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| Product | Description | |
|---|---|---|
| Glucagon receptor antagonists 1 | Glucagon receptor antagonists-1 is a highly potent glucagon receptor antagonist, which is activated by glucagon and is a member of the class B G-protein coupled family of receptors. Uses: Glucagon receptor antagonist. Synonyms: glucagon receptor antagonists 1; 1-(4-(2-(Benzyloxy)-4-fluorophenyl)-2,6-diisopropyl-5-(prop-1-en-1-yl)pyridin-3-yl)ethanol; 1-[4-(4-fluoro-2-phenylmethoxyphenyl)-2,6-di(propan-2-yl)-5-[(E)-prop-1-enyl]pyridin-3-yl]ethanol. Grades: ≥95%. CAS No. 503559-84-0. Molecular formula: C29H34FNO2. Mole weight: 447.59. |  |
| glucagon receptor antagonists-2 | glucagon receptor antagonists-2 is a highly potent antagonist of glucagon receptor. Synonyms: glucagon receptor antagonists 2; (6E)-3-fluoro-6-[3-[(1R)-1-hydroxyethyl]-2,6-di(propan-2-yl)-5-propyl-1H-pyridin-4-ylidene]cyclohexa-2,4-dien-1-one3-Pyridinemethanol, 4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-5-propyl-, (aR)-. CAS No. 202917-18-8. Molecular formula: C22H30FNO2. Mole weight: 359.48. | |
| glucagon receptor antagonists-3 | glucagon receptor antagonists-3 is a highly potent antagonist of glucagon receptor. Synonyms: glucagon receptor antagonists 3; 3-Pyridinemethanol, 4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-5-propyl-, (aR,4R)-rel- (9CI);(aphlaR,4R)-4-(4-Fluoro-2-hydroxyphenyl)-alpha-methyl-2,6-bis(1-methylethyl)-5-propyl-3-pyridinemethanol. CAS No. 202917-17-7. Molecular formula: C22H30FNO2. Mole weight: 359.48. | |
| glucagon receptor antagonists-4 | glucagon receptor antagonists-4 is a potent glucagon receptor antagonist with great oral bioavailability in vivo. Synonyms: PF-06291874; PF 06291874; PF06291874; PF-6291874; PF 6291874; PF6291874; glucagon receptor antagonists 4; β-Alanine, N-[4-[(1S)?-1-[3,?5-dimethyl-4-[4-(trifluoromethyl)?-1H-pyrazol-1-yl]?phenoxy]?butyl]?benzoyl]?-. CAS No. 1393124-08-7. Molecular formula: C26H28F3N3O4. Mole weight: 503.51. | |
| 2-Ethoxypyridin-4-ylboronic Acid | 2-Ethoxypyridin-4-ylboronic Acid is patented as a reagent to prepare spiro-imidazolone derivatives as glucagon receptor antagonists for treatment of diabetes. Group: Biochemicals. Grades: Highly Purified. CAS No. 1072946-58-7. Pack Sizes: 500mg, 1g. Molecular Formula: C7H10BNO3, Molecular Weight: 166.97. US Biological Life Sciences. |  Worldwide |
| 4-Oxocyclohexane carboxylic Acid | 4-Oxocyclohexane carboxylic Acid is used in the preparation of Indomethacin (I641000) analogues used in the treatment of prostate cancer. In addition it is used in the synthesis of β-alanine derivatives as glucagon receptor antagonists. Group: Biochemicals. Alternative Names: 4-Ketocyclohexane carboxylic Acid; 4-Ketocyclohexyl carboxyl ic Acid; 4-Oxo-1-cyclohexanecarboxylic Acid; 4-Oxocyclohexane carboxylic Acid; Cyclohexanone-4-carboxylic Acid. Grades: Highly Purified. CAS No. 874-61-3. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Cyclosomatostatin | Cyclosomatostatin is a non-selective somatostatin (sst) receptor antagonist. It blocks the effects of CRF-induced suppression of gastric empyting and sst on airway β-adrenergic function. It also prevents growth hormone, insulin, glucagon release and modulation of ACh release. It acts as a sst receptor agonist in human neuroblastoma cell line SH-SY5Y. Uses: Hormone antagonists. Synonyms: Cyclo(7-aminoheptanonyl-Phe-D-Trp-Lys-Thr[Bzl]); Cyclo[7-aminoheptanoyl-L-phenylalanyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-threonyl]. CAS No. 84211-54-1. Molecular formula: C44H57N7O6. Mole weight: 779.98. | |
