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| Product | Description | |
|---|---|---|
| FMK | FMK is a an irreversible RSK2 kinase inhibitor, that covalently modifies the C-terminal kinase domain of RSK. Uses: Scientific research. Group: Signaling pathways. CAS No. 821794-92-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-52101A. |  |
| FMK | FMK is a potent, highly specific and irreversible ribosomal s6 kinase (RSK) inhibitor that covalently modifies the C-terminal kinase domain of RSK. Its IC50 value is 15 nM. It could prevent the activation of the N-terminal kinase domain of RSK by the C-terminal kinase domain, but does not affect the activity of the N-terminal domain. It binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. It induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells. It is used to determine the role of RSK as a direct regulator of NHE1 phosphorylation and sarcolemmal NHE activity in this cell type, in response to 1-adrenergic stimulation. Uses: Fmk could prevent the activation of the n-terminal kinase domain of rsk by the c-terminal kinase domain, but does not affect the activity of the n-terminal domain. it is used to determine the role of rsk as a direct regulator of nhe1 phosphorylation and sarcolemmal nhe activity in this cell type, in response to 1-adrenergic stimulation. Synonyms: 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone;RSK2 kinase inhibitor. Grades: >98%. CAS No. 821794-92-7. Molecular formula: C18H19FN4O2. Mole weight: 342.37. |  |
| FMK 9a | FMK 9a is a covalent autophagin-1 inhibitor (IC50 = 80 and 73 μM in FRET and LRA assay). Synonyms: FMK-9a; FMK 9a; FMK9a; N-[(2S)-1-[(3-fluoro-2-oxopropyl)amino]-1-oxo-3-phenylpropan-2-yl]naphthalene-1-carboxamide. CAS No. 1955550-51-2. Molecular formula: C23H21FN2O3. Mole weight: 392.42. | |
| FMK-MEA | FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1414811-15-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-52101C. | |
| Biotin-AEVD-FMK | Biotin-AEVD-FMK is a biotin-labeled caspase-10 inhibitor that can be used as a probe for detecting caspase-10 by biotin ligand. Synonyms: Biotin-A-E(OMe)-V-Asp(OMe)-FMK; Biotin-Ala-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone. Grades: ≥95%. Molecular formula: C30H47FN6O10S. Mole weight: 702.80. | |
| Biotin-ASTD-FMK | Biotin-ASTD-FMK is a biotin-labeled inhibitor of endothelial monocyte-activated polypeptide II (EMAP II), which can be used as a probe for detecting EMAP II by biotin ligand. Synonyms: Biotin-Ala-Ser-Thr-Asp(OMe)-Fluoromethylketone; Biotin-ASTD-Fluoromethylketone; Biotin-ASTD(OMe)-fmk. Grades: ≥95%. Molecular formula: C26H41FN6O10S. Mole weight: 648.70. | |
| Biotin-FF-FMK | Biotin-FF-FMK is a biotin-labeled cathepsin inhibitor that selectively suppresses cathepsin B and cathepsin L. Synonyms: Biotin-Phe-Phe-CH2F; Biotin-Phe-Phe-Fluoromethylketone. Grades: ≥95%. Molecular formula: C29H35FN4O4S. Mole weight: 554.68. | |
| Biotin-LLY-FMK | Biotin-LLY-FMK is a biotin-labeled calpain inhibitor that can be used as a probe for detecting calpain II and cathepsin L by biotin ligand. Synonyms: Biotin-Leu-Leu-Tyr-Fluoromethylketone. Grades: ≥95%. Molecular formula: C32H48FN5O6S. Mole weight: 649.82. | |
| Boc-T-FMK | Boc-T-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Synonyms: Boc-T-Fluoromethyl Ketone. Grades: ≥95%. Molecular formula: C10H18FNO4. Mole weight: 235.26. | |
