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| Product | Description | |
|---|---|---|
| Glibenclamide | Glibenclamide (Glyburide) is an orally active ATP-sensitive K + channel ( K ATP ) inhibitor and can be used for the research of diabetes and obesity [1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein ( CFTR ) [3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability [4]. Glibenclamide can induce autophagy [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Glyburide. CAS No. 10238-21-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15206. |  |
| Glibenclamide | Glibenclamide. Group: Biochemicals. Grades: Purified. CAS No. 10238-21-8. Pack Sizes: 100mg. US Biological Life Sciences. |  Worldwide |
| Glibenclamide (5-Chloro-N- [4- (cyclohexyl ureidosulfonyl ) phene thyl ] -2-methoxybenzamide , Glyburide, N-p-[2- (5-Chloro-2-methoxybenzamido) ethyl]benzenesulfonyl-N?-cyclohexylurea) | Cell-permeable. An anti-diabetic agent. ATP-sensitive potassium channel (KATP) blocker. Inhibits KATP currents in the pancreatic beta cells causing an increase in intracellular Ca2+ and insulin secretion. Group: Biochemicals. Grades: Highly Purified. CAS No. 10238-21-8. Pack Sizes: 500mg, 1g. US Biological Life Sciences. | Worldwide |
| Glibenclamide impurity 10 | Glibenclamide impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 151890-69-6. Molecular formula: C19H21ClN2O6S. Mole weight: 440.9. Catalog: APB151890696. |  |
| Glibenclamide Impurity B | Glibenclamide Impurity B is an impurity in the synthesis of Gyburide. Synonyms: Methyl {{4-{2- [ (5-chloro-2-methoxybenzoyl) amino] ethyl}phenyl}sulfonyl}carbamate; N-[[4-[2-[ (5-Chloro-2-methoxybenzoyl) amino]ethyl]phenyl]sulfonyl]carbamic Acid Methyl Ester; [[4-[2-[ (5-Chloro-2-methoxybenzoyl) amino]ethyl]phenyl]sulfonyl]carbamic Acid Methyl. Grades: > 95%. CAS No. 21165-77-5. Molecular formula: C18H19ClN2O6S. Mole weight: 426.88. |  |
| Glibenclamide potassium salt | Glibenclamide potassium salt is a salt form of Glibenclamide, a KATP channel blocker used for the treatment of type 2 diabetes. Glibenclamide binds to and inhibits the sulfonylurea receptor 1 (SUR1), the regulatory subunit of the ATP-sensitive potassium channels (KATP) in pancreatic β cells. Uses: Antidiabetic. Synonyms: Glibenclamide potassium salt; Glyburide potassium salt; 23047-14-5; dipotassium; 5-chloro-N-[2-[4-[ (N-cyclohexyl-C-oxidocarbonimidoyl) sulfamoyl]phenyl]ethyl]-2-methoxybenzenecarboximidate; E99010; 5-chloro-N- (4- (N- (cyclohexylcarbamoyl) sulfamoyl) phenethyl) -2-methoxybenzamide potassium. Grades: 99%. CAS No. 23047-14-5. Molecular formula: C23H26ClK2N3O5S. Mole weight: 570.18. | |
| Glyburide. (5-Chloro-N- [2- [4- [ [ [ (cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] -2-methoxybenzamide, Adiab, Azuglucon, Bastiverit, Glibenclamide, Glidiabet, Glimidstada) | A second generation sulfonylurea with hypoglycemic activity. Group: Biochemicals. Alternative Names: 5-Chloro-N- [2- [4- [ [ [ (cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] -2-methoxybenzamide, Adiab, Azuglucon, Bastiverit, Glibenclamide, Glidiabet, Glimidstada. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Glyburide-d11 (5-Chloro-N- [2- [4- [ [ [ (cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] -2-methoxybenzamide-d11, Adiab-d11, Azuglucon-d11, Bastiverit-d11, Glibenclamide-d11, Glidiabet-d11, Glimidstada-d11 ) | A second generation sulfonylurea with hypoglycemic activity. Group: Biochemicals. Alternative Names: 5-Chloro-N- [2- [4- [ [ [ (cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] -2-methoxybenzamide-d11, Adiab-d11, Azuglucon-d11, Bastiverit-d11, Glibenclamide-d11, Glidiabet-d11, Glimidstada-d11. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Glyburide (Glibenclamide) | Pharmaceutical Secondary Standard; Certified Reference Material. Group: Pharmacopeia & metrological institutes standards. | |
| 5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide | Glibenclamide Impurity A is an impurity arising in the synthesis of Glyburide. Synonyms: 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide. Grades: > 95 %. CAS No. 16673-34-0. Molecular formula: C16H17ClN2O4S. Mole weight: 368.84. | |
