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Cell-permeable. An anti-diabetic agent. ATP-sensitive potassium channel (KATP) blocker. Inhibits KATP currents in the pancreatic beta cells causing an increase in intracellular Ca2+ and insulin secretion. Group: Biochemicals. Grades: Highly Purified. CAS No. 10238-21-8. Pack Sizes: 500mg, 1g. US Biological Life Sciences.
rac cis-3-Hydroxy Glyburide is a metabolite of Glyburide which is used as an antidiabetic (MII-metabolite). Group: Biochemicals. Alternative Names: rel-5-Chloro-N- [2- [4- [ [ [ [ [ (1R, 3S) -3-hydroxycyclohexyl] amino] carbonyl] amino] sulfonyl] phenyl] ethyl] -2-methoxybenzamide; cis-1-[[p-[2- (5-Chloro-o-anisamido) ethyl]phenyl]sulfonyl]-3- (3-hydroxycyclohexyl) urea; 3-cis-Hydroxycyclohexyl Glyburide; 3-cis-Hydroxyglibenclamide; cis-3-Hydroxyglyburide. Grades: Highly Purified. CAS No. 23074-02-4. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
rac cis-3-Hydroxy Glyburide-13C,d3
Labeled rac cis-3-Hydroxy Glyburide. rac cis-3-Hydroxy Glyburide is a metabolite of Glyburide which is used as an antidiabetic (labeled MII-metabolite). Group: Biochemicals. Alternative Names: el-5-Chloro-N- [2- [4- [ [ [ [ [ (1R, 3S) -3-hydroxycyclohexyl] amino] carbonyl] amino] sulfonyl] phenyl] ethyl] -2- (methoxy-13C, d3) benzamide; cis-1-[[p-[2- (5-Chloro-o-anisamido) ethyl]phenyl]sulfonyl]-3- (3-hydroxycyclohexyl) urea-13C, d3; 3-cis-Hydroxycyclohexyl Glyburide-13C,d3; 3-cis-Hydroxyglibenclamide-13C,d3; cis-3-Hydroxyglyburide-13C,d3. Grades: Highly Purified. CAS No. 1217848-91-3. Pack Sizes: 1mg. US Biological Life Sciences.
A metabolite of Glyburide which is used as an antidiabetic. Group: Biochemicals. Alternative Names: 5-Chloro-N- [2- [4- [ [ [ [ (4-hydroxycyclohexyl) amino] carbonyl] amino] sulfonyl] phenyl) ethyl] -2-methoxy-benzamide, 4-Hydroxyglibenclamide. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Glibenclamide Impurity A is an impurity arising in the synthesis of Glyburide. Synonyms: 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide. Grades: > 95 %. CAS No. 16673-34-0. Molecular formula: C16H17ClN2O4S. Mole weight: 368.84.
A metabolite of Glyburide which is used as an antidiabetic. Synonyms: 4-Hydroxyglibenclamide; rac trans-4-Hydroxy Glyburide; 23155-00-2; rac cis-4-Hydroxy Glyburide; 23155-04-6; 132054-81-0; trans-4-Hydroxyglyburide; 4-trans-Hydroxyglibenclamide; 4-trans-Hydroxy-glibenclamide; 4-Hydroxyglyburide, trans-; 4-trans-Hydroxycyclohexyl Glyburide; 8J8OD7PL2J; rac-trans-4-hydroxy Glyburide; 5-chloro-N-[2-[4-[ (4-hydroxycyclohexyl) carbamoylsulfamoyl]phenyl]ethyl]-2-methoxybenzamide; cis-5-Chloro-N-[2-[4-[[[[(4-hydroxycyclohexyl); aMino] carbonyl] aMino] sulfonyl] phenyl] ethyl] -2-MethoxybenzaMide; 5-Chloro-N- (4- (N- ( (4-hydroxycyclohexyl) carbamoyl) sulfamoyl) phenethyl) -2-methoxybenzamide. CAS No. 23155-00-2. Molecular formula: C23H28ClN3O6S. Mole weight: 510.
5-Chloro-N-(2-Phenylethyl)-2-Methoxy-Benzamide
5-Chloro-N-(2-Phenylethyl)-2-Methoxy-Benzamide is a metabolite of the antidiabetic, Glyburide. Synonyms: 5-Chloro-N-phenethyl-o-anisamide; N-Phenethyl-5-chloro-2-methoxybenzamide; 5-Chloro-2-methoxy-N-(2-phenylethyl)benzamide. Grades: > 95%. CAS No. 33924-49-1. Molecular formula: C16H16ClNO2. Mole weight: 289.76.
Dimethyl DL-glutamate hydrochloride
Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide Dimethyl DL-glutamate is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. Synonyms: Glutamic acid dimethyl ester; Dimethyl 2-aminopentanedioate; Dimethyl 2-aminopentanedioate hydrochloride; H-DL-Glu(OMe)-OMe.HCl; H-DL-Glu(Ome)-Ome. Grades: ≥ 98% (HPLC). CAS No. 13515-99-6. Molecular formula: C7H13NO4·HCl. Mole weight: 211.6.
Glibenclamide
Glibenclamide (Glyburide) is an orally active ATP-sensitive K + channel ( K ATP ) inhibitor and can be used for the research of diabetes and obesity [1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein ( CFTR ) [3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability [4]. Glibenclamide can induce autophagy [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Glyburide. CAS No. 10238-21-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15206.
Glibenclamide EP Impurity B
Glibenclamide EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Glyburide USP Related Compound B; methyl (4- (2- (5-chloro-2-methoxybenzamido) ethyl) phenyl) sulfonylcarbamate. CAS No. 21165-77-5. Molecular Formula: C18H19ClN2O6S. Mole Weight: 426.87. Catalog: APB21165775.
Glibenclamide potassium salt
Glibenclamide potassium salt is a salt form of Glibenclamide, a KATP channel blocker used for the treatment of type 2 diabetes. Glibenclamide binds to and inhibits the sulfonylurea receptor 1 (SUR1), the regulatory subunit of the ATP-sensitive potassium channels (KATP) in pancreatic β cells. Uses: Antidiabetic. Synonyms: Glibenclamide potassium salt; Glyburide potassium salt; 23047-14-5; dipotassium; 5-chloro-N-[2-[4-[ (N-cyclohexyl-C-oxidocarbonimidoyl) sulfamoyl]phenyl]ethyl]-2-methoxybenzenecarboximidate; E99010; 5-chloro-N- (4- (N- (cyclohexylcarbamoyl) sulfamoyl) phenethyl) -2-methoxybenzamide potassium. Grades: 99%. CAS No. 23047-14-5. Molecular formula: C23H26ClK2N3O5S. Mole weight: 570.18.
NLRP3-IN-2, an intermediate substrate in the synthesis of glyburide, inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size following myocardial ischemia/reperfusion in the mouse, without affecting glucose metabolism [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 16673-34-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W011082.
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