| Caspase-1/ICE Inhibitor Z-WEHD-FMK | Z-WEHD-FMK is an inhibitor of caspase-1, caspase-5 and cathepsin B, which can inhibit cell apoptosis in a variety of biological systems. Synonyms: CASPASE-1 INHIBITOR TFA SALT; Z-WEHD-FMK-TFA; Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK-TFA. Grades: >99%. CAS No. 210345-00-9. Molecular formula: C37H42FN7O11. Mole weight: 763.78. | |
| FICT-FF-FMK | FICT-FF-FMK is a fluorescein isothiocyanate (FITC)-conjugated inhibitor of cathepsin B and cathepsin L, which can be used for detecting cathepsin B and cathepsin L in live cells. Synonyms: FICT-Phe-Phe-FMK; FICT-Phe-Phe-Fluoromethylketone. Grades: >95%. Molecular formula: C41H34FN3O6S. Mole weight: 715.80. | |
| Fitc-AEVD-FMK | FITC-AEVD-FMK is a fluorescein isothiocyanate (FITC)-conjugated caspase-10 inhibitor that can be used as a marker for detecting caspase-10 in live cells. Synonyms: FITC-A-E(OMe)-V-Asp(OMe)-FMK; FITC-Ala-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone. Grades: ≥95%. Molecular formula: C41H44FN5O13S. Mole weight: 865.88. | |
| Fitc-ASTD-FMK | FITC-ASTD-FMK is a fluorescein isothiocyanate (FITC)-conjugated inhibitor of endothelial monocyte-activated polypeptide II (EMAP II), which can be used as a marker for detecting EMAP II in live cells. Synonyms: FITC-Ala-Ser-Thr-Asp(OMe)-Fluoromethylketone; FITC-ASTD(OMe)-fmk; FITC-Ala-Ser-Thr-Asp(OMe)-CH2F. Grades: ≥95%. Molecular formula: C37H38FN5O13S. Mole weight: 811.79. | |
| Fitc-LLY-FMK | FITC-LLY-FMK is a fluorescein isothiocyanate (FITC)-conjugated calpain inhibitor that can be used as a marker for detecting calpain II and cathepsin L in live cells. Synonyms: FITC-Leu-Leu-Tyr-Fluoromethylketone. Grades: ≥95%. Molecular formula: C43H45FN4O9S. Mole weight: 812.91. | |
| Fitc-YVAD-FMK | FITC-YVAD-FMK is a fluorescein isothiocyanate (FITC)-conjugated caspase-1 inhibitor that can be used as a marker for detecting caspase-1 in live cells. Synonyms: FITC-Tyr-Val-Ala-Asp(OMe)-Fluoromethylketone. Grades: ≥95%. Molecular formula: C44H44FN5O12S. Mole weight: 885.92. | |
| Z-AEVD-FMK | Z-AEVD-FMK is a cell-permeant and irreversible caspase-10 inhibitor. Synonyms: Z-Ala-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone; (5S,8S,11S,14S)-Methyl 14-(2-Fluoroacetyl)-11-isopropyl-8-(3-methoxy-3-oxopropyl)-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,1 3-tetraazahexadecan-16-oate; Z-A-E(OMe)-V-Asp(OMe)-FMK; Z-Ala-Glu(OMe)-Val-Asp(OMe)-FMK. Grades: ≥95%. CAS No. 1135688-47-9. Molecular formula: C28H39FN4O10. Mole weight: 610.63. | |
| Z-AEVD-FMK | Z-AEVD-FMK is a cleavable ADC linker for the synthesis of antibody active molecule conjugates (ADCs). Uses: Scientific research. Group: Signaling pathways. CAS No. 1135688-47-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125305. | |
| Z-ASTD-FMK | Z-ASTD-FMK is a cell-permeant and irreversible inhibitor of endothelial monocyte-activated polypeptide II (EMAP II). Synonyms: EMAP II inhibitor; Z-Ala-Ser-Thr-Asp(OMe)-Fluoromethylketone; Z-ASTD(OMe)-fmk; Cbz-Ala-Ser-Thr-Asp(OMe)-CH2F. Grades: ≥95%. Molecular formula: C24H33FN4O10. Mole weight: 556.54. | |
| Z-ATAD-FMK | Z-ATAD-FMK is a cell-permeant caspase-12 inhibitor. It was shown to suppress annular cell apoptosis in vitro. Synonyms: Caspase-12 Inhibitor; Z-ATAD-FMK; Z-ATAD-fluoromethylketone. Grades: ≥95%. Molecular formula: C24H33FN4O9. Mole weight: 540.54. | |
