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| Product | Description | |
|---|---|---|
| glutamate carboxypeptidase | A zinc enzyme produced by pseudomonads, Flavobacterium sp. and Acinetobacter sp. Its ability to hydrolyse pteroyl-L-glutamate (folic acid) has led to its use as a folate-depleting, antitumour agent. Type example of peptidase family M20. Group: Enzymes. Synonyms: carboxypeptidase G; carboxypeptidase G1; carboxypeptidase G2; glutamyl carboxypeptidase; N-pteroyl-L-glutamate hydrolase. Enzyme Commission Number: EC 3.4.17.11. CAS No. 9074-87-7. Carboxypeptidase G. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4063; glutamate carboxypeptidase; EC 3.4.17.11; 9074-87-7; carboxypeptidase G; carboxypeptidase G1; carboxypeptidase G2; glutamyl carboxypeptidase; N-pteroyl-L-glutamate hydrolase. Cat No: EXWM-4063. |  |
| glutamate carboxypeptidase II | A metallo-carboxypeptidase that is predominantly expressed as a membrane-bound enzyme of 94-100 kDa, but also exists in a soluble form. Hydrolyses α-peptide bonds in Ac-Asp-Glu, Asp-Glu, and Glu-Glu, but also γ-glutamyl bonds in γ-Glu-Glu, and folylpoly-γ-glutamates. With folylpoly-γ-glutamates, shows processive carboxypeptidase activity to produce pteroylmonoglutamate. Does not hydrolyse Ac-β-Asp-Glu. Known inhibitors: quisqualic acid, Ac-β-Asp-Glu, and 2-phosphonomethyl-pentanedioate. In peptidase family M28 of Vibrio leucyl aminopeptidase. The release of C-terminal glutamate from folylpoly-γ-glutamates is also catalysed by EC 3.4.17.11 (glutamate carboxypeptidase) and EC 3.4.19.9 (γ-Glu-X carboxypeptidase). Group: Enzymes. Synonyms: N-acetylated-γ-linked-acidic dipeptidase (NAALADas. Enzyme Commission Number: EC 3.4.17.21. CAS No. 9074-87-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4074; glutamate carboxypeptidase II; EC 3.4.17.21; 9074-87-7; N-acetylated-γ-linked-acidic dipeptidase (NAALADase); folate hydrolase; prostate-specific membrane antigen; pteroylpoly-γ-glutamate carboxypeptidase; microsomal γ-glutamyl carboxypeptidase; pteroylpolyglutamate hydrolase; folylpolyglutamate h | |
| 2-Hydroxyglutaric Acid Disodium Salt-13C4 | 2-Hydroxyglutaric Acid Disodium Salt-13C4 is the isotope (13C) labelled analog of 2-Hydroxyglutaric Acid Disodium Salt (H942575) which is a potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1429051-81-9. Pack Sizes: 1mg. Molecular Formula: C13C4H6Na2O5, Molecular Weight: 196.05. US Biological Life Sciences. |  Worldwide |
| 2-Hydroxyglutaric Acid Disodium Salt (contains up to 10% methanol) | 2-Hydroxyglutaric acid is a potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Alternative Names: 2-Hydroxypentanedioic Acid Sodium Salt. Grades: Highly Purified. CAS No. 40951-21-1. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 2-MPPA | 2-MPPA is a selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM), which is selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. 2-MPPA can be used in the treatment of neurological disorders associated with excessive activation of glutamatergic systems. Attenuates glutamate transmission resulting in the relief of neuropathic pain. This compound has neuroprotective properties. Synonyms: 2-(3-Mercaptopropyl)pentanedioic acid; 2-MPPA; 2 MPPA; 2MPPA. CAS No. 254737-29-6. Molecular formula: C8H14O4S. Mole weight: 206.26. |  |
