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| Product | Description | |
|---|---|---|
| (2-cyanoethyl) (2,2-bis(ethoxycarbonyl)-3-(4,4'-dimethoxytrityloxy)propyl-1) N,N-diisopropylphosphoramidite | N,N-diisopropylphosphoramidite, a catalytic compound, is an essential building block for oligonucleotide synthesis used in various therapeutic domains such as antisense therapy, siRNA, and gene editing. This efficient and highly pure chemical ensures the production of top-quality therapeutic oligonucleotides. Synonyms: Chemical phosphorylation reagent for oligonucleotide synthesis;Propanedioic acid, [[bis (4-methoxyphenyl) phenylmethoxy]methyl][[[[bis (1-methylethyl) amino] (2-cyanoethoxy)phosphino]oxy]methyl]-, diethyl ester; CP?; CPRII; 2-[ (4, 4'-Dimethoxytrityloxy) methyl]-2-[[ (diisopropylamino) (2-cyanoethoxy) phosphinooxy]methyl]malonic acid diethyl ester; Diethyl {[bis (4-methoxyphenyl) (phenyl) methoxy]methyl} ({[ (2-cyanoethoxy) (diisopropylamino) phosphino]oxy}methyl) malonate. Grades: ≥97% by HPLC. CAS No. 171285-25-9. Molecular formula: C39H51N2O9P. Mole weight: 722.80. |  |
| 3'-Amino-Modifier C6 dT CPG | Featuring a C6 modifier fused to deoxythymidine, 3'-Amino-Modifier C6 dT CPG stands as a steadfast solid support for the synthesis of oligonucleotides. Esteemed for its prowess in crafting modified oligonucleotides, this novel construct reigns supreme in the realms of gene editing, siRNA research, and antisense therapy. Synonyms: 5'-Dimethoxytrityl-5-[N-(trifluoroacetylaminohexyl)-3-acrylimido]-2'-deoxyUridine, 3'-succinoyl-long chain alkylamino-CPG. | |
| 4-Thio-ethyl-UTP | 4-Thio-ethyl-UTP, a compound extensively utilized in biomedical research, particularly in the field of RNA splicing and editing, is an immensely versatile alternative substrate to UTP, especially when investigating the function of RNA editing enzymes. Its exclusive selectivity for specific RNA sequences further enhances its usefulness, rendering it an essential tool for studying cancer and genetic disorders. Synonyms: 4-Thio-ethyl-uridine-5'-triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C11H19N2O14P3S (free acid). Mole weight: 528.26 (free acid). | |
| 4'-Thiouridine | 4'-Thiouridine is a nucleoside analogue employed in the biomedical sector for investigative endeavors, predominantly within nucleic acid examinations. Its assimilation into RNA molecules facilitates the exploration of RNA's intricate framework and its inherent functionalities. Research elucidating RNA editing mechanisms and the ramifications of nucleoside modifications on genetic expression finds immense utility in this compound. Synonyms: 1-(4-Thio-beta-D-ribofuranosyl)uracil; Uridine, 4'-thio-; 4'-O-Thiauridine; 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl)pyrimidine-2,4(1H,3H)-dione. Grades: ≥95%. CAS No. 6741-73-7. Molecular formula: C9H12N2O5S. Mole weight: 260.27. | |
| 5'-Aldehyde-Modifier C2 Phosphoramidite | 5'-Aldehyde-Modifier C2 Phosphoramidite, an essential reagent for bioconjugation and labeling of oligonucleotides, is an attractive option for introducing aldehydes into DNA strands in a site-selective and efficient manner. With its potential applications in gene editing, diagnostics, and drug discovery, this product provides researchers with a versatile tool for developing advanced therapies. The wide range of possibilities provided by this reagent sets it apart from other options on the market, making it an essential component in any research lab dealing with DNA analyses. Synonyms: 2-[4-(5,5-Diethyl-1,3-dioxan-2-yl)phenoxy]ethan-1-yl-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. CAS No. 433684-36-7. Molecular formula: C25H41N2O5P. Mole weight: 480.58. | |
| Cas9-C-NLS Nuclease | Cas9-C-NLS Nuclease. Cas9-c-nls nuclease is the recombinant streptococcus pyogenes cas9 (wt) protein with a c-terminal nucleic localization signal (nls). it can be used for genome editing by inducing site-specific dna double stranded breaks. cas9 protein forms a very stable ribonucleoprotein (rnp) complex with the guide rna (grna) component of the crispr/cas9 system, which can localize to the nucleus immediately once entering the cell with the guide of the nls. compared with the mrna or plasmid systems, transcription and translation processes are not required. this dna-free system avoids the risk of inserting foreign dna into the genome, which can be quite useful for gene editing-based disease therapy. our highly pure and active cas9 nuclease meets all of the researchers requirements (e.g. in vitro cleavage assay, rnp complex transfection, micro injection). Group: Cloning Enzymes. Purity: 50μg; 100μg. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol PH 7.4 at 25°C. Cat No: CE-3502. |  |
