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| Product | Description | |
|---|---|---|
| Deruxtecan | Deruxtecan analog is a drug-linker conjugate for antibody-drug conjugate (ADC). Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan (DS-8201a), which is a HER2-targeting antibody-drug conjugate. DS-8201a significantly suppressed tumor growth in an immunocompetent mouse model with human HER2-expressing CT26.WT (CT26.WThHER2) cells. DS-8201a is currently in clinical trials. Synonyms: Deruxtecan Analog; Deruxtecan, Trastuzumab deruxtecan; DS-8201a; DS8201a; DS 8201a; Exatecan derivative; DX-8951 derivative; DX 8951; DX8951; N-[6-(2, 5-Dioxo-2, 5-dihydro-1H-pyrrol-1-yl)hexanoyl]glycylglycyl-L-phenylalanyl-N-[(2-{[(1S, 9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10, 13-dioxo-2, 3, 9, 10, 13, 15-hexahydro-1H, 12H-benzo[de]pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-1-yl]amino}-2-oxoethoxy)methyl]glycinamide. Grades: ≥95%. CAS No. 1599440-13-7. Molecular formula: C52H56FN9O13. Mole weight: 1034.05. |  |
| Deruxtecan | Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative (DX-8951 derivative) with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan (DS-8201a), which is a HER2-targeting antibody-drug conjugate. DS-8201a significantly suppressed tumor growth in an immunocompetent mouse model with human HER2-expressing CT26.WT (CT26.WThHER2) cells. DS-8201a is currently in clinical trials. Group: Inhibitors. Alternative Names: Deruxtecan, Trastuzumab deruxtecan; DS-8201a; DS8201a; DS 8201a; exatecan derivative; DX-8951 derivative; DX 8951; DX8951. CAS No. 1599440-13-7. Molecular formula: C52H56FN9O13. Mole weight: 1034.07. Appearance: Solid powder. Purity: >98%. IUPACName: Glycinamide, N-[6-(2, 5-dihydro-2, 5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S, 9S)-9-ethyl-5-fluoro-2, 3, 9, 10, 13, 15-hexahydro-9-hydroxy-4-methyl-10, 13-dioxo-1H, 12Hbenzo[de]pyrano[3', 4':6, 7]indolizino[1, 2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]-. Canonical SMILES: CC[C@@]1 (O) C (OCC2=C1C=C3N (C2=O) CC (C3=NC4=CC (F) =C5C) =C6C4=C5CC[C@@H]6NC (COCNC (CNC ([C@@H] (NC (CNC (CNC (CCCCCN7C (C=CC7=O) =O) =O) =O) =O) CC8=CC=CC=C8) =O) =O) =O) =O. Catalog: ACM1599440137. |  |
| Flucloxacillin Impurity G | An impurity of Flucloxacillin. Flucloxacillin is a narrow-spectrum beta-lactam antibiotic of the penicillin class. Synonyms: (5R)-Flucloxacillin N4-[N-[[3-(2-Chloro-6-fluoro-phenyl)-5-methyl-4-isoxazolyl]carbonyl]-glycinyl] Penilloic Acid. Grades: ≥95%. Molecular formula: C32H27Cl2F2N5O9S. Mole weight: 766.55. | |
| peptidyl-glycinamidase | Inactivates vasopressin and oxytocin by splitting off glycinamide. Also cleaves ester substrates of trypsin and chymotrypsin. Although glycinamide is by far the preferred leaving group, other aminoacylamides may also be released, e.g. phenylalaninamide. The toad skin enzyme is inhibited by diisopropyl fluorophosphate. Group: Enzymes. Synonyms: carboxyamidase; peptidyl carboxy-amidase; peptidyl-aminoacylamidase; carboxamidopeptidase; peptidyl amino acid amide hydrolase. Enzyme Commission Number: EC 3.4.19.2. CAS No. 94047-14-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4087; peptidyl-glycinamidase; EC 3.4.19.2; 94047-14-0; carboxyamidase; peptidyl carboxy-amidase; peptidyl-aminoacylamidase; carboxamidopeptidase; peptidyl amino acid amide hydrolase. Cat No: EXWM-4087. |  |
| TCN-201 (3-Chloro-4-fluoro-N- [ (4-{ [2- (phenylcarbonyl) hydrazino] carbonyl}phenyl) methyl] benzenesulfonamide, NMDA Antagonist X) | A negative allosteric modulator selective for NR2A containingnMDA receptors (pIC50 = 6.8 and <4.3uM for NR2A and NR2B, respectively). No effect on NR2B-containingnMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containingnMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent. Group: Biochemicals. Grades: Highly Purified. CAS No. 852918-02-6. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
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