| Z-DEVD-FMK | Z-DEVD-FMK Inhibitor. Uses: Scientific use. Product Category: T6005. CAS No. 210344-95-9. |  |
| Z-DEVD-FMK | Z-DEVD-FMK is a cell-permeant, irreversible caspase-3 inhibitor that can be used as an anaesthetic agent. It has been shown to suppress tumor cell apoptosis. Uses: Cysteine proteinase inhibitors. Synonyms: Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK; Caspase-3 Inhibitor; Z-D(OMe)E(Ome)VD(OMe)-FMK; benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone; Caspase-3 Inhibitor II; Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone; Z-DEVD-fluoromethylketone. Grades: ≥95%. CAS No. 210344-95-9. Molecular formula: C30H41FN4O12. Mole weight: 668.67. | |
| Z-DQMD-FMK | Z-DQMD-FMK has been found to be a Caspase-3 inhibitor and could induce small cell lung cancer cell death in vitro. Synonyms: Z-D(OMe)QMD(OMe)-fmk; benzyloxycarbonyl-Asp(OMe)-Gln-Met-Asp(OMe)-fluoromethylketone; Z-Asp(OMe)-Gln-Met-Asp(OMe) fluoromethyl ketone; L-Methioninamide, N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-glutaminyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester; methyl (5S,8S,11S,14S)-8-(3-amino-3-oxopropyl)-14-(2-fluoroacetyl)-5-(2-methoxy-2-oxoethyl)-11-(2-(methylthio)ethyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate. Grades: ≥95%. CAS No. 767287-99-0. Molecular formula: C29H40FN5O11S. Mole weight: 685.72. | |
| Z-FA-FMK | Z-FA-FMK ((1S)-Z-FA-FMK) is a potent Cathepsin B and L inhibitor. Z-FA-FMK blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective synthetic retinoid-related molecules (RRMs). Z-FA-FMK inhibits apoptosis. Z-FA-FMK inhibits caspase activity and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Z-FA-FMK is a viral inhibitor. Z-FA-FMK inhibits reovirus replication in a susceptible host [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (1S)-Z-FA-FMK. CAS No. 197855-65-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0109A. | |
| Z-FA-FMK | Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibitits papain and cruzain. Group: Biochemicals. Grades: Highly Purified. CAS No. 197855-65-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H23FN2O4, Molecular Weight: 386.42. US Biological Life Sciences. |  Worldwide |
| Z-FF-FMK | Z-FF-FMK is a cell-permeant and irreversible inhibitor of cathepsin B and cathepsin L. Synonyms: Cathepsin L Inhibitor I; Z-Phe-Phe-CH2F; Z-Phe-Phe-fluoromethyl ketone. Grades: ≥95%. CAS No. 105608-85-3. Molecular formula: C27H27FN2O4. Mole weight: 462.52. | |
| Z-IETD-FMK | Z-IETD-FMK Inhibitor. Uses: Scientific use. Product Category: T7019. CAS No. 210344-98-2. | |
| Z-IETD-FMK | Z-IETD-FMK is a selective and cell permeable caspase 8 inhibitor. Z-IETD-FMK inhibits T cell proliferation induced by PHA or anti-CD3 plus anti-CD28 without toxicity of resting T cells. Synonyms: caspase-8 inhibitor; Z-IE(OMe)TD(OMe)-FMK; Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH2F; Z-Ile-Glu(OMe)-Thr-Asp(OMe) fluoromethylketone; N-benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone. Grades: ≥95%. CAS No. 210344-98-2. Molecular formula: C30H43FN4O11. Mole weight: 654.69. | |