| 2- (Phosphonomethyl) pentanedioic Acid | 2- (Phosphonomethyl) pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia. Group: Biochemicals. Grades: Highly Purified. CAS No. 173039-10-6. Pack Sizes: 10mg, 50mg. Molecular Formula: C6H11O7P, Molecular Weight: 226.12. US Biological Life Sciences. | Worldwide |
| 2-PMPA | 2-PMPA is a highly potent and selective inhibitor of glutamate carboxypeptidase 2 (Ki= 275 pM) and the neuropeptidase N-acetylated α-linked acidic dipeptidase (NAALADase). Synonyms: 2-(phosphonomethyl)pentanedioic acid; 2-PMPA cpd; 2-PMPA; 2PMPA; 2PMPA. CAS No. 173039-10-6. Molecular formula: C6H11O7P. Mole weight: 226.12. | |
| 2-PMPA | 2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II ( GCPII ) with an IC 50 of 300 pM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-(Phosphonomethyl)pentanedioic acid. CAS No. 173039-10-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100788. |  |
| (2R)-2-Hydroxyglutaric Acid Disodium Salt | A potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Grades: Highly Purified. CAS No. 103404-90-6. Pack Sizes: 10mg, 25mg, 100mg. Molecular Formula: C?H?Na?O?. US Biological Life Sciences. | Worldwide |
| (2R)-2-Hydroxyglutaric Acid Disodium Salt-13C5 | (2R)-2-Hydroxyglutaric Acid Disodium Salt-13C5 is the isotope labelled analog of (2R)-2-Hydroxyglutaric Acid Disodium Salt (H942565); a potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1648909-80-1. Pack Sizes: 500ug, 5mg. Molecular Formula: 13C5H6Na2O5. US Biological Life Sciences. | Worldwide |
| (2R)-2-Hydroxyglutaric Acid Disodium Salt-d5 | (2R)-2-Hydroxyglutaric Acid Disodium Salt-d5 is the isotope labelled analog of (2R)-2-Hydroxyglutaric Acid Disodium Salt (H942565); a potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C5HD5Na2O5. US Biological Life Sciences. | Worldwide |
| (2R)-2-Hydroxyglutaric Acid Octyl Ester Sodium Salt | The octyl ester derivative of (2R)-2-Hydroxyglutaric Acid , the potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Alternative Names: (2R)-2-Hydroxypentanedioic Acid Octyl Ester Sodium Salt. Grades: Highly Purified. CAS No. 1391068-16-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (2R)-Octyl-α-hydroxyglutarate | (2R)-Octyl-α-hydroxyglutarate is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1391194-67-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C13H24O5, Molecular Weight: 260.33. US Biological Life Sciences. | Worldwide |
| (2R)-Octyl-α-hydroxyglutarate-d17 | (2R)-Octyl-α-hydroxyglutarate-d17 is labelled (2R)-Octyl-α-hydroxyglutarate (O287600) which is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C13H7D17O5, Molecular Weight: 277.43. US Biological Life Sciences. | Worldwide |
| (2S)-2-Hydroxyglutaric Acid | (2S)-2-Hydroxyglutaric Acid is a potential glutamate carboxypeptidase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 13095-48-2. Pack Sizes: 25mg, 50mg. Molecular Formula: C5H8O5, Molecular Weight: 148.11. US Biological Life Sciences. | Worldwide |
