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Formononetin is an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen. Group: Biochemicals. Alternative Names: 7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one; 7-Hydroxy-4'-methoxy- isoflavone; 7-Hydroxy-3-(4-methoxyphenyl)chromen-4-one; 7-Hydroxy-4'-methoxyisoflavone; Biochanin B; Daidzein 4'-methyl ether; Flavosil; Formonentin; Formonetin; Formononetol; Myconate; NSC 93360. Grades: Highly Purified. CAS No. 485-72-3. Pack Sizes: 1g. US Biological Life Sciences.
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Formononetin
Formononetin is a potent FGFR2 inhibitor with an IC 50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Biochanin B; Flavosil; Formononetol. CAS No. 485-72-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-N0183.
Formononetin
Formononetin - Product ID: NST-10-17. Category: Flavonoids. Alternative Names: Biochanin B, Daidzein 4'-methyl ether, Flavosil, Formonentin, Formonetin, Formononetol, Myconate, Myconate HB, Mycotech, Neochanin. Purity: 98%. Test method: HPLC. CAS No. 485-72-3. Pack Sizes: 25g, 50g, 125g, 250g. Appearance: White to slightly grey powder. Molecular formula: C16H12O4. Mole weight: 268.26. Storage: +2 +8 °C.
Formononetin-b-D-glucuronide sodium salt is a bioactive derivative originating from formononetin is an isoflavone occurring naturally in numerous plant species. It is used in the research of osteoporosand estrogen-related disorders. Synonyms: 3-(4-Methoxyphenyl)-4-oxo-4H-1-benzopyran-7-yl b-D-glucuronic acid; 7-Hydroxy-4-methoxyisoflavone-7-O-b-D-glucuronide; Formononetin-7-O-Glucuronide; Biochanin B-7-O-b-D-glucuronide. CAS No. 18524-03-3. Molecular formula: C22H19O10Na. Mole weight: 466.37.
Sodium formononetin-3(acute)-sulfonate
Sodium formononetin-3'-sulfonate is a water-sol. derivate of formononetin. It has a protective potential against myocardial infarction injury. It not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities. Synonyms: Sul-F. Grades: >98%. CAS No. 949021-68-5. Molecular formula: C16H11NaO7S. Mole weight: 370.31.
Specifically methylates 2,4',7-trihydroxyisoflavanone on the 4'-position. No activity with isoflavones. The enzyme is involved in formononetin biosynthesis in legumes. The protein from pea (Pisum sativum) also methylates (+)-6a-hydroxymaackiain at the 3-position (cf. EC 2.1.1.270, (+)-6a-hydroxymaackiain 3-O-methyltransferase). Group: Enzymes. Synonyms: SAM:2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase; HI4'OMT; HMM1; MtIOMT5; S-adenosyl-L-methionine:2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase. Enzyme Commission Number: EC 2.1.1.212. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1814; 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase; EC 2.1.1.212; SAM:2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase; HI4'OMT; HMM1; MtIOMT5; S-adenosyl-L-methionine:2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase. Cat No: EXWM-1814.
4'-methoxyisoflavone 2'-hydroxylase
A heme-thiolate protein (P-450). Acts on isoflavones with a 4'-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC 1.14.13.89, isoflavone 2'-hydroxylase, is less specific and acts on other isoflavones as well as 4'-methoxyisoflavones. Group: Enzymes. Synonyms: isoflavone 2'-monooxygenase (ambiguous); isoflavone 2'-hydroxylase (ambiguous). Enzyme Commission Number: EC 1.14.13.53. CAS No. 110183-49-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0860; 4'-methoxyisoflavone 2'-hydroxylase; EC 1.14.13.53; 110183-49-8; isoflavone 2'-monooxygenase (ambiguous); isoflavone 2'-hydroxylase (ambiguous). Cat No: EXWM-0860.
isoflavone 2'-hydroxylase
A heme-thiolate protein (P-450). Acts on daidzein, formononetin and genistein. EC 1.14.13.53, 4'-methoxyisoflavone 2'-hydroxylase, has the same reaction but is more specific as it requires a 4'-methoxyisoflavone. Group: Enzymes. Synonyms: isoflavone 2'-monooxygenase; CYP81E1; CYP Ge-3. Enzyme Commission Number: EC 1.14.13.89. CAS No. 110183-49-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0897; isoflavone 2'-hydroxylase; EC 1.14.13.89; 110183-49-8; isoflavone 2'-monooxygenase; CYP81E1; CYP Ge-3. Cat No: EXWM-0897.
The 6-position of the glucose residue of formononetin can also act as acceptor; some other 7-O-glucosides of isoflavones, flavones and flavonols can also act, but more slowly. Group: Enzymes. Synonyms: flavone/flavonol 7-O-β-D-glucoside malonyltransferase; flavone (flavonol) 7-O-glycoside malonyltransferase; malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase; MAT-7; malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase; malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase. Enzyme Commission Number: EC 2.3.1.115. CAS No. 93585-97-8, 78413-09-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2054; isoflavone-7-O-β-glucoside 6''-O-malonyltransferase; EC 2.3.1.115; 93585-97-8, 78413-09-9; flavone/flavonol 7-O-β-D-glucoside malonyltransferase; flavone (flavonol) 7-O-glycoside malonyltransferase; malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase; MAT-7; malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase; malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase. Cat No: EXWM-2054.
isoflavone 7-O-glucosyltransferase
The 4'-methoxy isoflavones biochanin A and formononetin and, more slowly, the 4'-hydroxyisoflavones genistein and daidzein, can act as acceptors. The enzyme does not act on isoflavanones, flavones, flavanones, flavanols or coumarins. Group: Enzymes. Synonyms: uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase; UDPglucose-favonoid 7-O-glucosyltransferase; UDPglucose:isoflavone 7-O-glucosyltransferase. Enzyme Commission Number: EC 2.4.1.170. CAS No. 97089-62-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2395; isoflavone 7-O-glucosyltransferase; EC 2.4.1.170; 97089-62-8; uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase; UDPglucose-favonoid 7-O-glucosyltransferase; UDPglucose:isoflavone 7-O-glucosyltransferase. Cat No: EXWM-2395.
Ononin
Ononin is an orally active isoflavone. Ononin inhibits the ERK/JNK/p38 and PI3K/Akt/mTOR pathways. Ononin regulates Apoptosis. Ononin has anti-tumor effects on laryngeal cancer and lung cancer. Ononin has neuroprotective effects. Ononin alleviates endoplasmic reticulum stress and diabetic nephropathy [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. Alternative Names: Ononoside; Formononetin 7-O-β-D-glucopyranoside. CAS No. 486-62-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0270.
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