Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Fumagillin | Fumagillin is a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an an anti-infective and antiangiogenic agent. Group: Biochemicals. Alternative Names: Methionine aminopeptidase-2 Inhibitor; (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3- (3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8- decatetraenedioic acid ester. Grades: Highly Purified. CAS No. 23110-15-8. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C26H34O7, Molecular Weight: 458.54. US Biological Life Sciences. |  Worldwide |
| Fumagillin | Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV-1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: NSC9168; NSC 9168; NSC-9168; Fumidil B; Fumagillin, trade name: Fumagilina; Fugillin; Fumidil. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 23110-15-8. Molecular formula: C26H34O7. Mole weight: 458.55 g/mol. Purity: ≥98%. IUPACName: (2E,4E,6E,8E)-10-(((3R,4S,5S,6R)-5-methoxy-4-((2R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl)oxy)-10-oxodeca-2,4,6,8-tetraenoic acid. Canonical SMILES: O=C(O)/C=C/C=C/C=C/C=C/C(O[C@H](CC1)[C@@H](OC)[C@H]([C@@]2(C)OC2C/C=C(C)\C)[C@]31CO3)=O. Product ID: ACM23110158. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Fumagillin | Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV?1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity. Uses: Scientific research. Group: Natural products. Alternative Names: Amebacilin; NSC9168. CAS No. 23110-15-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-B0751. |  |
| Fumagillin from Aspergillus fumigatus | ?90%, powder. Group: Fluorescence/luminescence spectroscopy. |  |
| cis-Fumagillin methyl ester | Cis-Fumagillin methyl ester is originally isolated from Penicillum sp. F2757. It inhibits the MetAP2 and MetAPI with IC50 of 6.3nmol/L and <200nmol/L, respectively. Molecular formula: C27H36O7. Mole weight: 472.57. |  |
| Beloranib | Beloranib is a fumagillin-class methionine aminopetidase-2 (MetAP2) inhibitor. Beloranib decreases food intake, body weight, fat mass, and the size of adipocytes [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZGN-440; CKD-732 free base. CAS No. 251111-30-5. Pack Sizes: 1 mg. Product ID: HY-14811. | |
| Beloranib Hemioxalate | Beloranib Hemioxalate is the acidic form of beloranib , which is an analog of the natural chemical compound fumagillin and is an experimental injectable drug candidate for the treatment of obesity. Synonyms: CKD 732; (2E)-(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl Ester 3-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-propenoic Acid Ethanedioate (2:1). Grades: > 95%. CAS No. 529511-79-3. Molecular formula: C30H42NO8. Mole weight: 544.67. | |
| Fumagillol | Fumagillol is an analog of Fumagillin (F862650), a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an an anti-infective and antiangiogenic agent. Group: Biochemicals. Alternative Names: (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]octan-6-ol; (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]octan-6-ol; [3R-[3α, 4α(2R*, 3R*), 5 β,6 β]]-5-Methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]octan-6-ol; (-)-Fumagillol; FOS 37. Grades: Highly Purified. CAS No. 108102-51-8. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C??H??O?, Molecular Weight: 282.38. US Biological Life Sciences. | Worldwide |
| Fumagillol | Fumagillol is a precursor of Fumagillin, which is an antimicrobial agent used for the treatment of microsporidiosis. Fumagillol also exhibits anti-infective and antiangiogenic effects. Synonyms: 1-Oxaspiro[2.5]octan-6-ol, 5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-, (3R,4S,5S,6R)-; (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]octan-6-ol; 1-Oxaspiro[2.5]octan-6-ol, 5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-, (3R,4S,5S,6R)-; 1-Oxaspiro[2.5]octan-6-ol, 5-methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-, [3R-[3α, 4α(2R*, 3R*), 5β, 6β]]-; (-)-Fumagillol; FOS 37; Gelcohol. Grades: 90%. CAS No. 108102-51-8. Molecular formula: C16H26O4. Mole weight: 282.38. | |
| Phortress | Phortress, a lysyl amide prodrug of the benzothiazole 5-fluoro 203, is an apoptosis stimulant potentially for the treatment of solid tumours. Phortress had no effect on HUVEC and MRCV cell proliferation and survival. Unlike paclitaxel and fumagillin, Phortress did not inhibit endothelial tube differentiation. Synonyms: (2S)-2,6-Diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]hexanamide dihydrochloride; Phortress; NSC 710305; NSC710305; NSC-710305; 5F-DF-203-L-lysinamide; 5FDF 203Llysinamide. Grades: ≥98% by HPLC. CAS No. 328087-38-3. Molecular formula: C20H23FN4OS.2HCl. Mole weight: 459.41. | |
| PPI-2458 | PPI-2458 is a synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class. Synonyms: PPI 2458; PPI2458; Metapro; NSC-720735. CAS No. 431077-35-9. Molecular formula: C22H36N2O6. Mole weight: 424.54. | |
| TNP-470 | TNP-470 is an analog of fumagillin, an antimicrobial agent isolated from the fungus Aspergillus fumigatus. TNP-470 was shown to inhibit angiogenesis, and irreversibly suppress methionine aminopeptidase-2 (MetAP2). Uses: Angiogenesis inhibitors. Synonyms: AGM-1470; O-(Chloroacetyl-carbamoyl) Fumagillol; NSC 642492. Grades: ≥98%. CAS No. 129298-91-5. Molecular formula: C19H28ClNO6. Mole weight: 401.9. | |
| TNP-470 (AGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470) | A cell-permeable Fumagillin analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50 = 1nM against human MetAP2), without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2alpha phosphorylation. A potent endothelial cytostasis inducer (IC50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC) in vitro and an effective anti-angiogenesis agent in vivo (2-100mg/kg in mice and rats; s.c.). Group: Biochemicals. Grades: Highly Purified. CAS No. 129298-91-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| XMT-1107 | XMT-1107 is a polymeric prodrug consisting of the fumagillol-derived small molecule XMT-1191 tethered to the hydrophilic, biodegradable70 kDa polymer poly[1- hydroxymethylethylene hydroxymethylformal] (PHF) with potential antiangiogenic and antineoplastic activities. Upon administration, fumagillin-derived polymer conjugate XMT-1107 releases XMT-1191, which may inhibit angiogenesis through the irreversible inhibition of the methionine aminopeptidase 2 (METAP2); although the exact mechanism of action has yet to be fully elucidated, this agent appears to induce cell cycle arrest in endothelial cells, inhibiting their proliferation and migration. Compared to an unconjugated fumagillin analog, XMT-1107 exhibits improved solubility and an extended half life due to its PHF backbone. METAP2, a member of the methionyl aminopeptidase family, binds two cobalt or manganese ions and protects the alpha subunit of eukaryotic initiation factor 2 (EIF2) from inhibitory phosphorylation by removing the amino-terminal methionine residue from nascent protein; this aminopeptidase may be overexpressed in a variety of tumor cell types. Synonyms: XMT-1107; XMT1107; XMT 1107; A poly(1-hydroxymethylethylene hydroxymethylformal) (Fleximer)-fumagillol conjugate. CAS No. 1252797-29-7. | |
Our database is helping our users find suppliers everyday.