| LGD-6972 | LGD-6972 is a glucagon receptor antagonist. Uses: Designed for use in research and industrial production. Additional or Alternative Names: LGD-6972; LGD 6972; LGD6972; MB-11262; MB 11262; MB11262. Product Category: Antagonists. Appearance: Solid powder. CAS No. 1207989-09-0. Molecular formula: C43H46N2O5S. Mole weight: 702.91. Purity: >98%. IUPACName: (R)-2-(4-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-4-yl)-3-oxo-3-((2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl)amino)propyl)benzamido)ethane-1-sulfonic acid. Canonical SMILES: O=C(NCCS(=O)(O)=O)C1=CC=C(C[C@H](C2=CC=C(C3=CC=C(C(C)(C)C)C=C3)C=C2)C(NC4=CC=C(C5=C(C)C=C(C)C=C5C)C=C4)=O)C=C1. Product ID: ACM1207989090. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 4-Bromo-2,6-xylidine | 4-Bromo-2,6-xylidine, is an organic building block used for the synthesis of various pharmaceutical compounds. It can be used for the synthesis of potent glucagon receptor antagonist for the treatment of diabetes mellitus. Group: Biochemicals. Alternative Names: 4-Bromo-2,6-dimethylbenzenamine; 2,6-Dimethyl-4-bromoaniline; 4-Bromo-2,6-dimethylaniline; 4-Bromo-2,6-dimethylbenzenamine; 4-Bromo-2,6-dimethylphenylamine; NSC 227944. Grades: Highly Purified. CAS No. 24596-19-8. Pack Sizes: 10g, 25g. US Biological Life Sciences. | Worldwide |
| AC 187 | AC 187 is a potent amylin receptor antagonist (IC50 = 0.48 nM) displaying 38- and 400-fold selectivity over calcitonin and CGRP receptors respectively. It inhibits amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. It increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo. Synonyms: Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2; N-acetyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide; AC187; salmon calcitonin (8-32) reduced; acetyl-(Asn30,Tyr32)sCT(8-37); AC-187. Grades: >98%. CAS No. 151804-77-2. Molecular formula: C127H205N37O40. Mole weight: 2890.25. | |
| AC 187 acetate | AC 187 acetate is a potent amylin receptor antagonist (IC50 = 0.48 nM) displaying 38- and 400-fold selectivity over calcitonin and CGRP receptors respectively. It inhibits amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. It increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels, and increases food intake in vivo. Synonyms: Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2.CH3CO2H; N-acetyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide acetic acid. Grades: ≥95%. Molecular formula: C129H209N37O42. Mole weight: 2950.26. | |
| Adomeglivant | Adomeglivant has been found to be a glucagon receptor antagonist that could probably be effective for both type-I and type-II diabetes mellitus. Synonyms: Adomeglivant; LY-2409021; Adomeglivant [USAN]; UNII-74Z5ZL2KVG; LY2409021; LY 2409021; 3- [ [4- [ (1S) -1- [4- (4-tert-butylphenyl) -3, 5-dimethylphenoxy] -4, 4, 4-trifluorobutyl] benzoyl] amino] propanoic acid. Grades: 98%. CAS No. 1488363-78-5. Molecular formula: C32H36F3NO4. Mole weight: 555.64. | |
| Arachidonyl serotonin | Arachidonyl serotonin is a dual target agent of transient receptor potential vanilloid-type I (TRPV1) antagonist and fatty acid amide hydrolase (FAAH) inhibitor, which is responsible for inactivation of anandamide and other endogenous cannabinoids. Its IC50 values are 37-40 nM and 5.6 μM for TRPV1 and FAAH respectively. It inhibits the FAAH activity isolated from mouse neuroblastoma cells with an IC50 value of 12 μM. It is a very tight binding, competitive inhibitor of FAAH. It does not inhibit cPLA2 and is essentially devoid of cannabimimetic activity. It was shown to be present in the ileum and jejunum of the gastrointestinal tract and modulate glucagon-like peptide-1 (GLP-1) secretion. It displays strong analgesic activity against both acute and chronic peripheral pain in rodents. Synonyms: AA-5HT; AA5HT; AA 5HT; N-arachidonoyl-serotonin; Arachidonoyl serotonin; N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; AA-5HT; AA5HT; N-arachidonoyl-serotonin; N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)icosa-5,8,11,14-tetraenamide. CAS No. 187947-37-1. Molecular formula: C30H42N2O2. Mole weight: 462.67. | |