| Cas9-N-NLS Nuclease | Cas9-N-NLS Nuclease. Cas9-n-nls nuclease is the recombinant streptococcus pyogenes cas9 (wt) protein with a n-terminal nucleic localization signal (nls) that can be used for genome editing by inducing site-specific dna double stranded breaks. cas9 protein forms a very stable ribonucleoprotein (rnp) complex with the guide rna (grna) component of the crispr/cas9 system, which can localize to the nucleus immediately once entering the cell with the guide of the nls. compared with the mrna or plasmid systems, transcription and translation processes are not required. this dna-free system avoids the risk of inserting foreign dna into the genome, which can be quite useful for gene editing-based disease therapy. our highly pure and active cas9 nuclease meets all of the researcher´s requirements (e.g. in vitro cleavage assay, rnp complex transfection, micro injection). Group: Cloning Enzymes. Purity: 50μg; 100μg. Storage: Store all components at -20 ?. Source: E.coli. Cat No: CE-3503. | |
| Cas9 Nuclease | Cas9 Nuclease. Recombinant streptococcus pyogenes cas9 (wt) nuclease is purified from e. coli.it can be used for genome editing by inducing site-specific double stranded breaks in double stranded dna. cas9 protein forms a very stable ribonucleoprotein (rnp) complex with the guide rna (grna) component of the crispr/cas9 system. the rnp complex recognizes the target site by matching grna with the genomic dna sequence and leads to dna breaks within 3 bases from the ngg pam (protospacer adjacent motif). with gencrispr cas9 nuclease, customers can screen highly efficient grna using in vitro dna cleavage assays. it could be a powerful tool for gene editing. Group: Cloning Enzymes. Purity: 10μg; 50μg. Storage: Store at -20 ?. Source: E.coli. Cat No: CE-3501. | |
| dNaM | dNaM is a synthetic biology tool used in genetic research for nucleotide modification. It allows for the creation of synthetic sequence-specific DNA-binding proteins for gene regulation and therapy. It has potential applications in treating genetic disorders and diseases like cancer through targeted gene editing. Grades: ≥ 97%. CAS No. 1117893-19-2. Molecular formula: C16H18O7. Mole weight: 274.31. | |
| dP-CE Phosphoramidite | dP-CE Phosphoramidite is a chemical compound widely used in the production of nucleic acid sequences for biomedical research. It is typically used as a building block for the synthesis of modified DNA or RNA that can be used for various applications including gene editing, drug development, and disease diagnosis. Its unique chemical properties make it highly efficient in the synthesis of oligonucleotides with enhanced binding affinity, specificity, and stability towards specific drugs or targets. Synonyms: 6H,8H-3,4-dihydro-pyrimido[4,5-c][1,2]oxazin-7-one, 8-[(5'-dimethoxytrityl-ß-D-deoxyribofuranosyl), 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C41H50N5O8P. Mole weight: 771.85. | |
| Mutation Detection Kit | Mutation Detection Kit. Mutation detection kit provides a simple, reliable, and rapid method for the detection of site specific cleavage of genomic dna that is extracted from cells transfected with constructs expressing engineered nucleases such as transcription activator-like effector nucleases (talen), clustered regularly interspaced short palindromic repeats (crispr)/cas9, or zinc-finger nucleases (zfn). mutation detection kit includes high-fidelity dna polymerase for amplifying the target regions from cells, and t7 endonuclease i for recognizing and detecting the mismatches caused by gene editing tools. it provides an easy and reliable approach for estimating the efficiency of genome editing. components. high-fidelity dna polymerase. 5x pcr reaction buffer. t7 endonuclease i. 10x gencrispr t7 endonuclease i reaction buffer. control template dna. control primer mix. protease k. dntp. Group: Cloning Enzymes. Purity: 25 reactions/kit. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol pH7.4, at 25°C. Cat No: CE-3508. | |
