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| Product | Description | |
|---|---|---|
| 5-hydroxyfuranocoumarin 5-O-methyltransferase | Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities. The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin, but has little activity on non-coumarin phenols. Caffeate, 5-hydroxyferulate and daphnetin are not substrates. Cu2+, Zn2+ and Co2+ cause enzyme inhibition. (see also EC 2.1.1.70, 8-hydroxyfuranocoumarin 8-O-methyltransferase). Group: Enzymes. Synonyms: furanocoumarin 5-methyltransferase; furanocoumarin 5-O-methyltransferase; bergaptol 5-O-methyltransferase; bergaptol O-methyltransferase; bergaptol methyltransferase; S-adenosyl-L-methionine:bergaptol O-methyltransferas. Enzyme Commission Number: EC 2.1.1.69. CAS No. 67339-12-2, 101637-31-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1970; 5-hydroxyfuranocoumarin 5-O-methyltransferase; EC 2.1.1.69; 67339-12-2, 101637-31-4; furanocoumarin 5-methyltransferase; furanocoumarin 5-O-methyltransferase; bergaptol 5-O-methyltransferase; bergaptol O-methyltransferase; bergaptol methyltransferase; S-adenosyl-L-methionine:bergaptol O-methyltransferase; BMT; S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase. Cat No: EXWM-1970. |  |
| 8-hydroxyfuranocoumarin 8-O-methyltransferase | Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase). Group: Enzymes. Synonyms: furanocoumarin 8-methyltransferase; furanocoumarin 8-O-methyl-transferase; xanthotoxol 8-O-methyltransferase; XMT; 8-hydroxyfuranocoumarin 8-O-methyltransferase; SAM:xanthotoxol O-methyltransferase; S-adenosyl-L-methionine:8-hydroxyfuranoco. Enzyme Commission Number: EC 2.1.1.70. CAS No. 67339-13-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1972; 8-hydroxyfuranocoumarin 8-O-methyltransferase; EC 2.1.1.70; 67339-13-3; furanocoumarin 8-methyltransferase; furanocoumarin 8-O-methyl-transferase; xanthotoxol 8-O-methyltransferase; XMT; 8-hydroxyfuranocoumarin 8-O-methyltransferase; SAM:xanthotoxol O-methyltransferase; S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase; xanthotoxol methyltransferase; xanthotoxol O-methyltransferase; S-adenosyl-L-methionine:xanthotoxol O-methyltransferase; S-adenosyl-L-methionine-xanthotoxol O-methyltransferase. Cat No: EXWM-1972. | |
| 6',7'-Dihydroxybergamottin | 6',7'-Dihydroxybergamottin (6,7-DHB), a furanocoumarin, is a potent CYP3A4 inhibitor [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 6,7-DHB. CAS No. 145414-76-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N8354. |  |
| 6',7'-Epoxybergamottin | 6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. Synonyms: Epoxybergamottin; 4-[(E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-enoxy]furo[3,2-g]chromen-7-one. Grades: ≥98%. CAS No. 206978-14-5. Molecular formula: C21H22O5. Mole weight: 354.4. |  |
| Angelicin | Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression ( IC 50 =28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB , and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2 , Bcl-xL , and Mcl-1 , while activating caspase-9 and caspase-3. Uses: Scientific research. Group: Natural products. Alternative Names: Isopsoralen. CAS No. 523-50-2. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-N0763. | |
| angelicin synthase | This P-450 monooxygenase enzyme is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'. Group: Enzymes. Synonyms: CYP71AJ4 (gene name). Enzyme Commission Number: EC 1.14.13.115. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0715; angelicin synthase; EC 1.14.13.115; CYP71AJ4 (gene name). Cat No: EXWM-0715. | |
| Bergamottin | Bergamottin (5-geranoxypsoralen) is a natural furanocoumarin found in the pulp of pomelos and grapefruits. It is also found in the peel and pulp of the bergamot orange, from which it was first isolated and from which its name is derived. It shows antiproliferative activity against HepG2 liver, HL-60 leukemia, and BGC-823 gastric cancer cell lines in a dose-dependent manner and induces cell death of CHO cells following near ultraviolet irradiation. Bergamottin inhibits the cytochrome P450 isoform 3A4 with Ki of 7.7 μM and is a mixed inhibitor of simvastatin drug metabolism with Ki of 174 μM. It also increases glucose consumption in HepG2 cells in a dose-dependent manner. Synonyms: 5-Geranoxypsoralen; Bergamottin. Grades: ≥98%. CAS No. 7380-40-7. Molecular formula: C21H22O4. Mole weight: 338.4. | |
| Bergapten | Grayish-white microcrystalline powder or yellow fluffy solid. (NTP, 1992);Solid. Group: Organic & printed electronics. Alternative Names: 2-g)(1)benzopyran-7-one,4-methoxy-7h-furo(;4-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one;4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one;4-Methoxy-7H-furo[3,2-g]chromen-7-one;4-Methoxy-furo[3,2-g]chromen-7-one;5-Methoxy-6,7-furanocoumarin;6-Hydroxy-4-methoxy-5-. CAS No. 484-20-8. Molecular formula: C12H8O4. Mole weight: 216.19. IUPACName: 4-methoxyfuro[3,2-g]chromen-7-one. Canonical SMILES: COC1=C2C=CC(=O)OC2=CC3=C1C=CO3. ECNumber: 207-604-5. Catalog: ACM484208. |  |