| Z-LEED-FMK | Z-LEED-FMK is a cell-permeant and irreversible caspase-13 inhibitor. Synonyms: Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-FMK; Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-Fluoromethylketone; methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-5-isobutyl-8,11-bis(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate. Grades: ≥95%. Molecular formula: C32H45FN4O12. Mole weight: 696.72. | |
| Z-LEHD-FMK | Z-LEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-9. Synonyms: Caspase-9 Inhibitor; Methyl (4S) -5-[[ (2S) -1-[[ (3S) -5-fluoro-1-methoxy-1, 4-dioxopentan-3-yl]amino]-3- (1H-imidazol-5-yl) -1-oxopropan-2-yl]amino]-4-[[ (2S) -4-methyl-2- (phenylmethoxycarbonylamino) pentanoyl]amino]-5-oxopentanoate; 2, 2, 2-trifluoroacetic acid. CAS No. 524746-03-0. Molecular formula: C34H44F4N6O12. Mole weight: 804.74. | |
| Z-LEVD-FMK | Z-LEVD-FMK is a cell-permeant and irreversible caspase-4 inhibitor. Synonyms: Z-LE(OMe)VD(OMe)-FMK; Z-Leu-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone; Cbz-Leu-Glu(OMe)-Val-Asp(OMe)-CH2F; Caspase 4 inhibitor. Grades: ≥95%. CAS No. 1135688-25-3. Molecular formula: C31H45FN4O10. Mole weight: 652.72. | |
| Z-LLY-FMK | Z-LLY-FMK is a cell-permeant and irreversible calpain inhibitor that is selective for calpain II, and also exhibits inhibitory effect against cathepsin L. It was shown to suppress hepatocyte apoptosis after bile duct ligation in rat. Synonyms: Calpain Inhibitor IV; Z-Leu-Leu-Tyr-FMK; Z-Leu-Leu-Tyr-Fluoromethylketone; N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide. Grades: ≥95%. CAS No. 133410-84-1. Molecular formula: C30H40FN3O6. Mole weight: 557.66. | |
| Z-Phe-DL-Ala-FMK | Z-FA-FMK is an irreversible cysteine protease inhibitor, and it also inhibits caspases-2, -3, -6, and -7. Z-FA-FMK suppresses the degradation of fibrillar collagen by fibroblasts and osteoclasts, and reduces LPS-induced cytokine production via inhibition of NF-kappaB-dependent gene expression in macrophages. Uses: Cysteine proteinase inhibitors. Synonyms: Z-Phe-DL-Ala-fluoromethylketone; Zfa-fmk; benzyloxycarbonyl-Phe-Ala-fluormethylketone; benzyloxycarbonylphenylalanyl-alanine fluoromethyl ketone; Carbamic acid, N-((1S)-2-((3-fluoro-1-methyl-2-oxopropyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-, phenylmethyl ester. Grades: ≥95%. CAS No. 197855-65-5. Molecular formula: C21H23FN2O4. Mole weight: 386.42. | |
| Z-VAD-FMK | solid. Group: Fluorescence/luminescence spectroscopyenzyme activators, inhibitors & substrates. |  |
| Z-VAD-FMK | Z-VAD-FMK Inhibitor. Uses: Scientific use. Product Category: T7020. CAS No. 161401-82-7. | |
| Z-VAD-FMK | Z-VAD-FMK is a broad spectrum pan-caspase inhibitor that inhibits the intracellular activation of caspase-like proteases. Synonyms: Z-VAD (OMe)-FMK; Caspase Inhibitor I. Grades: >98.0%. CAS No. 187389-52-2. Molecular formula: C22H30FN3O7. Mole weight: 467.49. | |
| Z-VAD-FMK (Cell permeable) | Cell-permeable, non-selective broad-spectrum caspase inhibitor. Binds irreversibly to the catalytic site of caspase proteases. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Potent inhibitor of caspase-1 activation in NLRP3-induced cells. Used in apoptosis and inflammasome studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 187389-52-2, 634911-81-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H30FN3O7. US Biological Life Sciences. | Worldwide |