| N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-5-methylcytosine 3'-CE phosphoramidite | N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-5-methylcytosine 3'-CE phosphoramidite is a synthetic nucleoside analog that finds use in the synthesis of oligonucleotides. Its multifarious applications range from treating cancer, viral infections, to genetic disorders. Beyond that, its unique properties make it a sought-after research tool in the fields of genome editing and gene therapy. Molecular formula: C47H53FN5O8P. Mole weight: 865.95. | |
| N6-Benzoyl-5'-O-benzyl-2'-O-tert-butyldimethylsilyladenosine 3'-CE phosphoramidite | N6-Benzoyl-5'-O-benzyl-2'-O-tert-butyldimethylsilyladenosine 3'-CE phosphoramidite is a crucial compound used in biomedicine. It is primarily employed for synthesizing modified RNA molecules necessary for various research purposes, especially in the field of gene editing and RNA therapeutics. This product plays a significant role in the development of potential treatments for genetic disorders, RNA-based vaccines, and RNA interference-based therapies. Synonyms: N6-Benzoyl-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-D-adenosine 3'-CE phosphoramidite. Molecular formula: C39H54N7O6PSi. Mole weight: 775.97. | |
| NLS-Cas9-NLS Nuclease | NLS-Cas9-NLS Nuclease. Nls-cas9-nls is produced by expression in an e. coli strain carrying a plasmid encoding the cas9 gene from streptococcus pyogenes with a double-ends nuclear localization signal (nls). it can be used for genome editing by inducing site-specific dna double stranded breaks. cas9 protein forms a very stable ribonucleoprotein (rnp) complex with the guide rna (grna) component of the crispr/cas9 system, which can localize to the nucleus immediately once entering the cell with the guide of the nls. compared with the mrna or plasmid systems, transcription and translation processes are not required. this dna-free system avoids the risk of inserting foreign dna into the genome, which can be quite useful for gene editing-based disease therapy. our highly pure and active cas9 nuclease meets all of the researcher´s requirements (e.g. in vitro cleavage assay, rnp complex transfection, micro injection). Group: Cloning Enzymes. Purity: 50μg; 100μg. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol pH7.4 at 25?. Cat No: CE-3504. | |
| Pseudoisocytidine-5'-Triphosphate | Pseudoisocytidine-5'-Triphosphate (PIC-TP), a fascinating and versatile nucleotide analog, serves as a crucial tool for RNA editing researchers. Acting as a substrate for TUTases, it enables the creation of functional 3'-terminal uridine residues in RNA. PIC-TP's potential therapeutic applications for viral infections and genetic diseases continue to be the focus of intense scientific investigation. Its unique properties and potential for reshaping RNA's structure demand continued exploration and scholarly research. Grades: ≥90% by AX-HPLC. Molecular formula: C9H16N3O14P3. Mole weight: 483.1. | |
| sgRNA Synthesis Kit | sgRNA Synthesis Kit. This product is designed to synthesize grnas in vitro. in the bacterial crispr/cas9 system, the cas9 nuclease associates with two rnas, the crispr rna (crrna) and the trans-activating crrna (tracrrna), to direct sequence-specific dna cleavage. the grna (guide rna) is a fusion of the natural crrna and tracrrna components. it contains an 18-20 base variable sequence that can be changed to target any dna sequence that is adjacent to an ngg proto-spacer adjacent motif (pam) on the 3 end of the target sequence. the sgrna synthesis kit allows user to fuse their choice of 18-20 base target sequence within the grna dna sequence provided, by pcr fusion. the kit also provides materials for in-vitro transcription of the generated grna dna in order to generate grnas which can be directly used for in-vivo genome editing. Group: Cloning Enzymes. Purity: 20 reactions/kit. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol PH 7.4, at 25°C. Cat No: CE-3510. | |