| BAY-27-9955 | BAY-27-9955 is a specific glucagon receptor antagonist. Synonyms: 1-[2-(4-fluorophenyl)-4,6-di(propan-2-yl)-3-propylphenyl]ethanol; BAY-27-9955; BAY-27-9955; BAY-27-9955; BAY-279955; BAY-279955; BAY-279955; (+)-3,5-diisopropyl-2-(1-hydroxyethyl)-6-propyl-4'-fluoro-1,1'-biphenyl. Grades: >98%. CAS No. 202855-56-9. Molecular formula: C23H31FO. Mole weight: 342.49. | |
| des-His1-[Glu9]-Glucagon (1-29) amide | A glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes) that displays no agonist activity. It binds to glucagon receptors to stimulate breakdown of inositol phospholipids by phospholipase C. It was shown to potentiate glucose-stimulated pancreatic insulin release in vitro. It blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats. Synonyms: (Des-His1,Glu9)-Glucagon (1-29) amide (human, rat, porcine); H-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2; L-seryl-L-glutaminyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparagyl-L-threoninamide. Grades: ≥95%. CAS No. 110084-95-2. Molecular formula: C148H221N41O47S. Mole weight: 3358.68. | |
| [Des-His1,Glu9]-Glucagon (1-29) amide trifluoroacetate salt | [Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes). It binds to glucagon receptors in a magnesium- and GTP-independent manner to stimulate breakdown of inositol phospholipids by phospholipase C, but has no effect on adenylate cyclase activity, in hepatocytes. In vivo, [Des-His1,Glu9]-glucagon (1-29) amide prevents glucagon-induced hyperglycemia in rabbits and decreases blood glucose in rats with diabetes induced by streptozotocin. Grades: ≥95%. Molecular formula: C148H221N41O47S·xCF3COOH. Mole weight: 3358.65. | |
| [D-p-Cl-Phe6,Leu17]-VIP | [D-p-Cl-Phe6,Leu17]-VIP is a selective vasoactive intestinal peptide (VIP) receptor antagonist (IC50 = 125.8 nM) with no activity at glucagon, secretin or GRF receptors. Synonyms: [D-p-Cl-Phe6, Leu17]-Vasoactive Intestinal Peptide human, porcine, rat. CAS No. 102805-45-8. Molecular formula: C148H239ClN44O42. Mole weight: 3342.24. | |
| Exendin 3 (9-39) | Exendin (9-39) is a specific and competitive glucagon-like peptide-1receptor antagonist (Kd = 1.7 nM at cloned human GLP-1 receptors). Exendin (9-39) inhibits insulin release and cAMP production caused by GLP-1 (7-36), exendin-3, and exendin-4. Synonyms: Exendin 9-39; Exendin 9 39; H-DL-Asp-DL-Leu-DL-Ser-DL-Lys-DL-Gln-DL-Met-DL-Glu-DL-Glu-DL-Glu-DL-Ala-DL-Val-DL-Arg-DL-Leu-DL-Phe-DL-xiIle-DL-Glu-DL-Trp-DL-Leu-DL-Lys-DL-Asn-Gly-Gly-DL-Pro-DL-Ser-DL-Ser-Gly-DL-Ala-DL-Pro-DL-Pro-DL-Pro-DL-Ser-NH2; DL-alpha-aspartyl-DL-leucyl-DL-seryl-DL-lysyl-DL-glutaminyl-DL-methionyl-DL-alpha-glutamyl-DL-alpha-glutamyl-DL-alpha-glutamyl-DL-alanyl-DL-valyl-DL-arginyl-DL-leucyl-DL-phenylalanyl-DL-isoleucyl-DL-alpha-glutamyl-DL-tryptophyl-DL-leucyl-DL-lysyl-DL-asparagyl-glycyl-glycyl-DL-prolyl-DL-seryl-DL-seryl-glycyl-DL-alanyl-DL-prolyl-DL-prolyl-DL-prolyl-DL-serinamide. Grades: ≥95%. CAS No. 133514-43-9. Molecular formula: C149H234N40O47S. Mole weight: 3369.76. | |
| Exendin(9-39) amide | Exendin(9-39) amide (Avexitide) is a glucagon-like peptide-1 ( GLP-1 ) antagonist that competes with endogenous GLP-1 for binding to GLP-1 receptors, thereby antagonizing the effects of excess GLP-1 secretion. Exendin(9-39) amide can be used to study postoperative hypoglycemia (PBH) [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Avexitide. CAS No. 133514-43-9. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P0264. |  |
