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Fmoc-5-fluoro-DL-tryptophan is a derivative of the amino acid tryptophan. It is commonly used as a building block in peptide synthesis due to its enhanced hydrophobicity and stability compared to other tryptophan analogs. The Fmoc group is a protecting group used to protect the reactive functional groups during peptide synthesis. Uses: Fmoc-5-fluoro-dl-tryptophan has a wide range of applications in scientific research. it is commonly used as a building block in peptide synthesis and has been used to study enzyme function and to develop novel therapeutic agents such as anticancer drugs. Group: Amino acids. Alternative Names: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-fluorotryptophan. CAS No. 138775-55-0. Molecular formula: C26H21FN2O4. Mole weight: 444.5. Purity: Peak Area by HPLC ≥95%. IUPACName: 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(5-fluoro-1H-indol-3-yl)propanoic acid. Canonical SMILES: C1=CC=C2C (=C1)C (C3=CC=CC=C32)COC (=O)NC (CC4=CNC5=C4C=C (C=C5)F)C (=O)O. Density: 1.4±0.1 g/cm3. Catalog: ACM138775550.
Used for the counterselection of TRP1, a commonly used genetic marker in the yeast Saccharoyces Cerevisiae. An antimetabolite for the tryptophan pathway in yeast, and is toxic by virtue of its antimetabolite conversion to 5-Fluorotryptophan. It can be used for the selection of tryptophan auxotroophs. Group: Biochemicals. Alternative Names: 2-Amino-5-fluorobenzoic Acid, 5-FAA. Grades: Highly Purified. CAS No. 446-08-2. Pack Sizes: 250mg, 1g, 5g, 10g, 25g, 50g. Molecular Formula: C7H6FNO2, Molecular Weight: 155.13. US Biological Life Sciences.
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7-Azido-4-methylcoumarin (AzMC)
Highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4- methylcoumarin (AMC) with a concomitant increase in fluorescence with lambdaex=365nm and lambdaem=450nm. Photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). Probe to monitor the enzymatic production of H2S in vitro and to visualize H2S in living cells. Tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CGL) and tryptophan synthase (TS)). Tool to identify novel cystathionine beta-synthase (CBS) inhibitors and activators. Suitable for high-throughput screening. Use of this product with DTT, TCEP and/or biological thiols at concentrations of >25mM should be avoided for maximum efficiency. Group: Biochemicals. Grades: Highly Purified. CAS No. 95633-27-5. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
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Ac-ANW-AMC
Ac-ANW-AMC is a 7-amino-4-methylcoumarin labelled fluorogenic peptidyl substrate and used for measuring chymotrypsin-like activity of the immunoproteasome. Synonyms: (S)-N1-((S)-3-(1H-indol-3-yl)-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxopropan-2-yl)-2-((S)-2-acetamidopropanamido)succinamide; N-Acetyl-L-alanyl-L-asparaginyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-tryptophanamide; Acetyl-Ala-Asn-Trp-7-amido-4-methylcoumarin. Grades: >99%. Molecular formula: C30H32N6O7. Mole weight: 588.61.
LP-533401
LP-533401 is an inhibitor of tryptophan 5-hydroxylase 1 (Tph1) that suppresses serotonin production in the gut. It prevents the development of osteoporosis in ovariectomized and aged mice. Synonyms: (2S)-2-Amino-3-[4-[2-amino-6-[2,2,2-trifluoro-1-[4-(3-fluorophenyl)phenyl]ethoxy]pyrimidin-4-yl]phenyl]propanoic acid. Grades: ≥98%. CAS No. 945976-43-2. Molecular formula: C27H22F4N4O3. Mole weight: 526.5.
Nemifitide acetate
Nemifitide acetate is an antidepressant with a pentapeptide structure similar to melanocyte-inhibiting factor (MIF). It binds to several receptors, including 5-HT2A (as an antagonist), NPY1, bombesin, MC4, and MC5, although only in micromolar concentrations. Synonyms: INN 00835 acetate; H-Phe(4-F)-Hyp-Arg-Gly-Trp-NH2.CH3CO2H; 4-fluoro-L-phenylalanyl-(4R)-4-hydroxy-L-prolyl-L-arginyl-glycyl-L-tryptophanamide acetic acid; 4-F-Phe-4-OH-Pro-Arg-Gly-Trp-NH2.CH3CO2H. Grades: ≥95%. Molecular formula: C35H47FN10O8. Mole weight: 754.85.