| tCnitro-CE Phosphoramidite | tCnitro-CE Phosphoramidite, a reagent vital for the synthesis of oligonucleotides, features a promising nitro group situated at the 5'-end capable of introducing a modification or label. Its applications in nucleic acid-based technologies like gene editing and diagnostics research remain unparalleled. Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-1'-(7-nitro-1,3-diaza-2-oxophenothiazin-1-yl)-2'-deoxy-ß-D-ribofuranosyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C45H49N6O9PS. Mole weight: 880.94. | |
| (Z)-4-Hydroxytamoxifen | (Z)-4-Hydroxytamoxifen is a metabolite of Tamoxifen and acts as an estrogen receptor antagonist. It exhibits more than 100-fold affinity over Tamoxifen. (Z)-4-Hydroxytamoxifen also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing. Synonyms: Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-; 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol; Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-; Phenol, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-, (Z)-; (Z)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-en-1-yl]phenol; 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; 4-Hydroxy-(Z)-tamoxifen; 4-Hydroxytamoxifen; Hydroxytamoxifen; ICI 79280; trans-4-Hydroxytamoxifen; trans-Hydroxytamoxifen. Grades: ≥98% by HPLC. CAS No. 68047-06-3. Molecular formula: C26H29NO2. Mole weight: 387.51. | |
| (Z)-4-Hydroxytamoxifen | (Z)-4-Hydroxy Tamoxifen is a metabolite of Tamoxifen. (Z)-4-Hydroxy Tamoxifen is a hydroxylated analogue of Tamoxifen. (Z)-4-Hydroxy Tamoxifen is a metabolite of Tamoxifen with anti-estrogenic properties. Estrogen receptor modulator. Activates intein-linked inactive Cas9 to reduce off target effects of CRISPR-mediated gene editing. Group: Biochemicals. Alternative Names: 4-[ (1Z) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; 4-Hydroxy-(Z)-tamoxifen; 4-Hydroxytamoxifen; Hydroxytamoxifen; ICI 79280. Grades: Highly Purified. CAS No. 68047-06-3. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C26H29NO2, Molecular Weight: 387.51. US Biological Life Sciences. |  Worldwide |
| Bacillus Coagulans Freeze Dried Powder | Bacillus coagulans is a lactic acid-forming bacterial species. The organism was first isolated and described as Bacillus coagulans in 1915 by B.W. Hammer at the Iowa Agricultural Experiment Station as a cause of an outbreak of coagulation in evaporated milk packed by an Iowa condensary. Separately isolated in 1935 and described as Lactobacillus sporogenes in the fifth edition of Bergey's Manual, it exhibits characteristics typical of both genera Lactobacillus and Bacillus, its taxonomic position between the families Lactobacillaceae and Bacillaceae was often debated. However, in the seventh edition of Bergey's, it was finally transferred to the genus Bacillus. DNA-based technology was used in distinguishing between the two genera of bacteria which are morphologically similar and possess similar physiological and biochemical characteristics. Applications: dietary supplements - capsules, powder, tablets. food - bars, powdered beverages. Group: Probiotics. Synonyms: Bacillus Coagulans Freeze Dried Powder; Bacillus Coagulans. Activity: 10 billion CFU/g or more. Stability: 24 Months. Appearance: White To Light Yellow-Colored, Free-Flowing Powder. Storage: Recommend storage at refrigeration (4 °C) or frozen temperature (-18 °C) in original, sealed package until processed. Form: Powder. Bacillus Strains. Cat No: PRBT-001. | |
| Morpholino C monomer | Morpholino C monomer, an essential component in DNA and RNA modification, facilitates the selective manipulation of genomic sequences or genes. This revolutionary approach demonstrates enormous potential in the treatment of notorious ailments including cancer and viral infections. Deploying Morpholino C monomer in biomedical research offers a novel and powerful tool to precisely edit genetic structures, opening up an innovative avenue for therapeutic intervention. Synonyms: (6-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate. Grades: 98%. CAS No. 1155373-31-1. Molecular formula: C37H37ClN5O5P. Mole weight: 698.15. | |
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