| (2S)-2-Hydroxyglutaric Acid Benzyl Octyl Diester | (2S)-2-Hydroxyglutaric Acid Benzyl Octyl Diester is the benzyl, octyl diester derivative of (2S)-2-Hydroxyglutaric Acid (H942570), the potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Alternative Names: Octyl L-2-Hydroxyglutarate Benzyl Ester. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| (2S)-2-Hydroxyglutaric Acid Disodium Salt | A potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Alternative Names: (2S)-2-Hydroxypentanedioic Acid; L-2-Hydroxyglutaric Acid Disodium Salt; (S)-α-Hydroxyglutaric Acid Disodium Salt; L-2-Hydroxyglutarate Disodium Salt. Grades: Highly Purified. CAS No. 63512-50-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| (2S)-2-Hydroxyglutaric Acid Disodium Salt-13C5 | (2S)-2-Hydroxyglutaric Acid Disodium Salt-13C5 is the isotope labelled analog of (2S)-2-Hydroxyglutaric Acid Disodium Salt (H942570); a potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: 13C5H6Na2O5. US Biological Life Sciences. | Worldwide |
| (2S)-2-Hydroxyglutaric Acid Disodium Salt-d5 | (2S)-2-Hydroxyglutaric Acid Disodium Salt-d5 is the isotope labelled analog of (2S)-2-Hydroxyglutaric Acid Disodium Salt (H942570); a potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C5HD5Na2O5. US Biological Life Sciences. | Worldwide |
| (2S)-Octyl-α-hydroxyglutarate | (2S)-Octyl-α-hydroxyglutarate is a cell permeable derivative of the L-isomer of 2-Hydroxyglutaric Acid (H942575), a potential inhibitor of glutamate carboxypeptidase. Also, being structurally similar to α-ketoglutarate, it competitively inhibits α-ketoglutarate dependent dioxygenases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1391194-64-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C13H24O5. US Biological Life Sciences. | Worldwide |
| (2S)-Octyl-α-hydroxyglutarate-d17 | (2S)-Octyl-α-hydroxyglutarate-d17 is labelled (2R)-Octyl-α-hydroxyglutarate (O287600) which is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C13H7D17O5, Molecular Weight: 277.43. US Biological Life Sciences. | Worldwide |
| Benzyl Acrylate (Stabilized with 50ppm of MEHQ) | Benzyl Acrylate, is a reagent that can be used in the preparation of 2- (Phosphonomethyl) pentanedioic Acid (P353900), a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates. Group: Biochemicals. Grades: Highly Purified. CAS No. 2495-35-4. Pack Sizes: 5g, 25g. Molecular Formula: C10H10O2. US Biological Life Sciences. | Worldwide |
| D-Dopa | D-Dopa is a non-competitive, allosteric inhibitor for glutamate carboxypeptidase II (GCPII) with an IC 50 of 200 nM. D-Dopa exhibits good pharmacokinetic characteristics, and low blood-brain barrier permeability in mouse model [1]. Uses: Scientific research. Group: Peptides. Alternative Names: 3-Hydroxy-D-tyrosine. CAS No. 5796-17-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W096171. | |
| γ-glutamyl hydrolase | A lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH. Commonly studied with folylpoly-γ-glutamate as substrate, with which the initial cleavage may release glutamate or poly-γ-glutamate of two or more residues, according to the species of origin of the enzyme. Final products are pteroyl-α-glutamate (folic acid) and free glutamate. Highly specific for the γ-glutamyl bond, but not for the C-terminal amino acid (leaving group). Action on γ-glutamyl bonds is independent of an N-terminal pteroyl moiety, but it is not known whether an N-terminal γ-Glu residue can be hydrolysed. Type example of peptidase family C26. Group: Enzymes. Synonyms: conjugase; folate conjugase; lysosomal γ-glutamyl carboxypeptid. Enzyme Commission Number: EC 3.4.19.9. CAS No. 9074-87-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4092; γ-glutamyl hydrolase; EC 3.4.19.9; 9074-87-7; conjugase; folate conjugase; lysosomal γ-glutamyl carboxypeptidase; γ-Glu-X carboxypeptidase; pteroyl-poly-γ-glutamate hydrolase; carboxypeptidase G; folic acid conjugase; poly(γ-glutamic acid) endohydrolase; polyglutamate hydrolase; poly(glutamic acid) hydrolase II; pteroylpoly-γ-glutamyl hydrolase. Cat No: EXWM-4092. | |