| Bergapten | Grayish-white microcrystalline powder or yellow fluffy solid. (NTP, 1992);Solid. Group: other materials. Alternative Names: 2-g)(1)benzopyran-7-one,4-methoxy-7h-furo(; 4-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one; 4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one; 4-Methoxy-7H-furo[3,2-g]chromen-7-one; 4-Methoxy-furo[3,2-g]chromen-7-one; 5-Methoxy-6,7-furanocoumarin; 6-Hydroxy-4-methoxy-5-. CAS No. 484-20-8. Product ID: 4-methoxyfuro[3,2-g]chromen-7-one. Molecular formula: 216.19. Mole weight: C12H8O4. COC1=C2C=CC(=O)OC2=CC3=C1C=CO3. InChI=1S/C12H8O4/c1-14-12-7-2-3-11 (13)16-10 (7)6-9-8 (12)4-5-15-9/h2-6H, 1H3. BGEBZHIAGXMEMV-UHFFFAOYSA-N. |  |
| Bergaptol | A hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 and 42.93 μM, respectively. Recent studies suggest that it may have antiproliferative and anticancer properties. Group: Biochemicals. Alternative Names: 4-Hydroxy-7H-furo[3,2-g][1]benzopyran-7-one; 4-Hydroxybergapten; 5-Hydroxy-6,7-furanocoumarin; 5-Hydroxypsoralen; NSC 341958. Grades: Highly Purified. CAS No. 486-60-2. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| Byakangelicol | Byakangelicol is a furanocoumarin derivative which shows inhibitory effects against P-glycoprotein at the blood-brain barrier. It acts as an anti-proliferative agent causing G2/M arrest in melanoma cells. Synonyms: (R)-(+)-9-(2,3-Epoxy-3-methylbutoxy)-4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one. Grades: >98%. CAS No. 26091-79-2. Molecular formula: C17H16O6. Mole weight: 316.3. | |
| Imperatorin (Pentosalen, Marmelosin, Ammidin, NSC 402949, BAN) | A furanocoumarin isolated from Opopanax chironium L. Displays anticancer properties. It induces apoptosis as well as DNA fragmentation at the G1/S phase of the cell cycle. Imperatorin sensitizes anoikis and inhibits anchorage-independent growth of lung cancer cells. Modulator of SMAD1/5/8, p38, ERK pathways. Also acts as a L-type calcium channel blocker. Group: Biochemicals. Alternative Names: 9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one. Grades: Highly Purified. CAS No. 482-44-0. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| (±)-Marmesin | (±)-Marmesin is a good precursor of the linear furanocoumarins. (±)-Marmesin derivatives have high degree of acetylcholinesterase inhibitory property [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 13710-70-8. Pack Sizes: 1 mg. Product ID: HY-N2176A. | |
| Methoxsalen | Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor. Uses: Scientific research. Group: Natural products. Alternative Names: 8-Methoxypsoralen; Xanthotoxin; 8-MOP. CAS No. 298-81-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-30151. | |
| nicotinate N-methyltransferase | This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:nicotinate N-methyltransferase. Other names in common use include furanocoumarin 8-methyltransferase, and furanocoumarin 8-O-methyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism. Group: Enzymes. Synonyms: furanocoumarin 8-methyltransferase; furanocoumarin 8-O-methyltransferase. Enzyme Commission Number: EC 2.1.1.7. CAS No. 9029-79-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1971; nicotinate N-methyltransferase; EC 2.1.1.7; 9029-79-2; furanocoumarin 8-methyltransferase; furanocoumarin 8-O-methyltransferase. Cat No: EXWM-1971. | |
| Periplogenin | Periplogenin is a naturally occurring furanocoumarin found in Angelica dahurica roots, with potent anti-psoriatic effects. Periplogenin induces adipocyte differentiation [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 514-39-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N2414. | |
| Phellopterin | A naturally occurring furanocoumarin found in roots of Angelica dahurica and in Seseli elatum. Inhibitor of insect cytochromes P 450. Strongly inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro. Activate adrenaline-induced lipolysis and activate ACTH-induced lipolysis. Group: Biochemicals. Alternative Names: 7H-Furo(3,2-g)[1]benzopyran-7-one,4-methoxy-9-[(3-methyl-2-butenyl)oxy]; 5-Benzofuranacrylic acid, 6-hydroxy-4-methoxy-7-[(3-methyl-2-butenyl)oxy]-, g-lactone (7CI); 7H-Furo[3,2-g][1]benzopyran-7-one, 4-methoxy-9-[(3-methyl-2-butenyl)oxy]- (8CI,9CI); (5-Methoxy-8)-g, g-dimethylallyloxy(2', 3', 6, 7-furanocoumarin). CAS No. 2543-94-4. Pack Sizes: 5mg. Molecular Formula: C17H16O5, Molecular Weight: 300.31. US Biological Life Sciences. | Worldwide |
| psoralen synthase | This microsomal cytochrome P-450-dependent enzyme is specific for (+)-marmesin, and to a much lesser extent 5-hydroxymarmesin, as substrate. Furanocoumarins protect plants from fungal invasion and herbivore attack. (+)-Columbianetin, the angular furanocoumarin analogue of the linear furanocoumarin (+)-marmesin, is not a substrate for the enzyme but it is a competitive inhibitor. Group: Enzymes. Synonyms: CYP71AJ1. Enzyme Commission Number: EC 1.14.13.102. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0701; psoralen synthase; EC 1.14.13.102; CYP71AJ1. Cat No: EXWM-0701. | |
| Visnagin | Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 82-57-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N1082. | |
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