| Z-VA-DL-D(OMe)-FMK trifluoroacetate salt | Z-VA-DL-D(OMe)-FMK (Z-VAD-FMK) is a pan-caspase inhibitor. Synonyms: Caspase-1 Inhibitor V; Z-VAD-FMK; Z-VAD(OMe)-FMK; Z-Val-Ala-DL-Asp(OMe)-Fluoromethyl Ketone. Grades: ≥95%. Molecular formula: C22H30FN3O7·xCF3COOH. Mole weight: 467.49. | |
| Z-VAD(OH)-FMK | Z-VAD(OH)-FMK, also known as Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone, is an irreversible tripeptide inhibitor of all caspases. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Z-VAD(OH)-FMK; Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 161401-82-7. Molecular formula: C21H28FN3O7. Mole weight: 453.47. Purity: >98%. IUPACName: (5S,8S,11S)-11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oic acid. Canonical SMILES: O=C(O)C[C@@H](C(CF)=O)NC([C@H](C)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O. Product ID: ACM161401827. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Z-VAD(OH)-FMK | Z-VAD(OH)-FMK is an irreversible pan-caspase inhibitor. Synonyms: Z VAD(OH) FMK. Grades: 98%. CAS No. 161401-82-7. Molecular formula: C21H28FN3O7. Mole weight: 453.46. | |
| Z-VAD(OMe)-FMK | Z-VAD(OMe)-FMK Inhibitor. Uses: Scientific use. Product Category: T6013. CAS No. 187389-52-2. | |
| Z-VDVAD-FMK | Z-VDVAD-FMK is a cell-permeant and irreversible caspase-2 inhibitor and can inhibits apoptosis in various cell lines. Synonyms: Z-VD(OMe)VAD(OMe)-FMK; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethyl ketone; benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone; L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-|A-aspartyl-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK. Grades: ≥95%. CAS No. 210344-92-6. Molecular formula: C32H46FN5O11. Mole weight: 695.74. | |
| Z-VEID-FMK | Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Z-VE(OMe)ID(OMe)-FMK. CAS No. 210344-96-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1007. | |
| Z-VRPR-FMK trifluoroacetate salt | Z-VRPR-FMK trifluoroacetate salt is an irreversible and cell-permeable MALT1 inhibitor. Z-VRPR-FMK dose-dependently inhibits T cell activation-induced cleavage of Bcl-10. Z-VRPR-FMK reduces NF-κB-dependent gene expression in lymphocytes. Synonyms: Z-Val-Arg-Pro-DL-Arg-FMK. Grades: >90%. Molecular formula: C31H49FN10O6.CF3CO2H. Mole weight: 790.81. | |
| Z-VRPR-FMK (Z-Val-Arg-Pro-DL-Arg-FMK. TFA) | Selective cell permeable and irreversible MALT1 inhibitor. Inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei. Group: Biochemicals. Grades: Purified. CAS No. 1381885-28-4 (free base). Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| Z-YVAD-FMK | Z-YVAD-FMK Inhibitor. Uses: Scientific use. Product Category: TP1466. CAS No. 210344-97-1. | |
| Z-YVAD-FMK | Z-YVAD-FMK is a cell-permeant and irreversible caspase-1 inhibitor with anti-inflammatory activity. Synonyms: Caspase-1 Inhibitor; Z-YVAD fluoromethylketone; Z-YVAD-FMK; Caspase-1 Inhibitor VI; Z-Tyr-Val-Ala-Asp(OMe)-FMK; Z-Tyr-Val-Ala-Asp(OMe)-fluoromethyl ketone; benzyloxycarbonyl-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone; methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-5-(4-hydroxybenzyl)-8-isopropyl-11-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate. Grades: ≥95%. CAS No. 210344-97-1. Molecular formula: C31H39FN4O9. Mole weight: 630.67. | |