| 5-?chloro-?N-? [2-? [4-? [ [ [ [ (trans-?4-?hydroxycyclohexyl) ?amino] ?carbonyl] ?amino] ?sulfonyl] ?phenyl] ?ethyl] ?-?2-?methoxy-Benzamide | A metabolite of Glyburide which is used as an antidiabetic. Synonyms: 4-Hydroxyglibenclamide; rac trans-4-Hydroxy Glyburide; 23155-00-2; rac cis-4-Hydroxy Glyburide; 23155-04-6; 132054-81-0; trans-4-Hydroxyglyburide; 4-trans-Hydroxyglibenclamide; 4-trans-Hydroxy-glibenclamide; 4-Hydroxyglyburide, trans-; 4-trans-Hydroxycyclohexyl Glyburide; 8J8OD7PL2J; rac-trans-4-hydroxy Glyburide; 5-chloro-N-[2-[4-[ (4-hydroxycyclohexyl) carbamoylsulfamoyl]phenyl]ethyl]-2-methoxybenzamide; cis-5-Chloro-N-[2-[4-[[[[(4-hydroxycyclohexyl); aMino] carbonyl] aMino] sulfonyl] phenyl] ethyl] -2-MethoxybenzaMide; 5-Chloro-N- (4- (N- ( (4-hydroxycyclohexyl) carbamoyl) sulfamoyl) phenethyl) -2-methoxybenzamide. CAS No. 23155-00-2. Molecular formula: C23H28ClN3O6S. Mole weight: 510. | |
| 6-Dehydrocortisol | 6-Dehydrocortisol. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6-Dehydrocortisol, Delta6-Hydrocortisone,1-[[4-[2-[(3,5-Di-chloro-2-methoxybenzoyl)amino]ethyl]phenyl]sulfonyl]-3-cyclohexylurea, Glibenclamide Imp. E (Pharmeuropa), NSC 12881, 11beta,17,21-Trihydroxypregna-4,6-diene-3,20-dione, Hydrocortisone Imp. E (EP), Pregna-4,6-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- (9CI), Delta6-Cortisol, Pregna-4,6-diene-3,20-dione, 11beta,17,21-trihydroxy- (8CI). CAS No. 600-99-7. Pack Sizes: 10MG. IUPAC Name: (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one. Molecular formula: C21H28O5. Mole weight: 360.44. Catalog: APS600997A. SMILES: C[C@]12CCC(=O)C=C1C=C[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23. Format: Neat. Shipping: Room Temperature. | |
| Glyburide potassium salt | Glyburide is a sulfonylurea receptor 1 (SUR1) inhibitor linked to ATP-sensitive potassium channel Kir6.2 with an IC50 value of 4.3 nM. Synonyms: Glibenclamide; 5-chloro-N- [2- [4- [ [ [ (cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] -2-methoxy-benzamide, monopotassium salt. Grades: ≥98%. CAS No. 52169-36-5. Molecular formula: C23H28ClN3O5S·K. Mole weight: 533.1. | |
| N,N-Diethylaminoethyl 2,2-diphenylvalerate hydrochloride (SKF-525A HCl) | Cytochrome P-459 inhibitor; blocks glibenclamide-sensitive K+ channels; inhibits neuronal nitric oxide synthetase; stimulates endothelial cell prostacyclin while inhibiting platelet thromboxane synthesis. Group: Biochemicals. Alternative Names: α-Phenyl-α-Propylbenzeneacetic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; 2,2-Diphenylvaleric Acid 2-(Diethylamino)ethyl Ester Hydrochloride; 2-(Diethylamino)ethyl 2,2-Diphenylvalerate Hydrochloride; Proadifen Hydrochloride; RP 5171; SKF 525; U 5446. Grades: Highly Purified. CAS No. 62-68-0. Pack Sizes: 250mg, 500mg, 1g, 5g. Molecular Formula: C??H??ClNO?, Molecular Weight: 389.96. US Biological Life Sciences. | Worldwide |
| Proadifen Hydrochloride | Proadifen hydrochloride is a Cytochrome P450 inhibitor (IC50 = 19μM) and stimulate endothelial cell prostacyclin production. Uses: Cytochrome p-459 inhibitor; blocks glibenclamide-sensitive k+ channels. Synonyms: 2-(diethylamino)ethyl 2,2-diphenylpentanoate;hydrochloride;SKF-525A, Hydrochloride; Proadifen hydrochloride; NSC 170997; NSC-170997; NSC170997. Grades: ≥98%. CAS No. 62-68-0. Molecular formula: C23H32ClNO2. Mole weight: 389.96. | |
| RS 79948 hydrochloride | RS 79948, a sulfur compound, is an α2-adrenoreceptor antagonist (Kd= 0.18, 0.19 and 0.42 nM for α2B α2C and α2A, respectively in rat). It increases insulin secretion and synergistically augments insulinotropic effect of glibenclamide. Synonyms: 6H-Isoquino[2,1-g][1,6]naphthyridine, 12-(ethylsulfonyl)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-, hydrochloride (1:1), (8aR,12aS,13aS)-; 6H-Isoquino[2,1-g][1,6]naphthyridine, 12-(ethylsulfonyl)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-, monohydrochloride, (8aR,12aS,13aS)-; 6H-Isoquino[2,1-g][1,6]naphthyridine, 12-(ethylsulfonyl)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-, monohydrochloride, [8aR-(8aα,12aα,13aα)]-; RS 79948-197; RS79948 hydrochloride; RS-79948 hydrochloride; (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine hydrochloride. Grades: ≥99% by HPLC. CAS No. 186002-54-0. Molecular formula: C19H28N2O3S.HCl. Mole weight: 400.96. | |
| SKF-525A, Hydrochloride - CAS 62-68-0 | Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. Group: Fluorescence/luminescence spectroscopy. | |
| SKF-525A, Hydrochloride (Proadifen, HCl, a-Phenyl-a-propylbenzeneacetic Acid 2-[Diethylamino]ethyl Ester, HCl) | Cytochrome P-459 inhibitor; blocks glibenclamide-sensitive K+ channels; inhibits neuronal nitric oxide synthetase; stimulates endothelial cell prostacyclin while inhibiting platelet thromboxane synthesis. Group: Biochemicals. Alternative Names: Proadifen, HCl, a-Phenyl-a-propylbenzeneacetic Acid 2-[Diethylamino]ethyl Ester, HCl. Grades: Highly Purified. Pack Sizes: 2g. US Biological Life Sciences. | Worldwide |
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