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| Product | Description | |
|---|---|---|
| glutamate carboxypeptidase II | A metallo-carboxypeptidase that is predominantly expressed as a membrane-bound enzyme of 94-100 kDa, but also exists in a soluble form. Hydrolyses α-peptide bonds in Ac-Asp-Glu, Asp-Glu, and Glu-Glu, but also γ-glutamyl bonds in γ-Glu-Glu, and folylpoly-γ-glutamates. With folylpoly-γ-glutamates, shows processive carboxypeptidase activity to produce pteroylmonoglutamate. Does not hydrolyse Ac-β-Asp-Glu. Known inhibitors: quisqualic acid, Ac-β-Asp-Glu, and 2-phosphonomethyl-pentanedioate. In peptidase family M28 of Vibrio leucyl aminopeptidase. The release of C-terminal glutamate from folylpoly-γ-glutamates is also catalysed by EC 3.4.17.11 (glutamate carboxypeptidase) and EC 3.4.19.9 (γ-Glu-X carboxypeptidase). Group: Enzymes. Synonyms: N-acetylated-γ-linked-acidic dipeptidase (NAALADas. Enzyme Commission Number: EC 3.4.17.21. CAS No. 9074-87-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4074; glutamate carboxypeptidase II; EC 3.4.17.21; 9074-87-7; N-acetylated-γ-linked-acidic dipeptidase (NAALADase); folate hydrolase; prostate-specific membrane antigen; pteroylpoly-γ-glutamate carboxypeptidase; microsomal γ-glutamyl carboxypeptidase; pteroylpolyglutamate hydrolase; folylpolyglutamate h. |  |
| 2-MPPA | 2-MPPA is a selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM), which is selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. 2-MPPA can be used in the treatment of neurological disorders associated with excessive activation of glutamatergic systems. Attenuates glutamate transmission resulting in the relief of neuropathic pain. This compound has neuroprotective properties. Synonyms: 2-(3-Mercaptopropyl)pentanedioic acid; 2-MPPA; 2 MPPA; 2MPPA. CAS No. 254737-29-6. Molecular formula: C8H14O4S. Mole weight: 206.26. |  |
| 2- (Phosphonomethyl) pentanedioic Acid | 2- (Phosphonomethyl) pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia. Group: Biochemicals. Grades: Highly Purified. CAS No. 173039-10-6. Pack Sizes: 10mg, 50mg. Molecular Formula: C6H11O7P, Molecular Weight: 226.12. US Biological Life Sciences. |  Worldwide |
| 2-PMPA | 2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II ( GCPII ) with an IC 50 of 300 pM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-(Phosphonomethyl)pentanedioic acid. CAS No. 173039-10-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100788. |  |
| Benzyl Acrylate (Stabilized with 50ppm of MEHQ) | Benzyl Acrylate, is a reagent that can be used in the preparation of 2- (Phosphonomethyl) pentanedioic Acid (P353900), a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates. Group: Biochemicals. Grades: Highly Purified. CAS No. 2495-35-4. Pack Sizes: 5g, 25g. Molecular Formula: C10H10O2. US Biological Life Sciences. | Worldwide |
| D-Dopa | D-Dopa is a non-competitive, allosteric inhibitor for glutamate carboxypeptidase II (GCPII) with an IC 50 of 200 nM. D-Dopa exhibits good pharmacokinetic characteristics, and low blood-brain barrier permeability in mouse model [1]. Uses: Scientific research. Group: Peptides. Alternative Names: 3-Hydroxy-D-tyrosine. CAS No. 5796-17-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W096171. | |
| γ-glutamyl hydrolase | A lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH. Commonly studied with folylpoly-γ-glutamate as substrate, with which the initial cleavage may release glutamate or poly-γ-glutamate of two or more residues, according to the species of origin of the enzyme. Final products are pteroyl-α-glutamate (folic acid) and free glutamate. Highly specific for the γ-glutamyl bond, but not for the C-terminal amino acid (leaving group). Action on γ-glutamyl bonds is independent of an N-terminal pteroyl moiety, but it is not known whether an N-terminal γ-Glu residue can be hydrolysed. Type example of peptidase family C26. Group: Enzymes. Synonyms: conjugase; folate conjugase; lysosomal γ-glutamyl carboxypeptid. Enzyme Commission Number: EC 3.4.19.9. CAS No. 9074-87-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4092; γ-glutamyl hydrolase; EC 3.4.19.9; 9074-87-7; conjugase; folate conjugase; lysosomal γ-glutamyl carboxypeptidase; γ-Glu-X carboxypeptidase; pteroyl-poly-γ-glutamate hydrolase; carboxypeptidase G; folic acid conjugase; poly(γ-glutamic acid) endohydrolase; polyglutamate hydrolase; poly(glutamic acid) hydrolase II; pteroylpoly-γ-glutamyl hydrolase. Cat No: EXWM-4092. | |
| Glutamate carboxypeptidase 2 (178-186) | Glutamate carboxypeptidase 2 (178-186) is a 9-aa peptide. Glutamate carboxypeptidase 2 has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Synonyms: Folate hydrolase 1 (178-186); Folylpoly-gamma-glutamate carboxypeptidase (178-186); Glutamate carboxypeptidase II (178-186); Membrane glutamate carboxypeptidase (178-186). | |
| γ-D-glutamyl-meso-diaminopimelate peptidase | A 45-kDa metallopeptidase from Bacillus sphaericus, the substrates being components of the bacterial spore wall. A member of peptidase family M14 (carboxypeptidase A family). Endopeptidase II has similar activity, but differs in cellular location, molecular mass and catalytic mechanism. Group: Enzymes. Synonyms: endopeptidase I; γ-D-glutamyldiaminopimelate endopeptidase; γ-D-glutamyl-L-meso-diaminopimelate peptidoglycan hydrolase; γ-glutamyl-L-meso-diaminopimelyl endopeptidase; γ-D-glutamyl-meso-diaminopimelate endopeptidase; γ-D-glutamyl-meso-diaminopimelic peptidoglycan hydrolase; γ-D-glutamyl-m. Enzyme Commission Number: EC 3.4.19.11. CAS No. 62572-28-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4083; γ-D-glutamyl-meso-diaminopimelate peptidase; EC 3.4.19.11; 62572-28-5; endopeptidase I; γ-D-glutamyldiaminopimelate endopeptidase; γ-D-glutamyl-L-meso-diaminopimelate peptidoglycan hydrolase; γ-glutamyl-L-meso-diaminopimelyl endopeptidase; γ-D-glutamyl-meso-diaminopimelate endopeptidase; γ-D-glutamyl-meso-diaminopimelic peptidoglycan hydrolase; γ-D-glutamyl-meso-diaminopimelic endopeptidase; γ-D-glutamyl-meso-D-aminopimelic endopeptidase. Cat No: EXWM-4083. | |
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