| 9-Ethynylphenanthrene | 9-Ethynylphenanthrene. Group: Small molecule semiconductor building blocks. CAS No. 32870-98-7. Product ID: 9-ethynylphenanthrene. Molecular formula: 202.26. Mole weight: C16H10. C#CC1=CC2=CC=CC=C2C3=CC=CC=C31. InChI=1S / C16H10 / c1-2-12-11-13-7-3-4-9-15 (13) 16-10-6-5-8-14 (12) 16 / h1, 3-11H. FMKVRRYQWWPOAL-UHFFFAOYSA-N. >98.0%(GC). |  |
| Bardoxolone | Bardoxolone (RTA 401; CDDO) is a novel nuclear regulatory factor ( NRf-2 ) activator. Bardoxolone is a potent necroptosis inhibitor that inhibits Z-VAD-FMK-induced necroptosis. Bardoxolone methyl enhances the antioxidant system, modulates inflammatory cytokines and inhibits apoptosis in rat kidney, demonstrating inhibition on APAP-induced acute kidney injury (AKI) and analgesic effect. Additionally, Bardoxolone methyl decreases Paclitaxel (PAC) (HY-B0015)-induced mitochondrial damage in neuronal cells. Bardoxolone methyl is promising for the research of chemotherapy-induced neuropathic pain and chronic kidney disease [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CDDO; RTA 401. CAS No. 218600-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14909. | |
| Boc-(3S)-3-amino-4-phenyl-2-butanone | Boc-(3S)-3-amino-4-phenyl-2-butanone. Group: Biochemicals. Alternative Names: Boc-Fmk(3S)-OH. Grades: Highly Purified. CAS No. 85613-64-5. Pack Sizes: 500mg, 1g, 2g, 5g. Molecular Formula: C15H21NO3. US Biological Life Sciences. | Worldwide |
| Caspase-1 Inhibitor VI | Caspase-1 Inhibitor VI, Z-YVAD-FMK, is a potent, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-5 Inhibitor I | Z-WEHD-FMK is a cell-permeable, potent, irreversible caspase-5 inhibitor, that also inhibits the activity of Caspase 1, 4, and 8. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase Inhibitor I - CAS 187389-52-2 | Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase Inhibitor VI - CAS 161401-82-7 | Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies. Group: Fluorescence/luminescence spectroscopy. | |
| CMK | CMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK. Uses: Scientific research. Group: Signaling pathways. CAS No. 821794-90-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-52101. | |
| Dictamine | Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.IC50 value:Target:Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-Methoxyfuro[2,3-b]quinoline. Product Category: Inhibitors. Appearance: Powder. CAS No. 484-29-7. Molecular formula: C12H9NO2. Mole weight: 199.21. Purity: 0.98. IUPACName: 4-Methoxyfuro[2,3-b]quinoline. Canonical SMILES: COC1=C2C=COC2=NC3=CC=CC=C31. Density: 1.19 g/ml. Product ID: ACM484297-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: Dictamina. | |
| EP1013 | EP1013 is a broad-spectrum caspase selective inhibitor with no observed toxicity in rodents, used in the research of type 1 diabetes. Synonyms: EP 1013; EP-1013; (3S) -5-fluoro-3-[[ (2S) -3-methyl-2- (phenylmethoxycarbonylamino) butanoyl]amino]-4-oxopentanoic acid; benzyloxycarbonyl-valyl-aspartic acid fluoromethyl ketone; EP1013; F573 compound; MX1013; N-benzyloxycabonyl-Val Asp-fluoromethyl ketone; Z-VD-FMK; zVD-FMK. CAS No. 223568-55-6. Molecular formula: C18H23FN2O6. Mole weight: 382.38. | |
| Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone | Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable and non-toxic inhibitor that binds irreversibly to activated caspase-3 in apoptotic cells. Synonyms: 6-FAM-D(OMe)E(OMe)VD(OMe)-FMK; L-Valinamide, N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-yl)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[1-(2-fluoroacetyl)-3-methoxy-3-oxopropyl]-, 1,2-dimethyl ester; Methyl (8S,11S,14S)-14-{[(3',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-6-yl)carbonyl]amino}-5-(fluoroacetyl)-8-isopropyl-11-(3-methoxy-3-oxopropyl)-3,7,10,13-tetraoxo-2-oxa-6,9,12-triazahexadecan-16-oate. Grades: ≥95%. CAS No. 1926163-65-6. Molecular formula: C43H45FN4O16. Mole weight: 892.83. | |
| Fluorescein-6-carbonyl-Tyr-Val-Ala-DL-Asp(OMe)-fluoromethylketone | Fluorescein-6-carbonyl-Tyr-Val-Ala-DL-Asp(OMe)-fluoromethylketone is an inhibitor of caspase-1. Synonyms: 6-FAM-YVAD(OMe)-FMK; L-Alaninamide, N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-yl)carbonyl]-L-tyrosyl-L-valyl-N-[1-(2-fluoroacetyl)-3-methoxy-3-oxopropyl]-; N-[(3',6'-Dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-6-yl)carbonyl]-L-tyrosyl-L-valyl-N-(5-fluoro-1-methoxy-1,4-dioxo-3-pentanyl)-L-alaninamide. Grades: ≥90%. CAS No. 1926163-69-0. Molecular formula: C44H43FN4O13. Mole weight: 854.84. | |
| Ivachtin | Ivachtin is a potent and non-competitive caspase-3 inhibitor. It exhibits 10-100 fold selectivity over other caspases and more potent anti-apoptotic activity than Z-VAD-FMK. Synonyms: Caspase-3 Inhibitor VII; 2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate. Grades: 99%. CAS No. 745046-84-8. Molecular formula: C20H21N3O7S. Mole weight: 447.46. | |
| MALT1 Inhibitor I, MI-2 (ALB-H03200218, 2-Chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide) | A cell-permeable chloromethyl amide that inhibits MALT1 proteolytic activity (IC50 = 5.84uM against MALT1 paracaspase domain dimer-catalyzed Ac-LRSR-AMC hydrolysis) in an irreversible manner via covalent interaction, displaying little or no activity against caspase-3, -8, or -9. Due to irreversible binding and effective intracellular accumulation (HBL-1 intracellular [MI-2]t = 2h = 5uM; Medium [MI-2]t = 0 = 0.2uM), MI-2 is at least 250-times more effective than Z-VRPR-FMK in blocking constitutive NF-kappaB activity and c-Rel nuclear translocation in HBL-1 cultures (equal or better blockage by 200nM MI-2 than by 50uM Z-VRPR-FMK). Shown to selectively inhibit MALT1-dependent ABC-DLBCL proliferation, but not the MALT1-independent growths of ABC- (HLY-1 and U2932) or GCB-DLBCL (OCI-Ly1 and OCI-Ly7) cells, both in cultures in vitro (GI50 in 48h = 200, 400, 400, and 500nM, respectively, against HBL-1, OCI-Ly3, OCI-Ly10, and TMD8) and in mice in vivo (65%,, 61%, and 0% suppression, respective Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| N-[ (Phenylmethoxy) carbonyl]-L-valyl-N-[3-fluoro-1- (2-methoxy-2-oxoethyl) -2-oxopropyl]-L-alaninamide | N-[ (Phenylmethoxy) carbonyl]-L-valyl-N-[3-fluoro-1- (2-methoxy-2-oxoethyl) -2-oxopropyl]-L-alaninamide. Group: Biochemicals. Alternative Names: Z-VAD-FMK; Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone. Grades: Highly Purified. CAS No. 634911-81-2. Pack Sizes: 1 mg. Molecular Formula: C22H30FN3O7, Molecular Weight: 467.49. US Biological Life Sciences. | Worldwide |