| GLP-1 (9-36) amide | GLP-1 (9-36) amide is an N-terminal truncated metabolite of glucagon-like peptide GLP-1-(7-36) formed by dipeptidyl peptidase-IV cleavage. GLP-1 (9-36) amide functions as a human GLP-1 receptor antagonist. Synonyms: Glucagon-like peptide-1 (9-36) amide; Glucagon-like peptide-1 (9 36) amide. CAS No. 161748-29-4. Molecular formula: C140H214N36O43. Mole weight: 3089.44. | |
| GLP-1(9-36)amide | GLP-1(9-36)amide is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide acts as an antagonist to the human pancreatic GLP-1 receptor [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 161748-29-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1141. | |
| GLP-1 antagonist | A glucagon-like peptide-1 (GLP-1) receptor antagonist. Synonyms: GLP-1 antagonist; GLP 1 antagonist; N-[[4,5-dimethyl-1-[(2-methylphenyl)methyl]imidazol-2-yl]methyl]-2,4-dimethoxy-N-(3-methylbutyl)benzamide. Grades: 99%. CAS No. 475466-57-0. Molecular formula: C28H37N3O3. Mole weight: 463.61. | |
| GLP-2 (rat) trifluoroacetate salt | GLP-2 is a gut peptide hormone that is primarily produced by enteroendocrine L cells of the small and large intestine. GLP-2 is an antagonist of the GLP-2 receptor (GLP-2R; Ki = 60 pM). Synonyms: Glucagon-like Peptide 2. Grades: ≥95%. Molecular formula: C166H256N44O56S·xCF3COOH. Mole weight: 3796.14. | |
| Glucagon-Like Peptide 1 Receptor Agonist | A nonpeptidic quinoxaline compound that acts as a GLP-1R agonist and an allosteric modulator of GLP-1 binding. Shown to induce GLP-1R-mediated cAMP production in BHK plasma membrane preparations (EC50=101nM) and potentiate glucose-dependent insulin release in pancreatic islets derived from wild-type, but not GLP-1R -/-, mice. Unlike GLP-1, its biological activity is not inhibited by orthosteric antagonists such as Exendin. Group: Biochemicals. Alternative Names: 6,7-dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-, 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline (DMB); Compound 2; GLP-1R Agonist. Grades: Highly Purified. CAS No. 281209-71-0. Pack Sizes: 5mg. Molecular Formula: C??H??Cl?N?O?S, Molecular Weight: 348.3. US Biological Life Sciences. | Worldwide |
| Glucagon receptor antagonist-2 | Glucagon receptor antagonist-2 is a highly potent glucagon receptor antagonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 202917-18-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-50158. | |
| Glucagon Receptor Antagonist I | Glucagon receptor antagonist I is a potent and competitive antagonist of the glucagon receptor (GCGR) with an IC50 value of 181 nM. Synonyms: GCGR Antagonist I; hGCGR Antagonist; N-[3-cyano-6-(1,1-dimethylpropyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-2-ethyl-butanamide. Grades: ≥99%. CAS No. 438618-32-7. Molecular formula: C20H30N2OS. Mole weight: 346.5. | |
| GRA Ex-25 | GRA Ex-25 is an orally active human glucagon receptor antagonist in a transgenic murine pharmacodynamic model, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively. GCGR has evolved as an attractive therapeutic target for the treatment of type II diabetes mellitus. Synonyms: 3- (4- ( (1- (4- (tert-butyl) cyclohexyl) -3- (4- (trifluoromethoxy) phenyl) ureido) methyl) benzamido) propanoic acid; GRA Ex-25; GRA Ex 25; GRA Ex25; GRAEx-25; GRAEx 25; GRAEx25. CAS No. 307983-31-9. Molecular formula: C29H36F3N3O5. Mole weight: 563.61. | |
| HTL26119 | HTL26119 is a glucagon-like peptide-1 receptor (GLP-1R) antagonist. Synonyms: HTL-26119; HTL 26119. Grades: ≥98% by HPLC. Molecular formula: C28H23Cl3N2O5. Mole weight: 573.85. | |
| L-168,049 | L-168,049 is a non-peptidyl, very selective and potent human glucagon receptor (hGR) antagonist. It displays high affinity to human GR with IC50 value of 3.7 nM, but shows moderate affinity for murine and canine GRs. It inhibits glucagon-stimulated cAMP synthesis in murine liver membranes and in CHO cells expressing hGR. It is orally active in vivo. Synonyms: L-168,049; L 168,049; L168,049; 2-(4-Pyridyl)-5-(4-chlorophenyl)-3-(5-bromo-2-propyloxyphenyl)pyrrole; 4-[3-(5-Bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine. Grades: ≥99% by HPLC. CAS No. 191034-25-0. Molecular formula: C24H20BrClN2O. Mole weight: 467.79. | |
