((2R,3S,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate. Molecular Formula: C10H13ClN5O7P. Mole Weight: 381.67. Catalog: APB05941.
Fludarabine Impurity 13
Fludarabine Impurity 13. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,3S,4R,5R)-5-(acetoxymethyl)-2-(6-amino-2-fluoro-9H-purin-9-yl)-3-methyltetrahydrofuran-3,4-diyl diacetate. Molecular Formula: C17H20FN5O7. Mole Weight: 425.37. Catalog: APB05942.
Fludarabine Impurity 14
Fludarabine Impurity 14. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,3S,4R,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol. Molecular Formula: C11H14FN5O4. Mole Weight: 299.26. Catalog: APB05938.
Fludarabine impurity 15
Fludarabine impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 36468-53-8. Molecular Formula: C5H10O5. Mole Weight: 150.13. Catalog: APB36468538.
Fludarabine Impurity 15
Fludarabine Impurity 15. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((2R,3R,4S,5S)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methyl dihydrogen phosphate. Molecular Formula: C11H15FN5O7P. Mole Weight: 379.24. Catalog: APB05940.
Fludarabine impurity 16
Fludarabine impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 25545-03-3. Molecular Formula: C5H10O5. Mole Weight: 150.13. Catalog: APB25545033.
Fludarabine Impurity 16
Fludarabine Impurity 16. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3R,4S,5S)-2-(acetoxymethyl)-5-chlorotetrahydrofuran-3,4-diyl diacetate. Molecular Formula: C11H15ClO7. Mole Weight: 294.69. Catalog: APB05939.
Fludarabine Impurity 17
Fludarabine Impurity 17. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3R,4S,5R)-2-(acetoxymethyl)-5-(2,6-diacetamido-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate. Molecular Formula: C20H24N6O9. Mole Weight: 492.44. Catalog: APB05937.
Fludarabine Impurity 18
Fludarabine Impurity 18. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3S,4S,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol. Molecular Formula: C10H12ClN5O4. Mole Weight: 301.69. Catalog: APB05936.
Fludarabine Impurity 19
Fludarabine Impurity 19. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3S,4S,5R)-2-(6-amino-2-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol. Molecular Formula: C10H12ClN5O4. Mole Weight: 301.69. Catalog: APB05935.
Fludarabine Impurity 20
Fludarabine Impurity 20. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,3S,4S,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol. Molecular Formula: C10H14N6O4. Mole Weight: 282.26. Catalog: APB05934.
Fludarabine Impurity 21
Fludarabine Impurity 21. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)tetrahydrofuran-2,3,4-triol. Molecular Formula: C9H12N6O4. Mole Weight: 268.23. Catalog: APB05933.
Fludarabine Impurity 22
Fludarabine Impurity 22. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3S,4S,5R)-2-(6-amino-2-ethoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol. Molecular Formula: C12H17N5O5. Mole Weight: 311.29. Catalog: APB05932.
Fludarabine Impurity 23
Fludarabine Impurity 23. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3R,4S,5S)-2-(acetoxymethyl)-5-(6-amino-2-fluoro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate. Molecular Formula: C16H18FN5O7. Mole Weight: 411.34. Catalog: APB05931.
Fludarabine Impurity 24
Fludarabine Impurity 24. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-amino-2-fluoro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate. CAS No. 15811-32-2. Molecular Formula: C16H18FN5O7. Mole Weight: 411.34. Catalog: APB15811322.
Fludarabine impurity 3
Fludarabine impurity 3. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C16H23FN5O12P. Mole Weight: 527.36. Catalog: APB08101.
Fludarabine phosphate
1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C10H13FN5O7P. CAS No. 75607-67-9. Prepack ID 56054450-1g. Molecular Weight 365.21. See USA prepack pricing.
Fludarabine phosphate
Fludarabine phosphate. Group: Biochemicals. Alternative Names: 9-b-D-Arabinofuranosyl-2-fluoroadenine 5-phosphate. Grades: Highly Purified. CAS No. 75607-67-9. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C10H13FN5O7P. US Biological Life Sciences.
Worldwide
Fludarabine phosphate
Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 118218 phosphate. CAS No. 75607-67-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0028.
Fludarabine Phosphate
Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. Uses: Antimetabolites, antineoplastic. Synonyms: Fludarabine 5'-monophosphate; 2-Fluoro-ARA AMP; Fludarabine monophosphate; FAMP; NSC-312887; 2-Fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine; 2-Fluoroadenine arabinoside 5'-monophosphate; ((2R,3S,4S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate; 9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate. Grades: ≥98% by HPLC. CAS No. 75607-67-9. Molecular formula: C10H13FN5O7P. Mole weight: 365.21.
Fludarabine phosphate impurity A
Fludarabine phosphate impurity A is an impurity of Fludarabine phosphate, the salient therapeutic recourse for chronic lymphocytic leukemia. Grades: > 95%. Molecular formula: C10H14N5O8P. Mole weight: 363.23.
Fludarabine phosphate impurity B
Fludarabine phosphate impurity B isan impurity of Fludarabine phosphate, a chemotherapy drug primarily used to treat chronic lymphocytic leukemia. Grades: > 95%. CAS No. 149297-79-0. Molecular formula: C5H5N5O. Mole weight: 151.13.
Fludarabine Phosphate Impurity C
Fludarabine Phosphate Impurity C is an impurity of Fludarabine Phosphate with pronounced application in the therapy of diverse malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL). Grades: > 95%. Molecular formula: C10H14FN5O10P2. Mole weight: 445.20.