| Q-VD-OPh (Anhydrous) | Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6- difluorophenoxy methyl (OPh) group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies. CAS Number:1135695-98-5 (anhydrous). Group: Biochemicals. Alternative Names: Q-Val-Asp-OPh; pan-Caspase Inhibitor; N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone, (3S) -5- (2, 6-Difluorophenoxy) -3-[[ (2S) -3-methyl-1-oxo-2-[ (2-quinolinylcarbonyl) amino]butyl]amino]-4-oxo-pentanoic Acid. Grades: Highly Purified. CAS No. 1135695-98-5. Pack Sizes: 1mg, 3x1mg, 5mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. | Worldwide |
| Selepressin | Selepressinis is an agonist of the vasopressin 1A receptor and can be used to treat vasodilatory hypotension in septic shock. Synonyms: Cbz-Phe-Ala-CH2F; Z-FA-fluoromethyl ketone; Zfa-fmk; Z-Phe-Ala-fluoromethyl ketone; benzyloxycarbonyl-Phe-Ala-fluormethylketone; Cathepsin B inhibitor. Grades: ≥95%. CAS No. 876296-47-8. Molecular formula: C21H23FN2O4. Mole weight: 386.42. | |
| Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone | Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone is a cell permeable inhibitor of caspase-8 and granzyme B. The bis-methyl ester of Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone blocks CD95-induced apoptosis. Synonyms: Z-IETD-FMK; Z-IE(OMe)TD(OMe)-FMK; Methyl (5S,8S,11S)-5-[(2S)-2-butanyl]-14-(fluoroacetyl)-11-[(1R)-1-hydroxyethyl]-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate. Grades: ≥95%. CAS No. 1926163-59-8. Molecular formula: C30H43FN4O11. Mole weight: 654.69. | |
| Z-Tyr-Val-Ala-DL-Asp-fluoromethylketone | Z-YVAD-FMK is a cell-permeable potent irreversible inhibitor of caspase-1 and -4. Synonyms: Z-YVAD-FMK. CAS No. 1926163-56-5. Molecular formula: C31H37FN4O10. Mole weight: 616.64. | |
| Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone | Z-VAD-FMK is an irreversible tripeptide inhibitor of all caspases, useful in studies involving enzymes. Synonyms: Z-vad-FMK; N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide; benzyloxycarbonyl-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone. CAS No. 634911-81-2. Molecular formula: C22H30FN3O7. Mole weight: 467.49. | |
| Z-Val-Arg-Pro-DL-Arg-fluoromethylketone | Z-Val-Arg-Pro-DL-Arg-fluoromethylketone, a cell-permeable and irreversible inhibitor of para-caspase MALT1, is based on the sequence of a published optimal tetrapeptide substrate for the A. thaliana metacaspase AtMC9. Synonyms: MALT1 Inhibitor; Z-VRPR-FMK; L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-(2-fluoroacetyl)butyl]-; Cbz-Val-Arg-Pro-DL-Arg-CH2F; N-[(Phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-(2-fluoroacetyl)butyl]-L-prolinamide. Grades: ≥95%. CAS No. 1926163-57-6. Molecular formula: C31H49FN10O6. Mole weight: 676.79. | |
| Z-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-fluoromethylketone | Z-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-fluoromethylketone is a cell-permeable fluoromethylketone that specifically inhibits caspase-2 and, to a lesser extent, caspase-3 and caspase-7. Synonyms: Z-VD(OMe)VAD(OMe)-FMK; Z-VDVA-(DL-Asp)-FMK; Methyl (5S,8S,11S,14S)-17-(fluoroacetyl)-5,11-diisopropyl-8-(2-methoxy-2-oxoethyl)-14-methyl-3,6,9,12,15-pentaoxo-1-phenyl-2-oxa-4,7,10,13,16-pentaazanonadecan-19-oate. Grades: ≥90%. CAS No. 1926163-61-2. Molecular formula: C32H46FN5O11. Mole weight: 695.73. | |
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