| LGD-6972 | LGD-6972 is an orally bioavailable small molecule glucagon receptor antagonist being developed as an adjunct to diet and exercise to improve glycemic control in adults with T2DM. Synonyms: LGD-6972; LGD 6972; LGD6972; 2- [ [4- [ (2R) -2- [4- (4-tert-butylphenyl) phenyl] -3-oxo-3- [4- (2, 4, 6-trimethylphenyl) anilino] propyl] benzoyl] amino] ethanesulfonic acid. CAS No. 1207989-09-0. Molecular formula: C43H46N2O5S. Mole weight: 702.9. | |
| MK 0893 | MK-0893 is a potent, selective glucagon receptor antagonist with high binding affinity with IC(50) of 6.6 nM and functional cAMP activity with IC(50) of 15.7 nM. It is selective for glucagon receptor relative to other family B GPCRs and is > 200 fold selectivity for GIPR, PAC1, GLP-1R, VPAC1 and VPAC2. It blunted glucagon-induced glucose elevation in hGCGR mice and rhesus monkeys. It may be a potential oral treatment for type 2 diabetes. It was selected for further preclinical and clinical evaluations. Uses: Mk-0893 may be a potential oral treatment for type 2 diabetes. Synonyms: MK 0893; MK0893; MK-0893; b-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-;Merk Glucagon antagonist;N-[4-[(1S)-1-[3-(3,5-Dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-beta-alanine;(S)-3-(4-(1-(3-(3,5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl)ethyl)benzamido)propanoic acid. Grades: >98 %. CAS No. 870823-12-4. Molecular formula: C32H27Cl2N3O4. Mole weight: 588.48. | |
| PF-06372222 | PF-06372222 is a small molecule negative allosteric modulator (NAM) of glucagon receptor (GCGR), which helps treat type 2 diabetes. It is also an antagonist of the glucagon-like peptide-1 receptor GLP-1R, which can inhibit glucagon secretion and glucose-dependent insulin secretion. Synonyms: N-{4-[(R)-(3,3-Dimethylcyclobutyl)({6-[4-(Trifluoromethyl)-1h-Imidazol-1-Yl]Pyridin-3-Yl}Amino)Methyl]Benzene-1-Carbonyl}-Beta-Alanine. Grades: ≥98% by HPLC. CAS No. 1407592-99-7. Molecular formula: C26H28F3N5O3. Mole weight: 515.5. | |
| Skyrin | Skyrin is an anthraquinone compound that can be isolated from almond fruit. Skyrin is a receptor-selective glucagon antagonist. Skyrin can inhibit the growth of tumor cells [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 602-06-2. Pack Sizes: 1 mg. Product ID: HY-119739. | |
| Skyrin (Rhodophyscin, Endothianin) | Non-peptidic anti-diabetic agent. Receptor-selective glucagon antagonist. Free radical species (.OH, R.) and singlet oxygen (1O2) scavenger. Mycotoxin. Cytotoxic. Antioxidant. Group: Biochemicals. Alternative Names: Rhodophyscin, Endothianin. Grades: Highly Purified. CAS No. 602-06-2. Pack Sizes: 1mg. Molecular Formula: C30H18O10. US Biological Life Sciences. | Worldwide |
| Skyrin, Talaromyces sp. (Rhodophyscin, Endothianin) | A non-peptidic anti-diabetic agent and a receptor-selective glucagon antagonist. Also acts as an antioxidant, free radical and singlet oxygen species scavenger. Group: Biochemicals. Grades: Highly Purified. CAS No. 602-06-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Volagidemab | Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: REMD-477; AMG-477. CAS No. 1233956-13-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99383. | |
| VU 0650991 | VU 0650991 is a selective and non-competitive glucagon-like peptide-1 (GLP-1) receptor antagonist with IC50 value of 650 nM. Synonyms: GLP-1R Antagonist 1; 7-(4-Chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione. Grades: ≥98% by HPLC. CAS No. 488097-06-9. Molecular formula: C16H11ClF6N4O2. Mole weight: 440.73. | |
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