Fludarabine Phosphate Impurity D
Fludarabine Phosphate Impurity D is an impurity of Fludarabine Phosphate, a well-established therapeutic agent efficacious in treating B-cell chronic lymphocytic leukemia (CLL). Grades: > 95%. Molecular formula: C5H4FN5. Mole weight: 153.12.
Fludarabine Phosphate Impurity F
Fludarabine Phosphate Impurity F is a byproduct found in the manufacturing process of the chemotherapy drug Fludarabine Phosphate, which is used to treat B-cell chronic lymphocytic leukemia and lymphoma. Its exact role in the biomedical industry is not well understood and further research is needed. Synonyms: [(2R,3S,4S,5R)-5-(6-amino-2-ethoxypurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate. Grades: > 95%. CAS No. 159002-28-5. Molecular formula: C12H18N5O8P. Mole weight: 391.28.
2',3'-O-Isopropylideneadenosine
2',3'-O-Isopropylideneadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 362-75-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W008048.
2-Aminoadenosine
2-Aminoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2096-10-8. Pack Sizes: 10 mM * 1 mL; 10 g; 25 g. Product ID: HY-W011548.
2-Fluoro-ara-ATP
2-Fluoro-ara-ATP is a remarkable and specialized inhibitor, is harnessed in elucidating ATP's intricate ramifications on biological systems. Its adeptness in modulating an array of signaling pathways intertwines with paramount significance, specifically pertaining to cellular expansion, proliferation, and metabolic alterations. Synonyms: (2F-ara-ATP); 2-Fluoro-ara-adenosine-5'-triphosphate, Tetralithium salt; 2-Fluoro-9-β-D-arabinofuranosyladenine-5'-triphosphate; Fludarabine-5'-triphosphate. Grades: ≥ 95% by HPLC. Molecular formula: C10H15FN5O13P3 (free acid). Mole weight: 525.17 (free acid).
2-Iodoadenosine
2-Iodoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 35109-88-7. Pack Sizes: 250 mg; 500 mg; 1 g. Product ID: HY-W008552.
3-O-Methyladenosine
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol (Adenosine, 3'-O-methyl- (8CI)(9CI)) is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 10300-22-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W393243.
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5'-O-(4,4'-DIMETHOXYTRITYL)ADENOSINE. CAS No. 81352-25-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-W097775.
8-Bromoadenosine
8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2946-39-6. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W013195.
9-(3,5-Di-O-phosphono- β-D-arabinofuranosyl)-2-fluoro-9H-purin-6-amine is derived from Fludarabine (F425000), which is used as an antineoplastic. Group: Biochemicals. Grades: Highly Purified. CAS No. 548774-53-4. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C10H14FN5O10P2, Molecular Weight: 445.19. US Biological Life Sciences.
Worldwide
MDM2 Antagonist IV, Nutlin-3a ((-)-4-(4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl)piperazine-2-one)
A cell-permeable and highly potent active enantiomer of Nutlin-3 that binds to the p53-binding pocket and blocks the interaction of p53 and MDM2 (IC50=90nM). Exhibits over 150-fold greater affinity for MDM2 than its less active enantiomer, Nutlin-3b. Induces p53 mediated apoptosis by both transcription-dependent and independent mechanisms. Shown to greatly potentiate the cytotoxic effects of chemotherapeutic agents and reduce tumor burden in vivo. Also shown to overcome ATM-mediated resistance to fludarabine in chronic lymphocyte leukemia. Cells treated with Nutlin-3a permanently lose their ability to proliferate and enter into a pattern of permanent senescence. Mouse embryonic fibroblasts with p53+/+ MEFs show significantly reduced reprogramming capabilities following Nutlin-3a treatment. Group: Biochemicals. Grades: Highly Purified. CAS No. 675576-98-4. Pack Sizes: 5mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences.
Worldwide
Recombinant mutant (Met62Val) purine nucleoside phosphorylase from E. coli
Purine nucleoside phosphorylase is an enzyme involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine. Mutations in the PNP gene are responsible for purine nucleoside phosphorylase deficiency. Applications: These enzymes are widely used for the synthesis of modified nucleotides (virasol, cladribine, fludarabine) which are efficient antiviral and antitumor drugs. Group: Enzymes. Synonyms: purine-nucleoside phosphorylase; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase;. Enzyme Commission Number: EC 2.4.2.1. CAS No. 9030-21-1. Purity: > 95 %. PNPase. Mole weight: 156 kDa. Activity: 27 U/mg. Appearance: Colourless clear liquid. Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Source: E. coli. Species: E. coli. purine-nucleoside phosphorylase; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; EC 2.4.2.1; 9030-21-1. Cat No: NATE-1000.
Recombinant uridine phosphorylase from E. coli
Uridine phosphorylase catalyzes the reversible phosphorolysis of uridine with the formation of ribose-1-phosphate and uracil. Applications: These enzymes are widely used for the synthesis of modified nucleotides (virasol, cladribine, fludarabine) which are efficient antiviral and antitumor drugs. Group: Enzymes. Synonyms: Uridine phosphorylase; EC 2.4.2.3; UrdPase; Upase; StUP. Enzyme Commission Number: EC 2.4.2.3. CAS No. 9030-22-2. Purity: > 85 %. Upase. Mole weight: 27.3 kDa (163.5 kDa - hexamer). Activity: more than 20 u/mg. Appearance: Colourless clear liquid. Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Source: E. coli. Species: E. coli. Uridine phosphorylase; EC 2.4.2.3; UrdPase; Upase; StUP. Cat No: NATE-0999.
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