| Gly-Xaa carboxypeptidase | From yeast. In peptidase family M20 (glutamate carboxypeptidase family). Group: Enzymes. Synonyms: glycine carboxypeptidase; carboxypeptidase a; carboxypeptidase S; peptidase α; yeast carboxypeptidase; Gly-X carboxypeptidase. Enzyme Commission Number: EC 3.4.17.4. CAS No. 9025-25-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4078; Gly-Xaa carboxypeptidase; EC 3.4.17.4; 9025-25-6; glycine carboxypeptidase; carboxypeptidase a; carboxypeptidase S; peptidase α; yeast carboxypeptidase; Gly-X carboxypeptidase. Cat No: EXWM-4078. | |
| Native Pseudomonas sp. Carboxypeptidase G | Carboxypeptidase G is a lysosomal, thiol-dependent protease, which progressively cleaves γ-glutamyl pteroyl poly-γ-glutamate yielding pteroyl-α-glutamate (folic acid) and free glutamate. It is considered highly specific for the γ-glutamyl bond, but not for the C-terminal amino acid of the leaving group.1 Molecular mass of this homodimer is approximately 90 kDa. The enzyme is activated by Zn2+ ions. Applications: Carboxypeptidase g from pseudomonas sp., or γ-glutamyl hydrolase, has been used in a study to assess the role of the putidaredoxin cooh-terminus in p-450cam (cytochrome m) hydroxylations. carboxypeptidase g from pseudomonas sp. has also been used in a study to investigate the effects of nitric oxide on pemetrexed cytotoxicity via no-cgmp signaling in lung adenocarcinoma cells. Group: Enzymes. Synonyms: γ-Glutamyl hydrolase; EC 3.4.17.11; 9074-87-7; glutamate carboxypeptidas. Enzyme Commission Number: EC 3.4.17.11. CAS No. 9074-87-7. Carboxypeptidase G. Activity: > 3 units/mg protein. Storage: -20°C. Form: lyophilized powder contains sodium acetate salt. Source: Pseudomonas sp. γ-Glutamyl hydrolase; EC 3.4.17.11; 9074-87-7; glutamate carboxypeptidase; carboxypeptidase G; carboxypeptidase G1; carboxypeptidase G2; glutamyl carboxypeptidase; N-pteroyl-L-glutamate hydrolase. Cat No: NATE-0102. | |
| PMPA sodium salt | PMPA is an inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated a-linked dipeptidase/NAALADase). Synonyms: PMPA tetrasodium. CAS No. 373645-42-2. Molecular formula: C6H7Na4O7P. Mole weight: 314.05. | |
| PSM P2 (711-719) | PSM P2 (711-719) is a 9-aa peptide. PSM P2 is a zinc metalloenzyme that resides in membranes. It is mainly expressed in four tissues of the body, including prostate epithelium, the proximal tubules of the kidney, the jejunal brush border of the small intestine and ganglia of the nervous system. Synonyms: Glutamate carboxypeptidase 2 (711-719); N-acetyl-L-aspartyl-L-glutamate peptidase I (711-719); NAAG peptidase (711-719); prostate-specific membrane antigen (PSMA) (711-719). | |
| ZJ 43 | ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki = 0.8 and 23 nM, respectively). It inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) and decreases the deleterious effects of excessive extracellular glutamate. ZJ 43 has been shown to reduce neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduce locomotor activity in the PCP-model of schizophrenia. Synonyms: ZJ 43; ZJ43; ZJ-43; N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid; (2S) -2- [ [ (1S) -1-carboxy-3-methylbutyl] carbamoylamino] pentanedioic acid. CAS No. 723331-20-2. Molecular formula: C12H20N2O7. Mole weight: 304.3. | |
| Carboxypeptidase G2 (CPG2) Inhibitor | A novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents. Synonyms: CPG2 Inhibitor; L-Glutamic acid, N-[[(4-methoxyphenyl)thio]carbonyl]-. Grades: >98%. CAS No. 192203-60-4. Molecular formula: C13H15NO6S. Mole weight: 313.33. | |
| FA-Glu-Glu-OH | FA-Glu-Glu-OH is the preferred substrate for carboxypeptidase O in humans and zebrafish. Synonyms: N-[(2E)-3-(2-Furyl)-2-propenoyl]-L-α-glutamyl-L-glutamic acid; L-Glutamic acid, N-[(2E)-3-(2-furanyl)-1-oxo-2-propen-1-yl]-L-α-glutamyl-; (S) -2- ( (S) -4-carboxy-2- ( (E) -3- (furan-2-yl) acrylamido) butanamido) pentanedioic acid; FA-EE-OH. Grades: ≥90%. CAS No. 1374423-90-1. Molecular formula: C17H20N2O9. Mole weight: 396.35. | |
| γ-D-glutamyl-meso-diaminopimelate peptidase | A 45-kDa metallopeptidase from Bacillus sphaericus, the substrates being components of the bacterial spore wall. A member of peptidase family M14 (carboxypeptidase A family). Endopeptidase II has similar activity, but differs in cellular location, molecular mass and catalytic mechanism. Group: Enzymes. Synonyms: endopeptidase I; γ-D-glutamyldiaminopimelate endopeptidase; γ-D-glutamyl-L-meso-diaminopimelate peptidoglycan hydrolase; γ-glutamyl-L-meso-diaminopimelyl endopeptidase; γ-D-glutamyl-meso-diaminopimelate endopeptidase; γ-D-glutamyl-meso-diaminopimelic peptidoglycan hydrolase; γ-D-glutamyl-m. Enzyme Commission Number: EC 3.4.19.11. CAS No. 62572-28-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4083; γ-D-glutamyl-meso-diaminopimelate peptidase; EC 3.4.19.11; 62572-28-5; endopeptidase I; γ-D-glutamyldiaminopimelate endopeptidase; γ-D-glutamyl-L-meso-diaminopimelate peptidoglycan hydrolase; γ-glutamyl-L-meso-diaminopimelyl endopeptidase; γ-D-glutamyl-meso-diaminopimelate endopeptidase; γ-D-glutamyl-meso-diaminopimelic peptidoglycan hydrolase; γ-D-glutamyl-meso-diaminopimelic endopeptidase; γ-D-glutamyl-meso-D-aminopimelic endopeptidase. Cat No: EXWM-4083. | |
| muramoylpentapeptide carboxypeptidase | A bacterial enzyme that requires a divalent cation for activity. Does not cleave the C-terminal D-alanine from the product of the above reaction, UDP-N-acetyl-muramoyl-L-alanyl-γ-D-glutamyl-6-carboxy-L-lysyl-D-alanine. Competitively inhibited by penicillins and cephalosporins. Group: Enzymes. Synonyms: D-alanine carboxypeptidase I; DD-carboxypeptidase; D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase; D-alanine-D-alanine-carboxypeptidase; carboxypeptidase D-alanyl-D-alanine; carboxypeptidase I; UDP-N-acetylmuramoyl-tetrapeptidyl-D-alanine alanine-hydrolase; D-alanyl-D-alanine peptidase; DD-peptidase; penicillin binding protein 5; PBP5; PdcA; VanY. Enzyme Commission Number: EC 3.4.17.8. CAS No. 9077-67-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4080; muramoylpentapeptide carboxypeptidase; EC 3.4.17.8; 9077-67-2; D-alanine carboxypeptidase I; DD-carboxypeptidase; D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase; D-alanine-D-alanine-carboxypeptidase; carboxypeptidase D-alanyl-D-alanine; carboxypeptidase I; UDP-N-acetylmuramoyl-tetrapeptidyl-D-alanine alanine-hydrolase; D-alanyl-D-alanine peptidase; DD-peptidase; penicillin binding protein 5; PBP5; PdcA; VanY. Cat No: EXWM-4080. | |
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